Sysril M 1mg/500mg Tablet

Prescription Required

Introduction of Glimepiride

Sysril M 1mg/500mg Tablet belongs to a category of medicines known as anti-diabetic drugs. It is a combination of two medicines used to treat type 2 diabetes mellitus in adults. It helps control blood sugar levels in people with diabetes.

Sysril M 1mg/500mg Tablet may be used alone or along with other medicines. It should be taken just before or with the first meal of the day. Take it regularly at the same time each day to get the maximum benefit. Your doctor will decide what dose is best for you and this may change from time to time according to your blood sugar levels.
Keep taking this medicine, even if you feel well or your blood sugar levels are controlled. If you stop it without consulting your doctor, your blood sugar levels could rise to put you at risk of diabetes complications such as kidney damage, blindness, nerve problems, and loss of limbs. Remember that it is only part of a treatment program that should also include a healthy diet, regular exercise, and weight reduction as advised by your doctor. Your lifestyle plays a big part in controlling diabetes.
The most common side effects of taking this medicine include low blood sugar levels (hypoglycemia), nausea, headache, and dizziness. Make sure you recognize the signs of having low blood sugar levels, such as sweating, dizziness, headache, and shaking, and know how to deal with them. To prevent this, it is important to have regular meals and always carry a fast-acting source of glucose such as sugary food or fruit juice with you. Drinking alcohol can also increase your risk of low blood sugar levels and hence should be avoided. Some people may experience an increase in weight with this medicine.
You should not take it if you have type 1 diabetes mellitus, diabetic ketoacidosis (high levels of acid in your blood), or if you have severe kidney or liver disease. Before taking this medicine, tell your doctor if you have ever had heart disease, thyroid disease, or some hormonal conditions, as it may not be suitable. Pregnant or breastfeeding women should also consult their doctor before taking it. Your blood sugar levels should be checked regularly and your doctor may also advise blood tests to monitor your blood cell counts and liver function.

Introduction of Metformin

Sysril M 1mg/500mg Tablet belongs to a category of medicines known as anti-diabetic drugs. It is a combination of two medicines used to treat type 2 diabetes mellitus in adults. It helps control blood sugar levels in people with diabetes.

Sysril M 1mg/500mg Tablet is best taken with food to avoid nausea and abdominal pain. You should take it regularly, at the same time each day, to get the most benefit. You should not stop taking this medicine unless your doctor recommends it. Your lifestyle plays a big part in controlling diabetes. Therefore, it is important to stay on the diet and exercise program recommended by your doctor while taking this medicine. 
The most common side effects of this medicine include nausea, vomiting, taste change, diarrhea, abdominal pain, and loss of appetite. Some people may develop hypoglycemia (low blood sugar level) when this medicine is taken along with other antidiabetic medicines, alcohol, or upon skipping a meal. Monitor your blood sugar levels regularly while taking it.
Before taking this medicine, inform your doctor if you have any kidney, liver, or heart problems. Pregnant or breastfeeding women should also consult their doctor before taking it. Your doctor will check your kidney function tests before starting treatment with it. Avoid excessive alcohol intake while taking it as this may increase the risk of developing some side effects.

Uses of Glimepiride

Uses of Metformin


Side effects of Glimepiride

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Sysril M

  • Hypoglycemia (low blood glucose level)
  • Headache
  • Nausea
  • Dizziness

Side effects of Metformin

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Sysril M

  • Nausea
  • Vomiting
  • Taste change
  • Diarrhea
  • Abdominal pain
  • Loss of appetite

How Glimepiride works

Sysril M 1mg/500mg Tablet is an antidiabetic medication. It works by increasing the amount of insulin released by the pancreas in order to lower blood glucose.

How Metformin works

Sysril M 1mg/500mg Tablet is an anti-diabetic medication (biguanide). It works by lowering glucose production in the liver, delaying the absorption of sugar (glucose) from the intestines, and increasing the body's sensitivity to insulin.

Safety advice

Alcohol
UNSAFE
It is unsafe to consume alcohol with Sysril M 1mg/500mg Tablet.
Pregnancy
CONSULT YOUR DOCTOR
Sysril M 1mg/500mg Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Breast feeding
SAFE IF PRESCRIBED
Sysril M 1mg/500mg Tablet is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Driving
CAUTION
Your ability to drive may be affected if your blood sugar is too low or too high. Do not drive if these symptoms occur.
Kidney
CAUTION
Sysril M 1mg/500mg Tablet should be used with caution in patients with kidney disease. Dose adjustment of Sysril M 1mg/500mg Tablet may be needed. Please consult your doctor.
Use of Sysril M 1mg/500mg Tablet is, however, not recommended in patients with severe kidney disease. Regular monitoring of kidney function test is advisable while you are taking this medicine.
Liver
CAUTION
Sysril M 1mg/500mg Tablet should be used with caution in patients with liver disease. Dose adjustment of Sysril M 1mg/500mg Tablet may be needed. Please consult your doctor.
Sysril M 1mg/500mg Tablet is generally started with low dose in patients with mild to moderate liver disease and its use is not recommended in patients with severe liver disease.

What if you forget to take Sysril M Tablet?

If you miss a dose of Sysril M 1mg/500mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.
Sysril M 1mg/500mg Tablet
₹4.5/Tablet
Insurol 1mg/500mg Tablet
Indo-Safe Pharmaceuticals
₹3/tablet
33% cheaper
Glycotus MF 1mg/500mg Tablet
Tusker Pharma Pvt Ltd
₹4.03/tablet
10% cheaper
Nuglim M Tablet
Three Dots Lifescience
₹4.59/tablet
2% costlier
Glimed MF 1mg/500mg Tablet
Knoll Pharmaceuticals Ltd
₹4.8/tablet
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Gliprez MF 1 Tablet
Snig Pharmaceuticals Pvt Ltd
₹5.15/tablet
14% costlier

Quick tips

Glimepiride

  • Glimepiride helps decrease high blood sugar level and avoid long-term complications of diabetes.
  • Take it shortly before or with the first main meal of the day (usually breakfast). Avoid skipping meals.
  • Exercise regularly, eat a healthy diet and take your other diabetes medicines (if prescribed) alongside.
  • Monitor your blood sugar level regularly while you are taking this medicine. 
  • Be careful while driving or operating machinery until you know how Glimepiride affects you.
  • It can cause hypoglycemia (low blood sugar level) when used with other antidiabetic medicines, alcohol or if you delay or miss a meal.
  • Always carry some sugary food or fruit juice with you in case you experience hypoglycemic symptoms such as cold sweats, cool pale skin, tremor and anxiety.
  • Your doctor may check your liver function regularly. Inform your doctor if you develop symptoms, such as abdominal pain, loss of appetite, or yellowing of the eyes or skin (jaundice).

Metformin

  • You have been prescribed Metformin to control the blood sugar level and reduce the risk of diabetic complications such as heart attacks.
  • Chances of weight gain and low blood sugar are lesser with this medicine as compared to other diabetes medicines.
  • Hypoglycemia (low blood sugar level) may occur when taken along with other antidiabetic medicines, alcohol or on delaying/skipping a meal. Carry a sugar source with you for immediate relief.
  • Tell your doctor immediately if you experience any deep or rapid breathing, persistent nausea, vomiting, and stomach pain as Metformin may cause a rare but serious condition called lactic acidosis, which is an excess of lactic acid in the blood.
  • Prolonged use of Metformin may lead to vitamin B12 deficiency which may lead to anemia, causing fatigue, pale skin, shortness of breath or headache. Notify your doctor if you experience any of these as you may require supplements.
  • Your doctor will monitor your blood sugar levels and kidney functions regularly while you are taking this medication.

Fact Box

Habit Forming
No
Therapeutic Class
ANTI DIABETIC

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FAQs

Glimepiride

Q. Does Glimepiride make you sleepy?

Glimepiride itself does not cause sleepiness. However, it may cause hypoglycemia (low blood sugar) when used with other anti-diabetes medicine. Because of this you may feel sleepy or have problems in sleeping.

Q. Is Glimepiride safe for kidneys?

Glimepiride does not affect kidneys in patients with normal kidney function. However, its use should be avoided in patients with severe kidney disease since Glimepiride is principally eliminated by the kidneys.

Q. Does Glimepiride cause memory loss?

No, it is not known that Glimepiride causes memory loss. However, the use of Glimepiride may cause low blood sugar which may cause problems with concentration and reduced alertness.

Q. Who should not take Glimepiride?

Glimepiride should be avoided by patients who are allergic to it, have severe kidney or liver disease, have G6PD-deficiency (an inherited condition affecting red blood cells) or are due to have surgery. Additionally, patients who are trying to get pregnant, are pregnant or breastfeeding, or have insulin-dependent diabetes (type 1 diabetes mellitus) should avoid taking Glimepiride.

Q. How long does it take for Glimepiride to start working?

Glimepiride takes about 2 to 3 hours to reduce blood sugar levels. You may not feel any difference, but this does not mean the medicine is not working. Continue taking the medication as directed by your doctor and if you have any concerns, discuss it with your doctor.

Q. How long do I need to take Glimepiride? Can I stop the medication?

Usually, the treatment for diabetes is suggested for a long term. You may have to continue the treatment life long. Glimepiride only controls the sugar levels but does not cure it. Do not stop taking Glimepiride without talking to your doctor. If you stop taking Glimepiride suddenly your diabetes may get worse.

Q. How and when to take Glimepiride?

Glimepiride is advised to be taken in the dose and duration suggested by your doctor. Generally, a single daily dose of Glimepiride is sufficient to control blood sugar levels. The dose should be taken whole with water shortly before or during breakfast. However, if you skip breakfast then the medicine should be taken shortly before or during your first main meal.

Q. What can happen if I take more than the recommended dose of Glimepiride?

Glimepiride should be taken strictly as advised by the doctor. Overdose of Glimepiride may significantly decrease your blood sugar levels (hypoglycemia). If you think you have taken an excess dose and experience a dip in your sugar level, consume enough sugar (e.g., a small bar of sugar cubes, sweet juice or sweetened tea) and inform a doctor immediately. Severe cases of hypoglycemia accompanied by loss of consciousness and coma require immediate medical treatment and admission into hospital.
Metformin

Q. What does Metformin do exactly?

People with type 2 diabetes are not able to make enough insulin or respond normally to the insulin made by their bodies. When this happens, the concentration of sugar/glucose increases in the blood. Metformin acts in several ways to reduce the increased levels of sugar in blood. Metformin decreases glucose production from the liver and decreases absorption of glucose from the intestine after taking food while improving the sensitivity of the body organs and muscles towards insulin. This helps improve the uptake of glucose from the blood. It also helps your body to respond better to the insulin it makes naturally.

Q. Does Metformin cause weight loss?

Yes, Metformin has been shown to cause weight loss in people who are overweight or obese. It may also cause a modest loss in weight in those overweight and obese individuals who are at risk for diabetes. In addition, patients who are sensitive or resistant to insulin may also show weight loss. But, do not start taking this medicine for weight loss on your own. Consult your doctor for the same.

Q. What are the benefits of taking Metformin?

Metformin is one of the first medicines that is given to patients with high blood sugar levels. It helps control blood sugar levels. It promotes the body’s response to the insulin made by the pancreas, decreases the amount of sugar made by the liver and decreases the amount of sugar absorbed by the intestines. Unlike other oral antidiabetic medicines, Metformin when taken alone, rarely causes low blood sugar as it prevents the pancreas from secreting more insulin. In addition to being a great medicine to lower blood sugar levels, it also helps in controlling weight gain.

Q. Can Metformin make you sleepy?

Metformin usually does not cause sleepiness and is well tolerated. However, the use of Metformin may rarely cause sleep disorders and insomnia. Sleepiness may be due to a very serious side effect called lactic acidosis, which particularly occurs if your kidneys are not working properly. Contact your doctor if you feel sleepy or tired while taking Metformin.

Q. How to take Metformin?

Take Metformin with or after a meal. Do not crush or chew the tablets and swallow it with a glass of water. If your doctor has prescribed one tablet a day, prefer taking it in the morning with breakfast. If you have been prescribed two tablets a day, then take one in the morning and other in the evening with dinner. In case of three doses a day, apart from morning and evening, you can take it with lunch. Taking Metformin with meals will reduce its digestive problems like indigestion, nausea, vomiting, diarrhea, stomach ache and loss of appetite.

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Disclaimer:

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover all possible side effects, drug interactions or warnings or alerts. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

  1. Glimepiride + Metformin. Karachi, Pakistan: Sanofi-Aventis Pakistan Ltd. [Accessed 23 Jan. 2019] (online) Available from:External Link
  2. Metformin Hydrochloride Prolonged Release & Glimepiride Tablets I.P. Ankleshwar: Sanofi India Limited; 2018. [Accessed 08 Apr. 2019] (online) Available from:External Link
  3. Glimepiride. Bridgewater, New Jersey: Sanofi-Aventis U.S. LLC.; 2009. [Accessed 08 Apr. 2019] (online) Available from:External Link
  4. Metformin hydrochloride. Princeton, New Jersey: Bristol-Myers Squibb Company. [Accessed 08 Apr. 2019] (online) Available from:External Link

Manufacturer/Marketer address

NO.3919, 1ST CROSS, GIRINAGAR 4TH PHASE, BANGALORE Bangalore KA 560085 INDIA
Country of origin: India

Expires on or after: March, 2022

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