Glimepiride + Metformin

Information about Glimepiride + Metformin

Glimepiride + Metformin Uses

Glimepiride+Metformin is used in the treatment of type 2 diabetes mellitus.

How Glimepiride + Metformin works

Glimepiride + Metformin is a combination of two antidiabetic medicines: Glimepiride and Metformin. Glimepiride is a sulfonylurea which works by increasing the amount of insulin released by the pancreas in order to lower the blood glucose. Metformin is a biguanide which works by lowering glucose production in the liver, delaying glucose absorption from intestines and increasing the body's sensitivity to insulin.

Common side effects of Glimepiride + Metformin

Hypoglycemia (low blood glucose level), Taste change, Nausea, Diarrhea, Stomach pain, Headache, Upper respiratory tract infection
CONTENT DETAILS
Written By
MDS, BDS
Reviewed By
MD (Pharmacology), MBBS
Last updated:
01 Oct 2021 | 07:03 AM (UTC)

Want to know more?

Read Our Editorial Policy

Available Medicine for Glimepiride + Metformin

53 to ₹15511 variant(s)
Gluconorm-GLupin Ltd
83 to ₹23819 variant(s)
GemerSun Pharmaceutical Industries Ltd
35 to ₹19514 variant(s)
Amaryl MSanofi India Ltd
157 to ₹3304 variant(s)
Glimestar-MMankind Pharma Ltd
46 to ₹2829 variant(s)
Azulix MFTorrent Pharmaceuticals Ltd
48 to ₹2209 variant(s)
Glimisave MEris Lifesciences Ltd
85 to ₹18312 variant(s)
Diapride MMicro Labs Ltd
40 to ₹42915 variant(s)
Glucoryl-MAlkem Laboratories Ltd
49 to ₹2167 variant(s)
Zoryl MIntas Pharmaceuticals Ltd
71 to ₹30011 variant(s)

Expert advice for Glimepiride + Metformin

  • You have been prescribed this combination medicine as it can control blood sugar better than metformin alone.
  • You should continue to exercise regularly, eat a healthy diet, and take your other diabetes medicines along with Glimepiride + Metformin.
  • Take it with food to lower your chance of having an upset stomach.
  • Monitor your blood sugar level regularly while you are taking this medicine. 
  • It can cause hypoglycemia (low blood sugar level) when used with other antidiabetic medicines, alcohol or if you delay or miss a meal. 
  • Inform your doctor about your diabetes treatment if you are due to have surgery under a general anesthetic.
  • Tell your doctor immediately if you experience any deep or rapid breathing or if you have persistent nausea, vomiting, and stomach pain as Glimepiride + Metformin may cause a rare but serious condition called lactic acidosis, which is an excess of lactic acid in the blood.
  • Your doctor may check your liver function regularly. Inform your doctor if you develop symptoms such as abdominal pain, loss of appetite, or yellowing of the eyes or skin (jaundice).

Frequently asked questions for Glimepiride + Metformin

Glimepiride + Metformin

Q. What are the recommended storage conditions for Glimepiride+Metformin?

Keep this medicine in the container or the pack it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.

Q. Can the use of Glimepiride+Metformin lead to lactic acidosis?

Yes, the use of Glimepiride+Metformin can lead to lactic acidosis. It is a medical emergency which is caused by increased levels of lactic acid in the blood. It is also known as MALA (Metformin-associated lactic acidosis). It is a rare side effect associated with the use of metformin and therefore, it is considered to be harmful for patients with underlying kidney disease, old age patients or who take large amounts of alcohol. Symptoms of lactic acidosis may include muscle pain or weakness, dizziness, tiredness, feeling of cold in arms and legs, difficulty in breathing, nausea, vomiting, stomach pain or slow heart rate. If you have these symptoms, stop taking Glimepiride+Metformin and consult your doctor immediately.

Q. What is Glimepiride+Metformin?

Glimepiride+Metformin is a combination of two medicines: Glimepiride and Metformin. This medicine is used in the treatment of type 2 diabetes mellitus (DM). It improves blood glucose levels in adults when taken along with proper diet and regular exercise. Glimepiride lowers the blood glucose levels by increasing the release of insulin from the pancreas. Metformin works by lowering the glucose production in the liver and improving insulin sensitivity. This combination is not indicated for the treatment of type 1 DM.

Q. What are the possible side effects of Glimepiride+Metformin?

The use of Glimepiride+Metformin is associated with common side effects like hypoglycemia (low blood sugar level), altered taste, nausea, stomach pain, diarrhea, headache and upper respiratory tract infection. Its use can also lead to serious but rare side effects like lactic acidosis. On long-term use it can also lead to Vitamin B12 deficiency.

Q. Can the use of Glimepiride+Metformin cause hypoglycemia?

Yes, the use of Glimepiride+Metformin can cause hypoglycemia (low blood sugar level). Symptoms of hypoglycemia include nausea, headache, irritability, hunger, sweating, dizziness, fast heart rate and feeling anxious or shaky. It happens more often if you miss or delay your food, drink alcohol, over-exercise or take other antidiabetic medicine along with it. So, regular monitoring of the blood sugar level is important. Always keep a quick source of sugar like glucose tablets, honey or fruit juice with you.

Q. Can the use of Glimepiride+Metformin lead to Vitamin B12 deficiency?

Yes, the use of Glimepiride+Metformin can cause Vitamin B12 deficiency on long-term use. It interferes with the absorption of Vitamin B12 in the stomach. If untreated, it may cause anemia and nerve problems and the patient can experience tingling sensation and numbness in hands and feet, weakness, urinary problems, change in mental status and difficulty in maintaining balance (ataxia). To avoid such problems, some researchers suggest an intake of Vitamin B12 from outside sources at least once every year.

Q. Is it safe to take alcohol while I am also taking Glimepiride+Metformin?

No, it is not safe to take Glimepiride+Metformin along with alcohol, as it may lower your blood sugar levels and lead to hypoglycemia. It can also increase the chances of lactic acidosis.

INDIA’S LARGEST HEALTHCARE PLATFORM

160M+
Visitors
27M+
Orders Delivered
1800+
Cities
Get the link to download App
Reliable

All products displayed on Tata 1mg are procured from verified and licensed pharmacies. All labs listed on the platform are accredited

Secure

Tata 1mg uses Secure Sockets Layer (SSL) 128-bit encryption and is Payment Card Industry Data Security Standard (PCI DSS) compliant

Affordable

Find affordable medicine substitutes, save up to 50% on health products, up to 80% off on lab tests and free doctor consultations.

India's only LegitScript and ISO/IEC 27001 certified online healthcare platform

Know More About Tata 1mgdownArrow

Access medical and health information

Tata 1mg provides you with medical information which is curated, written and verified by experts, accurate and trustworthy. Our experts create high-quality content about medicines, diseases, lab investigations, Over-The-Counter (OTC) health products, Ayurvedic herbs/ingredients, and alternative remedies.

Order medicines online

Get free medicine home delivery in over 1800 cities across India. You can also order Ayurvedic, Homeopathic and other Over-The-Counter (OTC) health products. Your safety is our top priority. All products displayed on Tata 1mg are procured from verified and licensed pharmacies.

Book lab tests

Book any lab tests and preventive health packages from certified labs and get tested from the comfort of your home. Enjoy free home sample collection, view reports online and consult a doctor online for free.

Consult a doctor online

Got a health query? Consult doctors online from the comfort of your home for free. Chat privately with our registered medical specialists to connect directly with verified doctors. Your privacy is guaranteed.