Syndyma 400mg/16ml Injection

Prescription Required
Manufacturer
SALT COMPOSITION
Storage
Store in a refrigerator (2 - 8°C). Do not freeze.

Introduction

Syndyma 400mg/16ml Injection is an anticancer medication. It is used in the treatment of cancer of colon and rectum, non-small cell lung cancer, kidney cancer, brain tumor, ovarian and cervical cancer. It helps to prevent the growth of new blood vessels that feed tumors and stops tumors from growing.

Syndyma 400mg/16ml Injection is an effective medicine, first-line option when used together with other cancer medicines. It is given as an infusion. That means you get it through a small needle in your vein or through a port, which is a device placed under your skin. The doctor will decide your dose and duration and will check you for signs of an infusion reaction such as high blood pressure and trouble breathing. You keep taking Syndyma 400mg/16ml Injection as long as your disease is controlled and your side effects are manageable. Your doctor will determine whether you should stop taking it or not. You may be advised to check blood pressure and levels of protein in urine while you are taking this medication.

The most common side effects of this medicine include rectal bleeding, taste change, and headache. Inform your doctor that you are taking this medication before undergoing any surgical procedure, as the drug has ability to lower the ability of wound healing. Other than this, it also enhances your risk of bleeding thus if you notice any unusual bleeding or bleeding consult with your doctor immediately.

Inform your doctor if you are pregnant, planning pregnancy or breastfeeding. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using.

Benefits of Syndyma Solution for Infusion

In Cancer of colon and rectum

Cancer of the colon and rectum, also known as colorectal cancer (CRC) or bowel cancer, is the development of cancer from two parts of the large intestine, namely, the colon or rectum. In this type of cancer, the person may notice symptoms such as blood in the stool, a change in bowel movements, weight loss, and fatigue. Syndyma 400mg/16ml Injection treats and also lowers the risk of developing further cancerous growths (polyps) and bowel cancer. It kills or stops the growth of cancer cells and also prevents the multiplication of cancer cells. It is an effective, yet very toxic medicine and you should discuss the risks and benefits with your doctor.

In Non-small cell lung cancer

Non-small cell lung cancer is one of the major kinds of lung cancer and it affects both smokers as well as non-smokers. Syndyma 400mg/16ml Injection helps treat non-small cell lung cancer and may be given alone or in combination with other medicines. It is a potent and very toxic medicine and you should discuss the risks and benefits with your doctor. You should avoid drinking alcohol or smoking while having this treatment and drink plenty of water to stay hydrated.

In Kidney cancer

Syndyma 400mg/16ml Injection is used to treat kidney cancer and its associated symptoms such as blood in the urine, unexplained low back pain or weight loss, fatigue, loss of appetite, etc. It stops cancer growth and prevents multiplication of cancer cells. This restricts the advancement of cancer to other unaffected regions. You need to follow your doctor’s instructions very carefully to recover.

In Brain tumor

Brain tumor is an abnormal mass or collection of cells that may be cancerous (malignant) or non-cancerous (benign). Syndyma 400mg/16ml Injection kills or stops the growth of cancer cells and also prevents the multiplication of cancer cells. Consult your doctor if you have any doubts.

In Ovarian cancer

Ovarian cancer is a cancer that begins in the female organs that produce eggs (ovaries). This type of cancer is usually detected very late and can be fatal too. It usually spreads to the pelvis and stomach. Syndyma 400mg/16ml Injection kills or stops the growth of cancer cells and also prevents the multiplication of cancer cells. It is an effective medicine but has some side effects that may be bothersome. So, you should discuss the risks and benefits with your doctor.

In Cervical cancer

Syndyma 400mg/16ml Injection is an anti-cancer medicine that is used to kill cancerous cells in cervical cancer, a cancer that develops in the cervix of a female. The affected female may have symptoms such as abnormal bleeding, foul smelling vaginal discharge, lower back pain, or may even have no symptoms at all. It has a lot of side effects and you must discuss the risks and benefits with your doctor before starting treatment with this medicine.

Side effects of Syndyma Solution for Infusion

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Syndyma

  • Rectal bleeding
  • Taste change
  • Headache
  • Nosebleeds
  • Back pain
  • Dry skin
  • High blood pressure
  • Protein in urine
  • Inflammation of the nose

How to use Syndyma Solution for Infusion

Your doctor or nurse will give you this medicine. Kindly do not self-administer.

How Syndyma Solution for Infusion works

Syndyma 400mg/16ml Injection is a anti-angiogenic medication. It works by blocking a protein called vascular endothelial growth factor (VEGF). This stops the formation of blood vessels that bring oxygen and nutrients to cancerous cells.

Safety advice

Alcohol
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Syndyma 400mg/16ml Injection. Please consult your doctor.
Pregnancy
CONSULT YOUR DOCTOR
Syndyma 400mg/16ml Injection may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Breast feeding
CONSULT YOUR DOCTOR
Syndyma 400mg/16ml Injection is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Driving
UNSAFE
Syndyma 400mg/16ml Injection may cause side effects which could affect your ability to drive.
Sleepiness and fainting have been reported with Syndyma 400mg/16ml Injection and this may impair your ability to drive.
Kidney
SAFE IF PRESCRIBED
Syndyma 400mg/16ml Injection is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Syndyma 400mg/16ml Injection may not be needed in these patients. Please consult your doctor.
Liver
SAFE IF PRESCRIBED
Syndyma 400mg/16ml Injection is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Syndyma 400mg/16ml Injection may not be needed in these patients. Please consult your doctor.

What if you forget to take Syndyma Solution for Infusion?

If you miss a dose of Syndyma 400mg/16ml Injection, please consult your doctor.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.
No substitutes found for this medicine

Quick tips

  • Syndyma 400mg/16ml Injection is an effective, first-line option when used together with other medicines for certain types of cancers such as colorectal, lung, cervical, and kidney cancers.
  • Syndyma 400mg/16ml Injection is given as an infusion. Your doctor or nurse will monitor you for signs of an infusion reaction such as high blood pressure and trouble breathing.
  • It can lower your wound healing ability. Inform your doctor that you are taking this medication before undergoing any surgical procedure.
  • It can increase the risk of bleeding. Inform your doctor if you notice any unusual bleeding or bleeding that doesn't stop easily.
  • Your doctor may regularly check your blood pressure and levels of protein in your urine while you are on Syndyma 400mg/16ml Injection.

Fact Box

Chemical Class
Monoclonal antibody (mAb)
Habit Forming
No
Therapeutic Class
ANTI NEOPLASTICS
Action Class
Vascular endothelial growth factor (VEGF) inhibitor

Patient concerns

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What is the purpose of Chemotherepy given at the time of radiotherapy in ca lung small cell carcinoma
Dr. Vijay Sharnangat
Medical Oncology and Hematology
This is given to enhance the therapeutic effect of radiation therapy which is curative for small cell lung cancer.
I want to know the symptoms of cancer as I am a smoker
Dr. Vijay Sharnangat
Medical Oncology and Hematology
Symptoms for cancer depends upon which organ involved. For smokers , definitely chronic , they have possibility to develop lung cancer, head and neck cancers, oesophagus cancer, pancreatic cancer, stomach cancer and so more on. General symptoms would be like loss of appetite, weight loss, low grade fever in some cases, chronic cough for long time.
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FAQs

Q. What kinds of cancer can Syndyma 400mg/16ml Injection be used for ?

Syndyma 400mg/16ml Injection is approved for the treatment of cancer of the colon or rectum that has spread to other parts of the body. It must be given along with chemotherapy. Other types of cancers that it helps with includes certain types of lung cancer, kidney cancer, ovarian cancer, cervical cancer, and glioblastoma (a type of brain tumor).

Q. How is Syndyma 400mg/16ml Injection given?

Syndyma 400mg/16ml Injection is given as an infusion. That means you get it through a small needle in your vein or through a port, which is a device placed under your skin. Your doctor will decide your dose and duration and will monitor you for signs of an infusion reaction.

Q. How long can I take Syndyma 400mg/16ml Injection for?

You keep taking Syndyma 400mg/16ml Injection as long as your disease is controlled and your side effects are manageable. Your doctor will determine whether you should stop taking Syndyma 400mg/16ml Injection. If your cancer progresses during this initial treatment, talk to your doctor if a different chemotherapy may be an option.

Q. How Syndyma 400mg/16ml Injection works differently from chemotherapy?

Chemotherapy attacks fast-growing cells, like cancer cells. In contrast, the purpose of Syndyma 400mg/16ml Injection is to prevent the growth of new blood vessels that feed tumors. This causes the tumour to shrink, or to stop growing.

Q. Does a person taking Syndyma 400mg/16ml Injection still need chemotherapy?

Chemotherapy is still needed along with taking Syndyma 400mg/16ml Injection. It makes chemotherapy work better.

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Disclaimer:

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover all possible side effects, drug interactions or warnings or alerts. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

  1. Chabner BA, Barnes J, Neal J, et al. Targeted Therapies: Tyrosine Kinase Inhibitors, Monoclonal Antibodies, and Cytokines. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1739-40.
  2. Chu E, Sartorelli AC. Cancer Chemotherapy. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 955.
  3. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 142-43.
  4. Bevacizumab. South San Francisco, California: Genentech, Inc.; 2004 [revised Sep. 2011]. [Accessed 26 Mar. 2019] (online) Available from:External Link
  5. Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Bevacizumab. [Updated 2019 Jul 20]. [Accessed 18 Feb. 2020] (online) Available from:External Link
  6. Central Drugs Standard Control Organisation (CDSCO). [Accessed 27 Mar. 2019] (online) Available from:External Link

Manufacturer/Marketer address

Cipla House, Peninsula Business Park, Ganpatrao Kadam Marg, Lower Parel, Mumbai-400013
Country of origin: India

Expires on or after: January, 2022

A licensed vendor partner from your nearest location will deliver Syndyma 400mg/16ml Injection. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.
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