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Nicophen 22.75mg Injection

Pheniramine (22.75mg)

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Nicophen 22.75mg Injection is an antihistamine used to treat allergic conditions (such as hay fever, drug rashes, allergic conjunctivitis, food allergy, etc.), respiratory tract conditions, and other skin conditions. It effectively reduces the severity, duration, and occurrence of symptoms and provides quick relief.

Written By Dr. Sakshi Jain, MS, BDS,
Reviewed By Dr. Mekhala Chandra, MD, MBBS,
Last updated on 06 Nov 2026 | 01:02 AM (IST)

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Instavil 22.75mg Injection

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Nicophen 22.75mg Injection

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Instavil 22.75mg Injection

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Pheniramine (22.75mg)

by Intas Pharmaceuticals Ltd

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General Information

Contains

Pheniramine (22.75mg)

Marketer

Abbott

Storage

Store below 30°C

The content is shown in English

Product introduction

Nicophen 22.75mg Injection is also used to treat and prevent motion sickness, symptoms of Meniere’s disease (such as nausea, vomiting, and vertigo), and other associated labyrinthine disturbances.

It is given as an injection into the veins or muscles under the supervision of a doctor. It should be used as per the instruction of your doctor. The dose and how often you take it depend on what you are taking it for. Your doctor will decide how much you need to improve your symptoms. You should take Nicophen 22.75mg Injection for as long as it is prescribed for you.

Sedation is the most common side effect of Nicophen 22.75mg Injection. Avoid driving or attention-seeking activities. If these bother you or appear serious, let your doctor know. There may be ways of reducing or preventing them. In some cases, it may cause dry mouth, so it is advised to drink more water, always carry sugar candy, or maintain oral hygiene.

Before taking this medicine, let your doctor know if you have glaucoma, asthma, or high blood pressure. Inform your doctor if you are pregnant or breastfeeding. Your doctor should also know about all other medicines you are taking, as many of these may make this medicine less effective or change the way it works. Generally, it is advised to avoid alcohol while on treatment with Nicophen 22.75mg Injection.

Uses of Nicophen Injection

Treatment of Allergic conditions
Treatment and prevention of Meniere's disease
Treatment of Respiratory disease with excessive mucus
Treatment of Skin conditions with inflammation & itching

Benefits of Nicophen Injection

Treatment of Allergic conditions
Nicophen 22.75mg Injection is widely used in allergic conditions such as hay fever, drug rashes, food allergies, allergic conjunctivitis, angioneurotic oedema, and serum sickness. It works by blocking histamine-mediated allergic responses, thereby reducing symptoms like itching, swelling, redness, sneezing, and watery eyes, and improving overall symptom control during allergic reactions.

Treatment and prevention of Meniere's disease
In Meniere’s disease, Nicophen 22.75mg Injection helps manage symptoms such as vertigo, nausea, and vomiting. Its antihistaminic and anti-emetic properties help stabilize inner ear–related symptoms, providing relief from dizziness and associated discomfort.

Treatment of Respiratory disease with excessive mucus
In respiratory conditions such as acute rhinitis and vasomotor rhinitis, where increased nasal secretions are present, Nicophen 22.75mg Injection helps relieve symptoms by blocking the effects of histamine. This reduces excessive mucus production, sneezing, and nasal irritation, helping improve breathing comfort and reducing discomfort associated with allergic or irritative respiratory conditions.

Treatment of Skin conditions with inflammation & itching
Nicophen 22.75mg Injection is beneficial in itching skin conditions such as eczema, urticaria, neurodermatitis, and other pruritic disorders. It helps reduce itching, redness, and skin irritation, which can improve comfort and prevent further skin damage caused by scratching.

Side effects of Nicophen Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Nicophen

Sedation

How to use Nicophen Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Nicophen Injection works

Nicophen 22.75mg Injection is an antiallergic medication. It works by blocking the action of a chemical messenger (histamine). This relieves symptoms of severe allergic reactions due to insect bite/sting, certain medicines, and hives (such as rashes and swelling).

All substitutes for Nicophen 22.75mg Injection

For information purposes only. Consult a doctor before taking any medicine.

Instavil 22.75mg Injection

by Intas Pharmaceuticals Ltd

₹3.75/injection

85% costlier

Quick tips

Inform your doctor if you have any other allergies, including food allergies.
Avoid consuming alcohol when taking the Nicophen 22.75mg Injection, as it may cause excessive sleepiness or drowsiness.
Inform your doctor if you are taking any other medications, e.g., antidepressants.
Keep sipping water or have sugar-free gum in order to relieve dryness in the mouth.
Avoid stepping outside during peak pollen season and protect yourself from dust and mites at home.

Safety advice

Alcohol

CAUTION

Alcohol should be used with caution while taking Nicophen 22.75mg Injection.

Pregnancy

CONSULT YOUR DOCTOR

The safety of Nicophen 22.75mg Injection during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.

Breast feeding

CONSULT YOUR DOCTOR

Information regarding the use of Nicophen 22.75mg Injection during breastfeeding is not available. Please consult your doctor.

Driving

UNSAFE

Nicophen 22.75mg Injection may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

Kidney

CONSULT YOUR DOCTOR

There is limited data available on the use of Nicophen 22.75mg Injection in patients with kidney disease. Please consult your doctor.

Liver

CAUTION

Nicophen 22.75mg Injection should be used with caution in patients with severe liver disease. Dose adjustment may be needed.

Interaction with drugs

Taking Nicophen with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Moderate

Dextromethorphan Hydrobromide (Oral Route)

Do not drive or do anything requiring concentration or alertness until you know how the medicines affect you.

Moderate

Ketamine (Injection Route)

If concurrent use is essential, your doctor may monitor your treatment and adjust the doses as per the observations.

Moderate

Tranylcypromine (Oral Route)

Do not take Tranylcypromine with Pheniramine. If concurrent use is essential, talk to your doctor.

Mild

Betahistine (Oral Route)

Take Pheniramine with Betahistine only if prescribed by your doctor. Pheniramine may block the action of Betahistine.

Frequently asked questions

What is Nicophen 22.75mg Injection used for?

Nicophen 22.75mg Injection is an antihistamine used to treat a variety of allergic conditions, including allergic rhinitis, urticaria, skin itching, insect bites, drug and food allergies, and allergic conjunctivitis. It is also used in conditions like Meniere’s disease and other inner-ear disorders to help relieve vertigo, nausea, and vomiting.

How does Nicophen 22.75mg Injection work?

It works by blocking the action of histamine, a chemical released during allergic reactions. By preventing histamine from acting on tissues, it helps reduce symptoms such as itching, redness, swelling, sneezing, excessive mucus secretion, dizziness, and nausea.

Can Nicophen 22.75mg Injection cause drowsiness?

Yes. Nicophen 22.75mg Injection may cause drowsiness, dizziness, or sedation, as it is a first-generation antihistamine. Patients should avoid driving, operating machinery, or performing tasks that require alertness until they know how the medicine affects them.

Who should not use Nicophen 22.75mg Injection?

Nicophen 22.75mg Injection should not be used in people who are allergic to pheniramine or similar antihistamines. Caution is advised in patients with glaucoma, enlarged prostate, urinary retention, asthma, or heart disease, and it should be used only under medical supervision in such cases.

Can I take paracetamol with Nicophen 22.75mg Injection?

Yes, paracetamol can be taken with Nicophen 22.75mg Injection. They are used together in conditions when the patient has a fever along with symptoms of allergy (like running nose, tearing of eyes etc).

Is Nicophen 22.75mg Injection good for a cold?

Nicophen 22.75mg Injection is effective in controlling symptoms of cold tearing of eyes, nasal stuffiness and discharge from the nose. All these symptoms are relieved by Nicophen 22.75mg Injection.

Can Nicophen 22.75mg Injection cause sleep?

Nicophen 22.75mg Injection has strong sleep-inducing effects. It is therefore not prescribed if a person is involved in any work that requires mental alertness.

Can Nicophen 22.75mg Injection cause weight loss?

No, Nicophen 22.75mg Injection is not known to cause weight loss.

Are Nicophen 22.75mg Injection and chlorpheniramine same?

No, Nicophen 22.75mg Injection and Chlorpheniramine are not same. They are similar in chemical structure and both are older antihistaminics. Nicophen 22.75mg Injection does not contain chlorine in it whereas Chlorpheniramine does. However, both are used in the treatment of allergic conditions.

Can I take vitamin C with Nicophen 22.75mg Injection?

Yes, vitamin C has a role in improving the immunity so it is given with Nicophen 22.75mg Injection for relieving the symptoms of common cold. No drug-drug interactions or any harmful effects have been reported when they are used together.

Can the use of Nicophen 22.75mg Injection increase blood pressure?

Nicophen 22.75mg Injection does not cause an increase in blood pressure. Please consult your doctor if you have increased blood pressure after taking Nicophen 22.75mg Injection as it would require proper diagnosis and treatment.

Is Nicophen 22.75mg Injection a steroid?

No, Nicophen 22.75mg Injection is not a steroid. It is an antihistaminic medicine used in the treatment of some allergic conditions.

Fact Box

Chemical Class

Pheniramines

Habit Forming

Therapeutic Class

DERMA

Action Class

First-Generation H1 Antihistamines

Related lab tests

Absolute Eosinophil Count

Peripheral Smear Examination

Total IgE

References

Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. p. 1100.
Pheniramine Maleate Injection [Prescribing Information]. Sirmour, Himachal Pradesh: Sanofi India Limited; 2021.

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Abbott
Address: 16th Floor, Godrej BKC, Plot – C, “G” Block, Bandra-Kurla Complex, Bandra (East), Mumbai – 400 051, India

Vendor Details

Country of origin: India

Lab tests offered by us

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Nicophen 22.75mg Injection

Nicophen 22.75mg Injection

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General Information

Contains

Marketer

Storage

Product introduction

Uses of Nicophen Injection

Benefits of Nicophen Injection

Side effects of Nicophen Injection

How to use Nicophen Injection

How Nicophen Injection works

All substitutes for Nicophen 22.75mg Injection

Instavil 22.75mg Injection

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Dextromethorphan Hydrobromide (Oral Route)

Ketamine (Injection Route)

Tranylcypromine (Oral Route)

Betahistine (Oral Route)

Frequently asked questions

What is Nicophen 22.75mg Injection used for?

How does Nicophen 22.75mg Injection work?

Can Nicophen 22.75mg Injection cause drowsiness?

Who should not use Nicophen 22.75mg Injection?

Can I take paracetamol with Nicophen 22.75mg Injection?

Is Nicophen 22.75mg Injection good for a cold?

Can Nicophen 22.75mg Injection cause sleep?

Can Nicophen 22.75mg Injection cause weight loss?

Are Nicophen 22.75mg Injection and chlorpheniramine same?

Can I take vitamin C with Nicophen 22.75mg Injection?

Can the use of Nicophen 22.75mg Injection increase blood pressure?

Is Nicophen 22.75mg Injection a steroid?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

Related lab tests

Absolute Eosinophil Count

Peripheral Smear Examination

Total IgE

References

User feedback

What are you using Nicophen Injection for?

How much was the improvement?

What were the side-effects while using Nicophen 22.75mg Injection?

How do you take Nicophen Injection?

Please rate Nicophen 22.75mg Injection on price

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Disclaimer

Marketer details

Vendor Details

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