Grandem Injection

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Introduction

Grandem Injection is an anti-emetic medicine commonly used to control nausea and vomiting caused due to any surgery, cancer drug therapy, or radiotherapy.

Grandem Injection will not relieve other side effects associated with cancer treatments. It is administered under the supervision of a healthcare professional and should be taken as advised by the doctor. It is important that you keep having the injections until your doctor decides it is safe to stop them. After this, your doctor may prescribe tablets instead of injections. 

The most common side effects of taking this medicine include injection site pain or reaction, headache, constipation, diarrhea, and weakness. These symptoms should disappear when you stop taking the medicine but if they bother you or do not go away, your doctor may be able to suggest ways of preventing or reducing them.

Before taking this medicine, tell your doctor if you have heart or liver problems or a blockage in your stomach or intestines. Also tell your doctor about other drugs you are using, especially medicines to treat epilepsy, heart problems, cancer, and depression. These may affect, or be affected by, this medicine. If you are pregnant or breastfeeding, ask advice from your healthcare team.

Uses of Grandem Injection

  • Nausea and vomiting due to chemotherapy

Benefits of Grandem Injection

In Nausea and vomiting due to chemotherapy

Grandem Injection blocks the action of chemicals in the body that can make you feel or be sick. It is often used to prevent nausea and vomiting associated with cancer treatment such as chemotherapy or radiation therapy. This medicine helps you recover more comfortably from these treatments. Grandem Injection is given as an injection by a doctor, in the dose that is best for you, depending on the condition you are being treated for. Do not self-administer this medicine to avoid any undesirable side effects.

Side effects of Grandem Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Grandem

  • Injection site pain
  • Constipation
  • Diarrhea
  • Headache
  • Weakness
  • Insomnia (difficulty in sleeping)

How to use Grandem Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Grandem Injection works

Grandem Injection is an antiemetic medication. It works by blocking the action of a chemical messenger (serotonin) in the brain that may cause nausea and vomiting during anti-cancer treatment (chemotherapy) or after surgery.

Safety advice

Alcohol
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Grandem Injection. Please consult your doctor.
Pregnancy
SAFE IF PRESCRIBED
Grandem Injection is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
Breast feeding
SAFE IF PRESCRIBED
Grandem Injection is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Driving
SAFE
Grandem Injection does not usually affect your ability to drive.
Kidney
SAFE IF PRESCRIBED
Grandem Injection is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Grandem Injection may not be needed in these patients. Please consult your doctor.
Liver
SAFE IF PRESCRIBED
Grandem Injection is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Grandem Injection may not be needed in these patients. Please consult your doctor.

What if you forget to take Grandem Injection?

If you miss a dose of Grandem Injection, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.
Grandem Injection
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Quick tips

  • You have been prescribed Grandem Injection for prevention of nausea and vomiting caused after surgery or due to chemotherapy and radiotherapy.
  • Grandem Injection is given as an injection under the supervision of a doctor.
  • If you vomit within one hour of taking a dose, take another dose.
  • Avoid heavy meals and try eating small nourishing snacks throughout the day. Also, sip water regularly to help avoid dehydration.

Fact Box

Chemical Class
Indazole Derivative
Habit Forming
No
Therapeutic Class
GASTRO INTESTINAL
Action Class
Serotonin antagonists (5-HT3 antagonists)

Interaction with drugs

Taking Grandem with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Brand(s): Acicod, Montokuf, Codine Sulphate
SERIOUS
Brand(s): Parvodex
SERIOUS
Brand(s): Nalfy, Nacphin, Ruffy
SERIOUS
Brand(s): Wintal
SERIOUS

Patient concerns

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NAUSEA AND VOMITING DUE TO COLD
Dr. Sunil Sekhri
Diabetology
Tab Domstal 1 tab Stat and keep yourself warm
Vomiting, nausea neck pain backside
Dr. Vijay Verma
ENT
Neck pain may be due to nausea NAD vomiting Visit physician for the same
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User feedback


FAQs

Q. What is Grandem Injection used for?

Grandem Injection is an antiemetic medicine used to treat and prevent nausea or vomiting caused after any surgical procedure or due to certain medicines, stomach upset, or cancer treatment. It also prevents nausea due to motion sickness to some extent.

Q. What are the side effects of Grandem Injection?

The most common side effects of Grandem Injection are sleepiness, weakness, headache, constipation and diarrhea. However, these are not usually bothersome and resolve in some time on their own. Consult your doctor, if the symptoms worry you or persist for a longer duration. Your doctor will suggest ways to cope up with these side effects and to prevent them in future.

Q. Is Grandem Injection safe to be used in pregnant women?

Grandem Injection did not show any adverse effects in research studies done on animals. However, since the safety and efficiency of Grandem Injection in pregnant women is unknown. It is not recommended to be used in women who are pregnant women or if you are planning to conceive unless prescribed by your doctor.

Q. Is Grandem Injection better than Ondansetron?

Grandem Injection and Ondansetron belong to the same class of medicines, that is serotonin 5-HT3 receptor antagonists. Both these medicines help prevent nausea and vomiting effectively. However, some studies suggest that Grandem Injection is more effective than Ondansetron. According to some reports, Grandem Injection is comparatively well tolerated, quicker in action and alleviates nausea and vomiting relatively faster.

Q. Does Grandem Injection cause constipation?

Yes, Grandem Injection may cause constipation as one of the common side effects. However, this is usually not bothersome. Taking a fiber-rich diet can enhance your digestion and avoid constipation. You may also consider taking laxatives for relief and drink plenty of water too. Avoid drinking alcohol as it may worsen your constipation. If you still face issues, please consult your doctor to know about ways to treat it.

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Disclaimer:

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover all possible side effects, drug interactions or warnings or alerts. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

  1. Granisetron. Place of publication: Hameln Pharma Plus GmBh; 2008 [revised 8 Oct 2018]. [Accesses on 28 Mar. 2019] (online) Available from:External Link
  2. PubChem. Granisetron. [Accessed 28 Mar. 2019] (online) Available from:External Link
  3. Drugs.com. Granisetron Pregnancy and Breastfeeding Warnings. [Accessed 28 Mar. 2019] (online) Available from:External Link

Manufacturer/Marketer address

Mercantile Chamber, 3rd Floor, 12, J.N. Heredia Marg, Ballard Estate, Mumbai – 400 001, India.
Country of origin: India

Expires on or after: December, 2022

A licensed vendor partner from your nearest location will deliver Grandem Injection. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.
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