Denbri Injection

Reviewed By Dr. Rajeev Sharma, MBA, MBBS

Last updated on 31 Mar 2026 | 06:36 PM (IST)

Denbri Injection is a medicine used in the treatment of osteoporosis in postmenopausal women and in men at increased risk of fractures. It makes the bones strong and reduce the risk of fractures.

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Cold stored

Stored between 2-8°C

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Denbri Injection

prefilled syringe of 1 ml Injection

₹26792

~~₹29312.6~~

Same composition

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prefilled syringe of 1 Injection

Denosumab (60mg/ml)

by Lupin Ltd

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General Information

Contains

Denosumab (60mg/ml)

Marketer

RPG Life Sciences Ltd

Storage

Store in a refrigerator (2 - 8°C). Do not freeze.

The content is shown in English

Product introduction

Denbri Injection is given by a healthcare professional and should not be self-administered. You should use it regularly and at the same time each day to get maximum benefit from it. Continue using it as recommended by your doctor and complete the dose even if you feel better. To make it more effective, take adequate amount of calcium and vitamin D supplements while on treatment with this medicine.

Some common side effects of this medicine include headache, pain in extremity, musculoskeletal pain, nerve pain, constipation, and rash. Talk to your doctor if any of these side effects does not go away with time or get worse. Your doctor may help with ways to reduce or prevent these symptoms.

To make sure the medicine is safe for you, before taking it, let your doctor know of all the other medicines you are taking. It is important for pregnant and breastfeeding mothers to ask the advice of their doctors before using this medicine.

Uses of Denbri Injection

Osteoporosis

Benefits of Denbri Injection

Osteoporosis
Osteoporosis is a condition where bones become weak and brittle, making them more prone to fractures even with minor falls or injuries. Denbri Injection helps slow down bone breakdown and increases bone density, reducing the risk of fractures in the spine, hip, and other bones. This supports stronger, healthier bones and improves overall bone strength.

Side effects of Denbri Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Denbri

Rash
Musculoskeletal (bone, muscle or joint) pain
Eczema
Upper respiratory tract infection
Sciatica
Pain in extremities
Back pain
Joint pain
Urinary tract infection
Constipation
Abdominal discomfort
Hair loss
Hypercholesterolemia (high cholesterol)
Cystitis
Nerve pain
Headache

How to use Denbri Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Denbri Injection works

Denbri Injection is a monoclonal antibody. It binds to a protein that causes bone loss, thereby strengthening the bone and minimizing the risk of fractures.

All substitutes for Denbri Injection

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

Denbri Injection is a medication used to treat thinning of the bones (called osteoporosis).
Take calcium and vitamin D to help build your bones when taking Denbri Injection.
Do not take if you are pregnant or plan to become pregnant.
May cause a rare problem of the jaw (osteonecrosis), mostly seen after a dental procedure. Tell your doctor if you develop sudden jaw pain.
Denbri Injection may also increase the risk of infection. Avoid being close to people with cold, flu or other contagious illnesses.
Tell your doctor if you develop a rash while taking Denbri Injection.
Denbri Injection is a medication used to treat thinning of the bones (called osteoporosis).
Take calcium and vitamin D to help build your bones when taking Denbri Injection.
Do not take if you are pregnant or plan to become pregnant.
May cause a rare problem of the jaw (osteonecrosis), mostly seen after a dental procedure. Tell your doctor if you develop sudden jaw pain.
Denbri Injection may also increase the risk of infection. Avoid being close to people with cold, flu or other contagious illnesses.
Tell your doctor if you develop a rash while taking Denbri Injection.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Denbri Injection. Please consult your doctor.

Pregnancy

UNSAFE

Denbri Injection is highly unsafe during pregnancy. It can cause serious harm to the unborn baby, including birth defects and pregnancy loss. Do not use this medicine if you are pregnant or planning to become pregnant.

Breast feeding

CAUTION

Denbri Injection should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from the body.

Driving

CONSULT YOUR DOCTOR

It is not known whether Denbri Injection alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. Please consult your doctor.

Kidney

SAFE IF PRESCRIBED

Denbri Injection is probably safe to use in patients with kidney disease. Limited data suggest dose adjustment may not be needed.

Liver

SAFE IF PRESCRIBED

Denbri Injection is probably safe to use in patients with liver disease. Limited data suggest dose adjustment may not be needed.

Interaction with drugs

Taking Denbri with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Moderate

Cinacalcet (Oral Route)

Your doctor may monitor your treatment and adjust the doses as per the observations. Denosumab may increase the metabolism of Cinacalcet.

Frequently asked questions

How long can you stay on Denbri Injection?

There is no optimal duration of treatment of osteoporosis with Denbri Injection. The patient’s response and tolerability to the medicine is continuously monitored through periodic assessments, especially after 5 years of use of Denbri Injection. Depending on this, the duration of taking Denbri Injection is decided.

Does Denbri Injection cause hair loss?

Yes, hair loss is a common side effect of Denbri Injection though it does not affect everyone. Discuss with your doctor if you have concerns regarding your hair loss.

Is Denbri Injection a chemotherapy drug?

Denbri Injection is not a chemotherapy drug. It is a protein (monoclonal antibody) that interferes with the action of another protein in order to treat bone loss and osteoporosis. Treatment with Denbri Injection makes the bones stronger and less likely to break.

How is Denbri Injection given and how often?

Denbri Injection is available as an injection and is given by a healthcare professional. It is given once in 6 months. Your doctor may also advise you to take calcium and vitamin D while taking Denbri Injection.

Can Denbri Injection be taken during pregnancy?

No, pregnant women should not take Denbri Injection. You must use an effective method of birth control during and for at least 5 months after the last dose of Denbri Injection if you can become pregnant.

How should Denbri Injection be stored?

Denbri Injection should be stored in a refrigerator at 36°F to 46°F (2°C to 8°C) in the original carton. Warm temperatures can make it ineffective, and therefore proper storage is necessary. When you remove it from the refrigerator, keep it at room temperature [up to 77°F (25°C)] in the original carton and use it within 14 days.

Does Denbri Injection cause osteonecrosis of the jaw?

Osteonecrosis is a rare side effect of Denbri Injection. It refers to the damage caused to the bone of jaw. To avoid this, you should maintain good oral hygiene and receive routine dental check ups while taking Denbri Injection. Contact your doctor and dentist immediately if you experience any problems with your mouth or teeth such as loose teeth, discharge, pain or swelling, or non-healing of sores. These could be signs of osteonecrosis of jaw.

How long can you stay on Denbri Injection?

Does Denbri Injection cause hair loss?

Yes, hair loss is a common side effect of Denbri Injection though it does not affect everyone. Discuss with your doctor if you have concerns regarding your hair loss.

Is Denbri Injection a chemotherapy drug?

How is Denbri Injection given and how often?

Can Denbri Injection be taken during pregnancy?

How should Denbri Injection be stored?

Does Denbri Injection cause osteonecrosis of the jaw?

Fact Box

Chemical Class

Peptides

Habit Forming

Therapeutic Class

PAIN ANALGESICS

Action Class

Bone Resorption Inhibitors- Monoclonal Antibodies

Related lab tests

Calcium

References

Bikle DD. Agents That Affects Bone Mineral Homoestasis. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 766.
Friedman PA. Agents Affecting Mineral Ion Homeostasis and Bone Turnover. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 1299.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. p. 370.
Denosumab. Milton Road, Cambridge: Amgen Ltd.; 2010 [revised Jun. 2018]. [Accessed 02 Apr. 2019] (online) Available from:
Denosumab [Prescribing Information]. Thousand Oaks, California: Amgen Manufacturing Limited; 2013. [Accessed 20 Feb. 2024] (online) Available from:

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: RPG Life Sciences Ltd
Address: 463, 4 th Floor, RPG HOUSE, Dr. Annie Besant Road, Worli, Mumbai – 400 030. Maharashtra, INDIA

Vendor Details

Country of origin: India

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Why we need a prescription?

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Prescriptions are complex documents. We proof read and recheck at various steps to provide you the right medication in the correct form and dose

In accordance with the law

Most medicines cannot be sold without a valid prescription, as per the Drugs and Cosmetics Act, 1940 and Rules, 1945

Denbri Injection

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General Information

Contains

Marketer

Storage

Product introduction

Uses of Denbri Injection

Benefits of Denbri Injection

Side effects of Denbri Injection

How to use Denbri Injection

How Denbri Injection works

All substitutes for Denbri Injection

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