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Pillpex 0.25 Tablet

Written By Dr. Swati Mishra, BDS
Reviewed By Dr. Rajeev Sharma, MBA, MBBS
Last updated on 25 Nov 2025 | 03:05 PM (IST)
Pillpex 0.25 Tablet is used in the treatment of Parkinson's disease and restless leg syndrome (an urge to move the legs usually accompanied or caused by uncomfortable and unpleasant leg sensations). It helps to treat excessive shaking by slowing down the body movements.
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Pillpex 0.25 Tablet is currently sold out
Same composition alternative:
Pramipex 0.25 Tablet
₹96.1₹106.41
Available alternative from Sun Pharmaceuticals
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Pillpex 0.25 Tablet
Pillpex 0.25 Tablet
strip of 10 tablets
₹61
₹67.5
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Same composition
Pramipex 0.25 Tablet
Pramipex 0.25 Tablet
strip of 10 tablets
by Sun Pharmaceutical Industries Ltd
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₹96.1
₹8.17 per tablet

₹81.7

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₹1200

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General Information

The content is shown in English
Pillpex 0.25 Tablet image
Pillpex 0.25 Tablet image

Product introduction

Pillpex 0.25 Tablet can be taken with or without food. However, take it at the same time each day as this helps to maintain a consistent level of medicine in the body. Take this medicine in the dose and duration as advised by your doctor and if you have missed a dose, take it as soon as you remember it. You should never skip any doses and finish the full course of treatment even if you feel better. This medication must not be stopped suddenly without talking to your doctor.


Some common side effects of this medicine include nausea, dry mouth, fatigue, hallucinations, constipation, and peripheral edema. It also causes dizziness and sleepiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you. Inform your doctor if you develop any unusual changes in mood, an abnormally high sex drive, an urge to gamble, or uncontrolled spending as these may prove very harmful.


Before you start Pillpex 0.25 Tablet, let your doctor know if you have any medical conditions. Inform your doctor about all the medications you are taking, as some medicines may interact with Pillpex 0.25 Tablet. Pregnant or breastfeeding women should consult their doctor before taking Pillpex 0.25 Tablet to ensure safety.

Benefits of Pillpex Tablet

Parkinson's disease
Pillpex 0.25 Tablet is used to help manage symptoms such as tremors, stiffness, and slowed movement in Parkinson’s disease, supporting better mobility and daily functioning.
Restless leg syndrome
In rest leg syndrome, Pillpex 0.25 Tablet helps relieve the uncomfortable urge to move the legs, especially at night, leading to improved sleep quality and overall comfort.

Side effects of Pillpex Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Pillpex
  • Dizziness
  • Sleepiness
  • Nausea
  • Fatigue
  • Hallucination
  • Constipation
  • Weakness
  • Insomnia (difficulty in sleeping)
  • Headache

How to use Pillpex Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Pillpex 0.25 Tablet may be taken with or without food.

How Pillpex Tablet works

Pillpex 0.25 Tablet works by mimicking the action of dopamine, a chemical messenger that is needed to control movement in the brain.

Quick tips

  • You have been prescribed Pillpex 0.25 Tablet to treat your symptoms of Parkinson's disease and/or restless leg syndrome.
  • It can be taken with or without food. Taking it with food may reduce nausea.
  • For restless leg syndrome, take this medicine 2 to 3 hours before bedtime.
  • Avoid activities that require you to be alert, such as driving a car until you know how this medication affects you.
  • When you first start taking Pillpex 0.25 Tablet, it may cause sudden drop in your blood pressure when you change positions. To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down.
  • Talk to your doctor in case you develop hallucinations or other changes in your behavior.
  • Inform your doctor if you develop compulsive behaviors that are hard to control, such as binge eating, gambling, spending money, and sexual urges.
  • Do not stop taking the medication suddenly without talking to your doctor.
  • You have been prescribed Pillpex 0.25 Tablet to treat your symptoms of Parkinson's disease and/or restless leg syndrome.
  • It can be taken with or without food. Taking it with food may reduce nausea.
  • Inform your doctor if you develop compulsive behaviors that are hard to control, such as binge eating, gambling, spending money, and sexual urges.
  • Avoid activities that require you to be alert, such as driving a car until you know how this medication affects you.
  • When you first start taking Pillpex 0.25 Tablet, it may cause sudden drop in your blood pressure when you change positions. To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down.
  • Talk to your doctor in case you develop hallucinations or other changes in your behavior.
  • Do not stop taking the medication suddenly without talking to your doctor.
  • For restless leg syndrome, take this medicine 2 to 3 hours before bedtime.

Safety advice

Alcohol

Alcohol

UNSAFE
Do not drink alcohol while you are taking this medicine. Pillpex 0.25 Tablet may cause excessive drowsiness when taken with alcohol.
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
The safety of Pillpex 0.25 Tablet during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.
Breast feeding

Breast feeding

CONSULT YOUR DOCTOR
Pillpex 0.25 Tablet may be unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. It should be used only if the expected benefit outweighs the potential risk. Please consult your doctor.
Pillpex 0.25 Tablet suppresses serum prolactin and may interfere with breastfeeding.
Driving

Driving

UNSAFE
Pillpex 0.25 Tablet may cause side effects that could affect your ability to drive.
Pillpex 0.25 Tablet can cause hallucinations (seeing, hearing or feeling things that are not there). This may affect your ability to drive.
Kidney

Kidney

CAUTION
Pillpex 0.25 Tablet should be used with caution in patients with kidney disease. Dose adjustment may be needed.
Liver

Liver

SAFE IF PRESCRIBED
Pillpex 0.25 Tablet is probably safe to use in patients with liver disease. Limited data suggest dose adjustment may not be needed.

Interaction with drugs

Taking Pillpex with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Moderate

Ziprasidone (Oral Route)

If concurrent use is essential, please consult your doctor, they may monitor your treatment and adjust the doses as per the observations. Ziprasidone may reduce efficacy of Pramipexole.
Moderate

Loxapine (Oral Route)

If concurrent use is essential, please consult your doctor, they may monitor your treatment and adjust the doses as per the observations. Loxapine may block the action of Pramipexole.
Moderate

Amisulpride (Oral Route)

If concurrent use is essential, please consult your doctor, they may monitor your treatment and adjust the doses as per the observations. Amisulpride may block the action of Pramipexole.
Moderate

Amisulpride (Injection Route)

If concurrent use is essential, please consult your doctor, they may monitor your treatment and adjust the doses as per the observations. Amisulpride may block the action of Pramipexole.
Moderate

Chlorpromazine (Oral Route)

If concurrent use is essential, please consult your doctor, they may monitor your treatment and adjust the doses as per the observations. Chlorpromazine may block the action of Pramipexole.

Frequently asked questions

A common side effect of Pillpex 0.25 Tablet is decrease in body weight which may be due to decrease in appetite. Uncommonly, it can also cause increase in weight. However, if you have concerns regarding your weight talk to your doctor or a nutritionist.
Yes, Pillpex 0.25 Tablet may cause sleepiness. You may also experience sudden episodes of falling asleep. If it occurs, restrict driving and using heavy machinery and inform your doctor.
Restless leg syndrome (RLS) is a condition that causes discomfort in the legs and a strong urge to move the legs, especially at night and when sitting or lying down. Pillpex 0.25 Tablet belongs to dopamine (neurotransmitter) agonist class of medicines. It acts by stimulating the dopamine receptors which is needed in the brain to control movement. Hence, it is used to improve RLS.
No, Pillpex 0.25 Tablet is not a muscle relaxant. It helps in improving movements and muscle control in Parkinson’s disease. It is a dopamine agonist and acts on dopamine receptors.
You should not stop Pillpex 0.25 Tablet without talking to your doctor. Sudden discontinuation of Pillpex 0.25 Tablet may cause neuroleptic malignant syndrome. The symptoms of malignant syndrome include loss of muscle movement, rigid muscles, fever, unstable blood pressure, increased heart rate, confusion, and depressed level of consciousness.
You should take Pillpex 0.25 Tablet as directed by your doctor. The doctor will decide your dose depending on the condition you are being treated for. Preferably it should be taken 2-3 hours before bedtime. Swallow the tablets whole with water. It can be taken with or without food, but taking it with food may help reduce the chances of nausea.
The serious side effects of Pillpex 0.25 Tablet include hallucinations (seeing things or hearing voices that do not exist), confusion, aggressive behavior, agitation, abnormal thoughts, changes in vision, abnormal body movements, and motions that you cannot control. It may also cause changes in the way you sit or stand that you cannot control, such as your neck bending forward, bending forward at the waist, or tilting sideways when you sit, stand or walk. Additionally, it may cause dark, red or cola-colored urine, muscle tenderness, muscle stiffness or aching and muscle weakness. Call your doctor immediately if you experience any of these.
Pillpex 0.25 Tablet may cause impulse control disorders in which you may have cravings or urge to behave in an unusual manner, which normally you would not do. Pillpex 0.25 Tablet may also make it hard for you to resist the impulse to carry certain activities which can harm you or others, like addictive gambling, excessive eating or spending money. Along with that, it may cause an abnormally high sex drive or preoccupation with an increase in sexual thoughts or feelings.

Fact Box

Chemical Class

Aralkylamines

Habit Forming

No

Therapeutic Class

NEURO CNS

Action Class

Dopamine Agonists
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: SAG Health Science Pvt Ltd
Address: 487/35, National Market, Peeragarhi, New Delhi-110087.

Vendor Details

Country of origin: India
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