Glimepiride + Metformin + Pioglitazone

This is a combination of three antidiabetic medicines: Glimepiride, Metformin and Pioglitazone. They work by different mechanisms to provide better control of blood sugar when single or dual therapy is not effective. Glimepiride is a sulfonylurea which works by increasing the amount of insulin released by the pancreas in order to lower the blood glucose. Metformin is a biguanide. It works by lowering glucose production in the liver, delaying glucose absorption from intestines and increasing the body's sensitivity to insulin. Pioglitazone is a thiazolidinedione which further increases insulin sensitivity.

Hypoglycemia (low blood sugar level), Nausea, Altered taste, Diarrhoea, Stomach pain, Headache, Edema (swelling), Weight gain, Blurred vision, Bone fracture, Respiratory tract infection