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Cinacalcet is used to treat secondary hyperparathyroidism in patients with serious kidney disease who need dialysis, in hypercalcemia patients with parathyroid cancer (hypercalcemia) or primary hyperparathyroidism (despite surgical removal of gland) or when surgical removal of enlarged parathyroid gland (a gland in neck which maintains calcium level in body) is not possible.

How it works

Cinacalcet belongs to a class of drugs called as calcimimetics. It works by signaling the parathyroid gland to produce less amount of chemical called parathyroid hormone which lowers the excess blood calcium levels resulting in thinning of bones.

Common side effects

Burning sensation, Chest pain, Convulsion, Dizziness, Muscle pain, Muscle cramp, Stomach upset, Tingling sensation of extremity, Tingling sensation, Weakness, Vomiting, Diarrhoea


Expert advice

  • Inform your doctor before taking cinacalcet if you have heart or liver problems, seizures (fits), history of life threatening hypocalcemia (low blood calcium levels) or if you have started or stopped smoking.
  • Consult your doctor before taking the medicine if you are pregnant, planning to become pregnant or breastfeeding.
  • Inform your doctor before taking the medicine if you are taking medicines used to treat skin or bacterial infections, fungal infections, HIV infection, heart problems, depression or high blood pressure.
  • Take this medicine with food or meals as may lead to better absorption of the drug.
  • Do not drive or operate heavy machinery after taking this drug as it may lead to dizziness.

Frequently asked questions


 Q. What is cinacalcet used for?
Cinacalcet is used to treat increased blood calcium levels cause due to a condition called as hyperparathyroidism.
Q. How does cinacalcet work?
Cinacalcet works by decreasing the level of parathyroid hormone which further prevents the increased level of calcium in the blood.

Content on this page was last updated on 30 September, 2016, by Dr. Varun Gupta (MD Pharmacology)