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Hydroxyurea

Information

Uses

Hydroxyurea is used in the treatment of sickle cell anemia

How it works

Hydroxycarbamide causes inhibition of DNA synthesis during the S-phase of cell division by acting as a ribonucleotide reductase inhibitor resulting to cell death. It is S-phase specific.

Common side effects

Megaloblastic anemia, Decreased white blood cell count (neutrophils), Oligospermia (low sperm count), Azoospermia (absence of sperms)

Available Medicine

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Content on this page was last updated on 16 February, 2017, by Dr. Varun Gupta (MD Pharmacology)