Macirol 10mg Tablet is a prescription medicine used to treat pulmonary arterial hypertension (high pressure in the blood vessels that carry blood from the heart to the lungs). It even helps to improve your quality of life, exercising ability and delay in disease progression.

Macirol 10mg Tablet is given alone or in combination with some other medicines. It should be taken with or without food. This medicine should be used regularly to get the most benefit from it. The dose and how often you take it depends on what you are taking it for. Your doctor will decide how much you need to improve your symptoms. You should take this medicine for as long as it is prescribed for you.

The most common side effects of this medicine include headache, swelling of the legs and ankles(edema), and inflammation of the airways. If these bother you or appear serious, let your doctor know. There may be ways of reducing or preventing them. Some serious side effects which mean your doctor should know immediately include Anemia (low number of red blood cells) and abnormal liver function such as nausea, vomiting, dark urine, fever, and dark urine. Your doctor might check you for blood tests to check for anemia and liver function.

Before taking this medicine, let your doctor know if you have liver dysfunctioning. Inform your doctor if you are pregnant or breastfeeding. Your doctor should also know about all other medicines you are taking as many of these may make this medicine less effective or change the way it works. You must avoid driving if this medicine makes you feel dizzy.

Uses of Macirol Tablet

Pulmonary arterial hypertension (PAH)

Benefits of Macirol Tablet

In Pulmonary arterial hypertension (PAH)

Pulmonary arterial hypertension can cause shortness of breath, tiredness, dizziness, chest pain and swelling in your ankles and legs. It is caused by thickening of walls of the arteries that supply your lungs making it hard for blood to get through. Macirol 10mg Tablet relaxes the blood vessels and can help lower the blood pressure in the arteries of your lungs. You will be able to carry out your daily activities more easily and feel less tired or dizzy.

Side effects of Macirol Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Macirol

Headache
Bronchitis (inflammation of the airways)
Nasopharyngitis (inflammation of the throat and nasal passages)
Anemia (low number of red blood cells)
Urinary tract infection
Influenza

How to use Macirol Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Macirol 10mg Tablet may be taken with or without food, but it is better to take it at a fixed time.

How Macirol Tablet works

Macirol 10mg Tablet is an endothelin receptor blocker. It blocks the action of endothelin (a natural substance) that causes blood vessels to narrow (constrict). This narrowing increases the pressure in the blood vessels of the lungs. Macirol 10mg Tablet helps relax these blood vessels and increases the supply of blood to the lungs.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Macirol 10mg Tablet. Please consult your doctor.

Pregnancy

UNSAFE

Macirol 10mg Tablet is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.

Breast feeding

UNSAFE

Macirol 10mg Tablet is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

Driving

UNSAFE

Macirol 10mg Tablet may cause side effects which could affect your ability to drive.

Kidney

CAUTION

Macirol 10mg Tablet should be used with caution in patients with kidney disease. Dose adjustment of Macirol 10mg Tablet may be needed. Please consult your doctor.

Liver

CAUTION

Macirol 10mg Tablet should be used with caution in patients with liver disease. Dose adjustment of Macirol 10mg Tablet may be needed. Please consult your doctor.

What if you forget to take Macirol Tablet?

If you miss a dose of Macirol 10mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.

Macirol 10mg Tablet

₹169.7/Tablet

Macitent 10mg Tablet

MSN Laboratories

₹196.8/tablet

16% costlier

Opsutan Tablet

Cipla Ltd

₹188/tablet

11% costlier

Macikad 10mg Tablet

Lupin Ltd

₹206.7/tablet

22% costlier

Quick tips

Your doctor has prescribed Macirol 10mg Tablet to treat high pressure in the blood vessels that carry blood from the heart to the lungs (the pulmonary arteries).
It helps improve your quality of life, exercising ability, and delay disease progression.
Notify your doctor if you are pregnant or planning to conceive or breastfeeding.
Your doctor may ask you to get routine blood tests done to check for anemia and to assess the functioning of your liver.
Do not drive or do anything requiring concentration until you know how Macirol 10mg Tablet affects you.
Inform your doctor if you notice weight gain, swelling of your arms and legs, or difficulty breathing.
Inform your doctor if you notice yellowing of skin/eye, dark urine, or stomach pain.

Fact Box

Chemical Class

Sulfamides Derivative

Habit Forming

Therapeutic Class

CARDIAC

Action Class

Endothelin receptor blocker

Interaction with drugs

Taking Macirol with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Ciclosporin

Brand(s): Imudrops, Neoral, Aurosporine

Life-threatening

Acenocoumarol

Brand(s): Altrom, Cenorol, Cgtrom

Serious

Warfarin

Brand(s): Cofarin, Warf, Uniwarfin

Serious

Phenindione

Brand(s): Dindevan

Serious

View all interactions

Patient concerns

Having high Pulmonary Atrial Hypertension

Dr. Nabajit Talukdar

Cardiology

What medicines r u on

Hiii my wife having hurt patient ( pulmonary hypertension ) she's taking pulmonext 5mg tablet but this tablet is very costly for me of Rs. 1450/- 10tab. I want to know any another tablet available in same drugs with low price

Dr. Sfurti Mann

Internal Medicine

This can't be decided online Your doctor is the best judge about your patients pulmonary hypertension

Hello Dr. My Dad is facing High Pulmonary Hypertension of 63 and average is 32. He has liver cirrhosis as well, he is advised for liver transplant. As the PAH is high cannot proceed with the surgery. Can you please advise if there is any way out. Age : 49yrs. Medicines for heart taken at present is : Ambrisentan 5mg Assurance 20mg Trimium Inhaler.

Dr. Nabajit Talukdar

Cardiology

Currently no other treatment apart from ambrisantan n assurance will have to wait n see response to medicines if pulmonary pressure comes down only then surgery possible

FAQs

Q. What is the recommendation for birth control while on Macirol 10mg Tablet?

Females who are able to get pregnant should use 2 acceptable methods of birth control during treatment with Macirol 10mg Tablet and 1 month of stopping it. This is because it takes some time to get the medicine flushed out of the body. If you have tubal sterilization, a progesterone implant, or have an IUD (intrauterine device), these methods can be used alone. Consult your doctor if you are not sure about the birth control method.

Q. How should Macirol 10mg Tablet be taken?

The prescribed dose of Macirol 10mg Tablet is advised to be taken once daily. It can be taken with or without food. It should be swallowed whole with water and not be crushed or chewed. For best results, it should be taken at the same time each day.

Q. Does Macirol 10mg Tablet affect fertility?

There is some evidence that it may decrease fertility in men. It could also be a reason for decreased sperm count. Hence, before taking Macirol 10mg Tablet, discuss with your doctor about the risks of taking Macirol 10mg Tablet.

Q. While taking Macirol 10mg Tablet do I need to get any tests done?

Your doctor will get blood tests done before and during the treatment. This is done to test whether you have anemia (reduced hemoglobin or decreased red blood cell count) and whether your liver is functioning properly.

Q. What is the most important information I need to know about Macirol 10mg Tablet?

You should be aware that Macirol 10mg Tablet can cause serious birth defects if taken during pregnancy. Hence, females who are pregnant should not start treatment with Macirol 10mg Tablet or they should not get pregnant while taking Macirol 10mg Tablet.

Q. Does Macirol 10mg Tablet have any effect on blood pressure?

Yes, Macirol 10mg Tablet may affect the blood pressure. It can cause lowering of blood pressure and may also cause headache. If you experience these side effects your ability to drive or using heavy machines may be affected.

Q. What are the warning symptoms of anaemia?

The symptoms of anaemia include dizziness, pallor (unhealthy pale appearance), weakness, fast heart rate, and palpitations. If you experience any of these consult your doctor.

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

Macitentan. Beerse Belgium: Janssen-Cilag International NV; 20 Dec. 2013 [revised Sep. 2018]. [Accessed on 1 Apr. 2019] (online) Available from:
Macitentan. Grenzach-Wyhlen Germany: Actelion Manufacturing GmbH; [Accessed 01 Apr. 2019] (online) Available from:
ScienceDirect. Macitentan. [Accessed 01 Apr. 2019] (online) Available from:
CiplaMed. Macitentan [Prescribing Information]. [Accessed 11 Jul. 2023]. (online) Available from:
Macitentan [Prescribing Information]. Telangana, India: MSN Laboratories Private Limited. [Accessed 11 Jul. 2023]. (online) Available from:

Marketer details

Name: Inviscus Lifescience LLP

Address: 202/203, Aditya Heritage Industrial Premises Society Ltd, Opp. HSBC, Mind space link road, Malad,Mumbai-400064

Country of origin: India

The list of available options shown with the same composition has been prepared upon the advice of registered medical practitioners, pharmacists affiliated with TATA 1MG. TATA 1MG does not promote any pharmaceutical product of any particular company, and all recommendations are based on the medical opinion, advisories from specialist medical and pharmaceutical professionals.