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Synacthene 250mg Injection

Written By Dr. Syeda Aafia, MBA, BDS
Reviewed By Dr. Rajeev Sharma, MBA, MBBS
Last updated on 12 Nov 2025 | 10:34 PM (IST)
Synacthene 250mg Injection serves as a diagnostic agent for Addison’s disease. It is injected into the body as an injection and this helps to treat the patient accordingly.
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General Information

Contains

Tetracosactide (250mg)

Marketer

Novartis India Ltd
The content is shown in English
Synacthene 250mg Injection image
Synacthene 250mg Injection image

Product introduction

This medicine is administered by a trained healthcare professional. Some side effects of this agent include hypersensitivity, psychological disturbances, increased intraocular pressure, salt and water retention. Let the doctor know if any of these bother you or do not go away.

Uses of Synacthene Injection

Benefits of Synacthene Injection

Addison's disease
Addison's disease, also called adrenal insufficiency, is an uncommon disorder that occurs when your body doesn't produce enough of some very essential hormones required for various body functions. Synacthene 250mg Injection serves as a diagnostic agent to determine the levels of these hormones. This helps the doctor to assess the patient’s condition and plan the treatment.

Side effects of Synacthene Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Synacthene
  • Hypersensitivity
  • Psychotic disorder
  • Increased intraocular pressure
  • Salt and water retention

How to use Synacthene Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Synacthene Injection works

Synacthene 250mg Injection triggers the release of steroids from the adrenal gland, and therefore it is used as a diagnostic agent for the ACTH stimulation test to assess adrenal gland function.

Quick tips

  • Inform your doctor immediately if you experience any allergic symptoms like rash, itching, difficulty breathing, or swelling of the face, lips, or tongue.
  • Do not receive any immunization or vaccination without your doctor’s approval while taking Synacthene 250mg Injection.
  • If you suffer an injury requiring medical help or are going to have surgery either during treatment with Synacthene 250mg Injection or within one year after treatment has stopped, tell the doctor, surgeon or anesthetist about this medicine.
  • Avoid driving or operating machinery or doing activities that require you to be alert until you know how this medicine affects you. 
  • Synacthene 250mg Injection may make you more susceptible to infections, thus, avoid close contact with anyone with an infectious disease.

Safety advice

Alcohol

Alcohol

CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Synacthene 250mg Injection. Please consult your doctor.
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
Information regarding the use of Synacthene 250mg Injection during pregnancy is not available. Please consult your doctor.
Breast feeding

Breast feeding

CONSULT YOUR DOCTOR
Information regarding the use of Synacthene 250mg Injection during breastfeeding is not available. Please consult your doctor.
Driving

Driving

CONSULT YOUR DOCTOR
It is not known whether Synacthene 250mg Injection alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. Please consult your doctor.
It may cause dizziness in some people, do not drive if you experience any such symptoms.
Kidney

Kidney

CONSULT YOUR DOCTOR
There is limited data available on the use of Synacthene 250mg Injection in patients with kidney disease. Please consult your doctor.
Liver

Liver

CONSULT YOUR DOCTOR
There is limited data available on the use of Synacthene 250mg Injection in patients with liver disease.

Interaction with drugs

Taking Synacthene with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Severe

Sodium Valproate (Oral Route)

Do not consume Tetracosactide with Sodium Valproate.
Severe

Sodium Valproate (Injection Route)

Do not consume Tetracosactide with Sodium Valproate.
Moderate

Indapamide (Oral Route)

If concurrent use is essential, your doctor may monitor your potassium levels closely.
Moderate

Clonazepam (Oral Route)

If concurrent use is essential, your doctor may monitor your treatment and adjust the doses as per the observations.
Moderate

Clonazepam (Injection Route)

If concurrent use is essential, your doctor may monitor your treatment and adjust the doses as per the observations.

Frequently asked questions

Synacthene 250mg Injection is used as a diagnostic test to find out if the adrenal glands, small glands next to the kidneys, are working as well as they should.
Synacthene 250mg Injection is given as an injection into the muscles by your doctor or a nurse.
For diagnostic test use, you will be given a single injection of Synacthene 250mg Injection. You will have two blood samples taken, one before the injection and the other 30 minutes after the injection. These blood samples will show whether your adrenal glands are functioning normally or not. For therapeutic use, Synacthene 250mg Injection will not cure your condition but it may relieve some of the symptoms. The injections can be continued for as long as they are beneficial.
As a doctor or nurse will be administering this medicine, you are unlikely to miss a dose. If you have any doubts, consult your doctor or nurse.
It is advisable to inform your doctor if you are taking medications for diabetes, high blood pressure, and convulsions before the start of the treatment with Synacthene 250mg Injection. It may be necessary to change the dose or in some cases to stop the medicine.

Fact Box

Chemical Class

Polypeptides

Habit Forming

No

Therapeutic Class

HORMONES

Action Class

Adrenocorticotropic Hormone (ACTH) Analogues

Related lab tests

ACTH Stimulation Test

Adreno Corticotrophic Hormone Plasma

Cortisol

Sodium

References

  1. Tetracosactide Hexaacetate [New Zealand Consumer Medicine Information]. Christchurch, New Zealand: Clinect NZ Pty Limited; 2020. [Accessed 25th Nov. 2022] (online) Available from:
  2. Tetracosactide Acetate [EMC SmPC]. Basildon, UK: Atnahs Pharma UK Ltd.; 2019. [Accessed 25th Nov. 2022] (online) Available from:
  3. Tetracosactide Zinc. Basildon, United Kingdom: Atnahs Pharma UK Ltd.; 2020. [Accessed 10 Nov. 2025] (online). Available from:
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Novartis India Ltd
Address: Sandoz House, Shiv Sagar Estate, Worli Mumbai -400 018, India

Vendor Details

Country of origin: India

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