Noxafil 100mg Tablet DR

Posaconazole (100mg)

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Noxafil 100mg Tablet DR is an antifungal medicine used to prevent and treat severe fungal infections, particularly in people with weakened immune systems. It is commonly prescribed to prevent invasive infections caused by Aspergillus and Candida species and to treat fungal infections of the mouth and throat.

Written By Dr. Subita Alagh, BDS,
Reviewed By Dr. Sachin Gupta, MD Pharmacology, MBBS,
Last updated on 12 Jul 2026 | 01:01 AM (IST)

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General Information

Contains

Posaconazole (100mg)

Marketer

MSD Pharmaceuticals Pvt Ltd

The content is shown in English

Product introduction

Noxafil 100mg Tablet DR should be taken with food. Take it exactly in the dose and duration prescribed by your doctor. Do not skip doses and complete the full course of treatment, even if you start to feel better. While taking this medicine, follow good hygiene practices and avoid contact with people who have infections, especially if your immune system is weak.

The most common side effects of Noxafil 100mg Tablet DR include diarrhea, nausea, fever, vomiting, headache, coughing, and hypokalemia (low potassium level). These are not usually serious, but let your doctor know if any of these side effects persist or worsen. They may be able to guide you on how to manage or prevent the side effects.

Talk to your doctor before taking Noxafil 100mg Tablet DR if you have ever had heart failure, kidney problems, or liver problems such as yellow skin (jaundice). If your course of treatment is for more than a month, your doctor may want to check your liver and potassium levels by testing your blood. Pregnant and breastfeeding women should not take this medicine without consulting their doctors.

Uses of Noxafil Tablet DR

Treatment of Severe fungal infections

Benefits of Noxafil Tablet DR

Treatment of Severe fungal infections
Noxafil 100mg Tablet DR is an antifungal medicine used to treat serious fungal infections. It is especially beneficial for patients who are severely immunocompromised, such as those with cancer or those undergoing chemotherapy or blood transfusions. This medicine is administered by a doctor or a nurse and should not be self-administered. The dose and duration of treatment will be determined by your doctor based on your condition. It is important to complete the full course of treatment, even if you start feeling better, to ensure the infection is fully cleared and does not return.

Side effects of Noxafil Tablet DR

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Noxafil

Decreased potassium level in blood
Cough
Vomiting
Headache
Fever
Nausea
Diarrhea

How to use Noxafil Tablet DR

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Noxafil 100mg Tablet DR should be taken with or after food.

How Noxafil Tablet DR works

Noxafil 100mg Tablet DR is an antifungal that works by inhibiting the enzyme essential for the synthesis of ergosterol, a key component of fungal cell membranes. It disrupts the production of ergosterol, damaging the fungal cell membrane, leading to cell death. This action makes it effective in preventing and treating invasive Aspergillus and Candida infections in immunocompromised patients, as well as treating oropharyngeal candidiasis, including cases resistant to other azoles like itraconazole or fluconazole.

Quick tips

Do not skip any doses and finish the full course of treatment even if you feel better.
Take Noxafil 100mg Tablet DR with food to enhance the absorption, preferably at the same time every day.
Do not take indigestion remedies (antacids) within two hours of taking Noxafil 100mg Tablet DR.
Your doctor may check your liver function before starting treatment and regularly thereafter.
Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Noxafil 100mg Tablet DR. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

The safety of Noxafil 100mg Tablet DR during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.

Breast feeding

CAUTION

Noxafil 100mg Tablet DR should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from the body.

Driving

UNSAFE

Noxafil 100mg Tablet DR may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
As you may feel dizzy, sleepy, or have blurred vision while taking Noxafil 100mg Tablet DR, which may affect your ability to drive.

Kidney

CAUTION

Noxafil 100mg Tablet DR should be used with caution in patients with severe kidney disease. Dose adjustment may be needed.
Regular monitoring of kidney function tests is advised while taking this medicine. Use of Noxafil 100mg Tablet DR is not recommended in patients with moderate to severe kidney disease.

Liver

SAFE IF PRESCRIBED

Noxafil 100mg Tablet DR is probably safe to use in patients with liver disease. Limited data suggest dose adjustment may not be needed.

Interaction with drugs

Taking Noxafil with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Life-threatening

Simvastatin (Oral Route)

Do not consume Simvastatin with Posaconazole. If Posaconazole is essential, your doctor may temporarily stop Simvastatin. Posaconazole may raise blood levels of Simvastatin.

Life-threatening

Lovastatin (Oral Route)

Do not consume Lovastatin with Posaconazole. If Posaconazole is essential, your doctor may temporarily stop Lovastatin. Posaconazole may raise blood levels of Lovastatin.

Severe

Atorvastatin (Oral Route)

Do not consume Atorvastatin with Posaconazole. If concurrent use is essential, watch out for symptoms such as muscle pains or weakness and consult your doctor if you experience them. They may adjust the doses as per the observations.

Severe

Ranolazine (Oral Route)

Do not consume Ranolazine with Posaconazole. If concurrent use is essential, watch out for symptoms of Ranolazine side effects such as nausea, vomiting, headache, dizziness, constipation or weakness and consult your doctor if you experience them. They may adjust the dose of Ranolazine accordingly. Posaconazole may raise blood levels of Ranolazine.

Severe

Pimozide (Oral Route)

Do not consume Pimozide with Posaconazole.

Frequently asked questions

What is Noxafil 100mg Tablet DR, and what is it used for?

Noxafil 100mg Tablet DR belongs to a class of medicines known as antifungal agents. It is used to treat serious fungal infections caused by organisms such as Aspergillus and Candida, particularly in patients who are at high risk of developing these infections. Noxafil 100mg Tablet DR is mainly prescribed to severely immunocompromised individuals, such as those with cancer or those undergoing chemotherapy or blood transfusions.

How is Noxafil 100mg Tablet DR taken?

Take Noxafil 100mg Tablet DR in the dose and duration prescribed by the doctor. The dose depends on the condition being treated and will be determined by your doctor. It is important to follow your doctor’s instructions carefully to gain the maximum benefit from Noxafil 100mg Tablet DR. Do not skip any doses and make sure to complete the full course of treatment.

Is Noxafil 100mg Tablet DR effective?

Noxafil 100mg Tablet DR is effective when used in the dose and duration prescribed by your doctor. Do not stop taking it even if your symptoms improve. Stopping the medication too early may cause the infection to return or worsen.

What are the side effects of Noxafil 100mg Tablet DR?

Some common side effects of Noxafil 100mg Tablet DR include cough, headache, nausea, and vomiting. These side effects are generally mild and tend to resolve on their own. However, consult your doctor if any of these symptoms persist or cause concern.

Fact Box

Chemical Class

Phenylpiperazines

Habit Forming

Therapeutic Class

ANTI INFECTIVES

Action Class

Fungal Ergosterol Synthesis Inhibitor

References

Bennett JE. Antifungal Agents. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. New York, New York: McGraw-Hill Medical; 2011. pp. 1581-82.
Sheppard D, Lampiris HW. Antifungal Agents. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 841.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1135-36.
Posaconazole. Kenilworth, New Jersey: Schering Plough; 2006. [Accessed 29 Mar. 2019] (online) Available from:
Central Drugs Standard Control Organisation (CDSCO). [Accessed 29 Mar. 2019] (online) Available from:
Noxafil [Prescribing Information]. Whitehouse Station, NJ: Merck & Co., Inc.; 2015. [Accessed 25 Jul. 2024] (online) Available from:

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: MSD Pharmaceuticals Pvt Ltd
Address: Platina, 8th Floor, C.59, G Block, Bandra Kurla Complex, Bandra (East) , Mumbai - 400098,

Vendor Details

Country of origin: India

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Noxafil 100mg Tablet DR

Noxafil 100mg Tablet DR

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General Information

Contains

Marketer

Product introduction

Uses of Noxafil Tablet DR

Benefits of Noxafil Tablet DR

Side effects of Noxafil Tablet DR

How to use Noxafil Tablet DR

How Noxafil Tablet DR works

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Simvastatin (Oral Route)

Lovastatin (Oral Route)

Atorvastatin (Oral Route)

Ranolazine (Oral Route)

Pimozide (Oral Route)

Frequently asked questions

What is Noxafil 100mg Tablet DR, and what is it used for?

How is Noxafil 100mg Tablet DR taken?

Is Noxafil 100mg Tablet DR effective?

What are the side effects of Noxafil 100mg Tablet DR?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

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