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Megaburn Capsule

Orlistat (120mg)

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Megaburn Capsule is a medicine used in the treatment of obesity. It helps the body in blocking the absorption of fats from the small intestines and stomach. This way it can help reduce calorie intake and weight loss over time.

Written By Dr. Lipika Khurana, PGDHHM, BDS,
Reviewed By Dr. Mekhala Chandra, MD, MBBS,
Last updated on 20 Jan 2026 | 01:18 AM (IST)

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General Information

Contains

Orlistat (120mg)

Marketer

Leeford Healthcare Ltd

Storage

Store below 30°C

The content is shown in English

Product introduction

Megaburn Capsule is geenrally taken orally 3 times daily, during (or up to 1 hour after) each main meal containing fat. It can also be taken up to 2 hours after midmeal. It works best when it is used along with regular physical activity and a healthy diet. It should not be taken for a long term unless your doctor tells you to do so. For better efficacy of the medicine, fat-rich foods should be avoided along with the medicine.

Some of the common side effects of Megaburn Capsule include the presence of fat in the stool, abdominal pain, and diarrhea. If any of the side effects bother you, tell your doctor without delay. They may be able to help you by adjusting your dose or prescribe you an alternate medicine.

Pregnant and breastfeeding women must take this medicine only with a valid prescription. Inform your doctor before taking the medicine if you have any other medical conditions or are taking any other medications. This medicine should not be considered as a long-term treatment unless you are prescribed by your doctor.

Uses of Megaburn Capsule

Obesity

Benefits of Megaburn Capsule

Obesity
Megaburn Capsule is used in obesity to help reduce excess body weight. It supports individuals in achieving and maintaining weight loss when combined with a controlled diet and physical activity, contributing to improved overall health and quality of life.

Side effects of Megaburn Capsule

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Megaburn

Fat in stool
Bowel incontinence
Flatus with discharge
Oily spotting
Oily evacuation
Increased bowel movements

How to use Megaburn Capsule

Take this medicine in the dose and duration as advised by your doctor. Megaburn Capsule should be taken with or after food.
Avoid Megaburn Capsule with high-fat meals such as olive oil, nuts & seeds (Brazil nuts), dark chocolate, butter and meat.

How Megaburn Capsule works

Megaburn Capsule is a lipase inhibitor. It works in the stomach and small intestine by blocking the absorption of fat from food by blocking enzymes responsible for the breakdown of fat.

All substitutes for Megaburn Capsule

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

Megaburn Capsule should be used along with regular physical activity and a healthy diet.
Take it during or up to 1 hour after each meal.
Skip your dose if you miss a meal or if your meal contains no fat.
A multivitamin supplement containing vitamins A, D, and K is recommended when taking Megaburn Capsule.
It should not be taken for longer than six months. If you have been unable to lose weight after 12 weeks of taking this medicine, you should stop taking it and consult your doctor.

Safety advice

Alcohol

SAFE

Consuming alcohol with Megaburn Capsule does not usually cause any harmful side effects.

Pregnancy

UNSAFE

Megaburn Capsule is highly unsafe during pregnancy. It can cause serious harm to the unborn baby, including birth defects and pregnancy loss. Do not use this medicine if you are pregnant or planning to become pregnant.

Breast feeding

CONSULT YOUR DOCTOR

Information regarding the use of Megaburn Capsule during breastfeeding is not available. Please consult your doctor.

Driving

CONSULT YOUR DOCTOR

It is not known whether Megaburn Capsule alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. Please consult your doctor.

Kidney

CAUTION

Megaburn Capsule should be used with caution in patients with severe kidney disease. Dose adjustment may be needed.

Liver

CONSULT YOUR DOCTOR

There is limited data available on the use of Megaburn Capsule in patients with liver disease.

Interaction with drugs

Taking Megaburn with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Severe

Ulipristal acetate (Oral Route)

watch out for severe diarrhea when taking Ulipristal acetate and Orlistat concurrently. Your doctor may recommend you to use barrier methods of contraception (like condoms) or copper IUD in case of severe diarrhea. Orlistat may reduce blood levels of Ulipristal acetate.

Severe

Levonorgestrel (Oral Route)

watch out for severe diarrhea when taking Levonorgestrel and Orlistat concurrently. Your doctor may recommend you to use barrier methods of contraception (like condoms) or copper IUD in case of severe diarrhea. Orlistat may reduce blood levels of Levonorgestrel.

Moderate

Glibenclamide (Oral Route)

Your doctor may monitor your diabetic control closely and adjust the dose of Orlistat as per the observations. Glibenclamide may raise blood levels of Orlistat and its active form.

Moderate

Progesterone (Natural Micronized) (Oral Route)

Watch out for severe diarrhea when taking Progesterone (Natural Micronized) and Orlistat concurrently. Your doctor may recommend you to use barrier methods of contraception (like condoms) or copper IUD in case of severe diarrhea. Orlistat may reduce blood levels of Progesterone (Natural Micronized).

Moderate

Metformin (Oral Route)

Your doctor may monitor your diabetic control closely and adjust the dose of Orlistat as per the observations. Orlistat may reduce blood levels of active form of Metformin.

Frequently asked questions

How long can you stay on Megaburn Capsule?

It is not advised to take Megaburn Capsule for more than 6 months. Consult your doctor and stop the medication if you do not experience any weight reduction 12 weeks after starting your treatment with Megaburn Capsule.

Who should not take Megaburn Capsule?

You should not take Megaburn Capsule if you are allergic to it, have difficulty absorbing food (chronic malabsorption syndrome), or have cholestasis (a condition where the flow of bile from the liver is blocked). Refrain from using Megaburn Capsule if you are taking cyclosporine medicine or blood thinners like warfarin. Along with that, avoid Megaburn Capsule if you are pregnant or breastfeeding.

What kind of diet should I follow while on Megaburn Capsule?

You should stick to a low-calorie, low-fat diet while taking Megaburn Capsule. Having a high-fat meal with Megaburn Capsule might increase the chances of developing unpleasant side effects. Try to eat more vegetables and fruits, have small portions, eat regularly, and do not skip any meals.

Can you drink alcohol on Megaburn Capsule?

Though alcohol does not interfere with the working of Megaburn Capsule, it is recommended that you cut down on or avoid alcohol. Alcohol contains calories, which will add to your weight. Hence, for effective weight reduction, it is best to avoid alcohol.

How quickly does Megaburn Capsule work?

Megaburn Capsule starts working quickly, within 24-48 hours of taking it. You may even notice fat in your stools. However, it may take about a week or two to show effective weight reduction, which will vary from person to person.

Is it important to follow an exercise program while taking Megaburn Capsule?

Yes, exercise may prove to be very helpful for effective weight reduction and maintenance of reduced weight. An exercise program and low-calorie intake will help maintain your weight even after discontinuation of the medicine.

How does Megaburn Capsule help with weight loss?

Megaburn Capsule belongs to a class of medicines known as lipase inhibitors. It targets the fat that you eat. It prevents about 25% of fat in your meals from being absorbed. This unabsorbed fat will get passed in the stools and removed from the body.

How should I take Megaburn Capsule?

Take Megaburn Capsule three times a day and swallow the capsule whole with water. Take it just before, during, or up to one hour after meals. The meal should be well-balanced and should include low-calorie ingredients. Do not take Megaburn Capsule if you miss a meal or your meal does not contain fat, as it will not work in the absence of fat.

How much weight can you lose in a week with Megaburn Capsule?

You should set a realistic goal of weight reduction. Aim to reduce 5-10% of your starting weight. This weight loss process should be gradual and at a steady pace. You should try to reduce by 0.5 kg per week.

Fact Box

Chemical Class

Leucine derivative

Habit Forming

Therapeutic Class

OTHERS

Action Class

Lipase Inhibitors

Related lab tests

Cholesterol - LDL

References

Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1030-31.
Orlistat [EMC SmPC]. GlaxoSmithKline Consumer Healthcare; 2018. [Accessed 05 Apr. 2019] (online) Available from:
Central Drugs Standard Control Organisation (CDSCO). Orlistat. [Accessed 03 Apr. 2019] (online) Available from:
Orlistat [Package Insert]. Mehsana, Gujarat: Torrent Pharmaceuticals Ltd. [Accessed 03 Aug. 2023] (online) Available from:
Orlistat [Prescribing Information]. Montgomery, AL: H2-Pharma, LLC; 2026. [Accessed 03 Aug. 2023] (online). Available from:

User feedback

Patients taking Megaburn Capsule

Once A Day

78%

Twice A Day

22%

What are you using Megaburn Capsule for?

Obesity

86%

Others

14%

How much was the improvement?

Poor

67%

Average

33%

What were the side-effects while using Megaburn Capsule?

No Side Effect

67%

Abdominal pain

33%

How do you take Megaburn Capsule?

Empty stomach

67%

With food

33%

Please rate Megaburn Capsule on price

Average

78%

Not Expensive

22%

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Leeford Healthcare Ltd
Address: 203, Mangalam, Kulupwadi, Borivali (E), Mumbai-400066

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Megaburn Capsule. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India

Lab tests offered by us

Why we need a prescription?

Megaburn Capsule

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General Information

Contains

Marketer

Storage

Product introduction

Uses of Megaburn Capsule

Benefits of Megaburn Capsule

Side effects of Megaburn Capsule

How to use Megaburn Capsule

How Megaburn Capsule works

All substitutes for Megaburn Capsule

Orlimax Capsule

Lipocut 120 Capsule

O-Stat 120 Capsule

Obelit Capsule

Orlica Capsule

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Ulipristal acetate (Oral Route)

Levonorgestrel (Oral Route)

Glibenclamide (Oral Route)

Progesterone (Natural Micronized) (Oral Route)

Metformin (Oral Route)

Frequently asked questions

How long can you stay on Megaburn Capsule?

Who should not take Megaburn Capsule?

What kind of diet should I follow while on Megaburn Capsule?

Can you drink alcohol on Megaburn Capsule?

How quickly does Megaburn Capsule work?

Is it important to follow an exercise program while taking Megaburn Capsule?

How does Megaburn Capsule help with weight loss?

How should I take Megaburn Capsule?

How much weight can you lose in a week with Megaburn Capsule?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

Related lab tests

Cholesterol - LDL

References

User feedback

Patients taking Megaburn Capsule

What are you using Megaburn Capsule for?

How much was the improvement?

What were the side-effects while using Megaburn Capsule?

How do you take Megaburn Capsule?

Please rate Megaburn Capsule on price

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

In case of any issues, contact us

Lab tests offered by us

Related/Popular tests