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Denbri Injection

Prescription Required
Store in a refrigerator (2 - 8°C). Do not freeze.

Product introduction

Denbri Injection is a medicine used in the treatment of osteoporosis in postmenopausal women and in men at increased risk of fractures. It makes the bones strong and reduce the risk of fractures.

Denbri Injection is given by a healthcare professional and should not be self-administered. You should use it regularly and at the same time each day to get maximum benefit from it. Continue using it as recommended by your doctor and complete the dose even if you feel better. To make it more effective, take adequate amount of calcium and vitamin D supplements while on treatment with this medicine.

Some common side effects of this medicine include headache, pain in extremity, musculoskeletal pain, nerve pain, constipation, and rash. Talk to your doctor if any of these side effects does not go away with time or get worse. Your doctor may help with ways to reduce or prevent these symptoms.

To make sure the medicine is safe for you, before taking it, let your doctor know of all the other medicines you are taking. It is important for pregnant and breastfeeding mothers to ask the advice of their doctors before using this medicine.

Uses of Denbri Injection

Benefits of Denbri Injection

In Osteoporosis

Osteoporosis is a common condition that weakens bones, making them fragile and more likely to break. It often occurs in women after menopause. This condition can be treated with bone-strengthening medicines. Denbri Injection slows down the rate at which bone is broken down in your body. This maintains bone density and reduces your risk of breaking a bone. The injection is given by a doctor or nurse and should not be self-administered.
You can help improve the strength of your bones by doing regular exercise (especially weight-bearing exercise), eating healthy foods containing calcium and Vitamin D and reducing your consumption of alcohol and tobacco. Supplements of calcium and Vitamin D3 are also effective.

Side effects of Denbri Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Denbri

  • Musculoskeletal (bone, muscle or joint) pain
  • Pain in extremities
  • Nerve pain
  • Constipation
  • Rash
  • Headache

How to use Denbri Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Denbri Injection works

Denbri Injection is a monoclonal antibody. It binds to a protein that causes bone loss, thereby strengthening the bone and minimizing the risk of fractures.

Safety advice

Caution is advised when consuming alcohol with Denbri Injection. Please consult your doctor.
Denbri Injection is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.
Breast feeding
Denbri Injection is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Denbri Injection does not usually affect your ability to drive.
Denbri Injection should be used with caution in patients with severe kidney disease. Dose adjustment of Denbri Injection may be needed. Please consult your doctor.
Denbri Injection should be used with caution in patients with severe liver disease. Dose adjustment of Denbri Injection may be needed. Please consult your doctor.

What if you forget to take Denbri Injection?

If you miss a dose of Denbri Injection, please consult your doctor.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.
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Quick tips

  • Denbri Injection is a medication used to treat thinning of the bones (called osteoporosis).
  • Take calcium and vitamin D to help build your bones when taking Denbri Injection.
  • Do not take if you are pregnant or plan to become pregnant.
  • May cause a rare problem of the jaw (osteonecrosis), mostly seen after a dental procedure. Tell your doctor if you develop sudden jaw pain.
  • Denbri Injection may also increase the risk of infection. Avoid being close to people with cold, flu or other contagious illnesses.
  • Tell your doctor if you develop a rash while taking Denbri Injection.

Fact Box

Chemical Class
Monoclonal antibody (mAb)
Habit Forming
Therapeutic Class

Patient concerns

Teriparatide is this injection advisable?
Dr. Akshat Goel
Yes, it's good in Osteoporosis
Details About osteoporosis treatment
Dr. Akshat Goel
Take Calcium and Vitamin-D3 supplements


Q. How long can you stay on Denbri Injection?

There is no optimal duration of treatment of osteoporosis with Denbri Injection. The patient’s response and tolerability to the medicine is continuously monitored through periodic assessments, especially after 5 years of use of Denbri Injection. Depending on this, the duration of taking Denbri Injection is decided.

Q. Does Denbri Injection cause hair loss?

Yes, hair loss is a common side effect of Denbri Injection though it does not affect everyone. Discuss with your doctor if you have concerns regarding your hair loss.

Q. Is Denbri Injection a chemotherapy drug?

Denbri Injection is not a chemotherapy drug. It is a protein (monoclonal antibody) that interferes with the action of another protein in order to treat bone loss and osteoporosis. Treatment with Denbri Injection makes the bones stronger and less likely to break.

Q. How is Denbri Injection given and how often?

Denbri Injection is available as an injection and is given by a healthcare professional. It is given once in 6 months. Your doctor may also advise you to take calcium and vitamin D while taking Denbri Injection.

Q. Can Denbri Injection be taken during pregnancy?

No, pregnant women should not take Denbri Injection. You must use an effective method of birth control during and for at least 5 months after the last dose of Denbri Injection if you can become pregnant.

Q. How should Denbri Injection be stored?

Denbri Injection should be stored in a refrigerator at 36°F to 46°F (2°C to 8°C) in the original carton. Warm temperatures can make it ineffective, and therefore proper storage is necessary. When you remove it from the refrigerator, keep it at room temperature [up to 77°F (25°C)] in the original carton and use it within 14 days.

Q. Does Denbri Injection cause osteonecrosis of the jaw?

Osteonecrosis is a rare side effect of Denbri Injection. It refers to the damage caused to the bone of jaw. To avoid this, you should maintain good oral hygiene and receive routine dental check ups while taking Denbri Injection. Contact your doctor and dentist immediately if you experience any problems with your mouth or teeth such as loose teeth, discharge, pain or swelling, or non-healing of sores. These could be signs of osteonecrosis of jaw.
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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.


  1. Bikle DD. Agents That Affects Bone Mineral Homoestasis. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 766.
  2. Friedman PA. Agents Affecting Mineral Ion Homeostasis and Bone Turnover. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 1299.
  3. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. p. 370.
  4. Denosumab. [Accessed 02 Apr. 2019] (online) Available from:External Link
  5. Denosumab. Milton Road, Cambridge: Amgen Ltd.; 2010 [revised Jun. 2018]. [Accessed 02 Apr. 2019] (online) Available from:External Link
  6. Denosumab [Prescribing Information]. Thousand Oaks, California: Amgen Manufacturing Limited; 2013. [Accessed 20 Feb. 2024] (online) Available from: External Link

Marketer details

Name: RPG Life Sciences Ltd
Address: 463, 4 th Floor, RPG HOUSE, Dr. Annie Besant Road, Worli, Mumbai – 400 030. Maharashtra, INDIA
Country of origin: India

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