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Hydrosar Capsule

Hydroxyurea (500mg)

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Hydrosar Capsule is a medicine prescribed for the treatment of sickle cell disease. It helps reduce the frequency of painful crises and the need for blood transfusions. It is also used to treat certain types of cancer, including chronic myeloid leukemia (CML) and head and neck cancers.

Written By Dr. Mayank, Pharm.D,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 13 Oct 2025 | 04:21 PM (IST)

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General Information

Contains

Hydroxyurea (500mg)

Marketer

Sarabhai Chemicals Ltd

Storage

Store below 30°C

The content is shown in English

Product introduction

Hydrosar Capsule may be taken with or without food. Take it exactly as prescribed by your doctor. Drink plenty of fluids while taking this medicine to stay well-hydrated. Regular follow-up visits and blood tests are necessary to monitor your response to the medicine and check for any side effects. Take folic acid supplements, if recommended by the doctor, as this medicine may reduce folate levels.

Common side effects of Hydrosar Capsule include loss of appetite, nausea, vomiting, diarrhea, constipation, and temporary hair loss. Some people may also experience low blood counts, leading to tiredness, infections, or easy bruising. If you notice fever, chills, unusual bleeding, or signs of infection, contact your doctor immediately. Staying well-hydrated and following your doctor’s advice can help reduce the risk of side effects.

Hydrosar Capsule should be used with caution and only under medical supervision. It should be avoided during pregnancy unless clearly necessary, as it may harm the unborn baby. Women of childbearing age should use effective contraception during treatment and for a period after stopping the drug. Men are also advised to use contraception during and after treatment, as the drug may affect sperm production.

Hydrosar Capsule may not be suitable for people with severe bone marrow problems or significant liver or kidney disease. Avoid live vaccines during treatment and limit exposure to people who are sick. Always inform your doctor about any other medicines or supplements you are taking before starting Hydrosar Capsule.

Uses of Hydrosar Capsule

Treatment of Head and neck cancer
Treatment of Blood cancer (Chronic myeloid leukaemia)
Treatment of Sickle cell disease

Benefits of Hydrosar Capsule

Treatment of Head and neck cancer
In patients with head and neck cancers, Hydrosar Capsule is often used alongside radiation therapy to enhance its effectiveness. It sensitizes cancer cells to radiation, improving treatment outcomes and helping to shrink tumors more effectively. This combined approach helps reduce pain, difficulty swallowing, and other cancer-related symptoms, thereby improving speech, eating, and daily comfort during therapy.

Treatment of Blood cancer (Chronic myeloid leukaemia)
Hydrosar Capsule helps manage chronic myeloid leukemia by controlling the excessive production of abnormal white blood cells. Reducing high white blood cell counts helps ease symptoms such as fatigue, weight loss, and spleen enlargement. This allows patients to feel more comfortable, lowers the risk of complications, and improves overall well-being.

Treatment of Sickle cell disease
Hydrosar Capsule reduces the frequency and severity of painful sickle cell crises. It increases fetal hemoglobin levels, helps red blood cells maintain a healthy shape, and reduces blockages in blood vessels. This results in fewer hospital visits, less pain, and better oxygen delivery throughout the body. This improves daily functioning and long-term quality of life for individuals with sickle cell disease.

Side effects of Hydrosar Capsule

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Hydrosar

Hair loss
Bone marrow depression
Low blood platelets
Skin rash
Mucositis
Decreased appetite
Cholestasis
Hepatitis (viral infection of liver)
Nausea
Vomiting
Diarrhea
Fatigue
Constipation
Stomatitis (Inflammation of the mouth)

How to use Hydrosar Capsule

Take this medicine in the dose and duration as advised by your doctor. Hydrosar Capsule may be taken with or without food, but it is better to take it at a fixed time.

How Hydrosar Capsule works

In cancer, hydroxyurea inhibits the enzyme ribonucleotide reductase, which plays a critical role in the synthesis of DNA by converting ribonucleotides into deoxyribonucleotides. This inhibition disrupts DNA synthesis, particularly in rapidly dividing cancer cells, resulting in cell cycle arrest and reduced tumor proliferation. In sickle cell disease, hydroxyurea increases the production of fetal hemoglobin (HbF) in red blood cells. Higher levels of HbF reduce the formation of sickled cells, improve red blood cell flexibility, enhance blood flow, and decrease the frequency of painful vaso-occlusive episodes and related complications.

All substitutes for Hydrosar Capsule

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

Follow your doctor’s instructions carefully. Do not change the dose or stop taking Hydrosar Capsule without your doctor’s advice, even if you feel better.
Drink plenty of fluids and stay hydrated while on treatment with Hydrosar Capsule. This helps support kidney function and may reduce side effects.
Routine monitoring is important to check your blood counts and ensure the medicine is working safely. Make sure to attend regular blood test appointments.
Do not receive live vaccines while taking Hydrosar Capsule, as your immune system may be weakened. Always check with your doctor before vaccination.
Hydrosar Capsule can harm an unborn baby. Both men and women should use reliable birth control during treatment and for a period after stopping the medicine (6 months for women, 1 year for men).

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Hydrosar Capsule. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

Hydrosar Capsule is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.

Breast feeding

CONSULT YOUR DOCTOR

Hydrosar Capsule is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

Driving

UNSAFE

Hydrosar Capsule may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

Kidney

CAUTION

Hydrosar Capsule should be used with caution in patients with kidney disease. Dose adjustment of Hydrosar Capsule may be needed. Please consult your doctor.
Regular monitoring of kidney function and some blood tests may be advised while taking this medicine.

Liver

CAUTION

Hydrosar Capsule should be used with caution in patients with liver disease. Dose adjustment of Hydrosar Capsule may be needed. Please consult your doctor.

Interaction with drugs

Taking Hydrosar with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Moderate

Interferon Alpha 2B (Injection Route)

Your doctor may closely monitor blood cell counts.

Moderate

Didanosine (Oral Route)

Your doctor may closely monitor functioning of your liver and pancreas.

Moderate

Stavudine (Oral Route)

Your doctor may closely monitor functioning of liver and pancreas.

Frequently asked questions

What is Hydrosar Capsule used for?

Hydrosar Capsule is used to prevent complications in people with sickle cell disease, as well as to treat certain cancers like chronic myeloid leukemia and head and neck cancers.

How does Hydrosar Capsule help in sickle cell disease?

It increases the level of fetal hemoglobin (HbF), which helps red blood cells stay in a normal shape, improving blood flow and reducing painful sickle cell crises.

What side effects should I watch out for?

Common side effects include low blood counts, nausea, mouth sores, and skin or nail changes. Serious signs to report include fever, infections, unusual bleeding, or shortness of breath.

Can I take Hydrosar Capsule during pregnancy or while trying to conceive?

No. Hydrosar Capsule can harm an unborn baby and affect fertility. Use effective contraception during treatment and for 6 months after (women) or 1 year after (men) stopping the medicine.

Do I need regular blood tests while on Hydrosar Capsule?

Yes. Regular blood tests are necessary to monitor your blood cell counts and ensure the medicine is safe and effective for you.

How to get relief from diarrhea while on treatment with Hydrosar Capsule?

Food items with soluble fiber can help relieve diarrhea as they help absorb excess fluid from the body. These food items include bananas (ripe), oranges, boiled potatoes, white rice, curd, and oatmeal. Diarrhea can cause dehydration in the body, so drink 8-10 glasses of water to avoid dehydration.

Does Hydrosar Capsule cause hair loss?

Yes, while taking this medicine, your hair may become brittle and break. You may also experience patchy hair loss or thinning. These conditions tend to resolve once treatment is stopped. Be gentle when brushing and washing hair to manage hair loss.

I have noticed some changes in my skin after taking Hydrosar Capsule? What should I do?

Use a moisturizer to get relief from rashes and dry and itchy skin. Avoid direct sunlight, wear protective clothing, and use sunscreen (SPF of more than 15) whenever you step outdoors. Do not go swimming if you have a rash because the chlorine in the water can make it worse. Avoid hot water baths and wear loose cotton fabric clothes. Your skin will tend to improve once treatment is stopped.

How to relieve constipation during the treatment?

To relieve constipation, include fiber in your diet (fruits and vegetables), drink 8-10 glasses of fluids a day, and keep active. A stool softener (with a doctor's prescription) once or twice a day may prevent constipation. If you do not have a bowel movement for 2-3 days, consult your doctor.

What precautions should I take to reduce the chances of getting infected during treatment with Hydrosar Capsule?

Since Hydrosar Capsule lowers the number of white blood cells and platelets in your blood, it puts you at risk of getting an infection. To prevent infections, avoid people who have infections. Check with your doctor immediately if you think you may be getting an infection, or if you get a fever or chills.

Fact Box

Chemical Class

Anti Metabolites, {Urea}

Habit Forming

Therapeutic Class

ANTI NEOPLASTICS

Action Class

Other Anticancer Agents

Related lab tests

Bcr-Abl Gene Translocation (Qualitative)

Bcr-Abl Gene Translocation (Quantitative)

Complete Blood Count

Peripheral Smear Examination

References

User feedback

Patients taking Hydrosar Capsule

Once A Day

73%

Thrice A Day

12%

Twice A Day

12%

Alternate Day

What are you using Hydrosar Capsule for?

Sickle cell anemia

69%

Others

31%

How much was the improvement?

Excellent

47%

Average

38%

Poor

16%

What were the side-effects while using Hydrosar Capsule?

No Side Effect

83%

Upset stomach

Low blood platelets

How do you take Hydrosar Capsule?

With food

77%

With or without food

15%

Empty stomach

Please rate Hydrosar Capsule on price

Average

42%

Expensive

39%

Not Expensive

19%

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Sarabhai Chemicals Ltd
Address: Shantisadan, Mirzapur Road, Ahmedabad -380001

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Hydrosar Capsule. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India

Lab tests offered by us

Why we need a prescription?

Provide right medicines

Prescriptions are complex documents. We proof read and recheck at various steps to provide you the right medication in the correct form and dose

In accordance with the law

Most medicines cannot be sold without a valid prescription, as per the Drugs and Cosmetics Act, 1940 and Rules, 1945

Hydrosar Capsule

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General Information

Contains

Marketer

Storage

Product introduction

Uses of Hydrosar Capsule

Benefits of Hydrosar Capsule

Side effects of Hydrosar Capsule

How to use Hydrosar Capsule

How Hydrosar Capsule works

All substitutes for Hydrosar Capsule

Hydreo 500mg Capsule

Myelostat 500mg Capsule

Cytodrox Capsule

Unidrea 500mg Capsule

Hydab 500mg Capsule

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Interferon Alpha 2B (Injection Route)

Didanosine (Oral Route)

Stavudine (Oral Route)

Frequently asked questions

What is Hydrosar Capsule used for?

How does Hydrosar Capsule help in sickle cell disease?

What side effects should I watch out for?

Can I take Hydrosar Capsule during pregnancy or while trying to conceive?

Do I need regular blood tests while on Hydrosar Capsule?

How to get relief from diarrhea while on treatment with Hydrosar Capsule?

Does Hydrosar Capsule cause hair loss?

I have noticed some changes in my skin after taking Hydrosar Capsule? What should I do?

How to relieve constipation during the treatment?

What precautions should I take to reduce the chances of getting infected during treatment with Hydrosar Capsule?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

Related lab tests

Bcr-Abl Gene Translocation (Qualitative)

Bcr-Abl Gene Translocation (Quantitative)

Complete Blood Count

Peripheral Smear Examination

References

User feedback

Patients taking Hydrosar Capsule

What are you using Hydrosar Capsule for?

How much was the improvement?

What were the side-effects while using Hydrosar Capsule?

How do you take Hydrosar Capsule?

Please rate Hydrosar Capsule on price

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

In case of any issues, contact us

Lab tests offered by us

Related/Popular tests