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Sitaday M 500 Tablet

Sitagliptin (50mg)+ Metformin (500mg)

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Sitaday M 500 Tablet is a combination of two medicines that control high blood sugar levels in people with type 2 diabetes mellitus. This helps prevent serious complications of diabetes, such as kidney damage and blindness and may reduce your chances of having a heart attack or stroke.

Written By Dr. Lipika Khurana, PGDHHM, BDS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 19 Mar 2026 | 03:00 PM (IST)

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General Information

Contains

Sitagliptin (50mg)+ Metformin (500mg)

Marketer

Mankind Pharma Ltd

Storage

Store below 30°C

The content is shown in English

Product introduction

Sitaday M 500 Tablet may be prescribed alone or along with other diabetes medications. It works best when used along with a healthy diet and regular exercise. Your dose will depend on your condition, blood sugar levels, and other medicines you are taking. Taking it with meals helps to reduce the chances of developing an upset stomach.

To get the most benefit, you should take it regularly, at the same time each day, and you should not stop unless your doctor recommends it. It is important to stay on the diet and exercise program recommended by your doctor while taking this medicine. Your lifestyle plays a big part in controlling diabetes.

The most common side effects of taking Sitaday M 500 Tablet include diarrhea, upper respiratory tract infection, and headache. Low blood sugar level (hypoglycemia) is a possible side effect if you are also taking other diabetes medicines like insulin or sulfonylurea. Hence, you need to know how to recognize and deal with it.

This medicine is not suitable for everyone. Before taking it, you should let your doctor know if you have ever had kidney, liver, or heart disease, problems with your pancreas, or if you drink a lot of alcohol. Pregnant or breastfeeding women should also consult their doctor before taking this medicine. Some other medicines may affect Sitaday M 500 Tablet, so tell your doctor about all the other medicines you are taking to ensure you are safe. You should try to avoid drinking alcohol as it lowers blood glucose. Your doctor will check your kidney function and blood sugar levels before and during treatment.

Uses of Sitaday M Tablet

Treatment of Type 2 diabetes mellitus

Benefits of Sitaday M Tablet

Treatment of Type 2 diabetes mellitus
Sitaday M 500 Tablet is a combination of two medicines that work together in different ways to lower your blood glucose levels. Lowering blood glucose levels is an essential part of managing diabetes. If you can control your blood glucose level, your risk of getting any of the serious complications of diabetes, such as kidney damage, eye damage, nerve problems, and loss of limbs, is also lowered. Additionally, proper control of diabetes can also reduce the risk of heart disease and stroke. Taking this medicine regularly, along with appropriate diet and exercise, will help you live an everyday, healthy life. You should keep using this medicine for as long as prescribed because it protects your future health.

Side effects of Sitaday M Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Sitaday M

Diarrhea
Upper respiratory tract infection
Headache

How to use Sitaday M Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Sitaday M 500 Tablet should be taken with or after food.

How Sitaday M Tablet works

Sitaday M 500 Tablet is a combination of two medicines: sitagliptin and metformin. Sitagliptin helps your pancreas produce more insulin, facilitates effective use of insulin by the body, and reduces excess sugar that your liver makes. Metformin is a biguanide that lowers glucose production in the liver, delays glucose absorption from the intestines, and increases the body's sensitivity to insulin. Together, they provide better control of blood sugar.

All substitutes for Sitaday M 500 Tablet

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

Take Sitaday M 500 Tablet with food to lower your chance of having an upset stomach.
Take it in addition to regular exercise and a healthy diet to lower blood sugar levels.
The chances of weight gain and low blood sugar are lower than with other diabetes medicines.
Monitor your blood sugar level regularly while you are taking this medicine.
Inform your doctor about your diabetes treatment if you are due to have surgery under a general anesthetic.
Tell your doctor immediately if you experience any deep or rapid breathing, persistent nausea, vomiting, and stomach pain, as Sitaday M 500 Tablet may cause a rare but serious condition called lactic acidosis, which is an excess of lactic acid in the blood.

Safety advice

Alcohol

UNSAFE

It is unsafe to consume alcohol with Sitaday M 500 Tablet

Pregnancy

UNSAFE

Sitaday M 500 Tablet is highly unsafe during pregnancy. It can cause serious harm to the unborn baby, including birth defects and pregnancy loss. Do not use this medicine if you are pregnant or planning to become pregnant.

Breast feeding

UNSAFE

Sitaday M 500 Tablet is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

Driving

CONSULT YOUR DOCTOR

It is not known whether Sitaday M 500 Tablet alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. Please consult your doctor.

Kidney

CAUTION

Sitaday M 500 Tablet should be used with caution in patients with severe kidney disease. Dose adjustment may be needed.
Use of Sitaday M 500 Tablet is, however, not recommended in patients with severe kidney disease. Regular monitoring of kidney function test is advisable while you are taking this medicine.

Liver

UNSAFE

Sitaday M 500 Tablet is unsafe to use in patients with liver disease and should be avoided.

Frequently asked questions

What is Sitaday M 500 Tablet?

Sitaday M 500 Tablet is a combination of two medicines: sitagliptin and metformin. This medicine is used in the treatment of type 2 diabetes mellitus. It improves blood glucose levels in adults when taken along with a proper diet and regular exercise. Metformin lowers glucose production in the liver and improves insulin sensitivity. Sitagliptin inhibits the enzyme DPP4 and increases insulin release from the pancreas. This combination is not indicated for patients below 18 years of age.

What are the possible side effects of Sitaday M 500 Tablet?

The use of Sitaday M 500 Tablet is associated with common side effects like diarrhea, headache, and upper respiratory tract infection. Its use can also lead to serious but rare side effects like lactic acidosis. On long-term use, it can also lead to vitamin B12 deficiency.

Are there any specific conditions in which Sitaday M 500 Tablet should not be taken?

The use of Sitaday M 500 Tablet should be avoided in patients with known allergies to any of the components or excipients of this medicine. The use of this medicine should be avoided in patients with severe kidney impairment, liver impairment, congestive heart failure, lactic acidosis, or diabetic ketoacidosis.

Is it safe to take alcohol while I am taking Sitaday M 500 Tablet?

No, it is not safe to consume alcohol along with Sitaday M 500 Tablet, as it can increase the chances of lactic acidosis.

Can the use of Sitaday M 500 Tablet lead to lactic acidosis?

Yes, the use of Sitaday M 500 Tablet can lead to lactic acidosis. It is a medical emergency caused by the increased levels of lactic acid in the blood. It is also known as MALA (metformin-associated lactic acidosis). It is a rare side effect associated with the use of metformin. Therefore, it is avoided in patients with underlying kidney disease, elderly patients, or those who take large amounts of alcohol. Symptoms of lactic acidosis may include muscle pain or weakness, dizziness, tiredness, a feeling of cold in arms and legs, difficulty in breathing, nausea, vomiting, stomach pain, or a slow heart rate. If you have these symptoms, stop taking sitagliptin + metformin and immediately consult your doctor.

Can the use of Sitaday M 500 Tablet lead to vitamin B12 deficiency?

Yes, using Sitaday M 500 Tablet can cause vitamin B12 deficiency in the long term. It interferes with the absorption of vitamin B12 in the stomach. If untreated, it may cause anemia and nerve problems, as a result of which the patient can feel a tingling sensation and numbness in hands and feet, weakness, urinary problems, a change in mental status, and difficulty maintaining balance (ataxia). To avoid such problems, some researchers suggest an intake of vitamin B12 from outside sources at least once every year.

What are the instructions for storage and disposal of Sitaday M 500 Tablet?

Keep this medicine tightly closed in the container or pack it came in. Store it according to the instructions on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children, or other people.

Fact Box

Habit Forming

Therapeutic Class

ANTI DIABETIC

Related lab tests

Glucose - Fasting Blood

Glucose - Postprandial Blood

Glycosylated Hemoglobin

References

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Mankind Pharma Ltd
Address: 208, Okhla Industrial Estate, Phase III, New Delhi - 110020

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Sitaday M 500 Tablet. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India

Lab tests offered by us

Why we need a prescription?

Sitaday M 500 Tablet

Save more with additional offers

General Information

Contains

Marketer

Storage

Product introduction

Uses of Sitaday M Tablet

Benefits of Sitaday M Tablet

Side effects of Sitaday M Tablet

How to use Sitaday M Tablet

How Sitaday M Tablet works

All substitutes for Sitaday M 500 Tablet

ISTamet 50mg/500mg Tablet

Janumet 50mg/500mg Tablet

Sitared-M Tablet 50/500

Lupisit M 50mg/500mg Tablet

SiTaxa M 50mg/500mg Tablet

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Frequently asked questions

What is Sitaday M 500 Tablet?

What are the possible side effects of Sitaday M 500 Tablet?

Are there any specific conditions in which Sitaday M 500 Tablet should not be taken?

Is it safe to take alcohol while I am taking Sitaday M 500 Tablet?

Can the use of Sitaday M 500 Tablet lead to lactic acidosis?

Can the use of Sitaday M 500 Tablet lead to vitamin B12 deficiency?

What are the instructions for storage and disposal of Sitaday M 500 Tablet?

Fact Box

Habit Forming

Therapeutic Class

Related lab tests

Glucose - Fasting Blood

Glucose - Postprandial Blood

Glycosylated Hemoglobin

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

In case of any issues, contact us

Lab tests offered by us

Related/Popular tests