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    Glimepiride + Metformin + Pioglitazone

    Information about Glimepiride + Metformin + Pioglitazone

    Glimepiride + metformin + pioglitazone uses

    Glimepiride+Metformin+Pioglitazone is used in the treatment of type 2 diabetes.

    How glimepiride + metformin + pioglitazone works

    This is a combination of three antidiabetic medicines: Glimepiride, Metformin and Pioglitazone. They work by different mechanisms to provide better control of blood sugar when single or dual therapy is not effective. Glimepiride is a sulfonylurea which works by increasing the amount of insulin released by the pancreas in order to lower the blood glucose. Metformin is a biguanide. It works by lowering glucose production in the liver, delaying glucose absorption from intestines and increasing the body's sensitivity to insulin. Pioglitazone is a thiazolidinedione which further increases insulin sensitivity.

    Common side effects of glimepiride + metformin + pioglitazone

    Hypoglycemia (low blood sugar level), Nausea, Taste change, Diarrhea, Stomach pain, Headache, Edema (swelling), Weight gain, Blurred vision, Bone fracture, Respiratory tract infection
    Content Details
    Last updated on:
    12 Dec 2018 | 10:49 AM (IST)
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    Expert advice for Glimepiride + Metformin + Pioglitazone

    • Glimepiride + Metformin + Pioglitazone is a combination of three medicines that provides better blood sugar control than either medicine alone.
    • You should continue to exercise regularly, eat a healthy diet, and take your other diabetes medicines along with Glimepiride + Metformin + Pioglitazone.
    • Take it with food to lower your chance of having an upset stomach.
    • Monitor your blood sugar level regularly while you are taking this medicine. 
    • Hypoglycemia (low blood sugar level) may occur when taken along with other antidiabetic medicines, alcohol or on delaying/skipping a meal. Carry a sugar source with you for immediate relief.

    Frequently asked questions for Glimepiride + Metformin + Pioglitazone

    Glimepiride + Metformin + Pioglitazone

    Q. Can I drink alcohol while taking Glimepiride+Metformin+Pioglitazone?

    No, it is not safe to drink alcohol while using Glimepiride+Metformin+Pioglitazone. Drinking alcohol may lower your blood sugar levels (hypoglycemia). Also, it can increase the chances of lactic acidosis.

    Q. What should I inform the doctor before taking Glimepiride+Metformin+Pioglitazone?

    Before taking Glimepiride+Metformin+Pioglitazone inform your doctor if you have congestive heart failure, kidney problems, liver problems, swelling of the back of the eye. Inform the doctor if you are pregnant, breastfeeding or a premenopausal woman. Let the doctor know if you are taking any prescription and non-prescription medicines, vitamins, and herbal supplements.

    Q. Can the use of Glimepiride+Metformin+Pioglitazone lead to Vitamin B12 deficiency?

    Yes, the use of Glimepiride+Metformin+Pioglitazone can cause vitamin B12 deficiency as it contains metformin in it. On long-term use, it interferes with absorption of vitamin B12 in the stomach.

    Q. Can the use of Glimepiride+Metformin+Pioglitazone cause hypoglycemia?

    Yes, the use of Glimepiride+Metformin+Pioglitazone can cause hypoglycemia (low blood sugar level). Symptoms of hypoglycemia include nausea, headache, irritability, hunger, sweating, dizziness, fast heart rate and feeling anxious or shaky. It happens more often if you miss or delay your meal, drink alcohol, over-exercise or take other antidiabetic medicine along with it. So, regular monitoring of blood sugar level is important. Always carry some sugary item like a candy or chocolate with you.

    Q. What are the instructions for the storage and disposal of Glimepiride+Metformin+Pioglitazone?

    Keep this medicine in the container it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.

    Content on this page was last updated on 12 December, 2018, by Dr. Varun Gupta (MD Pharmacology)