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Ursobond Tablet

Written By Dr. Lipika Khurana, PGDHHM, BDS
Reviewed By Dr. Sachin Gupta, MD Pharmacology, MBBS
Last updated on 26 Aug 2025 | 09:32 AM (IST)
Ursobond Tablet is a medicine used to dissolve certain gallstones and prevent them from forming. It helps break down the cholesterol that has converted into stones in your gallbladder, thereby dissolving the stones. It is also used to treat a type of liver disease called primary biliary cirrhosis.
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Ursobond Tablet image
Ursobond Tablet image
Ursobond Tablet image
Ursobond Tablet image

Product introduction

Ursobond Tablet should be swallowed whole after a meal and with a glass of milk or water. The dose will depend on what you are being treated for and your health condition. Take it regularly to get maximum benefit, and keep taking it for as long as prescribed (several months or longer). Keep taking it even if your symptoms disappear.


The most common side effects of Ursobond Tablet are abdominal pain, diarrhea, hair loss, itching, nausea, and rash. Not everyone gets these side effects. If you are worried about them or they do not go away, let your doctor know. They may be able to suggest ways to manage them or prescribe an alternative medicine.


Before taking this medicine, you should tell your doctor if you have an inflammation of the gallbladder or bile ducts, frequent cramp-like pain in your upper abdomen, coughing up blood, or gaining weight rapidly. Using this medicine can reduce or increase the effect of some other medicines, so tell your doctor about all the other medicines you are taking. Pregnant and breastfeeding women should consult their doctor before using this medicine to make sure it is safe for them.

Uses of Ursobond Tablet

Benefits of Ursobond Tablet

Treatment of Gallbladder stones
Ursobond Tablet is a medicine that helps decreases the amount of cholesterol produced by your liver. It helps to break down cholesterol that has formed into “stones” in the gallbladder. It may take several months to completely dissolve the stone, so you need to take the medicine regularly and as long as the doctor has prescribed it for it to be effective. There might be other medicines and certain lifestyle changes that can reduce your cholesterol level and make gallstones less likely, consult with your doctor.
Treatment of Primary biliary cirrhosis
Primary biliary cholangitis is a type of liver disease that gradually gets worse over time. It does not always have symptoms but, over time, it can lead to liver failure. Ursobond Tablet is used to treat this condition and may be used by itself or with other medicines. It can help prevent or delay liver damage in most people, especially if you start taking it in the early stages. Once you start this treatment, you will likely be taking it for the rest of your life. To make the medicine more effective and for general health benefits, you can help yourself by stopping smoking, keeping a healthy weight, and not drinking too much alcohol.

Side effects of Ursobond Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Ursobond
  • Abdominal pain
  • Diarrhea
  • Hair loss
  • Itching
  • Nausea
  • Rash

How to use Ursobond Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Ursobond Tablet is to be taken with food.

How Ursobond Tablet works

Ursobond Tablet is a hepatoprotective medication. It works by reducing the amount of cholesterol in the blood and helps dissolve gallbladder stones that are composed mainly of cholesterol. It also improves liver enzymes, protects liver cells from injury caused due to toxic bile acids, and improves liver function.

Quick tips

  • Ursobond Tablet should be taken after a meal with a glass of milk or water.
  • Eat a healthy diet, exercise regularly, and avoid alcohol intake.
  • Diarrhea may occur as a side effect. Drink plenty of fluids and inform your doctor if diarrhea persists or if you find blood in your stools.
  • Your doctor may monitor your liver function and bilirubin levels every month for the next 3 months after the start of therapy and every 6 months thereafter.
  • Do not stop taking the medication without talking to your doctor.

Safety advice

Alcohol

Alcohol

CAUTION
Caution is advised when consuming alcohol with Ursobond Tablet. Please consult your doctor.
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
Ursobond Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Breast feeding

Breast feeding

CAUTION
Ursobond Tablet should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from her body.
Driving

Driving

SAFE
Ursobond Tablet does not usually affect your ability to drive.
Kidney

Kidney

CONSULT YOUR DOCTOR
There is limited information available on the use of Ursobond Tablet in patients with kidney disease. Please consult your doctor.
Liver

Liver

CAUTION
Ursobond Tablet should be used with caution in patients with liver disease. Dose adjustment of Ursobond Tablet may be needed. Please consult your doctor.

Interaction with drugs

Taking Ursobond with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Moderate

Magaldrate (Oral Route)

Ensure a gap of at least 2 hours between taking Ursodeoxycholic Acid and Magaldrate.
Moderate

Allylestrenol (Oral Route)

Careful consideration is advised when taking Ursodeoxycholic Acid with Allylestrenol. Your doctor may monitor your treatment and adjust the doses as per the observations.
Moderate

Bezafibrate (Oral Route)

Do not consume Ursodeoxycholic Acid with Bezafibrate. If concurrent use is essential, your doctor may monitor the effects of Ursodeoxycholic Acid along with your overall treatment and adjust the doses as per the observations. Bezafibrate may reduce the efficacy of Ursodeoxycholic Acid.
Moderate

Cholestyramine (Oral Route)

Ensure a gap of at least 2 hours between taking Ursodeoxycholic Acid and Cholestyramine. Your doctor may monitor the effects of Ursodeoxycholic Acid. Cholestyramine may reduce blood levels of Ursodeoxycholic Acid.
Moderate

Colesevelam (Oral Route)

Ensure a gap of at least 4 hours between taking Ursodeoxycholic Acid and Colesevelam. Your doctor may monitor your treatment and adjust the doses as per the observations. Colesevelam may reduce blood levels of Ursodeoxycholic Acid.

Frequently asked questions

The suitable timing of taking this medicine might differ depending on your condition. Your doctor might instruct you to take 2 to 3 doses per day and suggest taking the last dose at bedtime. Ursobond Tablet should be taken with water or milk after food. When prescribed for dissolving gallstones, it is usually suggested to be taken once daily at night.
Ursobond Tablet is usually considered to be a safe and effective medicine. However, this medicine may have some common side effects, such as diarrhea. If diarrhea occurs, your doctor may reduce the dose, and if it persists, your treatment may be discontinued. Additionally, using this medicine as a long-term therapy may also affect your liver enzyme levels. To keep a check on this, your doctor will keep monitoring your liver enzyme levels regularly. Despite these minor side effects, this medicine is supposed to be a good alternative to surgery in some patients with gallstones.
Ursobond Tablet acts on the liver and gets concentrated in the bile secreted from the liver. This, as a result, suppresses the synthesis and secretion of cholesterol by the liver, thereby decreasing the cholesterol levels in bile. This medicine also acts by stopping the intestines from absorbing the bile salts and cholesterol. So, the reduced cholesterol saturation in the bile from the liver leads to the gradual dissolving of cholesterol from gallstones, leading to a decrease in size and their eventual dissolution. It also reduces elevated liver enzyme levels by increasing the bile flow through the liver, hence protecting the liver cells.
Yes, there is a chance of weight gain with Ursobond Tablet, but it is not common. The use of Ursobond Tablet can cause weight gain when prescribed in patients with liver disease associated with chronic stasis of bile in the small bile ducts of the liver. In such conditions, bile cannot flow from the liver to the small intestine. Again, the chance of weight gain varies from person to person depending on the disease, so consult your doctor if you experience weight gain.
While taking Ursobond Tablet, avoid taking an antacid preparation without consulting your doctor, as they decrease the effectiveness of Ursobond Tablet. You should also avoid medicines like cholestyramine or colestipol, as they affect the effectiveness of Ursobond Tablet. Ask your doctor about the time gap that should be maintained between Ursobond Tablet and these medicines. Also, avoid taking oral contraceptives, estrogenic hormones, and blood cholesterol-lowering agents such as clofibrate, as they may increase the chances of developing gallstones and act opposite to the Ursobond Tablet.

Fact Box

Chemical Class

Bile Acids and Salts

Habit Forming

No

Therapeutic Class

GASTRO INTESTINAL

Action Class

Hepatoprotective Agents

Related lab tests

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Manufacturer details

Name: Pure & Cure Healthcare Pvt. Ltd. (A subsidiary of Akums Drugs & Pharmaceuticals Ltd.)
Address: Plot No. 26A, 27-30, Sector-8A, I.I.E., SIDCUL, Ranipur, Haridwar-249 403, Uttarakhand/Vill. Manakpur, P.O. Lodhimajra, Baddi-173 205, Distt.-Solan, (H.P.)

Marketer details

Name: Parnasa Mediworld Pvt Ltd
Address: 14, Kaushalya Park, Hauz Khas, New Delhi, Delhi - 110016, India

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Ursobond Tablet. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India
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