
Tacflage Ointment
Written By Dr. Swati Mishra, BDS
Reviewed By Dr. Rajeev Sharma, MBA, MBBS
Last updated on 17 Jan 2026 | 07:38 PM (IST)
Tacflage Ointment is used to treat eczema (atopic dermatitis). It works by suppressing the activity of certain immune cells that cause inflammation (redness and swelling) of the skin. This relieves itching and improves rashes in atopic dermatitis.
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Tacflage Ointment
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General Information
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Product introduction
Tacflage Ointment is used for external use. It should be used 2-4 times a day on the affected area, or use it as suggested by the doctor. It should be applied slowly and evenly to the skin until it is rubbed in. You should not use it too often, and you should not cover the treated area with a bandage or plaster. You must inform your doctor if there’s no improvement even after two weeks of treatment or if the skin gets worse.
Use of this medicine may cause some common side effects such as erythema, headache, inflammation of the hair follicle, and application site reactions like burning, irritation, itching, and redness. This medicine is not normally recommended during pregnancy or while breastfeeding unless it is clearly needed.
Uses of Tacflage Ointment
Benefits of Tacflage Ointment
Treatment of Atopic dermatitis
Atopic dermatitis, also known as eczema, is a chronic skin condition causing red, itchy, and inflamed patches on the skin, often associated with allergies. Tacflage Ointment when applied topically suppresses the immune response in the skin, reducing the inflammatory reactions that lead to eczema flare-ups. This way, it provides relief and helps improve the quality of life for individuals with atopic dermatitis.
Atopic dermatitis, also known as eczema, is a chronic skin condition causing red, itchy, and inflamed patches on the skin, often associated with allergies. Tacflage Ointment when applied topically suppresses the immune response in the skin, reducing the inflammatory reactions that lead to eczema flare-ups. This way, it provides relief and helps improve the quality of life for individuals with atopic dermatitis.
Side effects of Tacflage Ointment
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Tacflage
- Application site reactions (burning, irritation, itching and redness)
- Skin infection
- Flushing (sense of warmth in the face, ears, neck and trunk)
- Rash
- Application site tingling
- Increased skin sensitivity
How to use Tacflage Ointment
This medicine is for external use only. Use it in the dose and duration as advised by your doctor. Check the label for directions before use. Clean and dry the affected area and gently massage the ointment.
How Tacflage Ointment works
Tacflage Ointment is an immunosuppressant. It works by suppressing the activity of certain immune cells that cause inflammation (redness and swelling) of the skin. This relieves itching and improves rashes in atopic dermatitis.
All substitutes for Tacflage Ointment
For information purposes only. Consult a doctor before taking any medicine.
Tacroz Ointment
by Glenmark Pharmaceuticals Ltd
₹18.1/gm of ointment
73% costlier
Tacroz Ointment
by Glenmark Pharmaceuticals Ltd
₹15.1/gm of ointment
44% costlier
Tacrotor 0.03% Ointment
by Torrent Pharmaceuticals Ltd
₹26.5/gm of ointment
153% costlier
T-Top Ointment
by Wallace Pharmaceuticals Pvt Ltd
₹21.5/gm of ointment
105% costlier
Talimus LS Ointment
by Ajanta Pharma Limited
₹66.4/gm of ointment
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Quick tips
- Tacflage Ointment is effective at treating eczema (atopic dermatitis) when other treatment options have failed.
- Apply thinly to affected areas of skin only. Clean the affected area and dry well before applying Tacflage Ointment. Avoid contact with water after application.
- Inform your doctor if there's no improvement even after two weeks of treatment, or if the skin gets worse.
- Don't cover the area being treated with airtight dressings such as bandages unless directed by a doctor, as this may increase the risk of side effects.
- Stop using Tacflage Ointment and consult your doctor if your eczema becomes infected.
- Continuous long-term use of the ointment should be avoided. Use as prescribed by your doctor.
Safety advice

Alcohol
No interaction found/established

Pregnancy
CONSULT YOUR DOCTOR
Information regarding the use of Tacflage Ointment during pregnancy is not available. Please consult your doctor.

Breast feeding
SAFE IF PRESCRIBED
Tacflage Ointment may be safe to use during breastfeeding. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.

Driving
No interaction found/established

Kidney
No interaction found/established

Liver
No interaction found/established
Interaction with drugs
Taking Tacflage with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Mild
Clarithromycin (Oral Route)
Talk to your doctor if you notice any unusual symptoms. Clarithromycin may decrease the metabolism of Tacrolimus.
Mild
Clarithromycin (Injection Route)
Talk to your doctor if you notice any unusual symptoms. Clarithromycin may decrease the metabolism of Tacrolimus.
Frequently asked questions
Tacflage Ointment is used to treat moderate to severe eczema (atopic dermatitis) in adults who do not respond to steroids or develop side effects when using them. In atopic dermatitis, the skin’s immune system undergoes an overreaction, causing skin inflammation, leading to itchiness, redness, and dryness. Tacflage Ointment acts on the abnormal immune response and alters it, thereby relieving the skin inflammation and itchiness.
Compared to other immunosuppressing medicines, Tacflage Ointment is a safe and effective short-term treatment for atopic dermatitis. When applied to the affected part of the skin, its absorption into the blood and body is minimal. Hence, the side effects are less compared to when taken through the oral route.
Long-term use of Tacflage Ointment has been found to have an increased risk of lymph node tumors called lymphoma. Some studies have found that a few patients who used Tacflage Ointment ointment or another similar medication developed skin cancer or lymphoma. Consult your doctor if you have to use Tacflage Ointment ointment for more than 6 weeks or if your eczema symptoms have not improved or are getting worse with time during your treatment.
No, Tacflage Ointment is not a steroid. It is a medicine that modulates the working of the immune system. It is used in the treatment of eczema, most commonly in atopic dermatitis. An advantage of Tacflage Ointment is that it does not cause skin thinning (atrophy) or other steroid-related side effects.
Fact Box
Chemical Class
Macrolide lactams
Habit Forming
No
Therapeutic Class
DERMA
Action Class
Calcineurin Inhibitors
References
- Burkhart C, Morrell D, Goldsmith L. Dermatological Pharmacology. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 1822.
- Lake DF, Briggs AD, Akporiaye ET. Immunopharmacology. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 972.
- Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1305-309.
- Tacrolimus monohydrate [EMC SmPC]. Hurley, Berkshire: Leo Laboratories Limited; 2018. [Accessed 17 Apr. 2019] (online) Available from:
- Central Drugs Standard Control Organisation (CDSCO). [Accessed 06 Apr. 2019] (online) Available from:
- Tacrolimus [Prescribing Information]. Dublin, Ireland: LEO Laboratories Ltd.; 2022. [Accessed 01 Aug. 2023]. (online) Available from:
- Tacrolimus monohydrate [Package Leaflet: Information for User]. Killorglin, Ireland: Astellas Ireland Co. Ltd.; 2024.
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Name: Jupiven Pharmaceuticals Pvt Ltd
Address: L- 199-B, PKT-L, DILSHAD GARDEN, DELHI- 110095 DELHI North East DL 110095 IN
Address: L- 199-B, PKT-L, DILSHAD GARDEN, DELHI- 110095 DELHI North East DL 110095 IN
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