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03 Dec 2019 | 05:43 PM (IST)
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Manocept 250mg Tablet


Overview

Introduction

Manocept 250mg Tablet belongs to a group of medicines called immunosuppressants. It is used with other medicines to prevent your body rejecting an organ (such as a kidney, heart or liver) after a transplant. It works by weakening your body’s immune system, so that it does not attack the new organ.

Manocept 250mg Tablet has many potential side effects. The most common are nausea, vomiting, diarrhea, stomach pain, headache, high blood pressure and changes in the number of white blood cells. Because it suppresses your immune system, you may catch more infections than usual. There is also an increased risk of developing some cancers for this reason. To reduce your risk of skin cancer, limit your exposure to the sun and use sunscreen. There is a long list of potential side effects. You should ask your doctor about them and what signs to look out for because some can be serious and need urgent medical attention.

The amount of this medicine you take and how often you take it depends on the type of transplant you have. Follow your doctor’s instructions on this. You should take it on an empty stomach, at least one hour before or two hours after a meal. Swallow it as a whole, do not crush, chew or break it. Take the medicine regularly to get the most benefit and keep taking it even if you feel well. If you stop taking it, you may increase the chances of rejecting your transplanted organ. The treatment will continue for as long as you need it to prevent rejection. 

Manocept 250mg Tablet can cause birth defects and abortion so do not take it if you are pregnant, planning to become pregnant or breastfeeding. You should talk to your doctor before taking this medicine if you have any signs of infection or if you have any unexpected bruising or bleeding. Your doctor also needs to know what other medicines you are taking as there are many which interact with this medicine and affect the way it works. You will have regular tests to check for any changes in the number of your blood cells and the amount of sugar and cholesterol in your blood.

Side effects of Manocept Tablet

Common
  • Nausea
  • Vomiting
  • Diarrhea
  • Abdominal pain
  • Headache
  • High blood pressure
  • Decreased white blood cell count (neutrophils)

How to use Manocept Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Manocept 250mg Tablet may be taken with or without food, but it is better to take it at a fixed time.

How Manocept Tablet works

Manocept 250mg Tablet is an immunosuppressant. It reduces the action of body's own defence system (the immune system) and prevents rejection of the transplanted organ.

Safety Advice

Alcohol
SAFE
Consuming alcohol with Manocept 250mg Tablet does not cause any harmful side effects.
Pregnancy
CONSULT YOUR DOCTOR
Manocept 250mg Tablet is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
Breastfeeding
UNSAFE
Manocept 250mg Tablet is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
Driving
SAFE
Manocept 250mg Tablet does not usually affect your ability to drive.
Kidney
SAFE IF PRESCRIBED
Manocept 250mg Tablet is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Manocept 250mg Tablet may not be needed in these patients. Please consult your doctor.
Liver
CONSULT YOUR DOCTOR
There is limited information available on the use of Manocept 250mg Tablet in patients with liver disease. Please consult your doctor.

Alternate Brands

For informational purposes only. Consult a doctor before taking any medicines.
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Quick Tips

  • Your doctor has prescribed Manocept 250mg Tablet to stop your body from rejecting a transplanted organ (e.g. kidney, heart or liver). 
  • It may take 6 to 12 weeks for Manocept 250mg Tablet to start working. Keep taking it as prescribed.
  • It may cause birth defects so birth control is required in females with reproductive potential.
  • It makes you more susceptible to getting infections. Avoid contact with people who have an infection. Consult your doctor immediately if you develop a sore throat, high temperature, any other signs of infections.
  • Protect yourself from direct sunlight by wearing protective clothing and applying a sunscreen with a high sun protection factor (SPF).
  • Take it with food to minimize possible side effects like nausea and stomach pain.
  • Your doctor may get regular blood tests done to monitor the levels of blood cells in your blood. Inform your doctor if you experience symptoms such as unexplained bruising or bleeding, sore throat, mouth ulcers, or fever.

Interaction with Drugs

Taking Manocept with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Brand(s): Thioprinz, Lazorin, Azarid
LIFE-THREATENING
Brand(s): Imorab, Equirab, Carig
LIFE-THREATENING
Brand(s): Avaxim, HAVpur, Havrix
LIFE-THREATENING
LIFE-THREATENING

Patient Concerns

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Is tablet TRANESMA (Tranexamic Acid Tablet IP 250mg) anyway related for treatment of Melasa or Face pigmentation.
Dr. Souvik Sardar
Skin Specialist
Yes It can be used
She is pregnant doctor given cephexien 375mg tablet but I have been given 250mg is it safe or not
Dr. Sfurti Mann
Diabetes Specialist
Cephalosporins can be given in pregnancy Consult your doctor for dosage
arrow
Do you have any questions related to Manocept 250mg Tablet ?

FAQs

Q. Can Manocept cause cancer?

Manocept may increase your chances of certain cancers like skin cancer and lymphoma (cancer of the lymph system). When outside, avoid unnecessary or prolonged exposure to sunlight, wear protective clothing, and apply sunscreen. Call your doctor if you experience a new skin sore or bump, a change in the size or color of a mole, a brown or black skin lesion (sore) with uneven edges, a sore whose one part does not look like the other, skin changes, sores that do not heal, unexplained fever, tiredness that does not go away, weight loss, or pain or swelling in the neck, groin, or armpits.

Q. Why has my doctor given me Manocept after I have had a kidney transplant?

Manocept is an immunosuppressant. Manocept has been prescribed to you to help your body accept the donor kidney. It does so by working on the cells of your immune system, which fight with any foreign substance and reject its presence. This helps in making the transplanted organ more acceptable to your body.

Q. How long does Manocept take to start working?

Manocept does not start working immediately and it may take about 8 to 12 weeks before you see any benefits. To ensure that your condition does not reappear, you may have to keep taking the medicine for several years.

Q. Is Manocept a steroid or a chemotherapy drug? Can it cause hair loss?

Manocept is neither a steroid nor a chemotherapy medicine. It is an immunosuppressant which means that it acts on your immune system to suppress or weaken it so that your body does not reject the donated organ of another person. Hair loss is a common side effect of Manocept.

Q. Do I need any special tests while taking Manocept?

Since Manocept can affect blood count and affect the kidneys and liver, your doctor will ask you to have a blood test before you start the treatment. Once the treatment starts, you will be required to take regular blood tests to check for any changes in the blood. These blood tests will help monitor your response to the medicine and the development of any side effects.

Q. My doctor has asked me to stay away from a person who has chicken pox or shingles. Why?

Manocept is an immunosuppressant, which means that it decreases the activity of the immune system. Since your immune system is already weak, if you come in contact with a patient of chicken pox or shingles, you may develop it too. This is the reason that your doctor has advised you to be cautious. Therefore, follow your doctor’s advice and contact your doctor immediately if you get chicken pox or shingles as you may require special treatment.

Q. What precautions should a female follow while taking Manocept?

Do not take Manocept if you are pregnant or are planning a pregnancy. There is a high risk of miscarriage (loss of the pregnancy) during the first 3 months of pregnancy. It may even cause birth defects (problems that are present at birth) in the baby. Therefore, you must use two acceptable forms of birth control together for 4 weeks before you start taking Manocept, during the treatment, and for 6 weeks after you stop taking Manocept. Your doctor will suggest the two birth control methods which suit you the best. It is important to use a second form of birth control along with birth control pills as Manocept may decrease the effectiveness of birth control pills.

Q. What precautions should a male follow while taking Manocept?

It is recommended that either the man or her partner should use reliable contraception during treatment and for 90 days after the treatment. Men should not donate semen during the therapy or for 90 days following discontinuation of Manocept.

Related Products

Disclaimer: 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover all possible side effects, drug interactions or warnings or alerts. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.
References
  1. Krensky AM, Bennett WM, Vincenti F. Immunosuppressants, Tolerogens, and Immunostimulants. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. New York, New York: McGraw-Hill Medical; 2011. pp. 1014-15.
  2. Lake DF, Briggs AD, Akporiaye ET. Immunopharmacology. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 973.
  3. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 943-45.
  4. Mycophenolate mofetil. Barnstaple, Devon: Accord-UK Ltd.; 2009 [revised 10 Apr. 2018]. [Accessed 06 Apr. 2019] (online) Available from:External Link
  5. Lake DF, Briggs AD. Immunopharmacology. In: Katzung BG, Trevor AG, editors. Basic & Clinical Pharmacology. 13th ed. New York, New York: McGraw-Hill Education; 2015. [Accessed 28 Jan. 2019] (online) Available from:External Link
  6. Central Drugs Standard Control Organisation (CDSCO). [Accessed 06 Apr. 2019] (online) Available from:External Link
  7. Mycophenolate mofetil. South San Francisco, California: Genentech USA, Inc.; 1995 [revised Feb. 2019]. [Accessed 17 Jun. 2019] (online) Available from:External Link
  8. Mycophenolate mofetil. Grenzach-Wyhlen, Germany: Roche Pharma AG; 2018. [Accessed 17 Jun. 2019] (online) Available from:External Link
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