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Tretwin C Gel is a combination of two medicines, used to treat acne, which appears as spots or pimples on your face, chest, or back. This medicine works by attacking the germs that cause them and rejuvenates sun-damaged skin.

Written By Dr. Sakshi Jain, MS, BDS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 12 Mar 2026 | 12:45 PM (IST)
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Tretwin C Gel image
Tretwin C Gel image

Product introduction

Tretwin C Gel is only meant for external use and should be used as advised by your doctor. You should normally wash and dry the affected area before applying a thin layer of the medicine. It should not be applied to broken or damaged skin. Avoid contact with your eyes, nose, or mouth. Rinse it off with water if you accidentally get it in these areas. It may take several weeks for your symptoms to improve, but you should keep using this medicine regularly. Do not stop using it as soon as your acne starts to get better. Ask your doctor when you should stop treatment.

Side effects like burning sensation, irritation, itching, redness, dryness, skin peeling, or skin inflammation (dermatitis) may be seen at the application site, in some people. These are usually temporary and resolve on their own. Consult your doctor if they bother you or do not go away.

It is a safe medicine, but you should inform your doctor if you have any problems with your bowels (intestines), if you have ever had bloody diarrhea caused by taking antibiotics or if you are using any other medicines to treat skin conditions. Consult your doctor about using this medicine if you are pregnant or breastfeeding.

Uses of Tretwin C Gel

Benefits of Tretwin C Gel

Treatment of Acne
Tretwin C Gel is a combination medicine that helps treat acne (commonly called pimples) by reducing the production of excessive oil in the skin that causes acne. This also kills acne-causing bacteria and prevents spots or pimples from appearing. It usually takes a few weeks to have a noticeable effect so keep using it even if it appears not to be working. Sometimes acne may get worse before it gets better, however, with proper use, your skin will get clearer. The earlier you start using it, the less likely you are to get scars. This medicine will help improve your mood and uplift your confidence as your skin becomes acne free.

Side effects of Tretwin C Gel

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Tretwin C
  • Erythema (skin redness)
  • Scaling
  • Burning sensation
  • Skin exfoliation
  • Nasopharyngitis (inflammation of the throat and nasal passages)
  • Cough
  • Sinus inflammation
  • Dryness

How to use Tretwin C Gel

This medicine is for external use only. Use it in the dose and duration as advised by your doctor. Check the label for directions before use. Clean and dry the affected area and apply the gel. Wash your hands after applying, unless hands are the affected area.

How Tretwin C Gel works

Tretwin C Gel is a combination of two medicines: Clindamycin and Tretinoin, which treats pimples (acne). Clindamycin is an antibiotic which works by penetrating into the skin and killing acne-causing bacteria. Tretinoin is a form of vitamin A which reduces oil production in the skin, replenishes the skin and helps keep your pores open.

Quick tips

  • Tretwin C Gel should be Applied as a thin layer onto clean, dry, unbroken skin affected by acne.
  • Clean the area to be treated with water and a non-medicated soap, and let it dry for 20-30 minutes before applying the medicine.
  • It may cause minor burning, stinging, or irritation when applied. Inform your doctor if this does not go away.
  •  Avoid contact with your eyes, nose or mouth. Rinse it off with water if you accidentally get the cream in these areas.
  • Avoid exposure to sunlight while using Tretwin C Gel as it increases the sensitivity of your skin. Use protective measures such as sun-cream or protective clothing.
  • Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.

Safety advice

Alcohol

Alcohol

No interaction found/established
Pregnancy

Pregnancy

UNSAFE
Tretwin C Gel is highly unsafe during pregnancy. It can cause serious harm to the unborn baby, including birth defects and pregnancy loss. Do not use this medicine if you are pregnant or planning to become pregnant.
Breast feeding

Breast feeding

CAUTION
Tretwin C Gel should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from the body.
Driving

Driving

No interaction found/established
Kidney

Kidney

No interaction found/established
Liver

Liver

No interaction found/established

Frequently asked questions

Tretwin C Gel should be used only as directed by your physician. The dose depends on the condition your are being treated for and the strength of the medicine you are using. Do not use more than instructed by your doctor. Follow your doctor’s instructions religiously and do not alter the dose on your own.
Tretwin C Gel works by replacing damaged skin cells with newer ones, thus rejuvenating the skin. However, it may take upto three to six months to achieve noticeable results. In some cases, it might take longer, depending upon the color of the post acne inflammatory pigmentation being treated, in relation to the normal surrounding skin.
Wash your face gently with mild soap and warm water and pat your skin dry with a towel. Just use a pea sized amount of Tretwin C Gel for applying over the entire face. Do not use more than the required dose as it may cause undesired side effects. Use it in the dose and duration as advised by your doctor.
Tretwin C Gel lightens post acne dark spots by replacing the damaged skin cells with newer ones. Thus, it lightens the skin tone and makes it brighter and clearer than before.
If your forget to apply Tretwin C Gel at your usual time, do not apply it as you remember in order to make up for the missed dose. Use it at your usual time only and do not double the dose as it may cause unwanted side effects.
It is potentially unsafe to use this medicine while you are pregnant or planning to become pregnant. It is not known whether this medicine.

Fact Box

Habit Forming

No

Therapeutic Class

DERMA
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Sanstuti Pharmaceuticals Pvt Ltd
Address: sanstuti pharmaceuticals pvt. ltd, 559, golf course road, a block, dlf phase 1, sector 43, gurugram, haryana 122002

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Tretwin C Gel. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India
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