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Last updated on:
10 Sep 2019 | 04:52 PM (IST)
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Tykerb 250 mg Tablet


Overview

Introduction of Tykerb Tablet

Tykerb 250 mg Tablet is used in the treatment of breast cancer.

Tykerb 250 mg Tablet should be taken in a dose as recommended by the doctor. You should continue to take it as long as your doctor advises for it. The duration of treatment varies according to your need and response to treatment. Your doctor may advise some tests for liver and heart function while your taking this medicine. You should check blood pressure while taking Tykerb 250 mg Tablet and inform doctor if you notice symptoms like severe headache, confusion, or vomiting.

Women who are undergoing treatment should use effective contraception method. It is important to avoid pregnancy during the treatment and for one month after completing the course of medicine. This medicine may make your skin more sensitive to sun, so it is better to use sunscreen and protective clothing when outdoors. Diarrhea may occur as its side effect, so drink plenty of fluids. But, you must inform doctor if it does not stop or you find blood in stools.

Uses of Tykerb Tablet

Tykerb Tablet side effects

Common
  • Nausea
  • Headache
  • Back pain
  • Breathing difficulty
  • Rash
  • Joint pain
  • Pain in extremity
  • Insomnia (difficulty in sleeping)
  • Vomiting
  • Weakness
  • Abdominal pain
  • Indigestion
  • Loss of appetite
  • Fatigue
  • Diarrhea
  • Cough
  • Mucosal inflammation
  • Constipation
  • Hot flashes
  • Stomatitis (Inflammation of the mouth)
  • Weight gain
  • Increased bilirubin in the blood
  • Liver damage

How to use Tykerb Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Tykerb 250 mg Tablet is to be taken empty stomach.

How Tykerb Tablet works

Tykerb 250 mg Tablet is an anti-cancer medication. This works against the HER2 (human epidermal growth factor receptor protein) receptors and EGFRs (epidermal growth factor receptor) which is responsible for the over-proliferation of cells. This is how it inhibits the growth of cancerous cells causing downstream signaling pathways.

Tykerb Tablet related warnings

Alcohol
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Tykerb 250 mg Tablet. Please consult your doctor.
Pregnancy
CONSULT YOUR DOCTOR
Tykerb 250 mg Tablet is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
Lactation
UNSAFE
Tykerb 250 mg Tablet is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
Driving
UNSAFE
Tykerb 250 mg Tablet may cause side effects which could affect your ability to drive.
Kidney
CAUTION
Tykerb 250 mg Tablet should be used with caution in patients with severe kidney disease. Dose adjustment of Tykerb 250 mg Tablet may be needed. Please consult your doctor.
Limited information is available on the use of Tykerb 250 mg Tablet in these patients. No dose adjustment is recommended in patients with mild to moderate kidney disease.
Liver
CAUTION
Tykerb 250 mg Tablet should be used with caution in patients with liver disease. Dose adjustment of Tykerb 250 mg Tablet may be needed. Please consult your doctor.
Limited information is available on the use of this medicine in patients with the severe liver disease.

Alternate Brands

For informational purposes only. Consult a doctor before taking any medicines.
Tykerb 250 mg Tablet
₹445/Tablet
Libset Tablet
Intas Pharmaceuticals Ltd
₹199.83/Tablet
save 55%

Expert Advice

  • Tykerb 250 mg Tablet is used for the treatment of thyroid cancer.
  • It should be taken 1 hour before or after the meal, preferably at the same time every day. 
  • Diarrhea may occur as a side effect. Drink plenty of fluids and inform your doctor if it doesn't stop or if you find blood in your stools.
  • Use a reliable contraceptive method to prevent pregnancy while you are taking this medicine and for a month after you stop taking it.
  • Monitor your blood pressure regularly while taking this medication. Inform your doctor if you notice symptoms of very high blood pressure such as severe headache, confusion, problems with your eyesight, nausea or vomiting.
  • It may cause serious bleeding problem. Inform your doctor if you get headaches, stomach pain or if you notice blood in your urine or stools.
  • Do not take this medicine if you are pregnant, planning to conceive or breastfeeding.

Patient Concerns

Questions Related to Tykerb

arrow
I had a 1-2 Stage breast cancer and mastectomy was done for left breast in 2011. Earlier I was taking Tamoxifen Citrate 20mg. Now, prescribed Altraz 1mg. Which is better and can I continue with Tamoxifen as Altraz is too costly.
Dr. Vijay Sharnangat
Cancer Specialist
Why this tablet is changed, has your doctor told you about that why he is changing your medicines.
surger and chemotherapy radiation therapy has done for breast cancer stage II. Presently hormone treatment is going on. Tamoxifen citrate tablet 20 is taking every day for 5 years as per dactors prescription. Can you suggest any new medicine for further treatment
Dr. Vijay Sharnangat
Cancer Specialist
No new medicines needed.
arrow
Do you have any questions related to Tykerb 250 mg Tablet?

User Feedback


FAQs

Q. Is Tykerb a chemotherapy medicine?

No, this is a targeted drug which belongs to a class of anti-cancer medicines. They are more specific than chemotherapy in their mechanisms of action. Tykerb belongs to tyrosine kinase inhibitors group of medicines. It works by blocking the action of the abnormal protein that signals cancer cells to multiply. This helps stop or slow the spread of cancer cells.

Q. Can Tykerb be given in combination with other anti-cancer drug?

Yes, Tykerb can be used with other anti-cancer drugs. Generally, it is used in combination with capecitabine to treat advanced breast cancer in patients who have already been treated with chemotherapy. Tykerb is also used with letrozole to treat breast cancer in post-menopausal women.

Q. How should I take Tykerb?

You should take Tykerb exactly as advised by your doctor. Swallow Tykerb tablets whole with a glass of water, at the same time each day. It is important that you take Tykerb 1 hour before or 1 hour after meals and at the same time in relation to food each day (e.g., you could always take your tablet one hour before breakfast).

Q. Does Tykerb have any effect on liver?

Tykerb may cause liver damage which can be severe or life threatening. Liver damage can occur as soon as several days or as late as several months after the start of treatment with Tykerb. Inform your doctor if you have or had liver disease. If you experience any of the symptoms such as itching, change in color of the skin or eyes (yellowing), discoloration of urine, pain in the upper right part of the stomach, unusual bleeding or bruising, or pale or dark stools, call your doctor immediately.

Q. How should I manage diarrhea while taking Tykerb?

If you suffer from diarrhoea while taking Tykerb, you should drink plenty of fluids (8 to 10 glasses a day) such as water, sports drinks, or other clear liquids. You should eat low-fat, high protein foods instead of fatty or spicy foods. Eating cooked vegetables instead of raw vegetables and removing the skin from fruits before eating can also be helpful. Try to avoid milk and milk products (including ice cream) and herbal supplements (some may cause diarrhoea). Inform the doctor, if the condition persists, who may interrupt the treatment depending on severity of diarrhoea.

Q. How can I take care of my skin while on Tykerb?

Your doctor will check your skin before and during the treatment. If you have sensitive skin, use a soap-free cleanser and beauty products that are fragrance-free and hypoallergenic . It is also advised that you use a sunscreen with an SPF (Sun Protection Factor) of 30 or higher. Inform your doctor immediately if you get a rash.

Q. What tests will the doctor advise before starting Tykerb?

You may need extra tests to check that your heart and liver are working properly. Tykerb may change the way your heart beats and pumps blood through your body. Your doctor will monitor you carefully to see whether Tykerb has affected your heart. Along with that, your doctor will get your liver function investigated. Based on the results of these tests, the doctor will decide whether dose adjustment or discontinuation of treatment is required.

Q. How long after Tykerb can I plan pregnancy?

Use an effective method of contraception to avoid pregnancy while you are taking Tykerb and continue for at least 1 week after the last dose. Inform your doctor if you become pregnant, who will decide whether to stop or continue treatment.

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Disclaimer: 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover all possible side effects, drug interactions or warnings or alerts. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.
References
  1. Chabner BA, Barnes J, Neal J, et al. Targeted Therapies: Tyrosine Kinase Inhibitors, Monoclonal Antibodies, and Cytokines. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1737-38.
  2. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 779-80.
  3. Lapatinib ditosylate monohydrate. Camberley, Surrey: Novartis Pharmaceuticals UK Ltd.; 2008 [revised 13 Dec. 2018]. [Accessed 23 Jan. 2019] (online) Available from:External Link
  4. Lapatinib. Research Triangle Park, North Carolina: GlaxoSmithKline; 2007 [revised Mar. 2015]. [Accessed 26 Mar. 2019] (online) Available from:External Link
  5. U.S. National Library of Medicine. Lapatinib. [Accessed 26 Mar. 2019] (online) Available from:External Link
  6. Central Drugs Standard Control Organisation (CDSCO). [Accessed 26 Mar. 2019] (online) Available from:External Link
Manufacturer/Marketer Address
Dr. Annie Besant Road, Mumbai - 400 030
A licensed pharmacy from your nearest location will deliver Tykerb 250mg Tablet. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your prescription and the availability of this medicine.
MRP
13350
30 tablets in 1 bottle
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