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Oxyphenbutazone is used in the treatment of prolonged joint pains conditions like Rheumatoid arthritis (inflammatory disorder that typically affects the small joints in hands and feet), osteoarthritis (stiffness, pain and loss of joint movement) and ankylosing spondylitis (a form of spinal arthritis). It is also used to suppress attacks of acute gout (pain and swelling of the small joints due to elevated levels of uric acid in the blood and subsequent deposition in the joints).

How it works

Oxyphenbutazone belongs to a class of drugs called non-steroidal anti-inflammatory (NSAIDs). It acts by blocking the action of chemical known as prostaglandins, thereby helping in reducing pain, fever, or any anti-inflammatory effects.

Common side effects

Nausea, Acute toxicity, Gastritis, Gastrointestinal bleeding, Decreased white blood cell count, Rash, Stomach upset, Abdominal cramp, Bloating


Expert advice

• Exercise caution if you are a hypertensive patient.
• Tell your doctor if you are taking any anticoagulants and oral hypoglycemic agents as oxyphenbutazone may worsen the side effects.
• Do not drive or operate machinery after taking oxyphenbutazone as it may cause dizziness and movement disorder.
• Tell your doctor if you are pregnant or breast-feeding or planning a pregnancy.
• Should not be given to patients allergic to oxyphenbutazone or any of its ingredients.
• Should not be given to patients having active peptic ulcers due to increased chances of bleeding.
• Should not be given to patients having moderate to severe liver disease.

Content on this page was last updated on 30 September, 2016, by Dr. Varun Gupta (MD Pharmacology)