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Ranobert 500 Tablet ER

Ranolazine (500mg)

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Ranobert 500 Tablet ER is used for the management of angina (heart-related chest pain). It helps prevent new attacks of angina but does not stop an acute attack once started. It relieves chest pain by making the heart work more efficiently.

Written By Dr. Subita Alagh, BDS,
Reviewed By Dr. Mekhala Chandra, MD, MBBS,
Last updated on 21 Sep 2025 | 06:10 PM (IST)

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General Information

Contains

Ranolazine (500mg)

Marketer

Hilbert Healthcare

Storage

Store below 30°C

The content is shown in English

Product introduction

Ranobert 500 Tablet ER should be taken in the dose as advised by your doctor, at the same time each day. It can be taken with or without food to avoid stomach upset. Your doctor will decide how often you should take this medicine. This may change from time to time depending on how well it is working. You should take this medicine regularly to get the most benefit, even if you feel fine. It prevents future harm. If you stop taking it, your chest pain may come back.

You can improve the health of your heart by making some lifestyle changes, such as quitting smoking, cutting down on alcohol, eating well, taking regular exercise, and managing stress. Some common side effects of this medicine include nausea, headache, dizziness, and constipation. Talk to your doctor if these bother you or do not go away.

Ranobert 500 Tablet ER may not be suitable for some people. Tell your doctor if you are suffering from any liver or kidney problems. Also, let your doctor know all other medications you are using, as some may affect or be affected by this medicine. This medicine is not usually recommended during pregnancy or breastfeeding.

Uses of Ranobert Tablet ER

Treatment of Angina (heart-related chest pain)

Benefits of Ranobert Tablet ER

Treatment of Angina (heart-related chest pain)
Ranobert 500 Tablet ER reduces the oxygen requirement of the heart and relaxes the heart muscles. It makes sure that your heart is able to perform its functions in the amount of oxygen supply available without causing stress on heart muscles. This makes it less likely that you will suffer chest pain caused by angina. This medicine can help increase your ability to exercise and go about your daily life more easily by reducing the frequency of angina attacks. You should take it regularly and as long as it is prescribed for it to work effectively.

Side effects of Ranobert Tablet ER

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Ranobert

Nausea
Headache
Dizziness
Constipation

How to use Ranobert Tablet ER

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Ranobert 500 Tablet ER may be taken with or without food, but it is better to take it at a fixed time.

How Ranobert Tablet ER works

Ranobert 500 Tablet ER is an anti-anginal medication. It works by decreasing the oxygen requirement of the heart by relaxing the heart muscle.

All substitutes for Ranobert 500 Tablet ER

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

Ranobert 500 Tablet ER improves HbA1c and blood sugar levels in diabetes patients.
It may cause dizziness or sleepiness. Do not drive or do anything requiring concentration until you know how it affects you.
Notify your doctor if you are taking any other medications along with Ranobert 500 Tablet ER.
It may produce changes in the ECG (QTc interval prolongation). It is recommended to get an ECG done within 1 to 2 weeks of starting the medication.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Ranobert 500 Tablet ER. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

Ranobert 500 Tablet ER may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

Breast feeding

CONSULT YOUR DOCTOR

Ranobert 500 Tablet ER is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

Driving

CONSULT YOUR DOCTOR

It is not known whether Ranobert 500 Tablet ER alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.

Kidney

CAUTION

Ranobert 500 Tablet ER should be used with caution in patients with kidney disease. Dose adjustment of Ranobert 500 Tablet ER may be needed. Please consult your doctor.
Use of Ranobert 500 Tablet ER is not recommended in patients with severe kidney disease.

Liver

CAUTION

Ranobert 500 Tablet ER should be used with caution in patients with liver disease. Dose adjustment of Ranobert 500 Tablet ER may be needed. Please consult your doctor.
Use of Ranobert 500 Tablet ER is not recommended in patients with moderate to severe liver disease.

Interaction with drugs

Taking Ranobert with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Life-threatening

Apomorphine (Injection Route)

Do not consume Ranolazine with Apomorphine.

Life-threatening

Apomorphine (Sublingual route)

Do not consume Ranolazine with Apomorphine.

Life-threatening

Aripiprazole (Oral Route)

Do not consume Ranolazine with Aripiprazole.

Life-threatening

Atazanavir (Oral Route)

Do not consume Ranolazine with Atazanavir.

Life-threatening

Darunavir (Oral Route)

Do not consume Ranolazine with Darunavir.

Frequently asked questions

What are the serious side effects of Ranobert 500 Tablet ER?

Ranobert 500 Tablet ER may cause changes in the electrical activity of the heart, which is known as QT prolongation. Your doctor may get regular tests done to check the electrical activity of your heart. Tell your doctor right away if you feel faint or lightheaded or if your heart starts beating irregularly or fast, as these may be symptoms of QT prolongation. Ranobert 500 Tablet ER may also cause kidney failure in patients who already have kidney problems. Therefore, your doctor may need to do tests to check how your kidneys are working.

I started taking Ranobert 500 Tablet ER about a week ago. Now I have noticed that my urine has become very dark, though I am taking plenty of fluids. Is there anything to worry about?

Dark urine while taking Ranobert 500 Tablet ER is not a common side effect, but it can sometimes happen. Monitor for other symptoms like yellowing of the skin/eyes (jaundice), severe fatigue, nausea, or unusual muscle pain. Consult your doctor as soon as possible to rule out any liver- or kidney-related issues. Check if you’re taking other medications that could cause urine discoloration, such as vitamins, antibiotics, or certain foods like beets.

In case I accidentally take an excess of Ranobert 500 Tablet ER, what will happen?

An excess of Ranobert 500 Tablet ER can cause nausea, vomiting, lightheadedness, double vision, tiredness, severe tremor, confusion, hallucinations, difficulty in speaking and walking, and you can even faint. If you have taken an excess of Ranobert 500 Tablet ER by mistake, call your doctor right away or seek emergency medical care in a nearby hospital.

Is it safe to take Ranobert 500 Tablet ER if I am already taking metoprolol?

Yes, it is safe to take the Ranobert 500 Tablet ER and metoprolol together. Ranobert 500 Tablet ER has minimal effect on blood pressure in patients with angina.

I am a diabetic and am taking metformin. My doctor has prescribed Ranobert 500 Tablet ER, is it safe to take both together?

If you are taking metformin along with Ranobert 500 Tablet ER, you have to be careful since Ranobert 500 Tablet ER may increase the levels of metformin in the body, which can lead to metformin toxicity. Talk to your doctor, who will modify the dose of metformin.

I have been taking simvastatin to keep my cholesterol levels in check. Can I take Ranobert 500 Tablet ER with it?

It is recommended not to take simvastatin and Ranobert 500 Tablet ER together because it may cause simvastatin toxicity, which may lead to symptoms like muscle weakness and soreness, fatigue, decreased urination, etc. Let your doctor know that you are already taking simvastatin. If it is still necessary to take it, then take it exactly as advised by the doctor.

Fact Box

Chemical Class

Acetanilide & piperazine derivative

Habit Forming

Therapeutic Class

CARDIAC

Action Class

Late Sodium channel blocker- angina

References

Opie LH, Horowitz JD. Nitrates and Newer Antianginals β-Blocking Agents. In: Opie LH, Gersh BJ, editors. Drugs for the Heart. 8th ed. Philadelphia, Pennsylvania: Elsevier Saunders; 2013. p. 56
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. p. 1200.
Ranolazine [Prescribing Information]. Mahwah, NJ: Lifestar Pharma LLC; 2025. [Accessed 09 Apr. 2025] (online) Available from:

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Hilbert Healthcare
Address: SCF 439, First & Second Floor, Motor Market Manimajra, Chandigarh -160101,India

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Ranobert 500 Tablet ER. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India

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Ranobert 500 Tablet ER

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General Information

Contains

Marketer

Storage

Product introduction

Uses of Ranobert Tablet ER

Benefits of Ranobert Tablet ER

Side effects of Ranobert Tablet ER

How to use Ranobert Tablet ER

How Ranobert Tablet ER works

All substitutes for Ranobert 500 Tablet ER

Ranozex Tablet ER

Ranx 500 Tablet ER

Rancv 500 Tablet ER

Ranopill 500 Tablet ER

Cartinex Tablet ER

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Apomorphine (Injection Route)

Apomorphine (Sublingual route)

Aripiprazole (Oral Route)

Atazanavir (Oral Route)

Darunavir (Oral Route)

Frequently asked questions

What are the serious side effects of Ranobert 500 Tablet ER?

I started taking Ranobert 500 Tablet ER about a week ago. Now I have noticed that my urine has become very dark, though I am taking plenty of fluids. Is there anything to worry about?

In case I accidentally take an excess of Ranobert 500 Tablet ER, what will happen?

Is it safe to take Ranobert 500 Tablet ER if I am already taking metoprolol?

I am a diabetic and am taking metformin. My doctor has prescribed Ranobert 500 Tablet ER, is it safe to take both together?

I have been taking simvastatin to keep my cholesterol levels in check. Can I take Ranobert 500 Tablet ER with it?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

In case of any issues, contact us

Lab tests offered by us

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