Syntharmin 0.25mg Injection

Reviewed By Dr. Mekhala Chandra, MD, MBBS

Last updated on 31 Mar 2026 | 02:31 PM (IST)

Syntharmin 0.25mg Injection is a medicine used to control bleeding from the uterus, that may occur after childbirth or an abortion. It works on the smooth muscle of the uterus and increases tone, rate, and amplitude of contractions thus reduces blood loss.

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Stored between 2-8°C

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General Information

Contains

Methylergometrine (0.25mg)

Marketer

Iscon Life Sciences

Storage

Store in a refrigerator (2 - 8°C). Do not freeze.

The content is shown in English

Product introduction

Syntharmin 0.25mg Injection is not for a self-administered, it is given as an injection into the veins or muscles by the doctor at hospital setting. It should be taken as your doctor's advice. The dose and how often you take it depends on what you are taking it for. Your doctor will decide how much you need to improve your symptoms.

The most common side effects of this medicine include headache, increase in blood pressure and seizure. If these bother you or appear serious, let your doctor know. There may be ways of reducing or preventing them. Generally, alcohol should be avoided while taking this medicine.

Before taking this medicine, let your doctor know if you have ever had heart disease or you have high blood pressure. Your doctor should also know about all other medicines you are taking as many of these may make this medicine less effective or change the way it works.

Uses of Syntharmin Injection

Post-delivery bleeding
Induction of labour

Benefits of Syntharmin Injection

Post-delivery bleeding
Post-delivery bleeding (also known as postpartum hemorrhage) is a serious condition where excessive bleeding occurs after childbirth. Syntharmin 0.25mg Injection helps by inducing strong contractions of the uterus, which aids in reducing bleeding and supports faster recovery after delivery.

Induction of labour
Induction of labour is sometimes necessary when there are health concerns for the mother or baby, or if the pregnancy goes beyond full term. Syntharmin 0.25mg Injection helps initiate or strengthen uterine contractions, assisting in the safe progression of labour when medically required.

Side effects of Syntharmin Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Syntharmin

High blood pressure
Headache
Seizure

How to use Syntharmin Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Syntharmin Injection works

Syntharmin 0.25mg Injection is an ergot alkaloid. It works by causing sustained contractions of the smooth muscles of the uterus. This results in compression of the blood vessels which controls bleeding after delivery.

Quick tips

Syntharmin 0.25mg Injection is used for the prevention and control of post-delivery bleeding.
It may also be used for the active management of the third stage of labor, to facilitate the delivery of the placenta.
It is given intravenously (into a vein) or intramuscularly (into the muscle) by a doctor or healthcare provider in a hospital or clinic.
Its dose may be repeated as required at intervals of 2 to 4 hours.
It should be avoided in patients, with high blood pressure, and heart disease.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Syntharmin 0.25mg Injection. Please consult your doctor.

Pregnancy

UNSAFE

Syntharmin 0.25mg Injection is highly unsafe during pregnancy. It can cause serious harm to the unborn baby, including birth defects and pregnancy loss. Do not use this medicine if you are pregnant or planning to become pregnant.

Breast feeding

CAUTION

Syntharmin 0.25mg Injection should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from the body.

Driving

CAUTION

Syntharmin 0.25mg Injection may cause dizziness or weakness due to changes in blood pressure. Do not drive if these symptoms occur.

Kidney

CAUTION

Syntharmin 0.25mg Injection should be used with caution in patients with kidney disease. Dose adjustment may be needed.

Liver

CAUTION

Syntharmin 0.25mg Injection should be used with caution in patients with liver disease. Dose adjustment may be needed.

Interaction with drugs

Taking Syntharmin with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Life-threatening

Itraconazole (Oral Route)

Do not consume Methylergometrine with Itraconazole. Itraconazole may raise blood levels of Methylergometrine.

Life-threatening

Ketoconazole (Oral Route)

Do not consume Methylergometrine with Ketoconazole. Ketoconazole may raise blood levels of Methylergometrine.

Life-threatening

Ketoconazole (Injection Route)

Do not consume Methylergometrine with Ketoconazole. Ketoconazole may raise blood levels of Methylergometrine.

Severe

Clarithromycin (Oral Route)

Do not consume Methylergometrine with Clarithromycin.

Severe

Clarithromycin (Injection Route)

Do not consume Methylergometrine with Clarithromycin.

Fact Box

Chemical Class

Lysergamides

Habit Forming

Therapeutic Class

GYNAECOLOGICAL

Action Class

Uterotonics & Abortificients

Related lab tests

Activated Partial Thromboplastin Time

Complete Blood Count

Prothrombin Time

Thrombin Time

References

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Iscon Life Sciences
Address: 607, Signature-1, Makarba Road, S.G Highway, Ahmedabad- 380051 Gujarat (India).

Vendor Details

Country of origin: India

Lab tests offered by us

Why we need a prescription?

Syntharmin 0.25mg Injection

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General Information

Contains

Marketer

Storage

Product introduction

Uses of Syntharmin Injection

Benefits of Syntharmin Injection

Side effects of Syntharmin Injection

How to use Syntharmin Injection

How Syntharmin Injection works

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Itraconazole (Oral Route)

Ketoconazole (Oral Route)

Ketoconazole (Injection Route)

Clarithromycin (Oral Route)

Clarithromycin (Injection Route)

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

Related lab tests

Activated Partial Thromboplastin Time

Complete Blood Count

Prothrombin Time

Thrombin Time

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

Related/Popular tests