Topoquis 4mg Injection

Reviewed By Dr. Rajeev Sharma, MBA, MBBS

Last updated on 01 Dec 2025 | 12:04 PM (IST)

Topoquis 4mg Injection is used in the treatment of ovarian cancer. It shows its working by stopping or slowing down the growth of cancer cells.

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General Information

Contains

Topotecan (4mg)

Marketer

Fresenius Kabi India Pvt Ltd

Storage

Store below 30°C

The content is shown in English

Product introduction

Topoquis 4mg Injection is given as an IV infusion into vein by a qualified medical professional. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.

The most common side effects of this medicine include tiredness, vomiting, weakness, nausea, and abdominal pain. This medicine may reduce the number of blood cells (decrease red blood and white blood cells) in your blood, thereby, increasing the susceptibility to infections. Inform your doctor if you notice fever, chills, sore throat, and severe diarrhea. Regular blood tests are required to check your blood cells along with heart, liver, and blood uric acid levels.

Before taking it, tell your doctor if you have heart disease, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.

Uses of Topoquis Injection

Ovarian cancer

Benefits of Topoquis Injection

Ovarian cancer
Ovarian cancer is a cancer that begins in the female organs that produce eggs (ovaries). This type of cancer is usually detected very late and can be fatal too. It usually spreads to the pelvis and stomach. Topoquis 4mg Injection kills or stops the growth of cancer cells and also prevents the multiplication of cancer cells. It is an effective medicine but has some side effects that may be bothersome. Consult your doctor to know about ways that can help you avoid these side effects.

Side effects of Topoquis Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Topoquis

Tiredness
Vomiting
Weakness
Nausea
Abdominal pain
Indigestion
Decreased white blood cell count
Decreased blood cells (red cells, white cells, and platelets)
Diarrhea
Injection site reactions (pain, swelling, redness)

How to use Topoquis Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Topoquis Injection works

Topoquis 4mg Injection is an anti-cancer medication. It works by suppressing the activity of an enzyme (topoisomerase I) involved in DNA multiplication of the cancer cells. This slows the growth of cancer cells and eventually kills them.

Quick tips

Topoquis 4mg Injection helps treat ovarian cancer.
It is given by a drip into a vein (intravenous infusion).
Do not drive or operate machinery as Topoquis 4mg Injection may cause tiredness, drowsiness or weakness.
Use a reliable contraceptive method to prevent pregnancy while you are taking this medicine.
Your doctor may get regular blood tests done to monitor your blood cells during treatment with this medicine.
Inform your doctor immediately if you notice any signs of infection such as fever, sore throat, rash or severe diarrhea.

Safety advice

Alcohol

SAFE

Consuming alcohol with Topoquis 4mg Injection does not usually cause any harmful side effects.

Pregnancy

CONSULT YOUR DOCTOR

Topoquis 4mg Injection is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.

Breast feeding

UNSAFE

Topoquis 4mg Injection is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

Driving

UNSAFE

Topoquis 4mg Injection may cause side effects that could affect your ability to drive.
Topoquis 4mg Injection can make you feel tired and this may affect your ability to drive.

Kidney

CAUTION

Topoquis 4mg Injection should be used with caution in patients with kidney disease. Dose adjustment may be needed.
Use of Topoquis 4mg Injection is not recommended in patients with end-stage kidney disease.

Liver

SAFE IF PRESCRIBED

Topoquis 4mg Injection is safe to use in patients with liver disease. No dose adjustment is recommended.

Interaction with drugs

Taking Topoquis with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Severe

Filgrastim (Injection Route)

Avoid Filgrastim within 24 hours before and 24 hours after the last dose of Topotecan.

Severe

Pegfilgrastim (Injection Route)

Avoid Pegfilgrastim within 24 hours before and 24 hours after the last dose of Topotecan.

Severe

Sargramostim (Injection Route)

Avoid Sargramostim within 24 hours before and 24 hours after the last dose of Topotecan.

Severe

Lenograstim (Injection Route)

Avoid Lenograstim within 24 hours before and 24 hours after the last dose of Topotecan.

Severe

Molgramostim (Injection Route)

Avoid Molgramostim within 24 hours before and 24 hours after the last dose of Topotecan.

Frequently asked questions

How often is Topoquis 4mg Injection given?

Generally Topoquis 4mg Injection treatment is for 4 cycles of 21 day each, patient is given Topoquis 4mg Injection for first 5 days of each cycle.

Does Topoquis 4mg Injection cause hair loss?

Yes, Topoquis 4mg Injection may cause temporary hair loss.

Does Topoquis 4mg Injection cause flare reaction?

Yes, Topoquis 4mg Injection may cause flare reaction.

How long does Topoquis 4mg Injection take to work?

Topoquis 4mg Injection may start its action once the infusion is started, however, the complete effect may be assessed only after completion of 4 cycles.

Is Topoquis 4mg Injection a vesicant?

Topoquis 4mg Injection is a vesicant (irritant).

Is Topoquis 4mg Injection effective?

Yes Topoquis 4mg Injection is effective if used at prescribed doses for the prescribed duration as advised by your doctor.

What is Topoquis 4mg Injection chemotherapy?

It is a treatment therapy that includes Topoquis 4mg Injection with or without combination of other drugs in treatment of cancer (Usually ovarian or lung cancer).

How is Topoquis 4mg Injection administered?

Topoquis 4mg Injection is either administered orally as a capsule or as an intravenous Infusion in the arm over a period of 30 min.

Fact Box

Chemical Class

Camptothecins

Habit Forming

Therapeutic Class

ANTI NEOPLASTICS

Action Class

Topoisomerase Inhibitors

References

Chabner BA, Bertino J, Cleary J, et al. Cytotoxic Agents. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1711-12.
Chu E, Sartorelli AC. Cancer Chemotherapy. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 951.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. p. 1383.
Topotecan hydrochloride. Camberley, Surrey: Novartis Pharmaceuticals UK Ltd.; 1996 [revised 23 Apr. 2018]. [Accessed 24 Jan. 2019] (online) Available from:
Topotecan. Unterach, Austria: Ebewe Pharma; 1996 [revised Feb. 2014]. [Accessed 27 Mar. 2019] (online) Available from:
Central Drugs Standard Control Organisation (CDSCO). [Accessed 27 Mar. 2019] (online) Available from:
Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Topotecan. [Updated 2018 Dec 3]. [Accessed 19 Feb. 2020] (online) Available from:

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Fresenius Kabi India Pvt Ltd
Address: Fresenius Kabi AG , Else-Kröner-Straße 1 , 61352 Bad Homburg , Germany

Vendor Details

Country of origin: India

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Why we need a prescription?

Topoquis 4mg Injection

Save more with additional offers

General Information

Contains

Marketer

Storage

Product introduction

Uses of Topoquis Injection

Benefits of Topoquis Injection

Side effects of Topoquis Injection

How to use Topoquis Injection

How Topoquis Injection works

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Filgrastim (Injection Route)

Pegfilgrastim (Injection Route)

Sargramostim (Injection Route)

Lenograstim (Injection Route)

Molgramostim (Injection Route)

Frequently asked questions

How often is Topoquis 4mg Injection given?

Does Topoquis 4mg Injection cause hair loss?

Does Topoquis 4mg Injection cause flare reaction?

How long does Topoquis 4mg Injection take to work?

Is Topoquis 4mg Injection a vesicant?

Is Topoquis 4mg Injection effective?

What is Topoquis 4mg Injection chemotherapy?

How is Topoquis 4mg Injection administered?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

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