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Palbo Capsule

Written By Dr. Syeda Aafia, MBA, BDS
Reviewed By Dr. Mekhala Chandra, MD, MBBS
Last updated on 06 Apr 2026 | 04:05 PM (IST)
Palbo Capsule is used to treat patients with certain types of breast cancer (estrogen receptor-positive, human epidermal growth factor receptor 2-negative) which have spread to other organs. It is given together with hormonal anticancer therapies.
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Palbo Capsule
Palbo Capsule
bottle of 21 capsules
₹5167
₹5742.15
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Same composition
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General Information

The content is shown in English
Palbo Capsule image
Palbo Capsule image
Palbo Capsule image
Palbo Capsule image

Product introduction

Palbo Capsule should be taken with food, but try to have it at the same time every day to get the most benefits.  Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.

Some common side effects of this medicine include fatigue, hair loss, rash, vomiting, and diarrhea. This medicine may reduce the number of blood cells (decrease red blood and white blood cells) in your blood, thereby, increasing the susceptibility to infections. It is better to inform your doctor if you notice symptoms of infection like fever, chills, and weakness, bleeding or bruising and nose bleed. It might also cause dizziness if it happens avoid driving or attention-seeking activities.

Before taking it, tell your doctor if you have heart disease, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.

Uses of Palbo Capsule

Benefits of Palbo Capsule

Breast cancer
Breast cancer occurs when abnormal cells in the breast grow uncontrollably and can spread to surrounding tissues or other parts of the body. Palbo Capsule helps slow the growth and division of cancer cells, allowing healthy cells more time to recover. This supports better disease control, helps manage symptoms, and can improve treatment outcomes when used as part of a prescribed cancer therapy plan.

Side effects of Palbo Capsule

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Palbo
  • Fever
  • Diarrhea
  • Fatigue
  • Hair loss
  • Rash
  • Vomiting
  • Nausea
  • Decreased appetite
  • Infection
  • Stomatitis (Inflammation of the mouth)
  • Anemia (low number of red blood cells)
  • Weakness
  • Decreased white blood cell count
  • Decreased blood cells (red cells, white cells, and platelets)

How to use Palbo Capsule

Take this medicine in the dose and duration as advised by your doctor. Palbo Capsule should be taken with or after food.

How Palbo Capsule works

Palbo Capsule is an anti-cancer medication. Cyclin dependent kinase 4 and 6 (chemical messengers) are downstream of signaling pathways which lead to the proliferation of cells. This medicine works by inhibiting cyclin dependent kinase 4 and 6, thus arrests the cancer cell cycle (cell growing process). It also targets the estrogen (hormone) receptor-positive breast cancer cells by disrupting the cell cycle.

Quick tips

  • Take it with food, preferably at the same time every day. 
  • If you forget to take the medicine or vomit, skip the missed dose and follow a regular schedule. Do not take a double dose to make up missed dose
  • Use effective contraception method to prevent pregnancy while taking this medicine.
  • It may cause dizziness. Avoid driving or any activity requiring mental focus until you know how it affects you.
  • You may be asked for regular blood tests while taking this medication. Inform your doctor if you notice symptoms of infection like fever, chills, and weakness.
  • Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.
  • Do not stop taking the medication without talking to your doctor first.
  • Take it with food, preferably at the same time every day. 
  • If you forget to take the medicine or vomit, skip the missed dose and follow a regular schedule. Do not take a double dose to make up missed dose
  • Use effective contraception method to prevent pregnancy while taking this medicine.
  • It may cause dizziness. Avoid driving or any activity requiring mental focus until you know how it affects you.
  • You may be asked for regular blood tests while taking this medication. Inform your doctor if you notice symptoms of infection like fever, chills, and weakness.
  • Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.
  • Do not stop taking the medication without talking to your doctor first.

Safety advice

Alcohol

Alcohol

CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Palbo Capsule. Please consult your doctor.
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
Palbo Capsule is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.
Breast feeding

Breast feeding

UNSAFE
Palbo Capsule is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
Driving

Driving

UNSAFE
Palbo Capsule may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
It may cause fatigue in some people. If this happens, you should exercise caution when driving or using machines.
Kidney

Kidney

CAUTION
Palbo Capsule should be used with caution in patients with severe kidney disease. Dose adjustment may be needed.
Liver

Liver

CAUTION
Palbo Capsule should be used with caution in patients with severe liver disease. Dose adjustment may be needed.

Interaction with drugs

Taking Palbo with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Severe

Carbamazepine (Oral Route)

Do not consume Palbociclib with Carbamazepine. Carbamazepine may reduce blood levels of Palbociclib.
Severe

Enzalutamide (Oral Route)

Do not consume Palbociclib with Enzalutamide. Enzalutamide may reduce blood levels of Palbociclib.
Severe

Fosphenytoin (Injection Route)

Do not consume Palbociclib with Fosphenytoin. Fosphenytoin may reduce blood levels of Palbociclib.
Severe

Phenobarbitone (Oral Route)

Do not consume Palbociclib with Phenobarbitone. Phenobarbitone may reduce blood levels of Palbociclib.
Severe

Phenobarbitone (Injection Route)

Do not consume Palbociclib with Phenobarbitone. Phenobarbitone may reduce blood levels of Palbociclib.

Frequently asked questions

Palbo Capsule is an anti-cancer medicine. Palbo Capsule blocks proteins known as cyclin-dependent kinase inhibitors. Blocking these proteins can slow down the growth of cancer cells and delay the progression of the cancer.
The duration of treatment varies from person to person. Your doctor will decide the number of cycles you need to receive based on your condition, response to treatment and your tolerance to side effects. Your doctor may decrease your dose or stop your treatment temporarily or permanently if you experience certain side effects.
No, most of the side effects are reversible and disappear when the medicine is stopped. Neutropenia is a well-recognized adverse effect of Palbo Capsule in which the number of your white blood cells get reduced and your immune system gets weakened. As a result, you may be at greater risk of getting an infection while you are taking Palbo Capsule. However, this side effect disappears rapidly once you stop taking the medicine.
Yes, blood tests are important since this medicine can lower your blood counts. The regular blood tests check the effect of Palbo Capsule on your blood cells (white blood cells, red blood cells, and platelets). These tests should be done at the beginning of each chemotherapy cycle, on the 15th day of the first 2 cycles, and as clinically indicated.
Generally, Palbo Capsule is taken once daily for 21 consecutive days followed by 7 days off treatment to add up a complete cycle of 28 days. Take this medicine with food and at the same time each day. Swallow the whole capsules. Do not open, chew, or crush them. Do not take the capsules that are broken or cracked. If you vomit after taking Palbo Capsule, do not take another dose and continue your regular dosing schedule.
Women of childbearing potential who are receiving Palbo Capsule and their partners should use adequate contraceptive methods (e.g. double-barrier contraception such as condom and diaphragm). These methods should be used during therapy and for at least 3 weeks after completing therapy for females. Men who are on Palbo Capsule therapy should use birth control methods for at least 14 weeks after completing the therapy.
Male fertility may be affected during treatment with Palbo Capsule. Thus, men may consider sperm preservation prior to beginning therapy with Palbo Capsule.
The serious side effects of Palbo Capsule include shortness of breath, dizziness, weakness, unusual bleeding or bruising or nosebleeds. It may also cause fever, chills or signs of infection and fast, irregular or pounding heartbeat. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment.

Fact Box

Chemical Class

Pyridinylpiperazines

Habit Forming

No

Therapeutic Class

ANTI NEOPLASTICS

Action Class

Cyclin-Dependent Kinase Inhibitor
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Alkem Laboratories Ltd
Address: Alkem Laboratories Limited, Devashish Building, Alkem House, Senapati Bapat Road, Lower Parel, Mumbai - 400 013.

Vendor Details

Country of origin: India
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