Uses of Tri Zyromet G Tablet SR

Tri-Zyromet G1 Tablet is used in the treatment of type 2 diabetes.

Tri Zyromet G Tablet SR side effects

  • Hypoglycemia (low blood sugar level)
  • Nausea
  • Taste change
  • Diarrhea
  • Stomach pain
  • Headache
  • Edema (swelling)
  • Weight gain
  • Blurred vision
  • Bone fracture
  • Respiratory tract infection

How to use Tri Zyromet G Tablet SR

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Tri-Zyromet G1 Tablet is to be taken with food.
Tri-Zyromet G1 Tablet may cause stomach upset if taken empty stomach.

How Tri Zyromet G Tablet SR works

Tri-Zyromet G1 Tablet is a combination of three antidiabetic medicines: Glimepiride, Metformin and Pioglitazone. They work by different mechanisms to provide better control of blood sugar when single or dual therapy is not effective. Glimepiride is a sulfonylurea which works by increasing the amount of insulin released by the pancreas in order to lower the blood glucose. Metformin is a biguanide. It works by lowering glucose production in the liver, delaying glucose absorption from intestines and increasing the body's sensitivity to insulin. Pioglitazone is a thiazolidinedione which further increases insulin sensitivity.

Tri Zyromet G Tablet SR related warnings

Taking pioglitazone with alcohol may affect blood glucose levels in patients with diabetes.
Tri-Zyromet G1 Tablet may be unsafe to use during pregnancy.
Animal studies have shown adverse effects on the foetus, however, there are limited human studies. The benefits from use in pregnant women may be acceptable despite the risk. Please consult your doctor.
Tri-Zyromet G1 Tablet is probably safe to use during lactation. Limited human data suggests that the drug does not represent a significant risk to the baby.
Monitor the breastfed baby’s blood sugar during treatment with Tri-Zyromet G1 Tablet
Your ability to drive may be affected if your blood sugar is low or high. If this happens, do not drive.
Tri-Zyromet G1 Tablet should be used with caution in patients with kidney disease. Dose adjustment of Tri-Zyromet G1 Tablet may be needed. Please consult your doctor.
Use of Tri-Zyromet G1 Tablet is, however, not recommended in patients with severe kidney disease. Regular monitoring of kidney function test is advisable while you are taking this medicine.
Tri-Zyromet G1 Tablet should be used with caution in patients with liver disease. Dose adjustment of Tri-Zyromet G1 Tablet may be needed. Please consult your doctor.
Use of Tri-Zyromet G1 Tablet is not recommended in patients with severe liver disease.

Alternate Brands

For informational purposes only. Consult a doctor before taking any medicines.
Tri-Zyromet G1 Tablet
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Expert Advice

  • Tri-Zyromet G1 Tablet is a combination of three medicines that provides better blood sugar control than either medicine alone.
  • You should continue to exercise regularly, eat a healthy diet, and take your other diabetes medicines along with Tri-Zyromet G1 Tablet.
  • Take it with food to lower your chance of having an upset stomach.
  • Monitor your blood sugar level regularly while you are taking this medicine. 
  • Hypoglycemia (low blood sugar level) may occur when taken along with other antidiabetic medicines, alcohol or on delaying/skipping a meal. Carry a sugar source with you for immediate relief.

Patient Concerns

Questions Related to Tri Zyromet G

High cholesterol and lipid. Also type 2 diabetes under control. Vegetarian. Pls advise on dite
Dr. Waseem Mirza
Per day calorie intake should be between 1,500-1,800 calories with a proportion of 60:20:20 between carbohydrates, fats and proteins, respectively, take Healthy fats from raw nuts, olive oil, fish oils, flax seeds etc, fresh Fruits and vegetables,whole grains, legumes and other high-fibre diet, avoid refined carbohydrate diet,if u eat non veg u can take fish, poultry egg white, pulses whereas avoid red meat, avoid saturated fats like ghee, butter, avoid sweet foods, take small but frequent meals, supplements containing omega 3 fatty acids like Multivite fm omega capsule Quit smoking, avoid too much alcohol intake, find ways to reduce stress like meditation, yoga, etc. Moderate exercise daily like a brisk walk for 1 km. hope it helps
I was diagnosed with type 2 diabetes in January and I m taking medicine. Now it's under control. Can you suggest me a meal plan that I can go for to control my weight and diabetes. Thank you
Dr. Shikha Mishra
eat 6-7 meals per day, which consist fruits, nuts, buttermilk,egg, homecooked food. Drink 3-4 litters of water.Be active whole day for personalized diet chart write to me on shikhamishra.nutrition@gmail.com do minimum 45 min exercise everyday like yoga, cardio or weights
Do you have any questions related to Tri-Zyromet G1 Tablet?


Q. Can I drink alcohol while taking Tri Zyromet G?

No, it is not safe to drink alcohol while using Tri Zyromet G. Drinking alcohol may lower your blood sugar levels (hypoglycemia). Also, it can increase the chances of lactic acidosis.

Q. What should I inform the doctor before taking Tri Zyromet G?

Before taking Tri Zyromet G inform your doctor if you have congestive heart failure, kidney problems, liver problems, swelling of the back of the eye. Inform the doctor if you are pregnant, breastfeeding or a premenopausal woman. Let the doctor know if you are taking any prescription and non-prescription medicines, vitamins, and herbal supplements.

Q. Can the use of Tri Zyromet G lead to Vitamin B12 deficiency?

Yes, the use of Tri Zyromet G can cause vitamin B12 deficiency as it contains metformin in it. On long-term use, it interferes with absorption of vitamin B12 in the stomach.

Q. Can the use of Tri Zyromet G cause hypoglycemia?

Yes, the use of Tri Zyromet G can cause hypoglycemia (low blood sugar level). Symptoms of hypoglycemia include nausea, headache, irritability, hunger, sweating, dizziness, fast heart rate and feeling anxious or shaky. It happens more often if you miss or delay your meal, drink alcohol, over-exercise or take other antidiabetic medicine along with it. So, regular monitoring of blood sugar level is important. Always carry some sugary item like a candy or chocolate with you.

Q. What are the instructions for the storage and disposal of Tri Zyromet G?

Keep this medicine in the container it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.
Information last updated by Dr. Varun Gupta, MD Pharmacology on 13th Sep 2018.
The medicine details are for information purpose only. Consult a doctor before taking any medicine.
Manufacturer/Marketer Address
C-302, Dev Aurum Complex, Anandnagar Cross Road, Prahladnagar Road, Ahmedabad – 380015., Gujarat, INDIA
As per the Drugs and Cosmetics Act, Ministry of Health and Family Welfare