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Glimepiride + Metformin + Pioglitazone

Information about Glimepiride + Metformin + Pioglitazone

How Glimepiride + Metformin + Pioglitazone works

Glimepiride + Metformin + Pioglitazone is a combination of three antidiabetic medicines: Glimepiride , Metformin and Pioglitazone. They work by different mechanisms to provide better control of blood sugar when single or dual therapy is not effective. Glimepiride is a sulfonylurea which works by increasing the amount of insulin released by the pancreas in order to lower the blood glucose. Metformin is a biguanide. It works by lowering glucose production in the liver, delaying glucose absorption from intestines and increasing the body's sensitivity to insulin. Pioglitazone is a thiazolidinedione which further increases insulin sensitivity.

Common side effects of Glimepiride + Metformin + Pioglitazone

Hypoglycemia (low blood glucose level), Nausea, Diarrhea, Headache, Edema (swelling), Anemia (low number of red blood cells), Upper respiratory tract infection, Dizziness, Vomiting, Flatulence, Bronchitis (inflammation of the airways)
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Reviewed By
MBA, MD Pharmacology
Last updated
18 Feb 2020 | 11:54 AM (UTC)

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Expert advice for Glimepiride + Metformin + Pioglitazone

  • Take it with food to lower your chance of having an upset stomach.
  • It may cause hypoglycemia (low blood sugar level) when used with other antidiabetic medicines, alcohol or if you delay or miss a meal.
  • Always carry some sugary food or fruit juice with you in case you experience hypoglycemic symptoms such as cold sweats, cool pale skin, tremor, and anxiety.
  • Your doctor may check your liver function regularly. Inform your doctor if you develop symptoms such as abdominal pain, loss of appetite, or yellowing of the eyes or skin (jaundice).

Frequently asked questions for Glimepiride + Metformin + Pioglitazone

Glimepiride + Metformin + Pioglitazone

Q. Can I drink alcohol while taking Glimepiride+Metformin+Pioglitazone?

No, it is not safe to drink alcohol while using Glimepiride+Metformin+Pioglitazone. Drinking alcohol may lower your blood sugar levels (hypoglycemia). Also, it can increase the chances of lactic acidosis.

Q. What should I inform the doctor before taking Glimepiride+Metformin+Pioglitazone?

Before taking Glimepiride+Metformin+Pioglitazone inform your doctor if you have congestive heart failure, kidney problems, liver problems, swelling of the back of the eye. Inform the doctor if you are pregnant, breastfeeding or a premenopausal woman. Let the doctor know if you are taking any prescription and non-prescription medicines, vitamins, and herbal supplements.

Q. Can the use of Glimepiride+Metformin+Pioglitazone lead to Vitamin B12 deficiency?

Yes, the use of Glimepiride+Metformin+Pioglitazone can cause vitamin B12 deficiency as it contains metformin in it. On long-term use, it interferes with absorption of vitamin B12 in the stomach.

Q. Can the use of Glimepiride+Metformin+Pioglitazone cause hypoglycemia?

Yes, the use of Glimepiride+Metformin+Pioglitazone can cause hypoglycemia (low blood sugar level). Symptoms of hypoglycemia include nausea, headache, irritability, hunger, sweating, dizziness, fast heart rate and feeling anxious or shaky. It happens more often if you miss or delay your meal, drink alcohol, over-exercise or take other antidiabetic medicine along with it. So, regular monitoring of blood sugar level is important. Always carry some sugary item like a candy or chocolate with you.

Q. What are the instructions for the storage and disposal of Glimepiride+Metformin+Pioglitazone?

Keep this medicine in the container it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.


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