Hydroford 500 Capsule

Hydroxyurea (500mg)

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Hydroford 500 Capsule is a medicine prescribed for the treatment of sickle cell disease. It helps reduce the frequency of painful crises and the need for blood transfusions. It is also used to treat certain types of cancer, including chronic myeloid leukemia (CML) and head and neck cancers.

Written By Dr. Sakshi Jain, MS, BDS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 17 Aug 2026 | 01:04 AM (IST)

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Hydroford 500 Capsule

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Cytodrox Capsule

strip of 10 capsules

Hydroxyurea (500mg)

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General Information

Contains

Hydroxyurea (500mg)

Marketer

Johnlee Pharmaceuticals Pvt Ltd

Storage

Store below 30°C

The content is shown in English

Product introduction

Hydroford 500 Capsule may be taken with or without food. Take it exactly as prescribed by your doctor. Drink plenty of fluids while taking this medicine to stay well-hydrated. Regular follow-up visits and blood tests are necessary to monitor your response to the medicine and check for any side effects. Take folic acid supplements, if recommended by the doctor, as this medicine may reduce folate levels.

Common side effects of Hydroford 500 Capsule include loss of appetite, nausea, vomiting, diarrhea, constipation, and temporary hair loss. Some people may also experience low blood counts, leading to tiredness, infections, or easy bruising. If you notice fever, chills, unusual bleeding, or signs of infection, contact your doctor immediately. Staying well-hydrated and following your doctor’s advice can help reduce the risk of side effects.

Hydroford 500 Capsule should be used with caution and only under medical supervision. It should be avoided during pregnancy unless clearly necessary, as it may harm the unborn baby. Women of childbearing age should use effective contraception during treatment and for a period after stopping the drug. Men are also advised to use contraception during and after treatment, as the drug may affect sperm production.

Hydroford 500 Capsule may not be suitable for people with severe bone marrow problems or significant liver or kidney disease. Avoid live vaccines during treatment and limit exposure to people who are sick. Always inform your doctor about any other medicines or supplements you are taking before starting Hydroford 500 Capsule.

Uses of Hydroford Capsule

Treatment of Head and neck cancer
Treatment of Blood cancer (Chronic myeloid leukaemia)
Treatment of Sickle cell disease

Benefits of Hydroford Capsule

Treatment of Head and neck cancer
In patients with head and neck cancers, Hydroford 500 Capsule is often used alongside radiation therapy to enhance its effectiveness. It sensitizes cancer cells to radiation, improving treatment outcomes and helping to shrink tumors more effectively. This combined approach helps reduce pain, difficulty swallowing, and other cancer-related symptoms, thereby improving speech, eating, and daily comfort during therapy.

Treatment of Blood cancer (Chronic myeloid leukaemia)
Hydroford 500 Capsule helps manage chronic myeloid leukemia by controlling the excessive production of abnormal white blood cells. Reducing high white blood cell counts helps ease symptoms such as fatigue, weight loss, and spleen enlargement. This allows patients to feel more comfortable, lowers the risk of complications, and improves overall well-being.

Treatment of Sickle cell disease
Hydroford 500 Capsule reduces the frequency and severity of painful sickle cell crises. It increases fetal hemoglobin levels, helps red blood cells maintain a healthy shape, and reduces blockages in blood vessels. This results in fewer hospital visits, less pain, and better oxygen delivery throughout the body. This improves daily functioning and long-term quality of life for individuals with sickle cell disease.

Side effects of Hydroford Capsule

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Hydroford

Bone marrow suppression
Decreased white blood cell count (lymphocytes)

How to use Hydroford Capsule

Take this medicine in the dose and duration as advised by your doctor. Hydroford 500 Capsule may be taken with or without food.

How Hydroford Capsule works

In cancer, hydroxyurea inhibits the enzyme ribonucleotide reductase, which plays a critical role in the synthesis of DNA by converting ribonucleotides into deoxyribonucleotides. This inhibition disrupts DNA synthesis, particularly in rapidly dividing cancer cells, resulting in cell cycle arrest and reduced tumor proliferation. In sickle cell disease, hydroxyurea increases the production of fetal hemoglobin (HbF) in red blood cells. Higher levels of HbF reduce the formation of sickled cells, improve red blood cell flexibility, enhance blood flow, and decrease the frequency of painful vaso-occlusive episodes and related complications.

All substitutes for Hydroford 500 Capsule

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

Follow your doctor’s instructions carefully. Do not change the dose or stop taking Hydroford 500 Capsule without your doctor’s advice, even if you feel better.
Drink plenty of fluids and stay hydrated while on treatment with Hydroford 500 Capsule. This helps support kidney function and may reduce side effects.
Routine monitoring is important to check your blood counts and ensure the medicine is working safely. Make sure to attend regular blood test appointments.
Do not receive live vaccines while taking Hydroford 500 Capsule, as your immune system may be weakened. Always check with your doctor before vaccination.
Hydroford 500 Capsule can harm an unborn baby. Both men and women should use reliable birth control during treatment and for a period after stopping the medicine (6 months for women, 1 year for men).

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Hydroford 500 Capsule. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

Hydroford 500 Capsule is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.

Breast feeding

CONSULT YOUR DOCTOR

Hydroford 500 Capsule may be unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. It should be used only if the expected benefit outweighs the potential risk. Please consult your doctor.

Driving

UNSAFE

Hydroford 500 Capsule may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

Kidney

CAUTION

Hydroford 500 Capsule should be used with caution in patients with kidney disease. Dose adjustment may be needed.
Regular monitoring of kidney function and some blood tests may be advised while taking this medicine.

Liver

CAUTION

Hydroford 500 Capsule should be used with caution in patients with liver disease. Dose adjustment may be needed.

Interaction with drugs

Taking Hydroford with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Moderate

Interferon Alpha 2B (Injection Route)

Your doctor may closely monitor blood cell counts.

Moderate

Didanosine (Oral Route)

Your doctor may closely monitor functioning of your liver and pancreas.

Moderate

Stavudine (Oral Route)

Your doctor may closely monitor functioning of liver and pancreas.

Frequently asked questions

What is Hydroford 500 Capsule used for?

Hydroford 500 Capsule is used to prevent complications in people with sickle cell disease, as well as to treat certain cancers like chronic myeloid leukemia and head and neck cancers.

How does Hydroford 500 Capsule help in sickle cell disease?

It increases the level of fetal hemoglobin (HbF), which helps red blood cells stay in a normal shape, improving blood flow and reducing painful sickle cell crises.

What side effects should I watch out for?

Common side effects include low blood counts, nausea, mouth sores, and skin or nail changes. Serious signs to report include fever, infections, unusual bleeding, or shortness of breath.

Can I take Hydroford 500 Capsule during pregnancy or while trying to conceive?

No. Hydroford 500 Capsule can harm an unborn baby and affect fertility. Use effective contraception during treatment and for 6 months after (women) or 1 year after (men) stopping the medicine.

Do I need regular blood tests while on Hydroford 500 Capsule?

Yes. Regular blood tests are necessary to monitor your blood cell counts and ensure the medicine is safe and effective for you.

How to get relief from diarrhea while on treatment with Hydroford 500 Capsule?

Food items with soluble fiber can help relieve diarrhea as they help absorb excess fluid from the body. These food items include bananas (ripe), oranges, boiled potatoes, white rice, curd, and oatmeal. Diarrhea can cause dehydration in the body, so drink 8-10 glasses of water to avoid dehydration.

Does Hydroford 500 Capsule cause hair loss?

Yes, while taking this medicine, your hair may become brittle and break. You may also experience patchy hair loss or thinning. These conditions tend to resolve once treatment is stopped. Be gentle when brushing and washing hair to manage hair loss.

I have noticed some changes in my skin after taking Hydroford 500 Capsule? What should I do?

Use a moisturizer to get relief from rashes and dry and itchy skin. Avoid direct sunlight, wear protective clothing, and use sunscreen (SPF of more than 15) whenever you step outdoors. Do not go swimming if you have a rash because the chlorine in the water can make it worse. Avoid hot water baths and wear loose cotton fabric clothes. Your skin will tend to improve once treatment is stopped.

How to relieve constipation during the treatment?

To relieve constipation, include fiber in your diet (fruits and vegetables), drink 8-10 glasses of fluids a day, and keep active. A stool softener (with a doctor's prescription) once or twice a day may prevent constipation. If you do not have a bowel movement for 2-3 days, consult your doctor.

What precautions should I take to reduce the chances of getting infected during treatment with Hydroford 500 Capsule?

Since Hydroford 500 Capsule lowers the number of white blood cells and platelets in your blood, it puts you at risk of getting an infection. To prevent infections, avoid people who have infections. Check with your doctor immediately if you think you may be getting an infection, or if you get a fever or chills.

Fact Box

Chemical Class

Carboximidic acid derivative

Habit Forming

Therapeutic Class

ANTI NEOPLASTICS

Action Class

Other Anticancer Agents

Related lab tests

Bcr-Abl Gene Translocation (Qualitative)

Bcr-Abl Gene Translocation (Quantitative)

Complete Blood Count

Peripheral Smear Examination

References

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Johnlee Pharmaceuticals Pvt Ltd
Address: 42/44, Babu Genu Road, Shop No. 06, 2nd Floor, Om Shanti Co-op Housing Society, Kalbadevi Road, Mumbai-400002. (India)

Vendor Details

Country of origin: India

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Hydroford 500 Capsule

Hydroford 500 Capsule

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General Information

Contains

Marketer

Storage

Product introduction

Uses of Hydroford Capsule

Benefits of Hydroford Capsule

Side effects of Hydroford Capsule

How to use Hydroford Capsule

How Hydroford Capsule works

All substitutes for Hydroford 500 Capsule

Myelostat 500mg Capsule

Cytodrox Capsule

Unidrea 500mg Capsule

Hydab 500mg Capsule

Hydrogem 500mg Capsule

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Interferon Alpha 2B (Injection Route)

Didanosine (Oral Route)

Stavudine (Oral Route)

Frequently asked questions

What is Hydroford 500 Capsule used for?

How does Hydroford 500 Capsule help in sickle cell disease?

What side effects should I watch out for?

Can I take Hydroford 500 Capsule during pregnancy or while trying to conceive?

Do I need regular blood tests while on Hydroford 500 Capsule?

How to get relief from diarrhea while on treatment with Hydroford 500 Capsule?

Does Hydroford 500 Capsule cause hair loss?

I have noticed some changes in my skin after taking Hydroford 500 Capsule? What should I do?

How to relieve constipation during the treatment?

What precautions should I take to reduce the chances of getting infected during treatment with Hydroford 500 Capsule?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

Related lab tests

Bcr-Abl Gene Translocation (Qualitative)

Bcr-Abl Gene Translocation (Quantitative)

Complete Blood Count

Peripheral Smear Examination

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

Related/Popular tests