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Last updated on:
03 Oct 2019 | 10:13 PM (IST)
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Pangraf 0.5 Capsule

Prescription Required

Overview

Introduction of Pangraf Capsule

Pangraf 0.5 Capsule is used for prevention of organ rejection in transplant patients. It works by suppressing body’s immune response, so that body can accept the new organ.

You should take it in a dose and duration as advised by the doctor. But, before taking it report to doctor if you have any known allergy to this medication. Your doctor may get regular blood tests done to check the levels of blood cells in your blood. Remember to inform doctor if you experience unexplained bleeding, fever, or general illness. Your doctor may advice for monitoring of kidney function.

It may cause nausea, stomach pain and diarrhea as its side effects.

Pangraf Capsule side effects

Common
  • Nausea
  • Stomach pain
  • Liver damage
  • Diarrhea
  • Kidney damage
  • Increased thirst
  • Increased glucose level in blood

How to use Pangraf Capsule

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Pangraf 0.5 Capsule may be taken with or without food, but it is better to take it at a fixed time.
Avoid Pangraf 0.5 Capsule with high-fat meals such as olive oil, nuts & seeds (Brazil nuts), dark chocolate, butter and meat.

How Pangraf Capsule works

Pangraf 0.5 Capsule is an immunosuppressant. It works by suppressing your body’s immune response following transplant of an organ (eg. liver, kidney, heart). This helps your body to accept the new organ as if it were your own.

Pangraf Capsule related warnings

Alcohol
UNSAFE
It is unsafe to consume alcohol with Pangraf 0.5 Capsule
Pregnancy
CONSULT YOUR DOCTOR
Pangraf 0.5 Capsule may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Lactation
CONSULT YOUR DOCTOR
Pangraf 0.5 Capsule is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Driving
UNSAFE
Pangraf 0.5 Capsule may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Kidney
CAUTION
Pangraf 0.5 Capsule should be used with caution in patients with kidney disease. Dose adjustment of Pangraf 0.5 Capsule may be needed. Please consult your doctor.
Liver
CAUTION
Pangraf 0.5 Capsule should be used with caution in patients with liver disease. Dose adjustment of Pangraf 0.5 Capsule may be needed. Please consult your doctor.

What if you miss a dose of Pangraf Capsule?

If you miss a dose of Pangraf 0.5 Capsule, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Alternate Brands

For informational purposes only. Consult a doctor before taking any medicines.
Pangraf 0.5 Capsule
₹22.46/Capsule
Vingraf 0.5 Capsule
Emcure Pharmaceuticals Ltd
₹19.79/Capsule
save 12%
Takfa 0.5 Capsule
Intas Pharmaceuticals Ltd
₹22.88/Capsule
2% costlier
₹24.22/Capsule
8% costlier
Prograf 0.5mg Capsule
Astellas Pharma Inc
₹22.47/Capsule
same price
Tacroren 0.5 Capsule
La Renon Healthcare Pvt Ltd
₹20/Capsule
save 11%

Expert Advice

  • Pangraf 0.5 Capsule is used to prevent organ rejection in transplant patients.
  • It may take 3 to 4 months for the medication to work. Keep taking it as prescribed.
  • Your doctor may get regular blood tests done to check the levels of blood cells in your blood. Inform your doctor if you experience unexplained bruising or bleeding, sore throat, mouth ulcers, fever, or general illness. 
  • Your doctor may monitor your kidney function regularly. Drink 8 to 10 glasses of water per day to help with your kidney function.
  • Do not stop taking Pangraf 0.5 Capsule without talking to your doctor first.

Interaction with Drugs

Taking Pangraf with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Brand(s): Begenta, Indogenta, Spagen
SERIOUS
Brand(s): Antep
SERIOUS
Brand(s): Densol
SERIOUS
Brand(s): Shinosun
SERIOUS
Brand(s): Itraspan, Canzit, Cositra
SERIOUS
Brand(s): Samwell
SERIOUS
Brand(s): Clorocin, Vecol
SERIOUS
Brand(s): Auxicasp, Canducid
SERIOUS
Brand(s): Ranisol, Vepred, Catapred
SERIOUS

Patient Concerns

Questions Related to Pangraf

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Hello sir am PATIENT a transplant patient Now am using pangraf 1mg, azoran50,&omnacortil5mg my question is shall go to gym for toning ma body 9 year after ma transplant Pls give me a good advice from ur side
Dr. Khoobsurat Najma
Ask A Chemist
Mr PATIENT can go for any physical activity after permission from the doctor who did a transplant on you.
Suffering from nephritis, prescribed rituximab inj IV for 4 weeks. What are chances of being cured? What is the risks of rituximab? Following is the brief synopsis of his disease so far. 1. Albumin detected at age 4 (1981) and treated with prednisolone 2. Biopsy done at CMC, Vellore (1983) showed minimal change disease and treated with prednisolone 3. From 1983 to 1990 on and off steroids (prednisolone)leading to severe obesity and stunted growth and frequent relapses 4. 1990 Treated at Apollo Hospital, Chennai with Endoxon for 8 weeks, developed cellulitis of right thigh, remission achieved. 5. 1993 Treated with Chlorambucil 6. FROM 1995 to 2005 no medicines taken and albumin free, even though had Jaundice in 2001 still there was no relapse 7. Oct 2005 relapse, edema and treated with omnacortil 120 mg alternate day and albumin free without medicine for 6 months 8. In Sep 2006 developed urticarial vasculitis and treated with Dapsone for 7 days 9. In Dec 2006 again relapse after severe cough and cold; treated with omnacortil 10. In November 2007 briefly on CELLCEPT 500mg on advice of Anup Kumar Barman (Guwahati) but stopped by UCD Nautiyal of Jaipur Golden (New Delhi) 11. In Sep 2008 BIOPSY shows minimal lesion nephropathy 12. In Nov 2009 took Myfortic 360mg 1 tab twice daily 13. From April 2010 started Tacrolimus/ Pangraf at 6mg BD, deflazacort 36mg OD and completely stopped deflazacort after 3months and tacrolimus reduced to 0.5mg BD after 6months but relapsed after 8 months 14. From 2011 pangraf dose started again 3mg BD with deflazacort, remission achieved but again relapse after pangraf reduced to 1mg BD 15. Repeated relapses continuing from 2011 till 2014. In 2014 Pangraf started at 2mg twice daily and deflazacort at 36 mg daily, deflazacort stopped but relapse again when pangraf reduced to 1mg in morning and 2mg in evening. 16. From 2014-16 Tacrolimus 2mg+2mg morning and evening, deflazacort 36mg when relapsed and tapering, Presently frequent relapses in the period Medicine Vingraf 2mg twice daily, deflacort 12mg OD. Recently remission on 15mg defcort after relapses but again relapses at 9mg defcort. For cough taking alerfix M from yesterday. No other significant medication in this period.
Dr. Debashis Mukherjee
General Physician
You have to be in touch with your nephrologist
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FAQs

Q. Who should not take Pangraf?

Patients who are allergic to it or have a weak immune system, high blood pressure and kidney failure should avoid Pangraf. This medicine should also be avoided in pregnant or breast-feeding women, and in people who plan to receive any live vaccines (e.g. MMR vaccine). It should also be avoided in patients who have an increased risk of skin cancer.

Q. What should I tell my doctor before taking Pangraf?

Inform your doctor if you are pregnant, have allergies, long-term infection, high blood sugar, or high blood pressure. You should also inform your doctor if you have high blood potassium levels or a weakened immune system. Make your doctor aware in case you have a history of any medication, have recently received or are scheduled to receive a live vaccine.

Q. Which vaccines should not be taken while taking Pangraf?

You should avoid taking any live vaccines while taking Pangraf. These may include vaccinations for measles, mumps, rubella, BCG (TB vaccine), yellow fever, chicken pox and typhoid. You should also avoid taking polio drops (by mouth) or flu vaccine (through nose).

Q. Is Pangraf an antibiotic?

Yes, Pangraf is a type of antibiotic which belongs to a group called macrolides. It is mostly used after organ transplantation. This medicine’s immune-suppressing property helps prevent organ rejection after kidney, heart, or liver transplant.

Q. What should I be aware of before I start taking Pangraf?

As this medicine suppresses the immune system, hence there is always an increased risk of infection. Moreover, Pangraf can in some cases increase the risk of some kind of cancers like skin and lymph gland cancer (lymphoma). It can lower the ability of your immune system to fight infections. Consult your doctor before you start taking this medication and in case you notice any symptoms of infections like fever, sweats or chills, cough or flu-like symptoms, muscle aches, warm, red, or painful areas on your skin.

Related Products

Disclaimer: 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover all possible side effects, drug interactions or warnings or alerts. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.
References
  1. Burkhart C, Morrell D, Goldsmith L. Dermatological Pharmacology. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 1822.
  2. Lake DF, Briggs AD, Akporiaye ET. Immunopharmacology. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 972.
  3. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1305-309.
  4. Tacrolimus monohydrate. Camberley, Surrey: Sandoz Limited; 2010 [revised 27 Mar. 2017]. [Accessed 23 Jan. 2019] (online) Available from:External Link
  5. Drugs.com.Tacrolimus. [Accessed 06 Apr. 2019] (online) Available from:External Link
  6. Tacrolimus. Princeton, New Jersey: Sandoz Inc; 2009. [Accessed 06 Apr. 2019] (online) Available from:External Link
  7. Central Drugs Standard Control Organisation (CDSCO). [Accessed 06 Apr. 2019] (online) Available from:External Link
Manufacturer/Marketer Address
Ambala- Chandigarh Highway, Lalru – 140501, Punjab
A licensed pharmacy from your nearest location will deliver Pangraf 0.5 Capsule. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your prescription and the availability of this medicine.
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