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MD (Pharmacology), MBBS
Last updated:
19 Nov 2020 | 04:48 PM (IST)
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Ondrea 500mg Capsule

Prescription Required
SALT COMPOSITION
Storage
Store at room temperature (10-30°C)

Introduction

Ondrea 500mg Capsule is used in the treatment of some kinds of cancer and to prevent painful episodes associated with sickle cell anemia. It may be also used to treat some other conditions. It is sometimes used with certain other medicines as part of combination chemotherapy.

Ondrea 500mg Capsule can be taken with or without food, but try to have it at the same time every day to get the most benefits. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.

The most common side effects of this medicine include hematological disorders, gastrointestinal symptoms, eating disorders, and weight loss. This medicine may reduce the number of blood cells in your blood thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells along with kidney, liver and heart function during treatment with this medicine.

Before taking it, tell your doctor if you have bleeding, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.

Benefits of Ondrea Capsule

In Head and neck cancer

Head and neck cancer includes cancer of the mouth, nose, sinuses or throat. Ondrea 500mg Capsule kills or stops the growth of cancer cells and also prevents the multiplication of cancer cells. It is a potent and very toxic medicine and you should discuss the risks and benefits with your doctor. You should avoid drinking alcohol or smoking while having this treatment and drink plenty of water to stay hydrated.

In Sickle cell anemia

Sickle cell anemia is a disorder of the red blood cells (RBCs) in which they lose their original round shape and flexibility, turn sickle shape and eventually die out. Ondrea 500mg Capsule makes your red blood cells bigger. It helps them stay rounder and more flexible and makes them less likely to turn into a sickle shape. The medicine does this by increasing a special kind of hemoglobin called hemoglobin F. Hemoglobin F is also called fetal hemoglobin because newborn babies have it. This helps to treat this disease and also prevents further complications that may be life-threatening.

Side effects of Ondrea Capsule

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Ondrea

  • Hematological disorder
  • Gastrointestinal disorder
  • Eating disorder
  • Loss of appetite

How to use Ondrea Capsule

Take this medicine in the dose and duration as advised by your doctor. Do not chew, crush or break it. Ondrea 500mg Capsule may be taken with or without food, but it is better to take it at a fixed time.

How Ondrea Capsule works

In cancer, Ondrea 500mg Capsule works by blocking an enzyme (ribonucleotide reductase) which is required for synthesis of DNA. This prevents the cancer cells from growing and multiplying. In sickle cell disease, it works by increasing fetal haemoglobin (HbF) levels in red blood cells (RBCs). This helps the RBCs assume a normal shape, improves blood flow and protects against complications such as painful sickle cell episodes.

Safety Advice

Alcohol
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Ondrea 500mg Capsule. Please consult your doctor.
Pregnancy
CONSULT YOUR DOCTOR
Ondrea 500mg Capsule is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
Breastfeeding
CONSULT YOUR DOCTOR
Ondrea 500mg Capsule is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Driving
UNSAFE
Ondrea 500mg Capsule may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Kidney
CAUTION
Ondrea 500mg Capsule should be used with caution in patients with kidney disease. Dose adjustment of Ondrea 500mg Capsule may be needed. Please consult your doctor.
Regular monitoring of kidney function test and some blood tests may be advised while you are taking this medicine.
Liver
CAUTION
Ondrea 500mg Capsule should be used with caution in patients with liver disease. Dose adjustment of Ondrea 500mg Capsule may be needed. Please consult your doctor.

Alternate Brands

For informational purposes only. Consult a doctor before taking any medicines.
Ondrea 500mg Capsule
₹10.0/Capsule
Hydrogem 500mg Capsule
Neon Laboratories Ltd
₹6.4/Capsule
save 36%
₹9.46/Capsule
save 5%
Riborea 500mg Capsule
Khandelwal Laboratories Pvt Ltd
₹12/Capsule
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Durea 500mg Capsule
Samarth Life Sciences Pvt Ltd
₹12.21/Capsule
22% costlier
₹13.77/Capsule
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Quick Tips

  • Take it at the same time every day, either with or without food.
  • It is advisable to stay hydrated and drink plenty of fluids while taking Ondrea 500mg Capsule.
  • Do not skip any dose and complete the course as suggested by your doctor.
  • Use an effective method of birth control to avoid pregnancy while taking this medication.
  • Your doctor may get regular blood tests done to monitor your electrolyte levels, liver function, blood cell count in your blood.

Fact Box

Chemical Class
Anti Metabolites, {Urea}
Habit Forming
No
Therapeutic Class
ANTI NEOPLASTICS

Patient Concerns

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I'm sickle cell patient now strong pain occurs what i can do ,my MRI report uploaded
Dr. Kamal Rijhwani
Physician
There is sickle cell society in NagpurFind on net and consult
the injection said is Haemaz fort Injection of 5 ml, total 4 nos. injection is injected to sickle cell disease patient, if Hb is 7 gram, what will be the effect to patient?
Dr. Pushkar Mani
Physician
we dont treat sickle cell anaemia online, u need to consult hematologist
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Disclaimer:

1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover all possible side effects, drug interactions or warnings or alerts. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

  1. Chabner BA, Bertino J, Cleary J, et al. Cytotoxic Agents. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1721-22.
  2. Masters SB. Agents Used in Anemias; Hematopoetic Growth Factors. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 578.
  3. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 672-75.
  4. Hydroxycarbamide. Reading, Berkshire: Nordic Pharma Limited; 2007 [revised 31 May 2018]. [Accessed 29 Jan. 2019] (online) Available from:External Link
  5. Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Hydroxyurea. [Updated 2020 Jan 20]. [Accessed 18 Feb. 2020] (online) Available from:External Link
  6. Central Drugs Standard Control Organisation (CDSCO). [Accessed 27 Mar. 2019] (online) Available from:External Link

Manufacturer/Marketer Address

50-AB, Government Industrial Estate, Charkop Naka, Kandivali West , Mumbai - 400067, Maharashtra, India
Country of Origin: India

Best Price
₹765
MRP900  Get 15% OFF
Inclusive of all taxes
90 capsules in 1 bottle
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