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Premarin Vaginal Cream 1
Premarin Vaginal Cream 2
Premarin Vaginal Cream 3
Premarin Vaginal Cream 4
Premarin Vaginal Cream 5
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Premarin Vaginal Cream

Conjugated Estrogens (0.625mg)
Genuine
Authenticity Assured
Prescription
required
Premarin Vaginal Cream is used to treat atrophic vaginitis, a condition caused by low estrogen levels. Atrophic vaginitis can lead to vaginal dryness, irritation, itching, and pain during intercourse. Premarin Vaginal Cream replenishes estrogen locally and helps restore moisture, thickness, and elasticity of vaginal tissues.

Written By Dr. Sakshi Jain, MS, BDS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 12 Oct 2026 | 01:05 AM (IST)
₹505 MRP ₹535.826% off 
(Inclusive of applicable taxes)
 
 
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General Information

The content is shown in English
Premarin Vaginal Cream 1
Premarin Vaginal Cream 2
Premarin Vaginal Cream 3
Premarin Vaginal Cream 4
Premarin Vaginal Cream 5

Product introduction

Premarin Vaginal Cream should be used exactly as prescribed by your doctor. It is applied inside the vagina using the applicator provided, usually at bedtime. For best results, continue using the medicine for the full duration prescribed, even if symptoms improve earlier. Staying hydrated, maintaining good vaginal hygiene, and avoiding irritants like scented soaps or douches can further help relieve symptoms and support treatment effectiveness.


Common side effects include headache, nausea, vomiting, and vaginal irritation, burning, itching, or discharge. These symptoms are usually temporary and improve as the body adjusts to the medication. If irritation persists or worsens, consult your doctor. If you experience unusual symptoms or signs of an allergic reaction, such as severe itching, swelling, or trouble breathing, seek medical attention immediately.


Before using Premarin Vaginal Cream, inform your doctor if you have a history of breast cancer, uterine cancer, blood clots, liver disease, or unexplained vaginal bleeding, as estrogen therapy may not be suitable for you. Avoid using Premarin Vaginal Cream if you are pregnant or breastfeeding. Consider regular medical check-ups, as that will help monitor your response to treatment and ensure safe use.

Uses of Premarin Vaginal Cream

Benefits of Premarin Vaginal Cream

Hormone replacement therapy
Hormone placement therapy (HRT) is a treatment to relieve symptoms of menopause such as hot flushes, vaginal dryness, and reduced sex drive. Since menopause can last for several years, this treatment can make a big improvement to your daily life and mood. Estrogen is one of two important hormones (the other is progesterone) used in this treatment. Vaginal tablets and gels are an easy way to deliver hormones but may not treat all the symptoms. You should use this medicine as it is prescribed, and for as long as it is prescribed by your doctor.

Side effects of Premarin Vaginal Cream

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Premarin
  • Breast pain
  • Nausea
  • Vomiting
  • Abdominal pain
  • High blood pressure
  • Migraine
  • Abdominal distension
  • Joint pain
  • Itching
  • Rash
  • Leukorrhea
  • Metrorrhagia (menstrual bleeding at irregular intervals)
  • Vaginal inflammation

How to use Premarin Vaginal Cream

This medicine is for external use only. Use it in the dose and duration as advised by your doctor. Check the label for directions before use. Clean and dry the affected area and apply the cream by using applicator. Wash your hands after applying.

How Premarin Vaginal Cream works

Premarin Vaginal Cream is a mixture of estrogens (a female sex hormone). As a part of the hormone replacement therapy, it works by maintaining the estrogen levels in the body in menopausal women. It also prevents the vaginal wall from becoming thin and dry thereby reducing inflammation.

Quick tips

  • Premarin Vaginal Cream can be applied to the external vaginal area or inserted into the vagina using the applicator provided.
  • It does not expose the rest of your body to the medicine, thereby avoiding side effects that happen more often with pills.
  • Do not have sex right after using Premarin Vaginal Cream, as some of the medicine can be absorbed into your partner's skin.
  • Inform your doctor if you experience any vaginal bleeding or spotting, abnormal vaginal discharge, or vaginal discomfort while using Premarin Vaginal Cream.
  • Do not use Premarin Vaginal Cream if you are pregnant or breastfeeding or have active or chronic liver dysfunction or disease.

Safety advice

Alcohol

Alcohol

No interaction found/established
Pregnancy

Pregnancy

UNSAFE
Premarin Vaginal Cream is highly unsafe during pregnancy. It can cause serious harm to the unborn baby, including birth defects and pregnancy loss. Do not use this medicine if you are pregnant or planning to become pregnant.
Breast feeding

Breast feeding

CONSULT YOUR DOCTOR
Premarin Vaginal Cream may be unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. It should be used only if the expected benefit outweighs the potential risk. Please consult your doctor.
Driving

Driving

No interaction found/established
Kidney

Kidney

No interaction found/established
Liver

Liver

No interaction found/established
All

Interaction with drugs

Taking Premarin with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Severe

Fulvestrant (Injection Route)

Avoid concurrent use.
Severe

Anastrozole (Oral Route)

Avoid concurrent use.
Severe

Pomalidomide (Oral Route)

If concurrent use is essential, your doctor may monitor your treatment and adjust the doses as per the observations.
Moderate

Diazepam (Injection Route)

If concurrent use is essential, watch out for bleeding and consult your doctor immediately. They may monitor your treatment and adjust the doses as per the observations. Conjugated Estrogens may slow down the removal of Diazepam from the body.
Moderate

Diazepam (Oral Route)

If concurrent use is essential, watch out for bleeding and consult your doctor immediately. They may monitor your treatment and adjust the doses as per the observations. Conjugated Estrogens may slow down the removal of Diazepam from the body.

Frequently asked questions

Premarin Vaginal Cream is a hormonal medicine that contains a blend of conjugated estrogens, which are female sex hormones. It is used to relieve vaginal symptoms caused by low estrogen levels, commonly occurring during menopause or due to certain medical conditions. Premarin Vaginal Cream helps reduce vaginal dryness, itching, irritation, and discomfort, restoring moisture and improving the thickness and elasticity of vaginal tissues. It helps alleviate pain during intercourse (dyspareunia) and severe vaginal tissue thinning (kraurosis vulvae), improving overall vaginal health and comfort.
Use Premarin Vaginal Cream exactly as prescribed by your doctor. Before applying, wash your hands thoroughly. Fill the applicator with the prescribed amount of Premarin Vaginal Cream, then gently insert it into the vagina and press the plunger to release the medication. After application, remove the applicator and clean it properly for future use. Always follow your doctor’s instructions regarding dosage and duration, and do not stop using it abruptly without medical advice.
If you forget to use Premarin Vaginal Cream, apply it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not apply a double dose to make up for the missed one, as this may increase the risk of side effects. If you frequently forget doses, consider setting a reminder or discussing alternative treatment options with your doctor.

Fact Box

Chemical Class

Steroid derivative

Habit Forming

No

Therapeutic Class

GYNAECOLOGICAL

Action Class

Estrogens
100% genuine products
100% genuine products
Safe & secure payments
Safe & secure payments
No contact delivery
No contact delivery
Fully sanitized facilities
Fully sanitized facilities

User feedback

Once A Day
72%
Twice A Day
14%
Alternate Day
4%
Twice A Week
4%
Once A Week
2%
Thrice A Day
2%
Thrice A week
1%
Others
48%
Hormone replacement therapy
26%
Dryness in vagina
22%
Contraception
4%
Average
42%
Excellent
30%
Poor
27%
No Side Effect
100%
With or without food
100%
Average
78%
Not Expensive
22%
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Pfizer Ltd
Address: The Capital, 1802, 18th Floor , Plot No. C-70, ‘G’ Block , Bandra Kurla Complex, Bandra East , Mumbai – 400051.

Vendor Details

Country of origin: Canada
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