Macirol 10mg Tablet

Macitentan (10mg)

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Macirol 10mg Tablet is a prescription medicine used to treat pulmonary arterial hypertension (high pressure in the blood vessels that carry blood from the heart to the lungs). It even helps to improve your quality of life, exercising ability and delay in disease progression.

Written By Dr. Subita Alagh, BDS,
Reviewed By Dr. Sachin Gupta, MD Pharmacology, MBBS,
Last updated on 22 Jul 2026 | 01:02 AM (IST)

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Macirol 10mg Tablet

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Macitentan (10mg)

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General Information

Contains

Macitentan (10mg)

Marketer

Inviscus Lifescience LLP

Storage

Store below 30°C

The content is shown in English

Product introduction

Macirol 10mg Tablet is given alone or in combination with some other medicines. It should be taken with or without food. This medicine should be used regularly to get the most benefit from it. The dose and how often you take it depends on what you are taking it for. Your doctor will decide how much you need to improve your symptoms. You should take this medicine for as long as it is prescribed for you.

The most common side effects of this medicine include headache, swelling of the legs and ankles(edema), and inflammation of the airways. If these bother you or appear serious, let your doctor know. There may be ways of reducing or preventing them. Some serious side effects which mean your doctor should know immediately include Anemia (low number of red blood cells) and abnormal liver function such as nausea, vomiting, dark urine, fever, and dark urine. Your doctor might check you for blood tests to check for anemia and liver function.

Before taking this medicine, let your doctor know if you have liver dysfunctioning. Inform your doctor if you are pregnant or breastfeeding. Your doctor should also know about all other medicines you are taking as many of these may make this medicine less effective or change the way it works. You must avoid driving if this medicine makes you feel dizzy.

Uses of Macirol Tablet

Pulmonary arterial hypertension (PAH)

Benefits of Macirol Tablet

Pulmonary arterial hypertension (PAH)
Pulmonary arterial hypertension (PAH) is a condition where the blood pressure in the arteries of the lungs becomes abnormally high, making it harder for the heart to pump blood through them. Macirol 10mg Tablet helps relax and widen these blood vessels, improving blood flow and reducing the strain on the heart. This helps ease symptoms such as shortness of breath and fatigue, supports better exercise capacity, and slows disease progression.

Side effects of Macirol Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Macirol

Headache
Bronchitis (inflammation of the airways)
Nasopharyngitis (inflammation of the throat and nasal passages)
Anemia (low number of red blood cells)
Urinary tract infection
Influenza

How to use Macirol Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Macirol 10mg Tablet may be taken with or without food.

How Macirol Tablet works

Macirol 10mg Tablet is an endothelin receptor blocker. It blocks the action of endothelin (a natural substance) that causes blood vessels to narrow (constrict). This narrowing increases the pressure in the blood vessels of the lungs. Macirol 10mg Tablet helps relax these blood vessels and increases the supply of blood to the lungs.

All substitutes for Macirol 10mg Tablet

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

Your doctor has prescribed Macirol 10mg Tablet to treat high pressure in the blood vessels that carry blood from the heart to the lungs (the pulmonary arteries).
It helps improve your quality of life, exercising ability, and delay disease progression.
Notify your doctor if you are pregnant or planning to conceive or breastfeeding.
Your doctor may ask you to get routine blood tests done to check for anemia and to assess the functioning of your liver.
Do not drive or do anything requiring concentration until you know how Macirol 10mg Tablet affects you.
Inform your doctor if you notice weight gain, swelling of your arms and legs, or difficulty breathing.
Inform your doctor if you notice yellowing of skin/eye, dark urine, or stomach pain.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Macirol 10mg Tablet. Please consult your doctor.

Pregnancy

UNSAFE

Macirol 10mg Tablet is highly unsafe during pregnancy. It can cause serious harm to the unborn baby, including birth defects and pregnancy loss. Do not use this medicine if you are pregnant or planning to become pregnant.

Breast feeding

UNSAFE

Macirol 10mg Tablet is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

Driving

CONSULT YOUR DOCTOR

It is not known whether Macirol 10mg Tablet alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. Please consult your doctor.

Kidney

CAUTION

Macirol 10mg Tablet should be used with caution in patients with severe kidney disease. Dose adjustment may be needed.

Liver

CAUTION

Macirol 10mg Tablet should be used with caution in patients with liver disease. Dose adjustment may be needed.

Interaction with drugs

Taking Macirol with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Severe

Carbamazepine (Oral Route)

Do not consume Macitentan with Carbamazepine. Carbamazepine may reduce blood levels of Macitentan.

Severe

Enzalutamide (Oral Route)

Do not consume Macitentan with Enzalutamide. Enzalutamide may reduce blood levels of Macitentan.

Severe

Fosphenytoin (Injection Route)

Do not consume Macitentan with Fosphenytoin. Fosphenytoin may reduce blood levels of Macitentan.

Severe

Phenobarbitone (Oral Route)

Do not consume Macitentan with Phenobarbitone. Phenobarbitone may reduce blood levels of Macitentan.

Severe

Phenobarbitone (Injection Route)

Do not consume Macitentan with Phenobarbitone. Phenobarbitone may reduce blood levels of Macitentan.

Frequently asked questions

What is the recommendation for birth control while on Macirol 10mg Tablet?

Females who are able to get pregnant should use 2 acceptable methods of birth control during treatment with Macirol 10mg Tablet and 1 month of stopping it. This is because it takes some time to get the medicine flushed out of the body. If you have tubal sterilization, a progesterone implant, or have an IUD (intrauterine device), these methods can be used alone. Consult your doctor if you are not sure about the birth control method.

How should Macirol 10mg Tablet be taken?

The prescribed dose of Macirol 10mg Tablet is advised to be taken once daily. It can be taken with or without food. It should be swallowed whole with water and not be crushed or chewed. For best results, it should be taken at the same time each day.

Does Macirol 10mg Tablet affect fertility?

There is some evidence that it may decrease fertility in men. It could also be a reason for decreased sperm count. Hence, before taking Macirol 10mg Tablet, discuss with your doctor about the risks of taking Macirol 10mg Tablet.

While taking Macirol 10mg Tablet do I need to get any tests done?

Your doctor will get blood tests done before and during the treatment. This is done to test whether you have anemia (reduced hemoglobin or decreased red blood cell count) and whether your liver is functioning properly.

What is the most important information I need to know about Macirol 10mg Tablet?

You should be aware that Macirol 10mg Tablet can cause serious birth defects if taken during pregnancy. Hence, females who are pregnant should not start treatment with Macirol 10mg Tablet or they should not get pregnant while taking Macirol 10mg Tablet.

Does Macirol 10mg Tablet have any effect on blood pressure?

Yes, Macirol 10mg Tablet may affect the blood pressure. It can cause lowering of blood pressure and may also cause headache. If you experience these side effects your ability to drive or using heavy machines may be affected.

What are the warning symptoms of anaemia?

The symptoms of anaemia include dizziness, pallor (unhealthy pale appearance), weakness, fast heart rate, and palpitations. If you experience any of these consult your doctor.

Fact Box

Chemical Class

Halopyrimidines

Habit Forming

Therapeutic Class

CARDIAC

Action Class

Endothelin Receptor Antagonists (ERAs)

References

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Inviscus Lifescience LLP
Address: 202/203, Aditya Heritage Industrial Premises Society Ltd, Opp. HSBC, Mind space link road, Malad,Mumbai-400064

Vendor Details

Country of origin: India

Lab tests offered by us

Why we need a prescription?

Home

Cardiac

Antihypertensives Non Herbal Peripherally Acting

Macirol 10mg Tablet

Macirol 10mg Tablet

Save more with additional offers

General Information

Contains

Marketer

Storage

Product introduction

Uses of Macirol Tablet

Benefits of Macirol Tablet

Side effects of Macirol Tablet

How to use Macirol Tablet

How Macirol Tablet works

All substitutes for Macirol 10mg Tablet

Macitent 10mg Tablet

Opsutan Tablet

Macikad 10mg Tablet

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Carbamazepine (Oral Route)

Enzalutamide (Oral Route)

Fosphenytoin (Injection Route)

Phenobarbitone (Oral Route)

Phenobarbitone (Injection Route)

Frequently asked questions

What is the recommendation for birth control while on Macirol 10mg Tablet?

How should Macirol 10mg Tablet be taken?

Does Macirol 10mg Tablet affect fertility?

While taking Macirol 10mg Tablet do I need to get any tests done?

What is the most important information I need to know about Macirol 10mg Tablet?

Does Macirol 10mg Tablet have any effect on blood pressure?

What are the warning symptoms of anaemia?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

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