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Melavel Solution

Written By Dr. Subita Alagh, BDS
Reviewed By Dr. Rajeev Sharma, MBA, MBBS
Last updated on 12 Mar 2026 | 12:45 PM (IST)
Melavel Solution is a medicine used along with controlled ultraviolet light for effective treatment of certain skin diseases like vitiligo and psoriasis.
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General Information

The content is shown in English
Melavel Solution image
Melavel Solution image

Product introduction

Melavel Solution is for external use only. Use It only under the direct supervision of your doctor. The affected area should be clean and dry before application. You must wash your hands thoroughly before and after applying this medicine. This medicine should be used regularly to get the most benefit from it. Do not use more than you need as it will not clear your condition faster and some side effects may be increased. If your condition goes on for longer than four weeks or gets worse at any time, let your doctor know. You can help this medication work better by keeping the affected areas clean.

Common side effects include redness of the skin, blisters on the skin, swelling, and itching at the site of application. Please consult your doctor if these side effects persist for a longer duration. Avoid direct contact with your eyes. In case of direct contact, wash your eyes with water and seek immediate medical attention.

The most common side effects of this medicine include burning, irritation, itching, and redness at the site of application. It may also make your skin sensitive to sunlight, so avoid exposure to sunlight. Use sunscreens and cover yourself with protective clothing for at least 8 hours after treatment. Melavel Solution is not recommended for children below 12 years of age. Avoid eating certain foods like limes, figs, parsley, parsnips, mustard, carrots, and celery, as they may increase the skin's sensitivity to light.

Uses of Melavel Solution

Benefits of Melavel Solution

Psoriasis
Psoriasis is a condition where the skin cells in the body grow too quickly and form scales and dry patches. They can grow anywhere, but most appear on the scalp, elbows, knees, and lower back. Melavel Solution reduces the scaly, itchy patches along with other symptoms of inflammation such as redness, swelling, or irritation which may develop on the different parts of the body. Use it for as long as it is prescribed to get the most benefit. It may take several months to become fully effective. You should avoid drinking alcohol while having this treatment and drink plenty of water to stay hydrated.
Vitiligo
Vitiligo is a condition in which the skin loses its natural color in patches. Melavel Solution effectively blocks that process in the skin that leads to discoloration. It also reduces any redness, rash, pain, or itchiness that may be caused by this condition. This improves your self-esteem and confidence as your appearance changes. You should always use it as prescribed to get the full benefits.

Side effects of Melavel Solution

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Melavel
  • Application site reactions (burning, irritation, itching and redness)

How to use Melavel Solution

Use this medicine in the dose and duration as advised by your doctor. Check the label for directions before use.

How Melavel Solution works

Melavel Solution is an organic compound. It is applied on the skin along with ultraviolet-A irradiation. It works by decreasing the number of cells the skin makes.

All substitutes for Melavel Solution

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

  • Melavel Solution is prescribed along with UV-A rays for the treatment of vitiligo and psoriasis.
  • Wear UVA-absorbing, wrap-around sunglasses and cover exposed skin or use a sunblock (SP 15 or higher) for the twenty-four (24) hour period following treatment with Melavel Solution.
  • Do not use perfumes, aftershave, deodorants or other cosmetics and toiletries while using Melavel Solution as they make your skin even more sensitive causing blistering of your skin.
  • Use extra caution for at least 48 hours following each treatment. After each treatment, cover your skin for at least 8 hours by wearing protective clothing.
  • Never take Melavel Solution more than the prescribed dose as it may cause burning or blistering of your skin after exposure to UV light.
  • Do not use it if you have a history of melanoma or certain other types of skin cancer.

Safety advice

Alcohol

Alcohol

No interaction found/established
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
Melavel Solution is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.
Breast feeding

Breast feeding

CONSULT YOUR DOCTOR
Melavel Solution may be unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. It should be used only if the expected benefit outweighs the potential risk. Please consult your doctor.
Driving

Driving

No interaction found/established
Kidney

Kidney

No interaction found/established
Liver

Liver

No interaction found/established

Interaction with drugs

Taking Melavel with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Moderate

Aminophylline (Oral Route)

Watch out for symptoms such as headache, nausea or tremor and consult your doctor if you experience them. They may adjust the dose of Aminophylline accordingly. Methoxsalen may raise blood levels of Aminophylline.
Moderate

Theophylline (Oral Route)

Watch out for symptoms such as headache, nausea or tremor and consult your doctor if you experience them. They may adjust the dose of Theophylline accordingly. Methoxsalen may raise blood levels of Theophylline.
Moderate

Theophylline (Injection Route)

Watch out for symptoms such as headache, nausea or tremor and consult your doctor if you experience them. They may adjust the dose of Theophylline accordingly. Methoxsalen may raise blood levels of Theophylline.
Moderate

Aminophylline (Injection Route)

Watch out for symptoms such as headache, nausea or tremor and consult your doctor if you experience them. They may adjust the dose of Aminophylline accordingly. Methoxsalen may raise blood levels of Aminophylline.

Frequently asked questions

Melavel Solution is used along with ultraviolet light (found in sunlight and some special lamps) in a treatment to treat vitiligo (a disease in which skin color is lost), and psoriasis (a skin condition associated with red and scaly patches), and treatment of white blood cells (called photopheresis) and is used to treat the skin problems associated with mycosis fungoides, which is a type of lymphoma
Melavel Solution works by modifying the way by which skin cells receive the ultraviolet light A (UVA) radiation, thereby clearing up the disease.

Fact Box

Chemical Class

8- methoxypsoralens

Habit Forming

No

Therapeutic Class

DERMA

Action Class

Psoralen & derivatives

References

  1. Robertson DB, Maibach HI. Dermatologic Pharmacology. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 1055.
  2. Burkhart C, Morrell D, Goldsmith L. Dermatological Pharmacology. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1813-14.
  3. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 891-92.
  4. ScienceDirect. Methoxsalen. [Accessed 03 Apr. 2019] (online) Available from:
  5. PubChem. Methoxsalen. [Accessed 03 Apr. 2019] (online) Available from:
  6. Central Drugs Standard Control Organisation (CDSCO). [Accessed 03 Apr. 2019] (online) Available from:
  7. Methoxsalen [Drug Label]. Greenville, NC: Patheon Manufacturing Services LLC; 2018. [Accessed 25 Jul. 2024] (online) Available from:
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Geolife Sciences
Address: F-409, Phase-8B, Indl. Focal Point Mohali-160062 (Pb.) India.

Vendor Details

Country of origin: India
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