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Sitafix-M Tablet

Written By Dr. Lipika Khurana, PGDHHM, BDS
Reviewed By Dr. Rajeev Sharma, MBA, MBBS
Last updated on 22 Sep 2025 | 01:58 PM (IST)
Sitafix-M Tablet is a combination of two medicines that control high blood sugar levels in people with type 2 diabetes mellitus. This helps prevent serious complications of diabetes, such as kidney damage and blindness and may reduce your chances of having a heart attack or stroke.
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Sitaford M 50mg/500mg Tablet
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Sitafix-M Tablet
Sitafix-M Tablet
strip of 15 tablets
₹130
₹143.44
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Same composition
Sitaford M 50mg/500mg Tablet
Sitaford M 50mg/500mg Tablet
strip of 15 tablets
Sitagliptin (50mg) + Metformin (500mg)
by Leeford Healthcare Ltd
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₹161
₹9.13 per tablet

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₹1200
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General Information

Contains

Sitagliptin (50mg)+ Metformin (500mg)

Marketer

Shield & Care Pharmaceuticals Pvt Ltd

Storage

Store below 30°C
The content is shown in English
Sitafix-M Tablet image
Sitafix-M Tablet image
Sitafix-M Tablet image
Sitafix-M Tablet image

Product introduction

Sitafix-M Tablet may be prescribed alone or along with other diabetes medications. It works best when used along with a healthy diet and regular exercise. Your dose will depend on your condition, blood sugar levels, and other medicines you are taking. Taking it with meals helps to reduce the chances of developing an upset stomach.

To get the most benefit, you should take it regularly, at the same time each day, and you should not stop unless your doctor recommends it. It is important to stay on the diet and exercise program recommended by your doctor while taking this medicine. Your lifestyle plays a big part in controlling diabetes.

The most common side effects of taking Sitafix-M Tablet include diarrhea, upper respiratory tract infection, and headache. Low blood sugar level (hypoglycemia) is a possible side effect if you are also taking other diabetes medicines like insulin or sulfonylurea. Hence, you need to know how to recognize and deal with it.

This medicine is not suitable for everyone. Before taking it, you should let your doctor know if you have ever had kidney, liver, or heart disease, problems with your pancreas, or if you drink a lot of alcohol. Pregnant or breastfeeding women should also consult their doctor before taking this medicine. Some other medicines may affect Sitafix-M Tablet, so tell your doctor about all the other medicines you are taking to ensure you are safe. You should try to avoid drinking alcohol as it lowers blood glucose. Your doctor will check your kidney function and blood sugar levels before and during treatment.

Uses of Sitafix-M Tablet

Benefits of Sitafix-M Tablet

Treatment of Type 2 diabetes mellitus
Sitafix-M Tablet is a combination of two medicines that work together in different ways to lower your blood glucose levels. Lowering blood glucose levels is an essential part of managing diabetes. If you can control your blood glucose level, your risk of getting any of the serious complications of diabetes, such as kidney damage, eye damage, nerve problems, and loss of limbs, is also lowered. Additionally, proper control of diabetes can also reduce the risk of heart disease and stroke. Taking this medicine regularly, along with appropriate diet and exercise, will help you live an everyday, healthy life. You should keep using this medicine for as long as prescribed because it protects your future health.

Side effects of Sitafix-M Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Sitafix-M
  • Diarrhea
  • Upper respiratory tract infection
  • Headache

How to use Sitafix-M Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Sitafix-M Tablet is to be taken with food.

How Sitafix-M Tablet works

Sitafix-M Tablet is a combination of two medicines: sitagliptin and metformin. Sitagliptin helps your pancreas produce more insulin, facilitates effective use of insulin by the body, and reduces excess sugar that your liver makes. Metformin is a biguanide that lowers glucose production in the liver, delays glucose absorption from the intestines, and increases the body's sensitivity to insulin. Together, they provide better control of blood sugar.

All substitutes for Sitafix-M Tablet

For information purposes only. Consult a doctor before taking any medicine.

ISTamet 50mg/500mg Tablet

by Sun Pharmaceutical Industries Ltd
₹10.6/tablet
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<h3 class=bodySemiBold>ISTamet 50mg/500mg Tablet</h3>

Janumet 50mg/500mg Tablet

by MSD Pharmaceuticals Pvt Ltd
₹23.27/tablet
168% costlier
<h3 class=bodySemiBold>Janumet 50mg/500mg Tablet</h3>

Sitaday M 500 Tablet

by Mankind Pharma Ltd
₹10.73/tablet
24% costlier
<h3 class=bodySemiBold>Sitaday M 500 Tablet</h3>

Sitared-M Tablet 50/500

by Sun Pharmaceutical Industries Ltd
₹10.6/tablet
22% costlier
<h3 class=bodySemiBold>Sitared-M Tablet 50/500</h3>

Lupisit M 50mg/500mg Tablet

by Lupin Ltd
₹13.5/tablet
56% costlier
<h3 class=bodySemiBold>Lupisit M 50mg/500mg Tablet</h3>

Quick tips

  • Take Sitafix-M Tablet with food to lower your chance of having an upset stomach.
  • Take it in addition to regular exercise and a healthy diet to lower blood sugar levels.
  • The chances of weight gain and low blood sugar are lower than with other diabetes medicines.
  • Monitor your blood sugar level regularly while you are taking this medicine. 
  • Inform your doctor about your diabetes treatment if you are due to have surgery under a general anesthetic.
  • Tell your doctor immediately if you experience any deep or rapid breathing, persistent nausea, vomiting, and stomach pain, as Sitafix-M Tablet may cause a rare but serious condition called lactic acidosis, which is an excess of lactic acid in the blood.

Safety advice

Alcohol

Alcohol

UNSAFE
It is unsafe to consume alcohol with Sitafix-M Tablet.
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
Information regarding the use of Sitafix-M Tablet during pregnancy is not available. Please consult your doctor.
Breast feeding

Breast feeding

CONSULT YOUR DOCTOR
Sitafix-M Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Driving

Driving

CAUTION
Your ability to drive may be affected if your blood sugar is too low or too high. Do not drive if these symptoms occur.
Kidney

Kidney

CAUTION
Sitafix-M Tablet should be used with caution in patients with kidney disease. Dose adjustment of Sitafix-M Tablet may be needed. Please consult your doctor.
Use of Sitafix-M Tablet is, however, not recommended in patients with severe kidney disease. Regular monitoring of kidney function test is advisable while you are taking this medicine.
Liver

Liver

UNSAFE
Sitafix-M Tablet is probably unsafe to use in patients with liver disease and should be avoided. Please consult your doctor.

Frequently asked questions

Sitafix-M Tablet is a combination of two medicines: sitagliptin and metformin. This medicine is used in the treatment of type 2 diabetes mellitus. It improves blood glucose levels in adults when taken along with a proper diet and regular exercise. Metformin lowers glucose production in the liver and improves insulin sensitivity. Sitagliptin inhibits the enzyme DPP4 and increases insulin release from the pancreas. This combination is not indicated for patients below 18 years of age.
The use of Sitafix-M Tablet is associated with common side effects like diarrhea, headache, and upper respiratory tract infection. Its use can also lead to serious but rare side effects like lactic acidosis. On long-term use, it can also lead to vitamin B12 deficiency.
The use of Sitafix-M Tablet should be avoided in patients with known allergies to any of the components or excipients of this medicine. The use of this medicine should be avoided in patients with severe kidney impairment, liver impairment, congestive heart failure, lactic acidosis, or diabetic ketoacidosis.
No, it is not safe to consume alcohol along with Sitafix-M Tablet, as it can increase the chances of lactic acidosis.
Yes, the use of Sitafix-M Tablet can lead to lactic acidosis. It is a medical emergency caused by the increased levels of lactic acid in the blood. It is also known as MALA (metformin-associated lactic acidosis). It is a rare side effect associated with the use of metformin. Therefore, it is avoided in patients with underlying kidney disease, elderly patients, or those who take large amounts of alcohol. Symptoms of lactic acidosis may include muscle pain or weakness, dizziness, tiredness, a feeling of cold in arms and legs, difficulty in breathing, nausea, vomiting, stomach pain, or a slow heart rate. If you have these symptoms, stop taking sitagliptin + metformin and immediately consult your doctor.
Yes, using Sitafix-M Tablet can cause vitamin B12 deficiency in the long term. It interferes with the absorption of vitamin B12 in the stomach. If untreated, it may cause anemia and nerve problems, as a result of which the patient can feel a tingling sensation and numbness in hands and feet, weakness, urinary problems, a change in mental status, and difficulty maintaining balance (ataxia). To avoid such problems, some researchers suggest an intake of vitamin B12 from outside sources at least once every year.
Keep this medicine tightly closed in the container or pack it came in. Store it according to the instructions on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children, or other people.

Fact Box

Habit Forming

No

Therapeutic Class

ANTI DIABETIC

Related lab tests

Glucose - Fasting Blood

Glucose - Postprandial Blood

Glycosylated Hemoglobin

References

  1. Sitagliptin/metformin hydrochloride. Haarlem, The Netherlands: Merck Sharp & Dohme BV; 2018. [Accessed 08 Apr. 2019] (online) Available from:
  2. Sitagliptin/Metformin hydrochloride. London, UK: European Medicines Agency; 2013. [Accessed 08 Apr. 2019] (online) Available from:
  3. Sitagliptin and metformin hydrochloride. [Accessed 08 Apr. 2019] (online) Available from:
  4. Sitagliptin and Metformin hydrochloride [Product Monograph]. Kirkland, Canada: Merck Canada Inc.; 2021. [Accessed 20 Oct. 2021] (online) Available from:
  5. Sitagliptin and Metformin hydrochloride [Product Monograph]. Kirkland, Canada: Merck Canada Inc.; 2017. [Accessed 20 Oct. 2021] (online) Available from:
  6. Sitagliptin and metformin hydrochloride [Prescribing Information]. Rahway, NJ: Merck Sharp & Dohme LLC; 2023. [Accessed 28th Sept. 2023] (online) Available from:
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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Shield & Care Pharmaceuticals Pvt Ltd
Address: Bhaily, Vadodara

Vendor Details

Country of origin: India

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