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Entacom Tablet

Entacapone (200mg)
Genuine
Authenticity Assured
Prescription
required
Entacom Tablet is used in the treatment of Parkinson's disease. It helps to treat wearing-off symptoms of Parkinson's disease, such as stiffness, tremors, muscle spasms, and poor muscle control.

Written By Dr. Swati Mishra, BDS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 07 Apr 2026 | 02:54 PM (IST)
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General Information

Contains

Entacapone (200mg)

Marketer

Intas Pharmaceuticals Ltd

Storage

Store below 30°C
The content is shown in English
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Entacom Tablet image
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Product introduction

Entacom Tablet is usually used in combination with carbidopa/levodopa. It may be taken with or without food, preferably at bedtime. However, take it at the same time each day as this helps to maintain a consistent level of medicine in the body. Take this medicine in the dose and duration as advised by your doctor.


Some common side effects of this medicine include nausea, vomiting, movement disorder, urine discoloration, and diarrhea. It may also cause dizziness and sleepiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you. It is common to have diarrhea with this medicine, so drink plenty of fluids and watch for weight loss. Inform your doctor if you develop any unusual changes in mood, an abnormally high sex drive, and hallucinations. It may cause your urine to change in a brownish-orange color but it is not harmful and usually resolves once treatment is completed. Please consult your doctor if these side effects worry you or do not go away.


If you have missed a dose, take it as soon as you remember it. This medication mustn't be stopped suddenly without talking to the doctor as it may worsen your condition. Your doctor may advise for periodic skin examination as it can cause melanoma.

Uses of Entacom Tablet

Benefits of Entacom Tablet

Parkinson's disease
Parkinson’s disease is a progressive nervous system disorder that affects movement, often causing tremors, stiffness, and slowed body motions. Entacom Tablet is used alongside other treatments to help manage the symptoms by improving the levels and effects of dopamine in the brain. This leads to more consistent control of movement, reducing "off" episodes when symptoms worsen, and enhancing the overall quality of life for individuals with Parkinson’s disease.

Side effects of Entacom Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Entacom
  • Nausea
  • Vomiting
  • Fatigue
  • Confusion
  • Constipation
  • Insomnia (difficulty in sleeping)
  • Nightmares
  • Hallucination
  • Dizziness
  • Diarrhea
  • Muscle coordination impaired
  • Abdominal pain
  • Dryness in mouth
  • Yellow discoloration of urine

How to use Entacom Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Entacom Tablet may be taken with or without food.

How Entacom Tablet works

Entacom Tablet is a selective reversible inhibitor that is given in combination with levodopa. It works by inhibiting a chemical messenger [catechol-O-methyl transferase (COMT)] which in turn helps in increasing the amount of dopamine (chemical messenger) in the brain. Thus, an adequate amount of dopamine in the brain helps to coordinate body movements.

All substitutes for Entacom Tablet

For information purposes only. Consult a doctor before taking any medicine.

Adcapone Tablet

by Sun Pharmaceutical Industries Ltd
₹9.08/tablet
4% costlier
<h3 class=bodySemiBold>Adcapone Tablet</h3>

Quick tips

  • You have been prescribed Entacom Tablet to enhance the effectiveness of levodopa for the treatment of Parkinson's disease.
  • It can make you very sleepy. Don't drive or do anything requiring concentration until you know how it affects you.
  • To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down.
  • Inform your doctor if you develop impulsive, unusual behavior and/or an abnormally high sex drive.
  • Talk to your doctor in case you develop hallucinations or other changes in your behavior.
  • It is common to have diarrhea with this drug. Therefore, drink plenty of fluids and watch for weight loss.
  • Do not get worried if you notice a reddish-brown discoloration in your urine as it is harmless in nature.
  • Do not stop taking the medication suddenly without talking to your doctor.

Safety advice

Alcohol

Alcohol

CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Entacom Tablet. Please consult your doctor.
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
The safety of Entacom Tablet during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.
Breast feeding

Breast feeding

CAUTION
Entacom Tablet should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from the body.
Driving

Driving

UNSAFE
Entacom Tablet may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Kidney

Kidney

CAUTION
Entacom Tablet should be used with caution in patients with severe kidney disease. Dose adjustment may be needed.
Liver

Liver

UNSAFE
Entacom Tablet is unsafe to use in patients with liver disease and should be avoided.

Interaction with drugs

Taking Entacom with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Moderate

Adrenaline (Injection Route)

Your doctor may monitor the effects of Adrenaline when taken concurrently with Entacapone.
Moderate

Apomorphine (Sublingual route)

If concurrent use is essential, your doctor may monitor Apomorphine levels along with your overall treatment and adjust the doses as per the observations. Entacapone may raise blood levels of Apomorphine.
Moderate

Apomorphine (Injection Route)

If concurrent use is essential, your doctor may monitor Apomorphine levels along with your overall treatment and adjust the doses as per the observations. Entacapone may raise blood levels of Apomorphine.
Moderate

Dobutamine (Injection Route)

Your doctor may monitor your treatment and adjust the doses as per the observations.
Moderate

Dopamine (Injection Route)

Your doctor may monitor your treatment and adjust the doses as per the observations.

Frequently asked questions

No, Entacom Tablet should not be crushed or split. Take it as a whole with a full glass of water at the same time as you take a dose of levodopa
Yes, Entacom Tablet may cause your urine to change to a brownish-orange color. This effect is common and is not harmful.
The combined use of Entacom Tablet and levodopa has been associated with cases of excessive daytime sleepiness and sudden sleep onset episodes. If you experience these symptoms, then you should neither drive nor operate other complex machinery. Consult your doctor if it becomes troublesome.
In impulse control disorders, you may get urges or cravings to behave in ways that are unusual for you. In such disorders, you cannot resist the impulse, drive or temptation to carry out certain activities that could harm yourself or others. Additionally, it may include addictive gambling, excessive eating or spending, an abnormally high sex drive or a preoccupation with an increase in sexual thoughts or feelings. In such a case, your doctor may suggest dose reduction or discontinuation of dose.
In case you take more than the recommended doses of Entacom Tablet, you may experience confusion, decreased activity, sleepiness, decreased muscle tone, skin discoloration, and urticaria. If any such symptoms occur, you should seek immediate medical attention in a nearby hospital or contact your doctor.
No, Entacom Tablet does not cross the blood-brain barrier. It is useful in prolonging the duration of the benefit obtained from individual doses of levodopa.
No, Entacom Tablet does not affect fertility. However, it should be avoided by pregnant and lactating women because there is no sufficient data to support the safety of this patient group.
No, it is not a dopamine agonist. Entacom Tablet is a selective and reversible inhibitor of COMT (catechol-O-methyltransferase) which works by increasing and maintaining sustained levels of levodopa when levodopa is given along with it.

Fact Box

Chemical Class

Hydroxycinnamic acid derivative

Habit Forming

No

Therapeutic Class

NEURO CNS

Action Class

Catechol-O-Methyltransferase (COMT) Inhibitors

References

  1. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 473-74.
  2. Entacapone. Espoo, Finland: Orion Corporation; 2000 [revised Jun. 2014]. [Accessed 25 Mar. 2019] (online) Available from:
  3. Entacapone. Newbury, Berkshire: Orion Pharma (UK) Limited; 1998 [revised 15 Dec. 2016]. [Accessed 28 Jan. 2019] (online) Available from:
  4. Merello M, Lees AJ, Webster R, et al. Effect of entacapone, a peripherally acting catechol-O-methyltransferase inhibitor, on the motor response to acute treatment with levodopa in patients with Parkinson's disease. J Neurol Neurosurg Psychiatry. 1994;57(2):186-89. [Accessed 19 Jun. 2019] (online) Available from:
  5. Entacapone. North Ryde, New South Wales: Novartis Pharmaceuticals Australia Pty Limited; 2013. [Accessed 19 Jun. 2019] (online) Available from:
  6. MedlinePlus. Entacapone. [Accessed on 25 Mar. 2019] (online) Available from:
  7. Entacapone [Prescribing Information]. East Hanover, N.J: Novartis Pharmaceuticals Corporation; 2020. [Accessed 25 Jul. 2024] (online) Available from:
  8. Entacapone [Prescribing Information]. Indianapolis, IN: MAJOR Pharmaceuticals; 2024. [Accessed 09 Jul. 2025] (online) Available from:
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User feedback

Twice A Day
40%
Four Times A Day
20%
Thrice A Day
20%
Once A Day
20%
Parkinson's disease
100%
Poor
50%
Average
50%
Nausea
40%
No Side Effect
20%
Constipation
20%
Confusion
20%
Empty stomach
67%
With food
33%
Not Expensive
33%
Average
33%
Expensive
33%
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Intas Pharmaceuticals Ltd
Address: Chinubhai Centre, Off. Nehru Bridge, Ashram Road, Ahmedabad - 380009. Gujarat. India.

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Entacom Tablet. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's â„ž and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India

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