Mephone 500mg Tablet

Reviewed By Dr. Rajeev Sharma, MBA, MBBS

Last updated on 13 Feb 2026 | 04:30 AM (IST)

Mephone 500mg Tablet belongs to a group of medicines called immunosuppressants. It is used with other medicines to prevent your body from rejecting an organ (such as a kidney, heart, or liver) after a transplant. It works by suppressing your body’s immune system so that it does not attack the new organ.

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General Information

Contains

Mycophenolate mofetil (500mg)

Marketer

Agrosaf Pharmaceuticals

Storage

Store below 30°C

The content is shown in English

Product introduction

The amount of Mephone 500mg Tablet you take and how often you take it depends on the type of transplant you have. Follow your doctor’s instructions on this. Take it on an empty stomach, at least 1 hour before or 2 hours after a meal, unless your doctor suggest otherwise. Swallow it as a whole, do not crush, chew, or break it. Take the medicine regularly to get maximum benefit and keep taking it even when you feel well. The treatment will continue for as long as you need it to prevent rejection.

The most common side effects of this medicine include vomiting, diarrhea, headache, high blood pressure, infections (viral, fungal, bacterial), and changes in the number of white blood cells amongst others. You may catch more infections than usual as medicine suppresses the immune system. There is also an increased risk of developing some cancers for this reason. To reduce your risk of skin cancer, limit your exposure to the sun and use sunscreen. There is a long list of potential side effects of this medicine. You should ask your doctor about them and what signs to look out for because some of them can be serious and need urgent medical attention.

Mephone 500mg Tablet can cause birth defects and abortion so do not take it if you are pregnant, planning to become pregnant, or breastfeeding. You should talk to your doctor before taking this medicine if you have any signs of infection or if you have any unexpected bruising or bleeding. You should also let your healthcare team know all other medicines you are taking as they may affect, or be affected by, this medicine. You will have regular tests to check for any changes in the number of your blood cells and the amount of sugar and cholesterol in your blood.

Uses of Mephone Tablet

Prevention of organ rejection in transplant patients

Benefits of Mephone Tablet

Prevention of organ rejection in transplant patients
Mephone 500mg Tablet belongs to a group of medicines known as immunosuppressive agents. It lowers your immune response and reduces the chance of your body attacking the transplanted organ. Organ rejection happens when your immune system treats the new organ as an invader and attacks it. This medicine may be used in combination with other medicines to suppress the immune system and help your body accept the new organ.

Side effects of Mephone Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Mephone

Diarrhea
Vomiting
Decreased white blood cell count (lymphocytes)
Bacterial infection

How to use Mephone Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Mephone 500mg Tablet is to be taken on an empty stomach.

How Mephone Tablet works

Mephone 500mg Tablet is an immunosuppressant. It reduces the action of the body's own defense system (the immune system) and prevents rejection of the transplanted organ.

All substitutes for Mephone 500mg Tablet

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

Your doctor has prescribed Mephone 500mg Tablet to stop your body from rejecting a transplanted organ (e.g. kidney, heart or liver).
It may take 6 to 12 weeks for Mephone 500mg Tablet to start working. Keep taking it as prescribed.
It may cause birth defects so birth control is required in females with reproductive potential.
It makes you more susceptible to getting infections. Avoid contact with people who have an infection. Consult your doctor immediately if you develop a sore throat, high temperature, any other signs of infections.
Protect yourself from direct sunlight by wearing protective clothing and applying a sunscreen with a high sun protection factor (SPF).
Take it with food to minimize possible side effects like nausea and stomach pain.
Your doctor may get regular blood tests done to monitor the levels of blood cells in your blood. Inform your doctor if you experience symptoms such as unexplained bruising or bleeding, sore throat, mouth ulcers, or fever.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Mephone 500mg Tablet. Please consult your doctor.

Pregnancy

UNSAFE

Mephone 500mg Tablet is highly unsafe during pregnancy. It can cause serious harm to the unborn baby, including birth defects and pregnancy loss. Do not use this medicine if you are pregnant or planning to become pregnant.

Breast feeding

CONSULT YOUR DOCTOR

Mephone 500mg Tablet may be unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. It should be used only if the expected benefit outweighs the potential risk. Please consult your doctor.

Driving

UNSAFE

Mephone 500mg Tablet may cause side effects that could affect your ability to drive.

Kidney

CAUTION

Mephone 500mg Tablet should be used with caution in patients with severe kidney disease. Dose adjustment may be needed.

Liver

CONSULT YOUR DOCTOR

There is limited data available on the use of Mephone 500mg Tablet in patients with liver disease.

Interaction with drugs

Taking Mephone with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Life-threatening

Natalizumab (Injection Route)

Do not consume Natalizumab with Mycophenolate mofetil.

Severe

Estradiol (Oral Route)

Effective contraception must be used before, during, and for at least 6 weeks after stopping Mycophenolate mofetil. It is recommended to consult your doctor. Mycophenolate mofetil may reduce the efficacy of Estradiol.

Severe

Progesterone (Oral Route)

Severe

Progesterone (Natural Micronized) (Oral Route)

Severe

Norethisterone (Oral Route)

Frequently asked questions

Can Mephone 500mg Tablet cause cancer?

Mephone 500mg Tablet may increase your chances of certain cancers like skin cancer and lymphoma (cancer of the lymph system). When outside, avoid unnecessary or prolonged exposure to sunlight, wear protective clothing, and apply sunscreen. Call your doctor if you experience a new skin sore or bump, a change in the size or color of a mole, a brown or black skin lesion (sore) with uneven edges or a sore whose one part does not look like the other, skin changes, sores that do not heal. Also, inform the doctor if you experience unexplained fever, tiredness that does not go away, weight loss, or pain or swelling in the neck, groin, or armpits.

Why has my doctor given me Mephone 500mg Tablet after I have had a kidney transplant?

Mephone 500mg Tablet is an immunosuppressant. Mephone 500mg Tablet has been prescribed to you to help your body accept the donor's kidney. It does so by working on the cells of your immune system, which fight with any foreign substance and reject its presence. This helps in making the transplanted organ more acceptable to your body.

Is Mephone 500mg Tablet a steroid or chemotherapy medicine? Can it cause hair loss?

Mephone 500mg Tablet is neither a steroid nor a chemotherapy medicine. It is an immunosuppressant which means that it acts on your immune system to suppress or weaken it so that your body does not reject the donated organ of another person. Hair loss is a common side effect of Mephone 500mg Tablet.

Do I need any special tests while taking Mephone 500mg Tablet?

Since Mephone 500mg Tablet can affect blood count and affect the kidneys and liver, your doctor will ask you to have a blood test before you start the treatment. Once the treatment starts, your doctor will suggest you take regular blood tests to check for any changes in the blood. These blood tests will help monitor your response to the medicine and the development of any side effects.

My doctor has asked me to stay away from a person who has chickenpox or shingles. Why?

Mephone 500mg Tablet is an immunosuppressant, which means that it decreases the activity of the immune system. Since your immune system is already weak, if you come in contact with a patient of chickenpox or shingles, you may develop it too. This is the reason that your doctor has advised you to be cautious. Therefore, follow your doctor’s advice and contact your doctor immediately if you get chickenpox or shingles as you may require special treatment.

What precautions should a female follow while taking Mephone 500mg Tablet?

Do not take Mephone 500mg Tablet if you are pregnant or are planning a pregnancy. There is a high risk of miscarriage (loss of the pregnancy) during the first 3 months of pregnancy. It may even cause birth defects (problems that are present at birth) in the newborn. Therefore, it is advised that you should use two acceptable forms of birth control together for 4 weeks before you start taking Mephone 500mg Tablet, during the treatment, and for 6 weeks after you stop taking Mephone 500mg Tablet. It is important to use a second form of birth control along with birth control pills as Mephone 500mg Tablet may decrease the effectiveness of birth control pills. Your doctor will suggest the two birth control methods that\ suit you the best.

What precautions should a male follow while taking Mephone 500mg Tablet?

It is recommended that either the man or her partner should use reliable contraception during treatment and for 90 days after the treatment. Men should not donate semen during the therapy or for 90 days following discontinuation of Mephone 500mg Tablet.

Fact Box

Chemical Class

Phthalides

Habit Forming

Therapeutic Class

ANTI NEOPLASTICS

Action Class

Immunosuppressant- Purine analogs

References

Krensky AM, Bennett WM, Vincenti F. Immunosuppressants, Tolerogens, and Immunostimulants. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. New York, New York: McGraw-Hill Medical; 2011. pp. 1014-15.
Lake DF, Briggs AD, Akporiaye ET. Immunopharmacology. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 973.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 943-45.
Mycophenolate mofetil. South San Francisco, California: Genentech USA, Inc.; 1995 [revised Feb. 2019]. [Accessed 17 Jun. 2019] (online) Available from:
Mycophenolate mofetil. Grenzach-Wyhlen, Germany: Roche Pharma AG; 2018. [Accessed 17 Jun. 2019] (online) Available from:
Central Drugs Standard Control Organisation. Mycophenolate mofetil. [Accessed 25 Jul. 2023] (online) Available from:
Ensley RD, Bristow MR, Olsen SL, et al. The use of mycophenolate mofetil (RS-61443) in human heart transplant recipients. Transplantation. 1993 Jul;56(1):75-82. [Accessed 01 Aug. 2023] (online) Available from:
Mycophenolate mofetil. Basel, Switzerland: F. Hoffmann-La Roche Ltd.; 2021. [Accessed 25 Jul. 2023] (online) Available from:
Cell Cept. Mycophenolate mofetil. [Accessed 25 Jul. 2023] (online) Available from:
Mycophenolate mofetil [Prescribing Information]. Ahmedabad, India: Intas Pharmaceuticals Limited; 2023. [Accessed 25 Jul. 2023] (online) Available from:
Mycophenolate mofetil [Prescribing Information]. South San Francisco, CA: Genentech USA, Inc.; 2025. [Accessed 13 Feb. 2026] (online). Available from:

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Agrosaf Pharmaceuticals
Address: Raman Tower, 2ND FLOOR, Sanjay Place, Agra, Uttar Pradesh 282002

Vendor Details

Country of origin: India

Lab tests offered by us

Why we need a prescription?

Mephone 500mg Tablet

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Save more with additional offers

General Information

Contains

Marketer

Storage

Product introduction

Uses of Mephone Tablet

Benefits of Mephone Tablet

Side effects of Mephone Tablet

How to use Mephone Tablet

How Mephone Tablet works

All substitutes for Mephone 500mg Tablet

Mycept 500 Tablet

Mycofit 500 Tablet

Mofilet 500 Tablet

Renodapt 500 Tablet

Mofetyl 500 Tablet

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Natalizumab (Injection Route)

Estradiol (Oral Route)

Progesterone (Oral Route)

Progesterone (Natural Micronized) (Oral Route)

Norethisterone (Oral Route)

Frequently asked questions

Can Mephone 500mg Tablet cause cancer?

Why has my doctor given me Mephone 500mg Tablet after I have had a kidney transplant?

Is Mephone 500mg Tablet a steroid or chemotherapy medicine? Can it cause hair loss?

Do I need any special tests while taking Mephone 500mg Tablet?

My doctor has asked me to stay away from a person who has chickenpox or shingles. Why?

What precautions should a female follow while taking Mephone 500mg Tablet?

What precautions should a male follow while taking Mephone 500mg Tablet?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

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