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Posaconazole is used for prophylaxis of invasive Aspergillus and Candida infections in patients who are at high risk of developing these infections due to being severely immunocompromised [such as hematopoietic stem cell transplant (HSCT) recipients with acute graft-verus-host disease (GVHD) or those with hematologic malignancies with prolonged neutropenia from chemotherapy]. It is also used for treatment of oropharyngeal candidiasis (OPC), including OPC refractory (rOPC) to itraconazole and/or fluconazole.

How it works

Posaconazole belongs to a class of medication called azole anti-fungals. It kills or stops the growth of certain kind of fungi which are responsible for causing fungal infection.

Common side effects

Cough, Diarrhoea, Fever, Electrolyte imbalance, Headache, Heartburn, Increased sweating, Insomnia, Rash, Itching, Mouth ulcer, Lip ulcer, Nose bleed, Nose pain, Sore throat, Stomach pain, Vomiting, Constipation


Expert advice

  • Seek medical attention if you have ongoing vomiting or diarrhea while using posaconazole, as it may not be effective during this time.
  • Use effective methods of contraception to avoid pregnancy during posaconazole treatment.
  • Do not drive or operate machinery as posaconazole can cause dizziness, sleepiness and blurred vision.

Frequently asked questions


Q. Is posaconazole soluble or susceptible to hydrolysis?
Posaconazole is soluble but is not naturally susceptible to hydrolysis.
Q. Is posaconazole used as a prophylaxis?
Posaconazole may be used on doctor’s recommendation for prophylaxis in cancer patients using chemotherapy since they are more susceptible to fungal infections.
Q. Where is posaconazole absorbed?
Posaconazole is absorbed in the gut.

Content on this page was last updated on 30 September, 2016, by Dr. Varun Gupta (MD Pharmacology)