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Syntharmin 0.25mg Injection

Methylergometrine (0.25mg)
Genuine
Authenticity Assured
Prescription
required
Cold stored
Stored between 2-8°C
Syntharmin 0.25mg Injection is a medicine used to control bleeding from the uterus, that may occur after childbirth or an abortion. It works on the smooth muscle of the uterus and increases tone, rate, and amplitude of contractions thus reduces blood loss.

Written By Dr. Sakshi Jain, MS, BDS,
Reviewed By Dr. Mekhala Chandra, MD, MBBS,
Last updated on 19 Jun 2026 | 02:44 PM (IST)
₹14.4 MRP ₹15.9410% off 
We do not facilitate sale of this product at present
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General Information

Contains

Methylergometrine (0.25mg)

Marketer

Iscon Life Sciences

Storage

Store in a refrigerator (2 - 8°C). Do not freeze.
The content is shown in English
Syntharmin 0.25mg Injection image
Syntharmin 0.25mg Injection image

Product introduction

Syntharmin 0.25mg Injection is not for a self-administered, it is given as an injection into the veins or muscles by the doctor at hospital setting. It should be taken as your doctor's advice. The dose and how often you take it depends on what you are taking it for. Your doctor will decide how much you need to improve your symptoms.

The most common side effects of this medicine include headache, increase in blood pressure and seizure.  If these bother you or appear serious, let your doctor know. There may be ways of reducing or preventing them. Generally, alcohol should be avoided while taking this medicine.

Before taking this medicine, let your doctor know if you have ever had heart disease or you have high blood pressure. Your doctor should also know about all other medicines you are taking as many of these may make this medicine less effective or change the way it works.

Uses of Syntharmin Injection

Benefits of Syntharmin Injection

Post-delivery bleeding
Post-delivery bleeding (also known as postpartum hemorrhage) is a serious condition where excessive bleeding occurs after childbirth. Syntharmin 0.25mg Injection helps by inducing strong contractions of the uterus, which aids in reducing bleeding and supports faster recovery after delivery.
Induction of labour
Induction of labour is sometimes necessary when there are health concerns for the mother or baby, or if the pregnancy goes beyond full term. Syntharmin 0.25mg Injection helps initiate or strengthen uterine contractions, assisting in the safe progression of labour when medically required.

Side effects of Syntharmin Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Syntharmin
  • High blood pressure
  • Headache
  • Seizure

How to use Syntharmin Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Syntharmin Injection works

Syntharmin 0.25mg Injection is an ergot alkaloid. It works by causing sustained contractions of the smooth muscles of the uterus. This results in compression of the blood vessels which controls bleeding after delivery.

Quick tips

  • Syntharmin 0.25mg Injection is used for the prevention and control of post-delivery bleeding.
  • It may also be used for the active management of the third stage of labor, to facilitate the delivery of the placenta.
  • It is given intravenously (into a vein) or intramuscularly (into the muscle) by a doctor or healthcare provider in a hospital or clinic.
  • Its dose may be repeated as required at intervals of 2 to 4 hours.
  • It should be avoided in patients, with high blood pressure, and heart disease.

Safety advice

Alcohol

Alcohol

CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Syntharmin 0.25mg Injection. Please consult your doctor.
Pregnancy

Pregnancy

UNSAFE
Syntharmin 0.25mg Injection is highly unsafe during pregnancy. It can cause serious harm to the unborn baby, including birth defects and pregnancy loss. Do not use this medicine if you are pregnant or planning to become pregnant.
Breast feeding

Breast feeding

CAUTION
Syntharmin 0.25mg Injection should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from the body.
Driving

Driving

CAUTION
Syntharmin 0.25mg Injection may cause dizziness or weakness due to changes in blood pressure. Do not drive if these symptoms occur.
Kidney

Kidney

CAUTION
Syntharmin 0.25mg Injection should be used with caution in patients with kidney disease. Dose adjustment may be needed.
Liver

Liver

CAUTION
Syntharmin 0.25mg Injection should be used with caution in patients with liver disease. Dose adjustment may be needed.

Interaction with drugs

Taking Syntharmin with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Life-threatening

Itraconazole (Oral Route)

Do not consume Methylergometrine with Itraconazole. Itraconazole may raise blood levels of Methylergometrine.
Life-threatening

Ketoconazole (Oral Route)

Do not consume Methylergometrine with Ketoconazole. Ketoconazole may raise blood levels of Methylergometrine.
Life-threatening

Ketoconazole (Injection Route)

Do not consume Methylergometrine with Ketoconazole. Ketoconazole may raise blood levels of Methylergometrine.
Severe

Clarithromycin (Oral Route)

Do not consume Methylergometrine with Clarithromycin.
Severe

Clarithromycin (Injection Route)

Do not consume Methylergometrine with Clarithromycin.

Frequently asked questions

Syntharmin 0.25mg Injection is used to control excessive bleeding from the uterus after childbirth or after certain pregnancy-related procedures. It helps the uterus contract firmly, which reduces blood loss and supports recovery after delivery. It may also be used during the third stage of labor to help with placenta delivery and reduce the risk of postpartum hemorrhage.
Syntharmin 0.25mg Injection contains Methylergometrine, which acts directly on the muscles of the uterus and causes strong, sustained uterine contractions. These contractions help compress the blood vessels in the uterus, reducing bleeding after childbirth. This action helps the uterus return to its normal size and lowers the risk of excessive blood loss.
During the third stage of labor, the placenta needs to separate from the uterus and be expelled safely. Syntharmin 0.25mg Injection helps strengthen uterine contractions, which can assist placenta delivery and reduce the chances of heavy bleeding after childbirth. This is one reason it is commonly used in hospital delivery settings.
Syntharmin 0.25mg Injection is administered by a doctor in a hospital or clinical setting. It is usually given as an injection into a muscle or a vein, depending on the medical situation. The dose and timing are decided by the treating doctor.
No. Syntharmin 0.25mg Injection is not meant for self-administration. It should only be given under medical supervision because monitoring may be required during and after treatment. Improper use may increase the risk of serious side effects.
Syntharmin 0.25mg Injection is generally used when rapid control of uterine bleeding is needed. Since it is given by injection, it starts acting quickly by stimulating uterine contractions and helping reduce blood loss. The exact response may vary depending on the patient's condition and route of administration.
Yes, an increase in blood pressure is a known side effect of Methylergometrine. This is why the medicine is used cautiously and usually avoided in individuals with uncontrolled hypertension or certain heart conditions. Blood pressure may be monitored during treatment when needed.
People with heart disease, coronary artery disease, or circulation-related disorders should inform their doctor before receiving Syntharmin 0.25mg Injection. This medicine may worsen these conditions and may not be suitable for everyone. Do not take Syntharmin 0.25mg Injection if you have chronic high blood pressure.
Syntharmin 0.25mg Injection causes strong uterine contractions. If used during pregnancy before labor begins, it may harm the unborn baby and may increase the risk of pregnancy complications. For this reason, it is considered unsafe during pregnancy unless specifically required in controlled obstetric situations.
Yes. Certain medicines, including some macrolide antibiotics and azole antifungal medicines, may increase methylergometrine levels in the body and raise the risk of serious side effects. Always inform your doctor about any recent or ongoing medications before treatment.
Several medicines may interact with Syntharmin 0.25mg Injection and affect blood pressure, circulation, or the way the medicine is processed by the body. Providing a complete list of prescription medicines, supplements, herbal products, and over-the-counter medicines helps reduce the risk of harmful interactions.
Yes, Methylergometrine may also be used in certain situations to help control uterine bleeding after abortion or miscarriage by helping the uterus contract effectively. Its use depends on the clinical condition and should always be decided by your doctor.
By increasing uterine tone and contractions, Syntharmin 0.25mg Injection helps the uterus shrink back toward its normal size after childbirth. This may reduce blood loss and support the normal recovery process following delivery.
Seek medical advice if bleeding continues heavily, becomes worse, or if you develop severe headache, chest pain, breathing difficulty, vision changes, fainting, high blood pressure symptoms, or unusual swelling. Persistent symptoms after delivery should not be ignored.

Fact Box

Chemical Class

Lysergamides

Habit Forming

No

Therapeutic Class

GYNAECOLOGICAL

Action Class

Uterotonics & Abortificients

Related lab tests

Activated Partial Thromboplastin Time

Complete Blood Count

Prothrombin Time

Thrombin Time

References

  1. MedIndia. Methylergometrine. [Accessed 3 Aprl. 2019] (online) Available from:
  2. Methylergometrine. East Hanover, New Jersey: Novartis Pharmaceuticals Corporation; 2012. [Accessed 03 Apr. 2019] (online) Available from:
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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Iscon Life Sciences
Address: 607, Signature-1, Makarba Road, S.G Highway, Ahmedabad- 380051 Gujarat (India).

Vendor Details

Country of origin: India

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