Romical Plus Tablet

Written By Dr. Lipika Khurana, PGDHHM, BDS

Reviewed By Dr. Rajeev Sharma, MBA, MBBS

Last updated on 19 Jan 2026 | 01:50 AM (IST)

Romical Plus Tablet helps increase intestinal absorption of calcium and phosphate, raises low blood calcium levels, and supports proper bone mineralization. These help in the management of calcium deficiency and metabolic bone diseases such as renal osteodystrophy, hypoparathyroidism, and osteoporosis.

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General Information

Contains

Calcitriol (0.25mcg)

Marketer

Roman Lifesciences Pvt Ltd

Storage

Store below 30°C

The content is shown in English

Product introduction

Romical Plus Tablet is also beneficial in increasing muscle mass, helps in the prevention and treatment of hypocalcemia, and helps in reducing fatigue and muscular pains. It boosts immunity and increases body resistance against infection.

This medicine is to be taken in the dosage as advised by the doctor. Consult your doctor if you plan to take any other form of vitamin D along with this medicine.

This medicine is generally tolerated with little or no side effects. In patients with kidney disease, dose adjustment may be required. Discussed with your doctor. Avoid or limit the consumption of alcohol while on treatment with this medicine.

Uses of Romical Plus Tablet

Treatment of Metabolic Bone disease

Benefits of Romical Plus Tablet

Treatment of Metabolic Bone disease
Romical Plus Tablet helps treat metabolic bone diseases by correcting abnormalities in calcium and phosphate balance and improving bone mineralisation. In renal osteodystrophy and secondary hyperparathyroidism due to chronic kidney disease, it improves calcium absorption, corrects hypocalcaemia, and lowers elevated parathyroid hormone levels, helping reduce bone pain and skeletal changes. In hypoparathyroidism and rickets, it restores calcium and phosphate levels, supporting normal bone development and strength. In post-menopausal osteoporosis, it increases calcium absorption and supports bone mineral density, helping reduce the risk of vertebral fractures.

Side effects of Romical Plus Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Romical Plus

Increased calcium level in blood
Rash
Urinary tract infection
Itching
Headache
Nausea
Abdominal pain
Erythema (skin redness)

How to use Romical Plus Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Romical Plus Tablet may be taken with or without food.

How Romical Plus Tablet works

Calcitriol is the active form of vitamin D that binds to vitamin D receptors in the intestine, bone, and kidneys to regulate calcium and phosphate homeostasis. It increases intestinal absorption of calcium and phosphate, supports normal bone mineralization, and corrects hypocalcemia. In conditions such as chronic kidney disease, where endogenous calcitriol production is reduced, supplementation helps normalize parathyroid hormone levels and improve metabolic bone abnormalities

All substitutes for Romical Plus Tablet

For information purposes only. Consult a doctor before taking any medicine.

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Quick tips

Romical Plus Tablet is used for the treatment of calcium deficiency and metabolic bone disease.
Inform your doctor if you have kidney problems or if you have ever had kidney stones.
Inform your doctor if you are taking an iron supplement, as the absorption rate might be affected.
Along with taking Romical Plus Tablet, maintain a healthy lifestyle, include calcium-rich food in your diet, exercise (regular weight-bearing exercise) with your doctor's advice, and take proper measures to reduce the risk of falls.
It is recommended that you take Romical Plus Tablet at bedtime, preferably at least 2 hours after dinner. You may lie down immediately after taking it if you wish.
If you take antacids (medicines to relieve heartburn) or medicines containing calcium you should take them at least 2 hours after taking Romical Plus Tablet to avoid interference.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Romical Plus Tablet. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

Romical Plus Tablet is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.

Breast feeding

CAUTION

Romical Plus Tablet should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from the body.

Driving

SAFE

Romical Plus Tablet does not usually affect your ability to drive.

Kidney

CAUTION

Romical Plus Tablet should be used with caution in patients with kidney disease. Dose adjustment may be needed.

Liver

SAFE IF PRESCRIBED

Romical Plus Tablet is probably safe to use in patients with liver disease. Limited data suggest dose adjustment may not be needed.

Interaction with drugs

Taking Romical Plus with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Moderate

Carbamazepine (Oral Route)

Your doctor may monitor your treatment and adjust the doses as per the observations. Carbamazepine may reduce efficacy of Calcitriol.

Moderate

Phenobarbitone (Oral Route)

Your doctor may monitor your treatment and adjust the doses as per the observations. Phenobarbitone may reduce efficacy of Calcitriol.

Moderate

Orlistat (Oral Route)

Ensure a gap of at least 2 hours between taking Calcitriol and Orlistat. It is recommended to take Calcitriol at bedtime.

Moderate

Digoxin (Oral Route)

Watch out for symptoms of Digoxin side effects such as impaired vision, skin rash, nausea, vomiting, diarrhea or dizziness and consult your doctor if you experience them. They may monitor and adjust the doses as per the observations.

Moderate

Phenytoin (Oral Route)

Your doctor may monitor your treatment and adjust the doses as per the observations. Phenytoin may reduce blood levels of Calcitriol.

Frequently asked questions

What is Romical Plus Tablet? What is it used for?

Romical Plus Tablet is the active form of vitamin D. It increases the levels of vitamin D in your blood which helps to increase calcium levels in the blood by increasing the absorption rate of calcium from your intestine. Thus, it is used in the treatment of calcium deficiency, postmenopausal osteoporosis, and other conditions associated with metabolic bone disorders.

Is Romical Plus Tablet effective?

Romical Plus Tablet is effective if used in the dose and duration advised by your doctor. Do not stop taking it even if you see improvement in your condition. If you stop using Romical Plus Tablet too early, the symptoms may return or worsen.

How should Romical Plus Tablet be taken?

Romical Plus Tablet should be taken in the dose and duration advised by your doctor. It can be taken with or without food. However, it would be best to take it at the same time each day to avoid the chances of missing a dose.

What if I forget to take a dose of Romical Plus Tablet?

If you forget a dose of Romical Plus Tablet, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take the next scheduled dose in the prescribed time. Do not double the dose to make up for the missed one as this may increase the chances of developing side effects.

Is Romical Plus Tablet safe?

Romical Plus Tablet is safe if used in the dose and duration advised by your doctor. Take it exactly as directed and do not skip any dose. Follow your doctor's instructions carefully and let your doctor know if any of the side effects bother you.

Fact Box

Chemical Class

Vitamin d derivative

Habit Forming

Therapeutic Class

VITAMINS MINERALS NUTRIENTS

Action Class

Vitamins

Related lab tests

Calcium

References

Central Drugs Standard Control Organisation (CDSCO). [Accessed 03 Apr. 2019] (online) Available from:
Calcitriol [Product Label]. Baden, Germany: Catalent Germany Eberbach GmbH; 2019. [Accessed 20 Jun, 2023] (online) Available from:
Calcitriol [Product Monograph]. Mississauga, Ontario: Hoffmann-La Roche Limited; 2016. [Accessed 20 Jun, 2023] (online) Available from:
Calcitriol [Summary of Product Characteristics]. Castleford,, UK: Teva UK Limited; 2022.

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Roman Lifesciences Pvt Ltd
Address: Ist Floor, 58 Kalyan Society, Karamsad Road, V.V.Nagar, Anand, Gujarat.

Vendor Details

Country of origin: India

Lab tests offered by us

Why we need a prescription?

Romical Plus Tablet

Save more with additional offers

General Information

Contains

Marketer

Storage

Product introduction

Uses of Romical Plus Tablet

Benefits of Romical Plus Tablet

Side effects of Romical Plus Tablet

How to use Romical Plus Tablet

How Romical Plus Tablet works

All substitutes for Romical Plus Tablet

ActiveD Tablet

Iwitrol Tablet

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Carbamazepine (Oral Route)

Phenobarbitone (Oral Route)

Orlistat (Oral Route)

Digoxin (Oral Route)

Phenytoin (Oral Route)

Frequently asked questions

What is Romical Plus Tablet? What is it used for?

Is Romical Plus Tablet effective?

How should Romical Plus Tablet be taken?

What if I forget to take a dose of Romical Plus Tablet?

Is Romical Plus Tablet safe?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

Related lab tests

Calcium

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

Related/Popular tests