Estraderm MX 50 Transdermal Patch

Reviewed By Dr. Lalit Kanodia, MBA, MD Pharmacology

Last updated on 23 Sep 2025 | 07:18 PM (IST)

Estraderm MX 50 Transdermal Patch is a female sex hormone (estrogen). This is a hormone replacement therapy (HRT) that is used to treat symptoms associated with menopause (hot flushes, vaginal dryness and itching), estrogen deficiency (hypoestrogenism), and thinning of bones (osteoporosis).

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General Information

Contains

Estradiol (1.5mg)

Marketer

Novartis India Ltd

Storage

Store below 30°C

The content is shown in English

Product introduction

Estraderm MX 50 Transdermal Patch should be used as per the provided instructions by the doctor. Even if your symptoms improve, you should continue the treatment as it has been prescribed. The course of the treatment must be completed for better efficacy.

The most common side effects of this medicine include breast discomfort, abnormal menstrual bleeding, application site reactions, headache, nausea, abdominal pain, and abdominal distension. If any of these side effects bother you, consult your doctor. Also, tell your doctor if you notice bleeding from your vagina or develop breast lumps.

Before using this medicine you should tell your doctor if you have unexplained vaginal bleeding or if you have ever had a blood clot in your legs or your lungs. Once you have started using this medicine you should have regular check-ups to discuss the benefits of your treatment. It should not interact with any other medicines but it is not usually recommended during pregnancy or breastfeeding.

Uses of Estraderm Transdermal Patch

Hormone replacement therapy

Benefits of Estraderm Transdermal Patch

Hormone replacement therapy
Hormone placement therapy (HRT) is a treatment to relieve symptoms of menopause such as hot flushes, night sweats, mood swings, vaginal dryness, and reduced sex drive. Since menopause can last for several years, this treatment can make a big improvement to your daily life and mood. Estrogen is one of two important hormones (the other is progesterone) used in this treatment. You should use this medicine as it is prescribed, and for as long as it is prescribed by your doctor.

Side effects of Estraderm Transdermal Patch

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Estraderm

Application site reactions (burning, irritation, itching and redness)
Breast discomfort
Abnormal menstrual bleeding
Headache
Nausea
Abdominal pain
Abdominal distension

How to use Estraderm Transdermal Patch

Use this medicine in dose and duration as advised by your doctor. Check the label before use. Make sure the skin is clean and dry. Remove the protective liner of the patch. Do not touch the sticky side. With sticky side down, place the patch evenly onto the skin.

How Estraderm Transdermal Patch works

Estraderm MX 50 Transdermal Patch contains a medication called estrogen (female sex hormone). It works by replacing estrogen that is normally produced by the body.

Quick tips

You have been prescribed Estraderm MX 50 Transdermal Patch as a part of hormone replacement therapy to relieve symptoms of menopause.
It may also be used for preventing osteoporosis in postmenopausal women who are at high risk of fractures.
It has a lower risk of side effects since lower amount of estrogen is used in patches.
Apply it once a week, to a clean, dry, unbroken, non-irritated area of skin below the waist, on the lower back or buttocks. Do not expose it to sunlight.
Replace it every 7 days, and apply on a different area of skin to prevent skin irritation.
Inform your doctor if you experience any unusual vaginal bleeding or spotting, abnormal vaginal discharge or vaginal discomfort while taking Estraderm MX 50 Transdermal Patch.
Stop using this medicine and inform your doctor immediately if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, or changes in vision. These could be symptoms of a blood clot in a vein.

Safety advice

Alcohol

No interaction found/established

Pregnancy

UNSAFE

Estraderm MX 50 Transdermal Patch is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.

Breast feeding

UNSAFE

Estraderm MX 50 Transdermal Patch is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

Driving

No interaction found/established

Kidney

CAUTION

Estraderm MX 50 Transdermal Patch should be used with caution in patients with kidney disease. Dose adjustment of Estraderm MX 50 Transdermal Patch may be needed. Please consult your doctor.

Liver

CAUTION

Estraderm MX 50 Transdermal Patch should be used with caution in patients with liver disease. Dose adjustment of Estraderm MX 50 Transdermal Patch may be needed. Please consult your doctor.
Use of Estraderm MX 50 Transdermal Patch is not recommended in patients who previously had liver disease and the liver function tests are still not normal.

Interaction with drugs

Taking Estraderm with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Severe

Tamoxifen (Oral Route)

Do not consume Tamoxifen with Estradiol if you have or had breast cancer. If essential, consult your doctor. Estradiol may reduce the efficacy of Tamoxifen.

Severe

Letrozole (Oral Route)

Do not consume Letrozole with Estradiol if you have or had breast cancer. If essential, consult your doctor.

Severe

Fulvestrant (Injection Route)

Do not consume Fulvestrant with Estradiol if you have or had breast cancer. If essential, consult your doctor. Estradiol may reduce the efficacy of Fulvestrant.

Severe

Anastrozole (Oral Route)

Do not consume Anastrozole with Estradiol if you have or had breast cancer. If essential, consult your doctor. Estradiol may reduce the efficacy of Anastrozole.

Severe

Raloxifene (Oral Route)

Do not consume Raloxifene with Estradiol. If concurrent use is essential, please consult your doctor. Estradiol may reduce the efficacy of Raloxifene.

Frequently asked questions

Where to apply Estraderm MX 50 Transdermal Patch?

It is applied to the skin. You can stick the patch on to a hairless area of skin below the waist. You can also use it in places like buttock, lower back, hip or abdomen. Make sure that the applied site is dry and clean.

What are the most common side effects of using Estraderm MX 50 Transdermal Patch?

The common side effects associated with Estraderm MX 50 Transdermal Patch are application site reaction (redness, pain or itching), breast pain or tenderness, breakthrough vaginal bleeding, headache, nausea and stomach pain. If any of these side effects bother you, please consult with your doctor.

How should Estraderm MX 50 Transdermal Patch be used?

Apply it exactly as advised by your doctor. It should be applied below the panty line and not on breasts or any other area of the body. You can also use it on your buttocks. Wash and dry the area before using. The area should be free of any cuts, bruises, lotions, or creams. When you change your patch, do not put the new one in the same place. To help reduce the chance of skin redness or irritation, wait at least 1 week before you reuse a spot.

Fact Box

Chemical Class

Estradiol Congeners

Habit Forming

Therapeutic Class

GYNAECOLOGICAL

Action Class

Estrogens

References

Levin ER, Hammes SR. Estrogens and Progestins. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1173-75.
Masters SB. Hypothalmic & Pituitary Hormones. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 701-702.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 500-501.
Estradiol. Luxembou: Merus Labs Luxco II S.à R.L; 2009 [revised 25 Apr. 2016]. [Accessed 03 Apr. 2019] (online) Available from:
Chaves RG, Lamounier JA. Breastfeeding and maternal medications. J Pediatr (Rio J). 2004;80(5 Suppl):S189-S198. [Accessed 03 Apr. 2019] (online) Available from:
Central Drugs Standard Control Organisation (CDSCO). [Accessed 04 Apr. 2019] (online) Available from:
Oestradiol [Package Leaflet]. Uxbridge, UK: Norgine Pharmaceuticals Limited. [Accessed 24 June 2023]. (online) Available from:

User feedback

Patients taking Estraderm MX 50 Transdermal Patch

Once A Day

60%

Once A Week

20%

Twice A Week

10%

Twice A Day

10%

What are you using Estraderm Transdermal Patch for?

Hormone replacement therapy

80%

Others

13%

Post menopausal osteoporosis

How much was the improvement?

Average

60%

Excellent

40%

What were the side-effects while using Estraderm MX 50 Transdermal Patch?

No Side Effect

82%

Breast tenderness

Nausea

How do you take Estraderm Transdermal Patch?

With or without food

56%

With food

33%

Empty stomach

11%

Please rate Estraderm MX 50 Transdermal Patch on price

Average

54%

Expensive

33%

Not Expensive

12%

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Novartis India Ltd
Address: Sandoz House, Shiv Sagar Estate, Worli Mumbai -400 018, India

Vendor Details

Country of origin: India

Lab tests offered by us

Why we need a prescription?

Provide right medicines

Prescriptions are complex documents. We proof read and recheck at various steps to provide you the right medication in the correct form and dose

In accordance with the law

Most medicines cannot be sold without a valid prescription, as per the Drugs and Cosmetics Act, 1940 and Rules, 1945

Estraderm MX 50 Transdermal Patch

Save more with additional offers

Save more with additional offers

General Information

Contains

Marketer

Storage

Product introduction

Uses of Estraderm Transdermal Patch

Benefits of Estraderm Transdermal Patch

Side effects of Estraderm Transdermal Patch

How to use Estraderm Transdermal Patch

How Estraderm Transdermal Patch works

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Tamoxifen (Oral Route)

Letrozole (Oral Route)

Fulvestrant (Injection Route)

Anastrozole (Oral Route)

Raloxifene (Oral Route)

Frequently asked questions

Where to apply Estraderm MX 50 Transdermal Patch?

What are the most common side effects of using Estraderm MX 50 Transdermal Patch?

How should Estraderm MX 50 Transdermal Patch be used?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

References

User feedback

Patients taking Estraderm MX 50 Transdermal Patch

What are you using Estraderm Transdermal Patch for?

How much was the improvement?

What were the side-effects while using Estraderm MX 50 Transdermal Patch?

How do you take Estraderm Transdermal Patch?

Please rate Estraderm MX 50 Transdermal Patch on price

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

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