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Midgram 2.5 Tablet

Midodrine (2.5mg)

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Midgram 2.5 Tablet is used to treat low blood pressure (hypotension). It is used in patients who experience dizziness due to low blood pressure while standing up suddenly from a sitting or lying position. This medicine causes tightening of blood vessels and results in an elevation of your blood pressure.

Written By Dr. Syeda Aafia, MBA, BDS,
Reviewed By Dr. Mekhala Chandra, MD, MBBS,
Last updated on 17 Sep 2026 | 03:49 PM (IST)

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General Information

Contains

Midodrine (2.5mg)

Marketer

Ingram Biosciences Pvt Ltd

Storage

Store below 30°C

The content is shown in English

Product introduction

Midgram 2.5 Tablet can be taken with or without food. This medicine is taken during daytime hours when people stand most often. Do not take it if you are going to lie down for a long time after the dose. You should always take this medicine as advised by the doctor and should never stop it without consulting the doctor. You should monitor your blood pressure regularly while taking this medicine.

Common side effects of this medicine include headache, nausea, rash, urinary retention, difficulty urinating, and flushing. It may also cause supine hypertension, which is an increase in your blood pressure while lying down. Consult your doctor if these side effects bother you.

Before taking this medicine, it is better to let your doctor know if you are suffering from any kidney or liver disease. Also, pregnant women and breastfeeding mothers should consult a doctor before taking it. You must inform the doctor about all the other medicines that you are taking apart from this medicine. Your doctor may ask for monitoring of kidney and liver function before and during treatment with this medicine.

Uses of Midgram Tablet

Treatment of Low blood pressure

Benefits of Midgram Tablet

Treatment of Low blood pressure
Midgram 2.5 Tablet is used in adults to relieve low blood pressure, which may occur due to a sudden change in posture from lying to sitting or standing up (orthostatic hypotension), during an operation, or after an injury. This medicine helps bring the blood pressure within the normal range. It therefore prevents any sudden fall or even serious complications that might have otherwise followed due to low blood pressure.

Side effects of Midgram Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Midgram

Discomfort when urinating
Piloerection
Goosebumps

How to use Midgram Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Midgram 2.5 Tablet may be taken with or without food.

How Midgram Tablet works

Midgram 2.5 Tablet is an alpha-adrenergic agonist. It works by activating specific receptors on blood vessels. This causes the blood vessels to tighten, which increases blood pressure.

All substitutes for Midgram 2.5 Tablet

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

Take Midgram 2.5 Tablet at least 4 hours before bedtime to avoid the risk of high blood pressure at night time.
Monitor your blood pressure regularly while taking this medicine.
Inform your doctor if you have a history of prostate disorder or blood circulation problems.
Inform your doctor immediately if you notice symptoms of chest pain, palpitations, headache, shortness of breath, and blurred vision.
Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Midgram 2.5 Tablet. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

The safety of Midgram 2.5 Tablet during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.

Breast feeding

CONSULT YOUR DOCTOR

Information regarding the use of Midgram 2.5 Tablet during breastfeeding is not available. Please consult your doctor.

Driving

CAUTION

Midgram 2.5 Tablet may cause dizziness or weakness due to changes in blood pressure. Do not drive if these symptoms occur.

Kidney

CAUTION

Midgram 2.5 Tablet should be used with caution in patients with severe kidney disease. Dose adjustment may be needed.

Liver

CONSULT YOUR DOCTOR

There is limited data available on the use of Midgram 2.5 Tablet in patients with liver disease.

Interaction with drugs

Taking Midgram with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Moderate

Selegiline (Oral Route)

Do not consume Selegiline with Midodrine. If concurrent use is essential, your doctor may monitor your blood pressure frequently.

Moderate

Rasagiline (Oral Route)

If concurrent use is essential, your doctor may monitor your blood pressure frequently.

Moderate

Safinamide (Oral Route)

If concurrent use is essential, your doctor may monitor your blood pressure frequently.

Moderate

Risperidone (Oral Route)

Talk to your doctor if you notice any unusual symptoms.Doctor may monitor your liver function. Midodrine may raise blood levels of the active form of Risperidone.

Moderate

Risperidone (Injection Route)

Talk to your doctor if you notice any unusual symptoms.Doctor may monitor your liver function. Midodrine may raise blood levels of the active form of Risperidone.

Frequently asked questions

Does Midgram 2.5 Tablet raise blood pressure?

Yes, Midgram 2.5 Tablet may cause high blood pressure when you are lying flat on your back (supine hypertension). This medicine should only be used by people whose low blood pressure affects their day-to-day lives and in people who cannot be treated successfully with other therapies.

Does Midgram 2.5 Tablet affect heart rate?

Midgram 2.5 Tablet may slow down the heart rate slightly. It should be used cautiously when used with other medicines (beta blockers, digitalis, etc.), which can further slow down the heart rate. Patients should be monitored if they experience symptoms that are suggestive of a slow heart rate.

Why can't I lie down after taking Midgram 2.5 Tablet?

You should not lie down immediately after taking Midgram 2.5 Tablet because of the risk of supine hypertension (high blood pressure, which occurs when you are lying flat on your back). Therefore, it is recommended to take the last daily dose at least 4 hours before bedtime. To lower the chance of high blood pressure while lying down at night, try keeping your head raised.

Does Midgram 2.5 Tablet work immediately?

Midgram 2.5 Tablet takes about 1 hour to show its effects. However, the action lasts for a short time only, the effect persists for about 2-3 hours.

How do I take Midgram 2.5 Tablet?

Midgram 2.5 Tablet should be taken exactly as directed by your doctor. Midgram 2.5 Tablet is taken orally with or without food. Swallow Midgram 2.5 Tablet as a whole with a glass of water. Usually, it is advised to take the medicine three times a day [morning, midday, and late afternoon (before 6 pm)] with a gap of at least 3 hours. Take the last daily dose of Midgram 2.5 Tablet before an evening meal and at least 4 hours before bedtime.

Who should not take Midgram 2.5 Tablet?

Midgram 2.5 Tablet is not advised for patients having an allergy to any component of the product, severe heart disease, unusually slow heart rate, high blood pressure, or conditions causing tightening of the arteries. Along with that, treatment with Midgram 2.5 Tablet should be avoided if the patient has an enlarged prostate gland, urinary retention (when the bladder can’t empty properly), pheochromocytoma (tumor of the adrenal medulla), acute or severe kidney disease, overactive thyroid, poor vision as a result of diabetes, and narrow-angle glaucoma (elevated pressure in the eye).

Is any monitoring required during Midgram 2.5 Tablet treatment?

You may need to check your blood pressure and get your kidney and liver function tests done before you start taking Midgram 2.5 Tablet. Once you begin the treatment, keep a constant track of your blood pressure and heart rate, especially after lying down.

How will I know that I have developed supine hypertension?

Symptoms of supine hypertension include chest pain, palpitations, shortness of breath, headache, and blurred vision. If you develop these symptoms, tell your doctor immediately. The doctor may reduce the dose of Midgram 2.5 Tablet or may discontinue treatment if the symptoms persist.

Can I take metoprolol with Midgram 2.5 Tablet?

Using Midgram 2.5 Tablet and metoprolol together can make your heart rate considerably slow. Hence, you need to be careful while using both together. If you experience slow pulse, dizziness, and fainting, inform your doctor as the dose of these medicines may need to be modified.

Fact Box

Chemical Class

Dimethoxybenzenes

Habit Forming

Therapeutic Class

CARDIAC

Action Class

Alpha-1 adrenoreceptor agonists

References

Westfall TC, WestfallIn DP. Adrenergic Agonists and Antagonists. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 295.
Biaggioni I, Robertson D. Adrenoreceptor Agonists & Sympathomimetic Drugs. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 139.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 915-16.
Central Drugs Standard Control Organisation (CDSCO). [Accessed 19 Mar. 2019] (online) Available from:
Midodrine hydrochloride [Product Information]. Lower Parel, Mumbai: CiplaMed; 2023. [Accessed 05 Mar. 2025] (online) Available from:
Midodrine Hydrochloride [Product Information]. Dublin, OH: Cardinal Health; 2024. [Accessed 05 Mar. 2025] (online) Available from:

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Ingram Biosciences Pvt Ltd
Address: Corp. off. : AR-1, Office No-D/126,Sector-3,Airoli,New Mumbai-400708

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Midgram 2.5 Tablet. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India

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Midgram 2.5 Tablet

Midgram 2.5 Tablet

Payment, Returns & Expiry

Cash on delivery available

7 day free return

Product expires after Dec, 2026

Price Info

Save more with additional offers

General Information

Contains

Marketer

Storage

Product introduction

Uses of Midgram Tablet

Benefits of Midgram Tablet

Side effects of Midgram Tablet

How to use Midgram Tablet

How Midgram Tablet works

All substitutes for Midgram 2.5 Tablet

Midgeo Tablet

Midorise 2.5 Tablet

Cipmido 2.5mg Tablet

Midodrive Tablet

Inramed 2.5 Tablet

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Selegiline (Oral Route)

Rasagiline (Oral Route)

Safinamide (Oral Route)

Risperidone (Oral Route)

Risperidone (Injection Route)

Frequently asked questions

Does Midgram 2.5 Tablet raise blood pressure?

Does Midgram 2.5 Tablet affect heart rate?

Why can't I lie down after taking Midgram 2.5 Tablet?

Does Midgram 2.5 Tablet work immediately?

How do I take Midgram 2.5 Tablet?

Who should not take Midgram 2.5 Tablet?

Is any monitoring required during Midgram 2.5 Tablet treatment?

How will I know that I have developed supine hypertension?

Can I take metoprolol with Midgram 2.5 Tablet?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

In case of any issues, contact us

Lab tests offered by us

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