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MD Pharmacology, MBBS
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Nicophen 22.75mg Injection

Prescription Required
Store below 30°C

Product introduction

Nicophen 22.75mg Injection is an antihistamine used to treat allergic conditions (such as hay fever, drug rashes, allergic conjunctivitis, food allergy, etc.), respiratory tract conditions, and other skin conditions. It effectively reduces the severity, duration, and occurrence of symptoms and provides quick relief.

Nicophen 22.75mg Injection is also used to treat and prevent motion sickness, symptoms of Meniere’s disease (such as nausea, vomiting and vertigo), and other associated labyrinthine disturbances.

It is given as an injection into veins or muscles under the supervision of a doctor. It should be used as per the instruction of your doctor. The dose and how often you take it depends on what you are taking it for. Your doctor will decide how much you need to improve your symptoms. You should take Nicophen 22.75mg Injection for as long as it is prescribed for you.

Sedation is the most common side effect of Nicophen 22.75mg Injection. Avoid driving or attention-seeking activities. If these bother you or appear serious, let your doctor know. There may be ways of reducing or preventing them. In some cases, it may cause dry mouth, so it is advised to drink more water, always carry sugar candy, or maintain oral hygiene.

Before taking this medicine, let your doctor know if you have glaucoma, asthma, or high blood pressure. Inform your doctor if you are pregnant, or breastfeeding. Your doctor should also know about all other medicines you are taking as many of these may make this medicine less effective or change the way it works. Generally, it is advised to avoid alcohol while on treatment with Nicophen 22.75mg Injection.

Uses of Nicophen Injection

  • Treatment of Allergic conditions
  • Treatment of Respiratory disease with excessive mucus
  • Treatment of Skin conditions with inflammation & itching
  • Treatment and prevention of Meniere's disease

Benefits of Nicophen Injection

In Treatment of Allergic conditions

Nicophen 22.75mg Injection provides relief from symptoms such as a blocked or runny nose, sneezing, and itchy or watery eyes. This will make it easier for you to go about your daily activities. It can also give relief from allergic reactions after insect bites and symptoms of hives and eczema such as rash, swelling, itching, and irritation.

This medicine rarely has any serious side effects and you may only need to take it on days you have symptoms. If you are taking it to prevent getting symptoms you should use it regularly to get the most benefit.

Side effects of Nicophen Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Nicophen

  • Sedation

How to use Nicophen Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Nicophen Injection works

Nicophen 22.75mg Injection is an antiallergic medication. It works by blocking the action of a chemical messenger (histamine). This relieves symptoms of severe allergic reactions due to insect bite/sting, certain medicines, hives (rashes, swelling etc).

Safety advice

Nicophen 22.75mg Injection may cause excessive drowsiness with alcohol.
Information regarding the use of Nicophen 22.75mg Injection during pregnancy is not available. Please consult your doctor.
Breast feeding
Nicophen 22.75mg Injection is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Larger doses or prolonged use of Nicophen 22.75mg Injection may cause sleepiness and other effects in the baby
Nicophen 22.75mg Injection may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
There is limited information available on the use of Nicophen 22.75mg Injection in patients with kidney disease. Please consult your doctor.
There is limited information available on the use of Nicophen 22.75mg Injection in patients with liver disease. Please consult your doctor.

What if you forget to take Nicophen Injection?

If you miss a dose of Nicophen 22.75mg Injection, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.
No substitutes found for this medicine

Quick tips

  • Inform your doctor if you have any other allergies including food allergies.
  • Avoid consuming alcohol when taking the Nicophen 22.75mg Injection, as it may cause excessive sleepiness or drowsiness.
  • Inform your doctor if you are taking any other medications, e.g., anti-depressants.
  • Keep sipping water or have sugar-free gum in order to relieve dryness in the mouth.
  • Avoid stepping outside during peak pollen season and protect yourself from dust and mites at home.

Fact Box

Chemical Class
Pyridines Derivatives
Habit Forming
Therapeutic Class
Action Class
H1 Antihistaminics (First Generation)

Interaction with drugs

Taking Nicophen with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Brand(s): Zuvair
Brand(s): Eurolam, Alwel, Tenzo
Brand(s): Salzor, Ribonyl, Azibion
Brand(s): Histiwel

Patient concerns

Allergic skin conditions in leg
Dr. Atula Gupta
kindly send the Pictures of affected area.
Liv 52 Kis conditions me use karna chahiye
Dr. Aanchal Maheshwari
In liver disease, lack of appetite, as adjuvant to antibiotics and many other

User feedback


Q. Can I take paracetamol with Nicophen 22.75mg Injection?

Yes, paracetamol can be taken with Nicophen 22.75mg Injection. They are used together in conditions when the patient has a fever along with symptoms of allergy (like running nose, tearing of eyes etc).

Q. Can Nicophen 22.75mg Injection cause sleep?

Nicophen 22.75mg Injection has strong sleep-inducing effects. It is therefore not prescribed if a person is involved in any work that requires mental alertness.

Q. Can Nicophen 22.75mg Injection cause weight loss?

No, Nicophen 22.75mg Injection is not known to cause weight loss.

Q. Are Nicophen 22.75mg Injection and chlorpheniramine same?

No, Nicophen 22.75mg Injection and Chlorpheniramine are not same. They are similar in chemical structure and both are older antihistaminics. Nicophen 22.75mg Injection does not contain chlorine in it whereas Chlorpheniramine does. However, both are used in the treatment of allergic conditions.

Q. Can I take vitamin C with Nicophen 22.75mg Injection?

Yes, vitamin C has a role in improving the immunity so it is given with Nicophen 22.75mg Injection for relieving the symptoms of common cold. No drug-drug interactions or any harmful effects have been reported when they are used together.

Q. Can the use of Nicophen 22.75mg Injection increase blood pressure?

Nicophen 22.75mg Injection does not cause an increase in blood pressure. Please consult your doctor if you have increased blood pressure after taking Nicophen 22.75mg Injection as it would require proper diagnosis and treatment.

Q. Is Nicophen 22.75mg Injection a steroid?

No, Nicophen 22.75mg Injection is not a steroid. It is an antihistaminic medicine used in the treatment of some allergic conditions.

Q. How is Nicophen 22.75mg Injection given?

Nicophen 22.75mg Injection is administered either slowly by intravenous route (1ml per minute) or intramuscularly.

Q. What is the dose of Nicophen 22.75mg Injection?

The dose of Nicophen 22.75mg Injection is 1-2 mL twice a day given intramuscularly or via slow intravenous injection.

Q. Can Nicophen 22.75mg Injection cause dry mouth?

Dry mouth may occur as a side effect. Frequent mouth rinses, good oral hygiene, increased water intake and sugarless candy may help.

Q. Does Nicophen 22.75mg Injection cause drowsiness?

Yes, Nicophen 22.75mg Injection causes drowsiness. Both the dosage and the time of administration should be carefully considered in patients whose activities (e.g., driving a vehicle or operating machinery) demand special concentration.

Q. Can Nicophen 22.75mg Injection be given to patients with severe liver disease?

Pheniramine present in Nicophen 22.75mg Injection is metabolised in the liver. Thus, your doctor will consider dose adjustments in case you have severe liver disease.

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.


  1. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. p. 1100.
  2. Pheniramine maleate [Summary of Product Characteristics]. Powai, Mumbai: Sanofi India Ltd.; 2021. [Accessed 01 Apr. 2019] (online) Available from:External Link
  3. ScienceDirect. Pheniramine. [Accessed 01 Apr. 2019] (online) Available from:External Link
  4. Pheniramine. [Accessed 01 Apr. 2019] (online) Available from:External Link

Marketer details

Name: Abbott
Address: 16th Floor, Godrej BKC, Plot – C, “G” Block, Bandra-Kurla Complex, Bandra (East), Mumbai – 400 051, India
Country of origin: India

Inclusive of all taxes
MRP2.16  12% OFF
2.0 ml in 1 vial
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