Donif Syrup

Reviewed By Dr. Rajeev Sharma, MBA, MBBS

Last updated on 23 Sep 2025 | 07:24 PM (IST)

Donif Syrup is a medicine used to control nausea and vomiting due to certain medical conditions like stomach upset. It is also used to prevent nausea and vomiting caused due to surgery, cancer drug therapy, or radiotherapy.

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Donif Syrup

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Ondansetron (4mg)

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General Information

Contains

Ondansetron (4mg)

Marketer

Positif Life sciences

Storage

Store below 30°C

The content is shown in English

Product introduction

Donif Syrup may be used alone or with other medications and can be taken with or without food. Your doctor will suggest the appropriate dose depending on what you are taking it for. The first dose is normally taken before the start of surgery, chemotherapy, or radiotherapy. After these treatments, take any further doses as prescribed by your doctor (normally only for a few days at most). Take it regularly at the same time(s) each day to get the most benefit. Be careful not to take too much.

Donif Syrup does not relieve other side effects associated with cancer treatments. Also, it has little effect on vomiting caused by motion sickness. The most common side effects of taking this medicine include headache, diarrhea or constipation, and feeling tired. These symptoms should disappear when you stop taking the medicine. However, if these side effects bother you or do not go away, your doctor may be able to suggest ways of preventing or reducing them.

Before taking Donif Syrup, tell your doctor if you have heart or liver problems or a blockage in your stomach or intestines. Also, tell your doctor about any other medicines you might be taking, especially medicines to treat epilepsy, heart problems, cancer, and depression. These may affect, or be affected by, this medicine. If you are pregnant or breastfeeding, ask for advice from your doctor.

Uses of Donif Syrup

Benefits of Donif Syrup

Treatment and prevention of Vomiting
Donif Syrup is used to prevent and treat vomiting by blocking signals in the brain that trigger the vomiting reflex. It provides quick relief and helps patients feel more comfortable, especially after surgery, chemotherapy, or certain illnesses.

Treatment and prevention of Nausea
Donif Syrup helps relieve nausea by blocking chemical signals in the brain that cause the feeling of sickness. It is especially useful for nausea related to chemotherapy, radiation therapy, or surgery, making patients feel more at ease.

Side effects of Donif Syrup

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Donif

Fatigue
Headache
Constipation
Diarrhea

How to use Donif Syrup

Take this medicine in the dose and duration as advised by your doctor. Check the label for directions before use. Measure it with a measuring cup and take it by mouth. Shake well before use. Donif Syrup may be taken with or without food, but it is better to take it at a fixed time.

How Donif Syrup works

Donif Syrup is an antiemetic medication. It works by blocking the action of a chemical messenger (serotonin) in the brain that may cause nausea and vomiting during anti-cancer treatment (chemotherapy) or after surgery.

All substitutes for Donif Syrup

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

You have been prescribed Donif Syrup for the prevention of nausea and vomiting caused by surgery or due to chemotherapy and radiotherapy.
It is fast-acting and starts working within 30 minutes.
If you vomit within one hour of taking a dose, take another dose.
Avoid heavy meals and try eating small, nourishing snacks throughout the day. Also, sip water regularly to help avoid dehydration.

Safety advice

Alcohol

CAUTION

Caution is advised when consuming alcohol with Donif Syrup. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

Information regarding the use of Donif Syrup during pregnancy is not available. Please consult your doctor.

Breast feeding

CONSULT YOUR DOCTOR

Information regarding the use of Donif Syrup during breastfeeding is not available. Please consult your doctor.

Driving

CONSULT YOUR DOCTOR

It is not known whether Donif Syrup alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.

Kidney

SAFE IF PRESCRIBED

Donif Syrup is safe to use in patients with kidney disease. No dose adjustment of Donif Syrup is recommended.
However, inform your doctor if you have an underlying kidney disease. Limited information is available in patients taking this medicine for more than one day.

Liver

CAUTION

Donif Syrup should be used with caution in patients with severe liver disease. Dose adjustment of Donif Syrup may be needed. Please consult your doctor.

Interaction with drugs

Taking Donif with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Life-threatening

Disopyramide (Oral Route)

Do not consume Ondansetron with Disopyramide.

Life-threatening

Amiodarone (Oral Route)

Do not consume Ondansetron with Amiodarone.

Life-threatening

Amiodarone (Injection Route)

Do not consume Ondansetron with Amiodarone.

Life-threatening

Amisulpride (Oral Route)

Do not consume Ondansetron with Amisulpride.

Life-threatening

Amisulpride (Injection Route)

Do not consume Ondansetron with Amisulpride.

Frequently asked questions

How quickly does Donif Syrup work?

Donif Syrup starts working within half an hour to 2 hours. It dissolves rapidly into the bloodstream and starts showing its effect.

What are the side effects of Donif Syrup?

The most common side effects of Donif Syrup are constipation, diarrhea, fatigue, and headache. However, these are usually not bothersome and resolve on their own after some time. Consult your doctor if these persist or worry you.

When should you take Donif Syrup?

Donif Syrup should be taken with a full glass of water, with or without food. It should be used exactly as per the dose and duration advised by the doctor. Usually, the first dose of Donif Syrup is taken before the start of your surgery, chemotherapy, or radiation treatment.

Is Donif Syrup a steroid?

No, Donif Syrup is an antiemetic and not a steroid. Donif Syrup is a selective 5-HT3 receptor antagonist. It is prescribed for the prevention and treatment of nausea and vomiting, which is commonly observed after surgery or due to cancer chemotherapy.

Does Donif Syrup work for seasickness?

No, Donif Syrup does not work for seasickness. This is because Donif Syrup has very little effect on the nausea associated with motion sickness.

Fact Box

Chemical Class

Carbazole Derivative

Habit Forming

Therapeutic Class

GASTRO INTESTINAL

Action Class

Serotonin 5-HT3 Receptor Antagonists

References

Sharkey KA, Wallace JL. Treatment of Disorders of Bowel Motility and Water Flux; Anti-Emetics; Agents Used in Biliary and Pancreatic Disease. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1341-42.
Katzung BG. Histamine, Serotonin, & the Ergot Alkaloids. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 285
Ondansetron. Portage, IN: Monosol Rx, LLC; 1991 [revised Jul. 2010]. [Accessed 28 Mar. 2019] (online) Available from:
Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Ondansetron. [Updated 2019 Feb 7]. [Accessed 20 Feb. 2020] (online) Available from:
Central Drugs Standard Control Organisation (CDSCO). [Accessed 28 Mar. 2019] (online) Available from:
Ondansetron hydrochloride [Prescribing Information]. Research Triangle Park, NC: GlaxoSmithKline; 2016. [Accessed 25 Jul. 2024] (online) Available from:
Ondansetron [Prescribing Information]. Mahwah, NJ: Glenmark Pharmaceuticals Inc.; 2021. [Accessed 19 Mar. 2025] (online) Available from:
Ondansetron [Prescribing Information]. 2022. [Accessed 19 Mar. 2025] (online) Available from:

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Positif Life sciences
Address: sco-228(top floor), sector 40-d, chandigarh, 160036

Vendor Details

Country of origin: India

Lab tests offered by us

Why we need a prescription?

Donif Syrup

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General Information

Contains

Marketer

Storage

Product introduction

Uses of Donif Syrup

Benefits of Donif Syrup

Side effects of Donif Syrup

How to use Donif Syrup

How Donif Syrup works

All substitutes for Donif Syrup

Vomigen 4mg Syrup

Onsett 4mg Syrup

Vomhit 4mg Syrup

Ondavom 4mg Syrup

Ondigo 4mg Syrup

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Disopyramide (Oral Route)

Amiodarone (Oral Route)

Amiodarone (Injection Route)

Amisulpride (Oral Route)

Amisulpride (Injection Route)

Frequently asked questions

How quickly does Donif Syrup work?

What are the side effects of Donif Syrup?

When should you take Donif Syrup?

Is Donif Syrup a steroid?

Does Donif Syrup work for seasickness?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

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