Information about Macitentan

Macitentan Uses

Macitentan is used in the treatment of pulmonary arterial hypertension (PAH).

How Macitentan works

Macitentan is an endothelin receptor blocker. It blocks the action of endothelin (a natural substance) that causes blood vessels to narrow (constrict). This narrowing increases the pressure in the blood vessels of the lungs. Macitentan helps relax these blood vessels and increases the supply of blood to the lungs.

Common side effects of Macitentan

Headache, Bronchitis (inflammation of the airways), Nasopharyngitis (inflammation of the throat and nasal passages), Anemia (low number of red blood cells), Urinary tract infection, Influenza
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Written By
MDS, BDS
Reviewed By
MD (Pharmacology), MBBS
Last updated
14 Jun 2022 | 01:00 PM (UTC)

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Available Medicine for Macitentan

MacitentMSN Laboratories
19211 variant(s)
OpsutanCipla Ltd
18371 variant(s)
MacirolInviscus Lifescience LLP
17501 variant(s)
MacikadLupin Ltd
20201 variant(s)

Expert advice for Macitentan

  • Your doctor has prescribed Macitentan to treat high pressure in the blood vessels that carry blood from the heart to the lungs (the pulmonary arteries).
  • It helps improve your quality of life, exercising ability, and delay disease progression.
  • Notify your doctor if you are pregnant or planning to conceive or breastfeeding.
  • Your doctor may ask you to get routine blood tests done to check for anemia and to assess the functioning of your liver.
  • Do not drive or do anything requiring concentration until you know how Macitentan affects you.
  • Inform your doctor if you notice weight gain, swelling of your arms and legs, or difficulty breathing.
  • Inform your doctor if you notice yellowing of skin/eye, dark urine, or stomach pain.

Frequently asked questions for Macitentan

Macitentan

Q. What is the recommendation for birth control while on Macitentan?

Females who are able to get pregnant should use 2 acceptable methods of birth control during treatment with Macitentan and 1 month of stopping it. This is because it takes some time to get the medicine flushed out of the body. If you have tubal sterilization, a progesterone implant, or have an IUD (intrauterine device), these methods can be used alone. Consult your doctor if you are not sure about the birth control method.

Q. How should Macitentan be taken?

The prescribed dose of Macitentan is advised to be taken once daily. It can be taken with or without food. It should be swallowed whole with water and not be crushed or chewed. For best results, it should be taken at the same time each day.

Q. Does Macitentan affect fertility?

There is some evidence that it may decrease fertility in men. It could also be a reason for decreased sperm count. Hence, before taking Macitentan, discuss with your doctor about the risks of taking Macitentan.

Q. While taking Macitentan do I need to get any tests done?

Your doctor will get blood tests done before and during the treatment. This is done to test whether you have anemia (reduced hemoglobin or decreased red blood cell count) and whether your liver is functioning properly.

Q. What is the most important information I need to know about Macitentan?

You should be aware that Macitentan can cause serious birth defects if taken during pregnancy. Hence, females who are pregnant should not start treatment with Macitentan or they should not get pregnant while taking Macitentan.

Q. Does Macitentan have any effect on blood pressure?

Yes, Macitentan may affect the blood pressure. It can cause lowering of blood pressure and may also cause headache. If you experience these side effects your ability to drive or using heavy machines may be affected.

Q. What are the warning symptoms of anaemia?

The symptoms of anaemia include dizziness, pallor (unhealthy pale appearance), weakness, fast heart rate, and palpitations. If you experience any of these consult your doctor.

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