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Trental 400 Tablet PR

Prescription Required
SALT COMPOSITION
Storage
Store below 30°C
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Product introduction

Trental 400 Tablet PR is used to treat peripheral vascular disease (poor circulation to the arms and legs) and intermittent claudication (pain on walking or at rest caused by poor circulation to the legs). It works by increasing the blood flow to the arms and legs.

Trental 400 Tablet PR reduces cramping in the legs that occur on walking in such patients. It also has beneficial effects in alcohol-related liver damage. This medicine should be taken regularly as advised by the doctor. You should take it with food and at a fixed time. You should never stop it abruptly without consulting the doctor. This medicine is only one part of a treatment program which should also include a healthy diet, regular exercise, and smoking cessation.

It may cause side effects like nausea, vomiting, diarrhea, headache, flushing (sense of warmth in the face, ears, neck, and trunk), and weakness. This medicine may not be suitable for some people. You must inform the doctor if you are suffering from any liver or kidney disease. Also, let your doctor know about all the other medications that you are using regularly. This medicine is not usually recommended during pregnancy or breastfeeding, so always consult your doctor before taking it.

Uses of Trental Tablet PR

Benefits of Trental Tablet PR

In Peripheral vascular disease

Peripheral vascular disease refers to the condition of disturbed blood circulation in blood vessels. Trental 400 Tablet PR prevents blood from clotting inside the veins and arteries. This helps the blood flow freely around your body thereby preventing a heart attack or stroke (or deep vein thrombosis or pulmonary embolism). It helps prevent the formation of blood clots and also prevents the existing ones from growing bigger in size. Make appropriate lifestyle changes (such as eating healthy and staying active) to maximize the effectiveness of this medicine.

In Intermittent claudication

Intermittent claudication refers to muscle pain on mild exertion (ache, cramp, numbness or sense of fatigue), classically in the calf muscle, which occurs during exercise or even walking, and it gets better with a short period of rest. Trental 400 Tablet PR helps relieve this pain in the legs that is caused due to disturbed blood supply in the legs. It helps prevent formation of blood clots, improves blood flow and maintains free flowing of blood in your body.

Side effects of Trental Tablet PR

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Trental

  • Bloating
  • Diarrhea
  • Flushing (sense of warmth in the face, ears, neck and trunk)
  • Headache
  • Heartburn
  • Lightheadedness
  • Nausea
  • Stomach discomfort
  • Vomiting
  • Weakness

How to use Trental Tablet PR

Use it as advised by your doctor or check the label for directions before use. Trental 400 Tablet PR is to be taken with food.

How Trental Tablet PR works

Trental 400 Tablet PR is a peripheral vasodilator. It works by decreasing the thickness (viscosity) of blood, allowing it to pass more easily through the blood vessels. This effect is beneficial in peripheral vascular disease, where the blood vessels in the arms and legs are narrowed.

Safety advice

Alcohol
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Trental 400 Tablet PR. Please consult your doctor.
Pregnancy
CONSULT YOUR DOCTOR
Trental 400 Tablet PR may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Breast feeding
SAFE IF PRESCRIBED
Trental 400 Tablet PR is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Driving
UNSAFE
Trental 400 Tablet PR may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Kidney
CAUTION
Trental 400 Tablet PR should be used with caution in patients with kidney disease. Dose adjustment of Trental 400 Tablet PR may be needed. Please consult your doctor.
Liver
CONSULT YOUR DOCTOR
There is limited information available on the use of Trental 400 Tablet PR in patients with liver disease. Please consult your doctor.

What if you forget to take Trental Tablet PR?

If you miss a dose of Trental 400 Tablet PR, skip it and continue with your normal schedule. Do not double the dose.\n

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.
No substitutes found for this medicine

Quick tips

  • Take it as per dose and duration suggested by your doctor.
  • Do not drive or perform activities that require mental focus until you know how Trental 400 Tablet PR affects you.
  • Your doctor may get regular blood tests done to monitor liver function while taking this medicine. 
  • Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.
  • Take it with food, preferably at the same time everyday to avoid missing a dose.

Fact Box

Chemical Class
Methylxanthine Derivative
Habit Forming
No
Therapeutic Class
CARDIAC
Action Class
Rheologic modifier

Interaction with drugs

Taking Trental with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Brand(s): Nimsun, Neil, Esulide
Life-threatening
Brand(s): Oxy Triactin, Sioril
Life-threatening
Brand(s): Pyregin, Alpagin, Novalgin RC
Life-threatening

Patient concerns

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I have been prescribed Trental 400 mg.How long should l take Trental 400 mg under prescription ?
Dr. Vikas Sharma
Neurology
duration depends on the the reason for giving this medicine
Type II diabetic patient having foot pain with blood clotting. The prescribed tab TRENTAL 400 is not available in market. FBS-218, RBS-313
Dr. Sanjay Bhatt
Physician
Trental is available in the market. Try with some other chemist shop. You needs to take diabetic medicine.
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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

  1. Katzung BG, Chatterjee K. Vasodilator & the Treatment of Angina Pectoris. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 205.
  2. Gersh BJ, Opie LH. Which Therapy for Which Condition? In: Opie LH, Gersh BJ, editors. Drugs for the Heart. 8th ed. Philadelphia, Pennsylvania: Elsevier Saunders; 2013. p. 528.
  3. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1089-90.
  4. Pentoxifylline. Guildford, Surrey: SANOFI; 2002 [revised 25 May 2016]. [Accessed 25 Jan. 2019] (online) Available from:External Link
  5. Drugs.com. Pentoxifylline. [Accessed 20 Mar. 2019] (online) Available from:External Link
  6. Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Pentoxifylline. [Updated 2018 Oct 31]. [Accessed 19 Feb. 2020] (online) Available from:External Link
  7. Central Drugs Standard Control Organisation (CDSCO). [Accessed 19 Mar. 2019] (online) Available from:External Link

Marketer details

Name: Sanofi India Ltd
Address: Sanofi House, CTS No.117-B, L&T Business Park, Saki Vihar Road, Powai, Mumbai 400072
Country of origin: India
Expires on or after: April, 2026

A licensed vendor partner from your nearest location will deliver Trental 400 Tablet PR. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

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Email ID: [email protected]
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India

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