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MRP: Rs. 169.10 for 1 vial(s) (1 injection each)
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Composition for PIPRAPEN

Piperacillin(2 gm)

food interaction for PIPRAPEN

alcohol interaction for PIPRAPEN

pregnancy interaction for PIPRAPEN

lactation interaction for PIPRAPEN

It can be taken with or without food, but it is better to take Piprapen 2gm injection at a fixed time.
Interaction with alcohol is unknown. Please consult your doctor.
Piprapen 2gm injection is probably safe to use during pregnancy.
Either animal studies have shown no adverse effect on the fetus, but there is no human studies or animal studies have shown an adverse effect that was not confirmed in human studies. Please consult your doctor.
Unknown. Human and animal studies are not available. Please consult your doctor.


Piperacillin(2 gm)


Piprapen 2gm injection, in combination with a beta lactamase inhibitor (tazobactam) is used to treat pneumonia, complicated intra-abdominal infections urinary tract and kidney infections, skin or soft tissue infections, burns or ulcers due to diabetes (diabetic foot and  serious infections of pelvic and respiratory tract  It is also used to treat decrease in white blood cells (neutropenia) with fever due to bacterial infection and hospital acquired infections.

How it works

Piprapen 2gm injection belongs to a group of medicines called beta-lactam antibiotic. It is a semi-synthetic, extended spectrum penicillin. It is available in fixed combinations with beta lactamase inhibitor (tazobactam) that extends its activity against resistant bacteria. It kills the bacteria by interrupting the bacterial cell wall (outer coating of bacteria) formation. As a result, the bacterial cell wall is weakened and ruptured, thereby killing the bacteria.

Common side effects

Nausea, Pain, Swelling, Inflammation of wall of vein, Inflammation of a vein, Itchy rash, Liver enzyme increased, Abnormal blood cell count, Allergic reaction, Constipation, Decreased blood pressure, Diarrhoea, Fungal infection, Headache, Increased creatinine level in blood, Indigestion, Insomnia, Itching, Jaundice, Mouth inflammation, Lip inflammation, Rash, Vomiting


No substitutes found

Expert advice for PIPRAPEN

  • It is usually given by a doctor or a nurse as an injection directly into the vein or muscle.
  • Tell the doctor if you have to provide a blood or urine sample for any test because piperacillin and tazobactam may cause false positive results.
  • Do not start or continue the piperacillin/tazobactam and consult your doctor, If you have known allergy to penicillin, tazobactam or other beta-lactam antibiotics, If you are pregnant or planning to become pregnant or breastfeeding.

Frequently asked questions for PIPRAPEN


Q. Is piperacillin related to penicillin?
Yes, piperacillin is a semi-synthetic, extended spectrum penicillin.
Q. Is piperacillin compatible with morphine?
Piperacillin is not reported to interact with morphine. Please follow the advice of the doctor regarding their simultaneous use.
Q. What is piperacillin tazobactam?
Piperacillin and tazobactam are used as combination therapy for bacterial infections. Tazobactam reduces the destruction of piperacillin from chemicals released from bacteria and extends their spectrum of activity.
Q. What organisms does piperacillin cover?
Piperacillin is mainly effective against enterococcus, listeria, and serious gram-negative infections. It does not act against methicillin-resistant staphylococci.
Q. Is piperacillin nephrotoxic?
Piperacillin may be nephrotoxic when taken along with vancomycin or when given to children with cancer or other impairments. Consult and inform your doctor about any medical problems you may have before taking piperacillin.
Q. Is piperacillin safe?
Piperacillin is relatively safe if used at prescribed doses for the prescribed duration as advised by your doctor.


Content on this page was last updated on 04 February, 2016, by Dr. Varun Gupta (MD Pharmacology)