Unitrexate 500 Injection

Reviewed By Dr. Mekhala Chandra, MD, MBBS

Last updated on 25 Nov 2025 | 03:05 PM (IST)

Unitrexate 500 Injection is a medicine used for treatment of cancer in various parts of the body such as breasts, head, neck, lungs, blood, bone, lymph, and uterus. It may be used with other medicines as part of combination therapy.

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Biotrexate 500mg Injection

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Unitrexate 500 Injection

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Same composition

Biotrexate 500mg Injection

vial of 1 Injection

Methotrexate (500mg)

by Biochem Pharmaceutical Industries

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General Information

Contains

Methotrexate (500mg)

Marketer

United Biotech Pvt Ltd

Storage

Store below 30°C

The content is shown in English

Product introduction

Unitrexate 500 Injection is given under the supervision of a healthcare professional and should not be self-administered. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. You should avoid drinking alcohol as it may increase your risk of liver damage.

The most common side effects of this medicine include nausea, vomiting, loss of appetite, abdominal pain, tiredness, mouth sores, and decreased white blood cells. Your doctor may advise you to take folic acid to reduce some of these. If they do not go away or get worse, tell your doctor. There may be ways of preventing or reducing these effects. It is a very strong medicine and some people may develop serious side effects while taking it. This medicine may lower your ability to fight infections and lead to problems with your blood, liver, or kidneys. Your doctor will advise you regular blood tests to check for these.

Before taking it, tell your doctor if have stomach, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. It may harm your baby. You and your partner should avoid becoming pregnant or fathering a child for several months after your treatment with it has stopped. Your doctor may perform several tests such as blood tests, X-rays, and physical examinations both before and during treatment with this medicine.

Uses of Unitrexate Injection

Cancer

Benefits of Unitrexate Injection

Cancer
Unitrexate 500 Injection belongs to a group of medicines called antimetabolites and is referred to as a cytotoxic. It works by slowing the growth of cancer cells in the body. It is used to treat a wide range of cancers such as acute leukemias, non-Hodgkin’s lymphoma, and solid tumors found in breast, lung, bladder, head and neck as well as cervical, ovarian and testicular cancer. It may be given alone or in combination with other medicines. It is a potent and very toxic medicine and you should discuss the risks and benefits with your doctor. You should avoid drinking alcohol while having this treatment and drink plenty of water to stay hydrated.

Side effects of Unitrexate Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Unitrexate

Abdominal pain
Indigestion
Loss of appetite
Nausea
Vomiting
Tiredness
Mouth sore
Decreased white blood cell count

How to use Unitrexate Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Unitrexate Injection works

Unitrexate 500 Injection is an anti-cancer medication. It works by blocking an enzyme (dihydrofolate reductase) involved in DNA synthesis in cancer cells. This slows the growth of cancer cells and eventually kills them.

All substitutes for Unitrexate 500 Injection

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

Unitrexate 500 Injection helps treat various types of cancer such as blood cancer, bone cancer, non-Hodgkin lymphoma (NHL), breast cancer, lung cancer, head and neck cancer, cervical cancer, ovarian cancer and testicular cancer.
Take it once a week, on the same day every week.
Drink plenty of liquids to stay hydrated while taking this medication.
Always take folic acid as advised by your doctor. This will help lessen the side effects of this medicine.
It may take 6 to 8 weeks for Unitrexate 500 Injection to work. Keep taking the medication as prescribed.
Avoid drinking alcohol while taking this medicine as it may increase the risk of side effects.
It can be harmful to an unborn baby. Avoid pregnancy for at least 6 months after your last dose.
Your doctor may get regular blood test done to monitor your kidney function, liver function and level of blood cells in your blood.

Safety advice

Alcohol

CAUTION

Alcohol should be used with caution while taking Unitrexate 500 Injection.

Pregnancy

UNSAFE

Unitrexate 500 Injection is highly unsafe during pregnancy. It can cause serious harm to the unborn baby, including birth defects and pregnancy loss. Do not use this medicine if you are pregnant or planning to become pregnant.

Breast feeding

UNSAFE

Unitrexate 500 Injection is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

Driving

UNSAFE

Unitrexate 500 Injection may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

Kidney

CAUTION

Unitrexate 500 Injection should be used with caution in patients with kidney disease. Dose adjustment may be needed.
Regular monitoring of kidney function test is advised while you are taking this medicine.

Liver

CAUTION

Unitrexate 500 Injection should be used with caution in patients with liver disease. Dose adjustment may be needed.
Use of Unitrexate 500 Injection is not recommended in patients with severe liver disease.

Interaction with drugs

Taking Unitrexate with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Severe

Filgrastim (Injection Route)

Do not consume Filgrastim from 24 hours before or 24 hours after taking Methotrexate. Please consult with your doctor. Methotrexate may reduce the efficacy of Filgrastim.

Severe

Sargramostim (Injection Route)

Do not consume Methotrexate from 1 day before until 1 day after taking Sargramostim. Please consult your doctor.

Severe

Lenograstim (Injection Route)

Do not consume Lenograstim from 24 hours before until 24 hours after undergoing cytotoxic chemotherapy.

Severe

Molgramostim (Injection Route)

Do not consume Methotrexate from 1 day before until 1 day after taking Molgramostim. Please consult your doctor.

Severe

Aceclofenac (Oral Route)

Please consult with your doctor. Doctor may monitor liver function and blood cell counts.

Fact Box

Chemical Class

Glutamic acid derivative

Habit Forming

Therapeutic Class

ANTI NEOPLASTICS

Action Class

Antimetabolite- Methotrexate

References

Chu E, Sartorelli AC. Cancer Chemotherapy. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 944-46.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 887-90.
Methotrexate [Product Information]. Taj Pharma. [Accessed 04 Aug. 2023]. (online) Available from:
Methotrexate [New Zealand Data Sheet]. Auckland, New Zealand: Novartis New Zealand Ltd; 2023. [Accessed 04 Aug. 2023]. (online) Available from:

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: United Biotech Pvt Ltd
Address: FC/B-1 (Extn.), Mohan Co-operative Industrial Estate Mathura Road, New Delhi - 110 044

Vendor Details

Country of origin: India

Lab tests offered by us

Why we need a prescription?

Provide right medicines

Prescriptions are complex documents. We proof read and recheck at various steps to provide you the right medication in the correct form and dose

In accordance with the law

Most medicines cannot be sold without a valid prescription, as per the Drugs and Cosmetics Act, 1940 and Rules, 1945

Unitrexate 500 Injection

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General Information

Contains

Marketer

Storage

Product introduction

Uses of Unitrexate Injection

Benefits of Unitrexate Injection

Side effects of Unitrexate Injection

How to use Unitrexate Injection

How Unitrexate Injection works

All substitutes for Unitrexate 500 Injection

Biotrexate 500mg Injection

Metho ML 500mg Injection

Plastomet Injection

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Filgrastim (Injection Route)

Sargramostim (Injection Route)

Lenograstim (Injection Route)

Molgramostim (Injection Route)

Aceclofenac (Oral Route)

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

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