Spexib Capsule

Reviewed By Dr. Sachin Gupta, MD Pharmacology, MBBS

Last updated on 23 Mar 2026 | 11:29 AM (IST)

Spexib Capsule is used in the treatment of non-small cell lung cancer. It shows its working by stopping or slowing down the growth of cancer cells.

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General Information

Contains

Ceritinib (150mg)

Marketer

Novartis India Ltd

Storage

Store below 30°C

The content is shown in English

Product introduction

Spexib Capsule should be taken with or without food, but try to have it at the same time every day to get the most benefits. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.

Fatigue, nausea, vomiting, and diarrhea are some common side effects of this medicine. Some serious side effects that might occur which need doctor consultation include tiredness, itchy skin, yellowing of your skin, and chest pain or discomfort, changes in your heartbeat. Your doctor may perform some blood tests before and after the treatment to check for liver, or blood sugar level.

Before taking it, tell your doctor if you have heart disease, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.

Uses of Spexib Capsule

Non-small cell lung cancer

Benefits of Spexib Capsule

Non-small cell lung cancer
Non-small cell lung cancer is one of the major kinds of lung cancer and it affects both smokers as well as non-smokers. Spexib Capsule helps treat non-small cell lung cancer and may be given alone or in combination with other medicines. It is a potent and very toxic medicine and you should discuss the risks and benefits with your doctor. You should avoid drinking alcohol while having this treatment and drink plenty of water to stay hydrated.

Side effects of Spexib Capsule

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Spexib

Diarrhea
Fatigue
Nausea
Vomiting

How to use Spexib Capsule

Take this medicine in the dose and duration as advised by your doctor. Spexib Capsule may be taken with or without food.

How Spexib Capsule works

Spexib Capsule is an anti-cancer medication. It works by blocking the action of the abnormal protein that signals cancer cells to multiply. This helps to stop or slow the spread of cancer cells.

Quick tips

Take it with or without food, preferably at the same time each day.
Diarrhea may occur as a side effect. Drink plenty of fluids and inform your doctor if it doesn't stop or if you find blood in your stools.
Use a reliable contraceptive method to prevent pregnancy while you are taking this medicine and for a month after you stop taking it.
Monitor your blood pressure regularly while taking this medication. Inform your doctor if you notice symptoms of very high blood pressure such as severe headache, confusion, problems with your eyesight, nausea or vomiting.
It may cause serious bleeding problem. Inform your doctor if you get headaches, stomach pain or if you notice blood in your urine or stools.
Do not take this medicine if you are pregnant, planning to conceive or breastfeeding.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Spexib Capsule. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

Spexib Capsule is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.

Breast feeding

CONSULT YOUR DOCTOR

Information regarding the use of Spexib Capsule during breastfeeding is not available. Please consult your doctor.

Driving

UNSAFE

Spexib Capsule may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

Kidney

CAUTION

Spexib Capsule should be used with caution in patients with severe kidney disease. Dose adjustment may be needed.

Liver

CAUTION

Spexib Capsule should be used with caution in patients with severe liver disease. Dose adjustment may be needed.

Interaction with drugs

Taking Spexib with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Life-threatening

Hydroxyzine (Oral Route)

Do not consume Hydroxyzine with Ceritinib.

Life-threatening

Domperidone (Oral Route)

Do not consume Domperidone with Ceritinib.

Life-threatening

Tetrabenazine (Oral Route)

Do not consume Tetrabenazine with Ceritinib.

Life-threatening

Hydroxychloroquine (Oral Route)

Do not consume Hydroxychloroquine with Ceritinib.

Life-threatening

Sevoflurane (Oral Route)

Do not consume Sevoflurane with Ceritinib.

Frequently asked questions

What is Spexib Capsule?

Spexib Capsule is a cancer medicine that contains the active substance ceritinib. It is used to treat patients with anaplastic lymphoma kinase (ALK)-positive metastatic non-small cell lung cancer (NSCLC).

What is ALK-positive NSCLC?

Anaplastic lymphoma kinase (ALK) gene is present in all the cells. When it loses its original structure, it changes its normal behavior and multiplies abnormally, causing lung cancer. This type of lung cancer is called ALK-positive NSCLC.

How does Spexib Capsule treat ALK-positive NSCLC?

Spexib Capsule treat ALK-positive NSCLC that has spread to other parts of the body. By blocking the activity of the abnormal ALK gene, it shrinks the tumor and also stops its further growth.

How should I take Spexib Capsule?

Take this medicine on an empty stomach, do not eat for 2 hours before, and do not eat for 2 hours after taking Spexib Capsule. Talk to your doctor in case of any doubts.

How will you know that Spexib Capsule is working?

Keep taking this medicine exactly as directed until your doctor tells you to stop. Regular scans will reveal whether your tumor is responding to the treatment. Your doctor will determine when those scans should be scheduled.

Are there any serious side effects of Spexib Capsule?

Yes, some people may develop serious side effects after taking this medicine. These may include fast or irregular heart rate, chest pain, lung inflammation (pneumonitis), liver disease, or severe diarrhea. Your doctor may need to adjust your treatment or stop Spexib Capsule temporarily or permanently.

What should I do if I develop liver problems while taking Spexib Capsule?

If you develop liver problems while taking this medicine, you must look for some signs and symptoms. These may include excessive tiredness, yellowish discoloration of your skin or white portion of the eyes, dark or brown urine, nausea, vomiting, or decreased appetite. Additionally, you may develop itching, easy bruising, and also pain on the right side of your stomach. In case you observe any of these, you should consult your doctor without any delay.

Can Spexib Capsule affect my lungs? What should I do?

Yes, this medicine might cause inflammation of the lungs (called pneumonitis). It is advisable to notify your doctor right away if you develop any new or worsening symptoms, including shortness of breath, trouble breathing, cough, or fever.

How to get relief from diarrhea while on treatment with Spexib Capsule?

Food items with soluble fiber can help relieve diarrhea as they help absorb excess fluid from the body. These food items include bananas (ripe), orange, boiled potatoes, white rice, curd, and oatmeal. Diarrhea can cause dehydration in the body, so drink 8-10 glasses of water to avoid dehydration. You can also have soups and juice frequently to hydrate yourself.

Does Spexib Capsule cause vision problems?

Yes, this medicine may cause vision problems. A regular eye examination is recommended in patients taking Spexib Capsule. If you notice any change in your vision or blurred vision, talk to your doctor.

I am a diabetic patient, will Spexib Capsule affect my sugar level?

Spexib Capsule might cause a rise in your sugar level. Monitor your blood sugar level regularly and consult your doctor immediately if you notice excessive thirst and hunger, increased frequency of urination, headaches, trouble thinking or concentrating.

I have noticed some changes in my skin after taking Spexib Capsule. What should I do?

Use a moisturizer to get relief from rashes, dry and itchy skin. Wear loose-fit cotton clothes and try to stay at an ambient room temperature. These conditions tend to resolve once treatment is stopped. However, if you develop yellow discoloration of your skin, inform your doctor immediately as this could be a sign of a liver problem.

Fact Box

Chemical Class

Phenylpiperidines

Habit Forming

Therapeutic Class

ANTI NEOPLASTICS

Action Class

Tyrosine Kinase Inhibitors (TKIs)

References

User feedback

What are you using Spexib Capsule for?

Non-small cell lung cancer

92%

Others

How much was the improvement?

Average

58%

Excellent

33%

Poor

What were the side-effects while using Spexib Capsule?

No Side Effect

20%

Vomiting

20%

Nausea

20%

Diarrhea

20%

Fatigue

20%

How do you take Spexib Capsule?

With food

75%

With or without food

25%

Please rate Spexib Capsule on price

Expensive

75%

Not Expensive

17%

Average

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Novartis India Ltd
Address: Sandoz House, Shiv Sagar Estate, Worli Mumbai -400 018, India

Vendor Details

Country of origin: Switzerland
A licensed vendor partner from your nearest location will deliver Spexib Capsule. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India

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Spexib Capsule

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General Information

Contains

Marketer

Storage

Product introduction

Uses of Spexib Capsule

Benefits of Spexib Capsule

Side effects of Spexib Capsule

How to use Spexib Capsule

How Spexib Capsule works

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Hydroxyzine (Oral Route)

Domperidone (Oral Route)

Tetrabenazine (Oral Route)

Hydroxychloroquine (Oral Route)

Sevoflurane (Oral Route)

Frequently asked questions

What is Spexib Capsule?

What is ALK-positive NSCLC?

How does Spexib Capsule treat ALK-positive NSCLC?

How should I take Spexib Capsule?

How will you know that Spexib Capsule is working?

Are there any serious side effects of Spexib Capsule?

What should I do if I develop liver problems while taking Spexib Capsule?

Can Spexib Capsule affect my lungs? What should I do?

How to get relief from diarrhea while on treatment with Spexib Capsule?

Does Spexib Capsule cause vision problems?

I am a diabetic patient, will Spexib Capsule affect my sugar level?

I have noticed some changes in my skin after taking Spexib Capsule. What should I do?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

References

User feedback

What are you using Spexib Capsule for?

How much was the improvement?

What were the side-effects while using Spexib Capsule?

How do you take Spexib Capsule?

Please rate Spexib Capsule on price

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

In case of any issues, contact us

Lab tests offered by us

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