Nexesa Injection 200

Darbepoetin alfa (200mcg)

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Cold stored

Stored between 2-8°C

Nexesa Injection 200 is used in the treatment of anemia that may have occurred due to chronic kidney disease or chemotherapy. It works by stimulating the bone marrow to produce more red blood cells.

Written By Dr. Syeda Aafia, MBA, BDS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 08 Sep 2026 | 11:27 AM (IST)

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0.4 ml Injection

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Gurgaon

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General Information

Contains

Darbepoetin alfa (200mcg)

Marketer

Lupin Ltd

Storage

Store in a refrigerator (2 - 8°C). Do not freeze.

The content is shown in English

Product introduction

Nexesa Injection 200 is a medicine that needs to be used with utmost care because it can lead to serious side effects. It is important that you seek treatment from a doctor who is experienced in providing this medical therapy. You should follow all the directions of the doctor strictly. It is given under the supervision of a healthcare professional.

Common side effects include abdominal pain, high blood pressure, rash, injection site pain, breathlessness, cough, and peripheral edema. Inform your doctor if there are symptoms of very high blood pressure, such as severe headache, problems with your eyesight, nausea, vomiting, or fits (seizures).

Your doctor may get your blood tests done regularly to monitor the levels of salts (electrolytes such as potassium), hemoglobin, and blood cells in your blood. You should stop taking it and consult with a doctor if you develop shortness of breath or a skin rash.

Before taking Nexesa Injection 200, tell your doctor if you have heart disease, high blood pressure, or have had a seizure or stroke. If you are pregnant or breastfeeding, or plan to become pregnant, consult your doctor to make sure it is safe for you.

Uses of Nexesa Injection

Benefits of Nexesa Injection

Treatment of Anemia due to cancer chemotherapy
Low red blood cell count is termed as anemia. Cancer treatment with chemotherapy often causes many side effects, one of the major ones being anemia. Nexesa Injection 200 stimulates the production of red blood cells in bone marrow and regulates the haemoglobin in the blood. This treats anemia in cancer patients receiving chemotherapy.

Treatment of Anemia due to chronic kidney disease
Anemia is a condition where your body does not have enough red blood cells to carry oxygen around your body. Chronic kidney disease (CKD) refers to the loss of normal kidney function over a long span of time. CKD progresses gradually over a few years but may become permanent if left untreated. CKD can lead to anemia. Nexesa Injection 200 can boost your levels of red blood cells and reduce the symptoms of anemia such as tiredness and weakness. Taking this injection improves the quality of life.

Side effects of Nexesa Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Nexesa

High blood pressure
Rash
Injection site pain
Convulsion

How to use Nexesa Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Nexesa Injection works

Nexesa Injection 200 is an erythropoiesis-stimulating agent (ESA). It works by stimulating the bone marrow (soft tissue inside the bones which produces red blood cells) to produce more red blood cells.

All substitutes for Nexesa Injection 200

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

Nexesa Injection 200 helps in the treatment of anemia that may have occurred due to chronic kidney disease or cancer chemotherapy.
It is given as a single injection under your skin; additionally, it can be given intravenously.
Your doctor may get your blood tests done regularly to monitor the levels of hemoglobin in your blood.
Stop taking Nexesa Injection 200 and inform your doctor if you develop shortness of breath or a skin rash.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Nexesa Injection 200. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

The safety of Nexesa Injection 200 during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.

Breast feeding

CONSULT YOUR DOCTOR

Information regarding the use of Nexesa Injection 200 during breastfeeding is not available. Please consult your doctor.

Driving

SAFE

Nexesa Injection 200 does not usually affect your ability to drive.

Kidney

SAFE IF PRESCRIBED

Nexesa Injection 200 is safe to use in patients with kidney disease. No dose adjustment is recommended.

Liver

CONSULT YOUR DOCTOR

There is limited data available on the use of Nexesa Injection 200 in patients with liver disease.

Interaction with drugs

Taking Nexesa with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Moderate

Thalidomide (Oral Route)

If concurrent use is essential, watch out for symptoms such as fatigue, shortness of breath, unusual paleness, easy bruising or bleeding and consult your doctor if you experience them. They may adjust the doses as per the observations. Darbepoetin alfa may raise blood levels of Thalidomide.

Moderate

Pomalidomide (Oral Route)

If concurrent use is essential, watch out for symptoms such as unusual bleeding, swelling in one leg or arm, new or worsening chest pain or sudden shortness of breath and consult your doctor if you experience them. They may adjust the doses as per the observations.

Moderate

Lenalidomide (Oral Route)

If concurrent use is essential, your doctor may monitor your treatment and adjust the doses as per the observations.

Mild

Telmisartan (Oral Route)

Your doctor may regularly monitor your blood pressure and potassium levels during the simultaneous use of these medicines. Telmisartan may reduce efficacy of Darbepoetin alfa.

Mild

Losartan (Oral Route)

Your doctor may regularly monitor your blood pressure and potassium levels during the simultaneous use of these medicines. Losartan may reduce efficacy of Darbepoetin alfa.

Frequently asked questions

How long does it take for Nexesa Injection 200 to start working?

You will be able to notice an increase in the count of red blood cells (hemoglobin levels) in 2-6 weeks of starting Nexesa Injection 200. If you have any other concerns, consult your doctor.

Is Nexesa Injection 200 safe to use?

Nexesa Injection 200 is a medicine that needs to be used with utmost care because it can lead to serious side effects and even death of the patient. It is important that you seek treatment from a doctor who is experienced in providing Nexesa Injection 200 therapy. Follow all the directions strictly.

Other than pure red cell aplasia (PRCA), can there be other reasons for not responding to Nexesa Injection 200?

You may not respond to Nexesa Injection 200 if you have deficiencies of iron, folic acid, or vitamin B12. It is important that you take measures to correct these deficiencies. Other reasons behind not responding to the treatment could be bleeding, infections, inflammation, and bone marrow fibrosis. Therefore, consult our doctor regarding the same.

Can Nexesa Injection 200 be used in children?

Yes, Nexesa Injection 200 is used to treat anemia due to chronic kidney disease in children who are above 1 year of age. The effectiveness of Nexesa Injection 200 and side effects seen in children are similar to adults. However, consult your doctor if you are not sure.

Can Nexesa Injection 200 affect blood pressure?

Yes, Nexesa Injection 200 can affect blood pressure. During initial therapy with Nexesa Injection 200, blood pressure should be monitored and those who have high blood pressure should take appropriate measures to control blood pressure. Your doctor may stop Nexesa Injection 200 if the blood pressure remains uncontrolled.

Who should not take Nexesa Injection 200?

Individuals who have cancer but have not been prescribed Nexesa Injection 200 by the doctor should not take it. Additionally, patients with uncontrolled hypertension (high blood pressure), patients with a history of anemia called pure red cell aplasia (PRCA) that starts after treatment with Nexesa Injection 200 or other erythropoietin medicines, and patients with a history of serious allergic reaction to this medicine should not take this medicine.

Fact Box

Chemical Class

Peptides

Habit Forming

Therapeutic Class

BLOOD RELATED

Action Class

Erythropoiesis-Stimulating Agents (ESAs)

Related lab tests

Complete Blood Count

Peripheral Smear Examination

References

Kaushansky K, Kipps TJ. Hematopoietic Agents: Growth Factors, Minerals, and Vitamins. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1071-72.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 358-59.
Darbepoetin alfa. Milton Road, Cambridge: Amgen Ltd.; 2001 [revised Sep. 2017]. [Accessed 23 Jan. 2019] (online) Available from:
Darbepoetin alfa. Thousand Oaks, CA: Amgen Inc.; 2001. [Accessed 07 Apr. 2019] (online) Available from:
Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006. Darbepoetin. [Accessed 17 Jun. 2023] (online) Available from:
Darbepoetin alfa [Prescribing Information]. Thousand Oaks, California: Amgen Inc.; 2019. [Accessed 17 Jun. 2023] (online) Available from:
Aranesp Injection (Darbepoetin alfa) [Product Information]. [Accessed 17 Jun. 2023] (online) Available from:

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Lupin Ltd
Address: 3rd floor Kalpataru Inspire, Off. W E Highway, Santacruz (East), Mumbai 400 055. India

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Nexesa Injection 200. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India

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Home

Blood Related

Erythropoietin Products

Nexesa Injection 200

Nexesa Injection 200

Payment, Returns & Expiry

Online payment only

We don’t take this product back

Product expires after Dec, 2026

Price Info

Save more with additional offers

General Information

Contains

Marketer

Storage

Product introduction

Uses of Nexesa Injection

Benefits of Nexesa Injection

Side effects of Nexesa Injection

How to use Nexesa Injection

How Nexesa Injection works

All substitutes for Nexesa Injection 200

Cresp Onco 200 Injection

Cresp 200mcg Injection

Ibidarb 200mcg Injection

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Thalidomide (Oral Route)

Pomalidomide (Oral Route)

Lenalidomide (Oral Route)

Telmisartan (Oral Route)

Losartan (Oral Route)

Frequently asked questions

How long does it take for Nexesa Injection 200 to start working?

Is Nexesa Injection 200 safe to use?

Other than pure red cell aplasia (PRCA), can there be other reasons for not responding to Nexesa Injection 200?

Can Nexesa Injection 200 be used in children?

Can Nexesa Injection 200 affect blood pressure?

Who should not take Nexesa Injection 200?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

Related lab tests

Complete Blood Count

Peripheral Smear Examination

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

In case of any issues, contact us

Lab tests offered by us

Related/Popular tests