Piril 20 Tablet MD
Prescription Required
Product introduction
Piril 20 Tablet MD is a pain-relieving medicine. It is used to treat moderate to severe pain in conditions such as osteoarthritis and rheumatoid arthritis. It helps relieve pain and swelling in the joints and muscles.
Piril 20 Tablet MD should be taken with food. This will prevent you from getting an upset stomach. The dose and duration will depend on what you are taking it for and how well it helps your symptoms. You should keep taking the medicine even if you feel better until the doctor says it is alright to stop using it.
The most common side effects of this medicine include mild vomiting, stomach pain, nausea, headache, and dizziness. If any of these side effects persist or get worse, you should let your doctor know. Your doctor may be able to suggest ways of preventing or reducing the symptoms.
Before using it, you should let your doctor know if you have a history of stomach ulcers, heart diseases, high blood pressure, and liver or kidney disease. Let your doctor also know about all the other medicines you are taking because they may affect, or be affected by, this medicine. Pregnant and breastfeeding mothers should consult their doctors before using the medicine.
Uses of Piril Tablet MD
Benefits of Piril Tablet MD
In Pain relief
Piril 20 Tablet MD is used for short-term relief of pain, inflammation, and swelling in conditions that affect joints and muscles. It works by blocking chemical messengers in the brain that tell us we have pain. It can help relieve pain in conditions like rheumatoid arthritis and osteoarthritis or even after a dental (tooth-related) surgery.
Take it as it is prescribed to get the most benefit. Do not take more or for longer than needed as that can be dangerous. In general, you should take the lowest dose that works, for the shortest possible time. This will help you to go about your daily activities more easily and have a better, more active, quality of life.
Take it as it is prescribed to get the most benefit. Do not take more or for longer than needed as that can be dangerous. In general, you should take the lowest dose that works, for the shortest possible time. This will help you to go about your daily activities more easily and have a better, more active, quality of life.
Side effects of Piril Tablet MD
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Piril
- Vomiting
- Stomach pain
- Nausea
- Headache
- Dizziness
How to use Piril Tablet MD
Take this medicine in the dose and duration as advised by your doctor. Do not handle the tablets with wet hands. Put it in your mouth but do not swallow it. Piril 20 Tablet MD is to be taken with food.
How Piril Tablet MD works
Piril 20 Tablet MD is a non-steroidal anti-inflammatory drug (NSAID). It works by blocking the release of certain chemical messengers that are responsible for inflammation (pain and swelling).
Safety advice
Alcohol
UNSAFE
It is unsafe to consume alcohol with Piril 20 Tablet MD.
Pregnancy
CONSULT YOUR DOCTOR
Piril 20 Tablet MD is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
Breast feeding
CONSULT YOUR DOCTOR
Piril 20 Tablet MD is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Driving
UNSAFE
Piril 20 Tablet MD may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Kidney
CAUTION
Piril 20 Tablet MD should be used with caution in patients with severe kidney disease. Dose adjustment of Piril 20 Tablet MD may be needed. Please consult your doctor.
Liver
CAUTION
Piril 20 Tablet MD should be used with caution in patients with liver disease. Dose adjustment of Piril 20 Tablet MD may be needed. Please consult your doctor.
What if you forget to take Piril Tablet MD?
If you miss a dose of Piril 20 Tablet MD, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
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Quick tips
- Inform your doctor if you are pregnant or planning to conceive or breastfeeding.
- Piril 20 Tablet MD helps relieve pain and swelling of various joints and muscles.
- Take it with food to avoid stomach upset.
- Your doctor will prescribe you the lowest effective dose of this medicine for the shortest possible time necessary to relieve your symptoms.
- It may cause dizziness and fatigue. Do not drive or do anything requiring concentration until you know how it affects you.
- Avoid consuming alcohol when taking this medicine as it may cause excessive drowsiness.
Fact Box
Chemical Class
Enolic acid Derivatives
Habit Forming
No
Therapeutic Class
PAIN ANALGESICS
Action Class
NSAID's- Non-Selective COX 1&2 Inhibitors (enolic acids)
Interaction with drugs
Taking Piril with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Concurrent use may result in fatal Methotrexate poisoning.
Careful consideration is advised when taking Methotrexate with Piroxicam. Your doctor may monitor your treatment and adj
Concurrent use may increase the risk of bleeding.
Do not consume Phenindione with Piroxicam. If concurrent use is essential, your doctor may monitor your treatment and adjust the
Concurrent use may increase the risk of serious damage to the kidneys.
If concurrent use is essential, your doctor may monitor your tacrolimus levels, potassium levels and kidney
Concurrent use may increase the risk of bleeding.
Do not consume Acenocoumarol with Piroxicam. If concurrent use is essential, your doctor may monitor your treatment and adjust th
Concurrent use may result in fatal Methotrexate poisoning.
Careful consideration is advised when taking Methotrexate with Piroxicam. Your doctor may monitor your treatment and adj
Patient concerns
FAQs
What is the difference between Piril 20 Tablet MD and diclofenac?
Both Piril 20 Tablet MD and diclofenac are pain killers. However, piroxicam is a non-selective COX (cyclooxygenase - an enzyme responsible for inflammation and pain) inhibitor whereas diclofenac has a bit more selectivity to a COX-2 enzyme. This selectivity of diclofenac is supposed to decrease the side effects as compared to Piril 20 Tablet MD.
What is the difference between Piril 20 Tablet MD and naproxen?
Both Piril 20 Tablet MD and naproxen are pain killers. Both are non-selective COX (cyclooxygenase - an enzyme responsible for inflammation and pain). Research studies have shown both are equally effective. However, gastric side effects are lesser with naproxen as compared to Piril 20 Tablet MD.
What is the difference between Piril 20 Tablet MD and meloxicam?
Both Piril 20 Tablet MD and meloxicam are pain killers. Both are non-selective COX (cyclooxygenase - an enzyme responsible for inflammation and pain). Research studies have shown both are equally effective. However, acute gastric side effects are lesser with meloxicam as compared to Piril 20 Tablet MD.
What is the difference between Piril 20 Tablet MD and ketoprofen?
Both Piril 20 Tablet MD and ketoprofen are pain killers. Both are non-selective COX (cyclooxygenase -an enzyme responsible for inflammation and pain). Research studies have shown ketoprofen topical gel is better and effective as compared to Piril 20 Tablet MD. Ketoprofen gel also showed excellent tolerability.
What is the difference between Piril 20 Tablet MD and tramadol?
Piril 20 Tablet MD is a COX (cyclooxygenase -an enzyme responsible for inflammation and pain) whereas Tramadol is a narcotic-like painkiller. Tramadol is a habit forming medicine.
What is the difference between Piril 20 Tablet MD and nimesulide?
Both Piril 20 Tablet MD and nimesulide are pain killers. However, Piril 20 Tablet MD is a non-selective COX (cyclooxygenase -an enzyme responsible for inflammation and pain) inhibitor whereas nimesulide is selective to the COX-2 enzyme. This selectivity of nimesulide is supposed to decrease the side effects as compared to piroxicam. It should not be used in children below 12 years of age.
Can Piril 20 Tablet MD be used in the treatment of chikungunya?
Usually, the platelet count does not dip in cases of chikungunya and painkillers like piroxicam can lead to the risk of increased bleeding tendency. So refrain from taking Piril 20 Tablet MD or any painkiller in the case of any fever with joint pain. Consult your doctor before starting Piril 20 Tablet MD.
Are Piril 20 Tablet MD and aspirin same?
No. Piril 20 Tablet MD and aspirin are not same. They belong to the same class of drugs known as COX (cyclooxygenase) inhibitors. They both are anti-inflammatory and analgesic.
Can Piril 20 Tablet MD be used along with dexamethasone?
No. Piril 20 Tablet MD should not be used with dexamethasone. They both increase each other's toxicity. There is an increased risk of GI ulceration.
Can Piril 20 Tablet MD be used with methocarbamol?
Yes. Methocarbamol can be used with Piril 20 Tablet MD as no serious side effects are known. Inform your doctor before starting any of the medication.
Can Piril 20 Tablet MD be used along with paracetamol?
Yes. Paracetamol can be used with Piril 20 Tablet MD as no serious side effects are known. Inform your doctor before starting any of the medication.
Is Piril 20 Tablet MD a NSAID?
Yes. Piril 20 Tablet MD is a non-steroidal anti-inflammatory drug (NSAID).
Is Piril 20 Tablet MD a sulfa drug?
Piril 20 Tablet MD is a sulphur containing compound. Piril 20 Tablet MD can cause serious adverse events in sensitive individuals. It can cause severe skin reactions like Steven Johnson Syndrome. Do inform your doctor if you have any kind of allergies.
Is Piril 20 Tablet MD a blood thinner?
No. Piril 20 Tablet MD is not a blood thinner. It is a pain killer. It should be avoided in a patient with a bleeding disorder.
Is Piril 20 Tablet MD a muscle relaxant?
No. Piril 20 Tablet MD is not a muscle relaxant. It is a pain killer which acts on COX (cyclooxygenase -an enzyme responsible for inflammation and pain) enzyme.
Is Piril 20 Tablet MD a narcotic?
No. Piril 20 Tablet MD is not a narcotic. It is a pain killer which acts on COX (cyclooxygenase -an enzyme responsible for inflammation and pain) enzyme to decrease the pain and inflammation.
Can Piril 20 Tablet MD be used in hypertension?
No. Piril 20 Tablet MD is not a medication to control hypertension. It is important to note that Piril 20 Tablet MD decreases the effectiveness of the antihypertensive medication when given together. Inform your doctor if you are taking antihypertensive medications before starting Piril 20 Tablet MD.
Can Piril 20 Tablet MD be used along with Losartan?
No. Piril 20 Tablet MD should not be combined with Losartan. It is important to note that Piril 20 Tablet MD decreases the effectiveness of the antihypertensive medication like losartan when given together leading to failure of antihypertensive therapy. Inform your doctor if you are taking antihypertensive medications before starting Piril 20 Tablet MD.
Can Piril 20 Tablet MD be used with Lisinopril?
No. Piril 20 Tablet MD should be avoided with lisinopril. It is important to note that piroxicam decreases the effectiveness of the antihypertensive medication like lisinopril when given together leading to failure of antihypertensive therapy. Inform your doctor if you are taking antihypertensive medications before starting Piril 20 Tablet MD.
Can Piril 20 Tablet MD be used with calcium channel blocker?
Yes. Piril 20 Tablet MD can be taken with calcium channel blocker. NSAIDs have been observed to reduce the effectiveness of all antihypertensive drugs except calcium channel blockers (ref: White 2007)
Can Piril 20 Tablet MD be used with Tizanidine?
Yes, Piril 20 Tablet MD can be combined with tizanidine. Piroxicam is a pain killer and tizanidine is a skeletal muscle relaxant. It is used in the condition like a backache.
Why is beta cyclodextrin added to Piril 20 Tablet MD?
Yes. Piril 20 Tablet MD can be combined with beta-cyclodextrin. Research has shown that combining Piril 20 Tablet MD with beta-cyclodextrin leads to faster onset of action of piroxicam and reduced gastric side effects.
Are there any alternatives of Piril 20 Tablet MD?
Yes. There are alternatives to Piril 20 Tablet MD. Pain killers are prescribed according to the disease condition. Consult your doctor before starting piroxicam or changing it to other medication.
What are the contraindications for Piril 20 Tablet MD?
Contraindications to piroxicam are an allergy, bleeding tendency, duodenal/gastric/peptic ulcer, stomatitis, Systemic Lupus Erythematosus (SLE), ulcerative colitis, upper GI disease, late pregnancy, cardiac disease, hepatic impairment, renal impairment.
Can Piril 20 Tablet MD be used in the treatment of allergy?
No. Piril 20 Tablet MD is not a drug to treat allergy. It is a pain killer.
How long does Piril 20 Tablet MD work?
Piril 20 Tablet MD is a long acting drug. Once the daily dose is enough for the relief of pain but it depends from person to person as the effectiveness of piroxicam increases when given for few weeks.
Can you get high by using Piril 20 Tablet MD?
No. Piril 20 Tablet MD is not known to cause high. It is a non-narcotic painkiller.
Can Piril 20 Tablet MD be used to treat menstrual cramp?
Piril 20 Tablet MD is not approved for the treatment of menstrual cramps. Research studies have shown that piroxicam is quite effective in significantly decreasing the menstrual cramps.
Can I use Piril 20 Tablet MD for a migraine?
Piril 20 Tablet MD is not approved for the treatment of migraine. Research studies have shown that Piril 20 Tablet MD is effective in significantly decreasing the pain associated with migraine without aura.
Is Piril 20 Tablet MD effective in back pain management?
Yes. It can be given for decreasing the back pain. However, you should consult your doctor for the exact cause of your back pain and then start the treatment. Do not self-medicate yourself with Piril 20 Tablet MD as the cause of back pain can be different for different person.
Is Piril 20 Tablet MD affective in gout management?
Yes. Piril 20 Tablet MD can be given for the treatment of acute gout. Research studies have shown Piril 20 Tablet MD to be highly effective in the treatment of acute gout.
Can you donate blood when on the medication with Piril 20 Tablet MD?
Yes. You can donate blood when on Piril 20 Tablet MD. Do inform your doctor before donating blood.
Can I use Piril 20 Tablet MD if I am a diabetic?
Piril 20 Tablet MD in a diabetic patient can only be taken only by consulting a doctor because these medicines have the propensity to cause renal failure when taken for a long period. Diabetes itself causes renal Piril 20 Tablet MD so taking piroxicam can lead to increased risk of renal failure by many folds.
Can I use Piril 20 Tablet MD if I have a deranged renal function?
No. Piril 20 Tablet MD should not be taken if you have a abnormal renal function because long-term administration of NSAIDs has resulted in renal papillary necrosis and another renal injury.
Can Piril 20 Tablet MD lead to skin reactions?
Yes. Piril 20 Tablet MD is known to cause skin reactions which can be very severe such as exfoliative dermatitis, Stevens-Johnson Syndrome (SJS), and toxic epidermal necrolysis (TEN), which can be fatal. These serious events may occur without warning. You should inform your doctor if you feel you have a mild rash and immediately discontinue the drug.
Can I use Piril 20 Tablet MD if I am pregnant?
No. Piril 20 Tablet MD should not be taken in pregnancy. It causes premature closure of the ductus arteriosus which can lead to fetal heart failure and death of the baby.
Can I use Piril 20 Tablet MD if I have peptic ulcer disease?
No. Piril 20 Tablet MD is contraindicated in cases of active peptic ulcer disease. Piril 20 Tablet MD is known to cause gastric ulceration and bleeding.
Can I use Piril 20 Tablet MD if I have asthma?
Some patients with asthma are hypersensitive to non-steroidal anti-inflammatory (NSAID) drugs like aspirin which can lead to acute attacks of asthma. Consult your doctor before starting this medication.
Can Piril 20 Tablet MD lead to difficulty in conception?
Yes. Piril 20 Tablet MD can sometimes cause reversible infertility. Piroxicam by its mechanism of action may delay or prevent rupture of ovarian follicles, which has been associated with reversible infertility in some women. Consult your doctor before starting this medication.
Can Piril 20 Tablet MD be used with diuretics?
No. Piril 20 Tablet MD should not be used with diuretics. Piril 20 Tablet MD reduces the natriuretic effect of furosemide and thiazides diuretics in some patients. This response has been attributed to inhibition of renal prostaglandin synthesis.
Can Piril 20 Tablet MD be used with lithium?
No. Piril 20 Tablet MD should not be used with lithium. Piril 20 Tablet MD leads to an elevation of plasma lithium levels and a reduction in renal lithium clearance. This is because of inhibition of renal prostaglandin synthesis by the NSAID. Consult and inform your doctor before starting this medication.
Can Piril 20 Tablet MD be used with warfarin?
No. Piril 20 Tablet MD should be avoided with warfarin as they both lead to increase in bleeding tendencies. Inform your doctor if you are taking any of the medications. If given together then the therapy should be monitored closely.
What increases the chances of getting a gastric ulcer when I am already taking Piril 20 Tablet MD?
The chances of gastric ulceration increases if you take medicines like corticosteroids and anticoagulants. Long term use, alcohol, smoking and old age are few other factors which can increase the chances of ulceration.
Who should not take a Non-Steroidal Anti-Inflammatory Drug (NSAID)/ Piril 20 Tablet MD?
Patients who had an asthma attack, hives, or other allergic reaction with aspirin or any other NSAID medicine or for pain right before or after heart bypass surgery.
What are the serious side effects of Piril 20 Tablet MD?
GI discomfort and, rarely, serious GI side effects, such as ulcers and bleeding, serious skin side effects such as exfoliative, Stevens-Johnson Syndrome (SJS), and toxic epidermal necrolysis, liver failure, renal damage.
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Disclaimer:
Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.References
- Furst DE, Ulrich RW, Varkey-Altamirano C. Nonsteroidal Anti-Inflammatory Drugs, Disease Modifying Antirheumatic Drugs, Nonopioids Analgesics, & Drugs Used in Gout. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 628.
- Grosser T, Smyth E, FitzGerald GA. Anti-Inflammatory, Antipyretic, and Analgesic Agents; Pharmacotherapy of Gout. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 989-90.
- Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1127-28.
- PubChem. Piroxicam. [Accessed 02 Apr. 2019] (online) Available from:
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- Chaves RG, Lamounier JA. Breastfeeding and maternal medications. J Pediatr (Rio J). 2004;80(5 Suppl):S189-S198. [Accessed 02 Apr. 2019] (online) Available from:
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- Piroxicam [Drug Label]. Mumbai, India: Pfizer Limited; 2022. [Accessed 06 Apr. 2024] (online) Available from:
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