Trifranil Tablet

Reviewed By Dr. Rajeev Sharma, MBA, MBBS

Last updated on 25 Nov 2025 | 03:05 PM (IST)

Trifranil Tablet is an antibiotic that fights bacteria. It is used to treat certain types of serious infections caused by bacteria. It works by killing the bacteria that cause these infections. However, it will not treat a viral infection.

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General Information

Contains

Chloramphenicol (50mg)

Marketer

Ikon Pharmachem Pvt Ltd

Storage

Store below 25°C

The content is shown in English

Product introduction

Trifranil Tablet can be taken with or without food. You should take it regularly at evenly spaced intervals as per the schedule prescribed by your doctor. Taking it at the same time every day will help you remember to take it.

The dose will depend on what you are being treated for, but you should always complete a full course of this antibiotic as prescribed by your doctor. Do not stop taking it until you have finished the course, even when you feel better. If you stop taking it early, some bacteria may survive, and the infection may come back.

Some people may develop side effects like vomiting, nausea, and diarrhea. These side effects are usually temporary and go away during treatment as your body adjusts to the medicine. Consult your doctor if these side effects bother you or do not go away.

Before starting treatment with this medicine, you should tell your doctor if you have liver or kidney problems or if you are allergic to any antibiotics. While using it, your doctor may advise some blood tests to monitor your blood cell counts. Pregnant and breastfeeding mothers should avoid the use of Trifranil Tablet or consult their doctor.

Trifranil Tablet may cause a condition called grey baby syndrome, where the baby’s skin appears grey, and the baby is listless and weak. This may be fatal and requires immediate medical attention.

Uses of Trifranil Tablet

Bacterial infections

Benefits of Trifranil Tablet

Bacterial infections
Trifranil Tablet is an antibiotic medicine that works by killing the infection-causing bacteria in your body. It is effective for bacterial infections of the throat, ears, urinary tract, skin, and soft tissues. This medicine usually makes you feel better within a few days, but you should continue taking it as prescribed even when you feel better. Stopping it early may make the infection come back and harder to treat.

Side effects of Trifranil Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Trifranil

Vomiting
Nausea
Diarrhea

How to use Trifranil Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Trifranil Tablet may be taken with or without food.

How Trifranil Tablet works

Trifranil Tablet is an antibiotic that stops the growth of bacteria. It does so by preventing the synthesis of essential proteins (50S ribosomal unit) required by bacteria to carry out vital functions. This does not directly kill the bacteria but prevents them from increasing in numbers (bacteriostatic) and eventually clears up the infection.

Quick tips

Do not skip any doses and finish the full course of treatment even if you feel better. Stopping it early may make the infection come back and harder to treat.
Your doctor may get blood tests done to check your blood cells before starting treatment and regularly thereafter.
Do not use Trifranil Tablet if you are pregnant, planning to conceive, or breastfeeding.
Inform your doctor if you have liver or kidney disease.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Trifranil Tablet. Please consult your doctor.

Pregnancy

UNSAFE

Trifranil Tablet is highly unsafe during pregnancy. It can cause serious harm to the unborn baby, including birth defects and pregnancy loss. Do not use this medicine if you are pregnant or planning to become pregnant.

Breast feeding

UNSAFE

Trifranil Tablet is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

Driving

SAFE

Trifranil Tablet does not usually affect your ability to drive.

Kidney

CAUTION

Trifranil Tablet should be used with caution in patients with kidney disease. Dose adjustment may be needed.

Liver

CAUTION

Trifranil Tablet should be used with caution in patients with liver disease. Dose adjustment may be needed.

Interaction with drugs

Taking Trifranil with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Severe

Cholera Vaccine (Inactivated) (Oral Route)

Do not consume Cholera Vaccine (Inactivated) two weeks before and at least 10 days after consuming Chloramphenicol. Please consult your doctor. Chloramphenicol may reduce the efficacy of Cholera Vaccine (Inactivated).

Severe

Purified Vi Polysaccharide Typhoid Vaccine (Injection Route)

Chloramphenicol may reduce the efficacy of Purified Vi Polysaccharide Typhoid Vaccine. Chloramphenicol may reduce the efficacy of Purified Vi Polysaccharide Typhoid Vaccine.

Moderate

Gliclazide (Oral Route)

If concurrent use is essential, watch out for symptoms such as confusion, headache, nausea, dizziness or faintness and consult your doctor if you experience them. They may monitor your diabetic control closely. Chloramphenicol may decrease the metabolism of Gliclazide.

Moderate

Glibenclamide (Oral Route)

Moderate

Glimepiride (Oral Route)

Frequently asked questions

How long does Trifranil Tablet takes to work?

Usually, Trifranil Tablet starts working soon after taking it. However, it may take some days to kill all the harmful bacteria and make you feel better.

What if I don't get better after using Trifranil Tablet?

Inform your doctor if you don't feel better after finishing the full course of treatment. Also, inform them if your symptoms are getting worse while using this medicine.

Can I stop taking Trifranil Tablet when my symptoms are relieved?

No, do not stop taking Trifranil Tablet and complete the full course of treatment even if you feel better. Your symptoms may improve before the infection is completely cured.

Fact Box

Chemical Class

Nitrobenzenes

Habit Forming

Therapeutic Class

ANTI INFECTIVES

Action Class

Bacterial Protein Synthesis Inhibitors- Chloramphenicol

Related lab tests

Complete Blood Count

Peripheral Smear Examination

References

MacDougall C, Chambers HF. Protein Synthesis Inhibitors and Miscellaneous Antibacterial Agents. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1526-29.
Chambers HF, Deck DH. Tetracyclines, Macrolides, Clindamycin, Chloramphenicol, Streptogramins, & Oxazolidiones. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 802-803.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 244-25.
Chloramphenicol [Prescribing Information]. Bristol, Tennessee: Monarch Pharmaceuticals; 2004. [Accessed 29 Mar. 2019] (online) Available from:
Chaves RG, Lamounier JA. Breastfeeding and maternal medications. J Pediatr (Rio J). 2004;80(5 Suppl):S189-98. [Accessed 29 Mar. 2019] (online) Available from:

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Ikon Pharmachem Pvt Ltd
Address: Ikon Pharmachem Pvt. Ltd., Dehradun, Uttarakhand, India, Phone : +91-135-2645621

Vendor Details

Country of origin: India

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Trifranil Tablet

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General Information

Contains

Marketer

Storage

Product introduction

Uses of Trifranil Tablet

Benefits of Trifranil Tablet

Side effects of Trifranil Tablet

How to use Trifranil Tablet

How Trifranil Tablet works

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Cholera Vaccine (Inactivated) (Oral Route)

Purified Vi Polysaccharide Typhoid Vaccine (Injection Route)

Gliclazide (Oral Route)

Glibenclamide (Oral Route)

Glimepiride (Oral Route)

Frequently asked questions

How long does Trifranil Tablet takes to work?

What if I don't get better after using Trifranil Tablet?

Can I stop taking Trifranil Tablet when my symptoms are relieved?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

Related lab tests

Complete Blood Count

Peripheral Smear Examination

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

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