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Irinotel Injection

Written By Dr. Sakshi Jain, MS, BDS
Reviewed By Dr. Mekhala Chandra, MD, MBBS
Last updated on 01 Dec 2025 | 12:04 PM (IST)
Irinotel Injection is used in the treatment of cancer of colon and rectum. It shows its working by stopping or slowing down the growth of cancer cells.
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1/2
5 ml Injection
 
 
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General Information

Contains

Irinotecan (100mg/5ml)

Marketer

Fresenius Kabi India Pvt Ltd

Storage

Store below 25°C
The content is shown in English
Irinotel Injection image
Irinotel Injection image

Product introduction

Irinotel Injection is given as an IV infusion into vein by a qualified medical professional. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.

The most common side effects of this medicine include fatigue, nausea, vomiting, weakness, and hair loss. This medicine may reduce the number of blood cells (decrease red blood and white blood cells) in your blood, thereby, increasing the susceptibility to infections. Inform your doctor if you notice fever, sore throat, and continuous episodes of diarrhea. Regular blood tests are required to check your blood cells along with heart, liver, and blood uric acid levels.

Before taking it, tell your doctor if you have heart disease, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.

Uses of Irinotel Injection

Benefits of Irinotel Injection

Cancer of colon and rectum
Cancer of the colon and rectum, also known as colorectal cancer (CRC) or bowel cancer, is the development of cancer from two parts of the large intestine, namely, the colon or rectum. In this type of cancer, the person may notice symptoms such as blood in the stool, a change in bowel movements, weight loss, and fatigue. Irinotel Injection treats and also lowers the risk of developing further cancerous growths (polyps) and bowel cancer. It kills or stops the growth of cancer cells and also prevents the multiplication of cancer cells. It is an effective, yet very toxic medicine and you should discuss the risks and benefits with your doctor. Avoid drinking alcohol or smoking while having this treatment and drink plenty of water to stay hydrated.

Side effects of Irinotel Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Irinotel
  • Fatigue
  • Nausea
  • Vomiting
  • Weakness
  • Hair loss
  • Fever
  • Anemia (low number of red blood cells)
  • Diarrhea
  • Decreased white blood cell count (neutrophils)
  • Decreased appetite
  • Mucosal inflammation

How to use Irinotel Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Irinotel Injection works

Irinotel Injection is an anti-cancer medication. It works by suppressing the activity of an enzyme (topoisomerase I) involved in DNA multiplication of the cancer cells. This slows the growth of cancer cells and eventually kills them.

All substitutes for Irinotel Injection

For information purposes only. Consult a doctor before taking any medicine.

Foiri 100 Injection

by Zydus Cadila
₹3975/injection
257% costlier
<h3 class=bodySemiBold>Foiri 100 Injection</h3>

Quick tips

  • Irinotel Injection is used in combination with other medicines for the treatment of metastatic cancer of the colon and rectum.
  • It is given via a drip into a vein (intravenous infusion).
  • It may cause dizziness and visual disturbances. Do not drive or do anything that requires mental focus until you know how it affects you.
  • Use a reliable contraceptive method to prevent pregnancy while you are taking this medicine.
  • Your doctor may get regular blood tests done to monitor your blood cells, kidney and liver function during treatment with this medicine.
  • Inform your doctor immediately if you notice any signs of infection such as fever, sore throat or rash.
  • Inform your doctor if you notice passage of blood in stools or experience dizziness or faintness, continuous episodes of nausea, vomiting, diarrhea or fever.

Safety advice

Alcohol

Alcohol

CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Irinotel Injection. Please consult your doctor.
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
Irinotel Injection is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.
Breast feeding

Breast feeding

UNSAFE
Irinotel Injection is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
Driving

Driving

UNSAFE
Irinotel Injection may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Kidney

Kidney

SAFE IF PRESCRIBED
Irinotel Injection is probably safe to use in patients with kidney disease. Limited data suggest dose adjustment may not be needed.
Use of this medicine is not recommended for patients on dialysis.
Liver

Liver

CONSULT YOUR DOCTOR
There is limited data available on the use of Irinotel Injection in patients with liver disease.

Interaction with drugs

Taking Irinotel with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Severe

Phenobarbitone (Oral Route)

Do not consume Irinotecan with Phenobarbitone. If concurrent use is essential, please consult your doctor. Phenobarbitone may fasten the elimination of Irinotecan and its active form.
Severe

Phenobarbitone (Injection Route)

Do not consume Irinotecan with Phenobarbitone. If concurrent use is essential, please consult your doctor. Phenobarbitone may fasten the elimination of Irinotecan and its active form.
Severe

Atazanavir (Oral Route)

Do not consume Irinotecan with Atazanavir. If Irinotecan is essential, ensure a gap of at least 1 week after discontinuing Atazanavir. Please consult your doctor. Atazanavir may raise blood levels of Irinotecan.
Severe

Carbamazepine (Oral Route)

Do not consume Irinotecan with Carbamazepine. If concurrent use is essential, please consult your doctor. Carbamazepine may fasten the elimination of Irinotecan and its active form.
Severe

Clarithromycin (Oral Route)

Do not consume Irinotecan with Clarithromycin. If Irinotecan is essential, ensure a gap of at least 1 week after discontinuing Clarithromycin. Please consult your doctor. Clarithromycin may raise blood levels of the active form of Irinotecan.

Frequently asked questions

Irinotel Injection is used to treat colon and rectal cancer, especially when the cancer has spread to other parts of the body. It is often used alone or in combination with other chemotherapy medicines.
Irinotel Injection is administered as an intravenous (IV) infusion by a doctor, usually over 90 minutes. It is not taken at home, and the dose depends on your body size, health condition, and treatment plan.
Yes. Irinotel Injection can cause serious side effects, such as severe diarrhea, dangerously low white blood cell counts, dehydration, infections, and allergic reactions. Prompt medical attention is important if you experience a high fever, chills, or persistent diarrhea.
Irinotel Injection can cause two types of diarrhea: early-onset and late-onset. Early diarrhea may occur within 24 hours and may include sweating or stomach cramps. Late diarrhea occurs more than 24 hours after treatment and can be severe. You may be prescribed anti-diarrhea medication to manage these symptoms.
Individuals should not take Irinotel Injection if they are allergic to it or have had severe side effects from it previously. It may not be suitable for individuals with certain liver or bowel conditions, or those who are severely dehydrated.
Yes. Irinotel Injection can lower the number of white blood cells in your body, making it harder to fight infections. It is important to avoid close contact with people who are sick and report signs of infection, such as fever or sore throat, immediately.
While on Irinotel Injection treatment, you should stay well hydrated, follow all instructions regarding medications to manage side effects, and report any symptoms of infection, breathing problems, or unusual bleeding. Avoid grapefruit juice, as it may interfere with the medicine’s effect.

Fact Box

Chemical Class

Camptothecins

Habit Forming

No

Therapeutic Class

ANTI NEOPLASTICS

Action Class

Topoisomerase Inhibitors

Related lab tests

Carcino Embryonic Antigen

References

  1. Chu E, Sartorelli AC. Cancer Chemotherapy. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 951.
  2. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 736-37.
  3. Irinotecan hydrochloride trihydrate. Sandwich, Kent: Pfizer Limited; 1995 [revised May 2018]. Accessed 26 Jan. 2019] (online) Available from:
  4. Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Irinotecan. [Updated 2018 Dec 3]. [Accessed 18 Feb. 2020] (online) Available from:
  5. Central Drugs Standard Control Organisation (CDSCO). [Accessed 26 Mar. 2019] (online) Available from:
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Fresenius Kabi India Pvt Ltd
Address: Fresenius Kabi AG​ , Else-Kröner-Straße 1 ​ , 61352 Bad Homburg , Germany

Vendor Details

A licensed vendor partner from your nearest location will deliver Irinotel Injection. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India

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Most medicines cannot be sold without a valid prescription, as per the Drugs and Cosmetics Act, 1940 and Rules, 1945
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